Detailed information for compound 1532178

Basic information

Technical information
  • TDR Targets ID: 1532178
  • Name: N'-(3,4-dichlorobenzoyl)pyridine-3-carbohydra zide
  • MW: 310.135 | Formula: C13H9Cl2N3O2
  • H donors: 2 H acceptors: 3 LogP: 2.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)Cl)Cl)NNC(=O)c1cccnc1
  • InChi: 1S/C13H9Cl2N3O2/c14-10-4-3-8(6-11(10)15)12(19)17-18-13(20)9-2-1-5-16-7-9/h1-7H,(H,17,19)(H,18,20)
  • InChiKey: MJNZUUOEYVXCTB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[(3,4-dichlorophenyl)-oxomethyl]-3-pyridinecarbohydrazide
  • N'-(3,4-dichlorobenzoyl)nicotinohydrazide
  • N'-(3,4-dichlorophenyl)carbonylpyridine-3-carbohydrazide
  • ZINC00333510
  • AG-670/36923042

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0515 0.7089
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0109 0.2498 0.2498
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0137 0.3193 1
Schistosoma mansoni carbonic anhydrase 0.0057 0.1176 0.152
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0106 0.2398 0.2398
Echinococcus granulosus carbonic anhydrase 0.0057 0.1176 0.152
Trypanosoma cruzi histone deacetylase 1, putative 0.0037 0.0669 0.2097
Schistosoma mansoni sterol O-acyltransferase 1 0.0317 0.7738 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0031 0.0515 0.0665
Schistosoma mansoni hypothetical protein 0.0029 0.0467 0.0604
Echinococcus granulosus histone deacetylase 3 0.0037 0.0669 0.0865
Brugia malayi TAR-binding protein 0.0044 0.0832 0.0832
Echinococcus multilocularis tar DNA binding protein 0.0044 0.0832 0.1075
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.1176 0.152
Entamoeba histolytica vacuolar protein sorting 26 0.0031 0.0515 0.7089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0045
Leishmania major carbonic anhydrase-like protein 0.0106 0.2398 0.7511
Echinococcus multilocularis sterol O acyltransferase 1 0.0317 0.7738 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0137 0.3193 1
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0031 0.0515 0.0665
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0138 0.0432
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0138 0.0138
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.1404 0.4396
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0138 0.0178
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.1404 0.1814
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0137 0.3193 0.4126
Brugia malayi latrophilin 2 splice variant baaae 0.0029 0.0467 0.0467
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.1404 0.1814
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0031 0.0515 0.0665
Schistosoma mansoni eyes absent homolog 0.0075 0.1631 0.2107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0138 0.0432
Schistosoma mansoni histone deacetylase 0.0037 0.0669 0.0865
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0137 0.3193 0.4126
Echinococcus multilocularis carbonic anhydrase 0.0057 0.1176 0.152
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.1176 0.1176
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.1404 0.4143
Brugia malayi hypothetical protein 0.0056 0.1153 0.1153
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0106 0.2398 0.7511
Echinococcus multilocularis lamin 0.0012 0.0045 0.0059
Loa Loa (eye worm) hypothetical protein 0.0056 0.1153 0.1153
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0031 0.0515 0.1612
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0515 0.0665
Onchocerca volvulus Putative GMP reductase 0.0057 0.1171 0.1171
Leishmania major glycerol uptake protein, putative 0.0031 0.0515 0.1612
Leishmania major histone deacetylase, putative 0.0037 0.0669 0.2097
Onchocerca volvulus 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0317 0.7738 0.7738
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1404 0.4143
Loa Loa (eye worm) hypothetical protein 0.0031 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0013 0.0073 0.0094
Echinococcus granulosus carbonic anhydrase 0.0057 0.1176 0.152
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0109 0.2498 0.2498
Toxoplasma gondii hypothetical protein 0.0057 0.1176 0.3684
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0515 0.0665
Brugia malayi MBOAT family protein 0.0031 0.0515 0.0515
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.1176 0.1176
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0515 0.7089
Trichomonas vaginalis histone deacetylase, putative 0.0037 0.0669 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1404 0.1814
Brugia malayi MBOAT family protein 0.0031 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0013 0.0073 0.0094
Brugia malayi diacylglycerol acyltransferase 0.0031 0.0515 0.0515
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0138 0.0432
Brugia malayi Muscleblind-like protein 0.0128 0.2953 0.2953
Echinococcus granulosus geminin 0.0078 0.1697 0.2193
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0515 0.7089
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0515 0.0665
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0137 0.3193 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0057 0.1171 0.1171
Schistosoma mansoni ap endonuclease 0.0016 0.0138 0.0178
Echinococcus multilocularis lamin dm0 0.0012 0.0045 0.0059
Plasmodium falciparum histone deacetylase 1 0.0037 0.0669 0.2241
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0031 0.0515 0.1723
Leishmania major inosine-5-monophosphate dehydrogenase 0.0137 0.3193 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0057 0.1176 0.1176
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0515 0.0665
Brugia malayi GMP reductase 0.0057 0.1171 0.1171
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.1176 0.152
Schistosoma mansoni lozenge 0.0051 0.1021 0.1319
Brugia malayi hypothetical protein 0.0075 0.1631 0.1631
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0106 0.2398 0.2398
Treponema pallidum alginate O-acetylation protein (algI) 0.0031 0.0515 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0138 0.0178
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0031 0.0515 0.0665
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0037 0.0669 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0106 0.2398 0.2398
Leishmania major histone deacetylase, putative 0.0037 0.0669 0.2097
Brugia malayi hypothetical protein 0.0129 0.299 0.299
Schistosoma mansoni intermediate filament proteins 0.0012 0.0045 0.0059
Trichomonas vaginalis histone deacetylase, putative 0.0037 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0515 0.0515
Onchocerca volvulus 0.0129 0.299 0.299
Schistosoma mansoni zinc finger protein 0.0031 0.0515 0.0665
Brugia malayi Intermediate filament tail domain containing protein 0.0012 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0407 1 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0072 0.155 0.0954
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.1404 0.4396
Loa Loa (eye worm) runx1 0.0051 0.1021 0.1021
Entamoeba histolytica hypothetical protein 0.0031 0.0515 0.7089
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.022 0.022
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0515 0.7089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0043 0.0807 0.0807
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0137 0.3193 0.4126
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0515 0.7089
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0012 0.0045 0.0045
Trypanosoma cruzi GUP1, putative 0.0031 0.0515 0.1612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0109 0.2498 0.3228
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0137 0.3193 1
Leishmania major hypothetical protein, conserved 0.0031 0.0515 0.1612
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0515 0.0665
Onchocerca volvulus 0.0012 0.0045 0.0045
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0073 0.0073
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0031 0.0515 0.1612
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0031 0.0515 0.0665
Echinococcus multilocularis musashi 0.0012 0.0045 0.0059
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0073 0.0094
Schistosoma mansoni hypothetical protein 0.0078 0.1697 0.2193
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0031 0.0515 0.0665
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0037 0.0669 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0515 0.7089
Echinococcus granulosus carbonic anhydrase 0.0057 0.1176 0.152
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0515 0.0665
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0832 0.1075
Loa Loa (eye worm) hypothetical protein 0.0075 0.1631 0.1631
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0129 0.2988 1
Toxoplasma gondii hypothetical protein 0.0031 0.0515 0.1612
Echinococcus granulosus muscleblind protein 0.0128 0.2953 0.3816
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0515 0.0515
Echinococcus granulosus GPCR family 2 0.0013 0.0073 0.0094
Trichomonas vaginalis histone deacetylase, putative 0.0037 0.0669 1
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0031 0.0515 0.0515
Toxoplasma gondii IMP dehydrogenas 0.0137 0.3193 1
Plasmodium vivax histone deacetylase 1, putative 0.0037 0.0669 0.2241
Echinococcus granulosus tar DNA binding protein 0.0044 0.0832 0.1075
Loa Loa (eye worm) hypothetical protein 0.0128 0.2953 0.2953
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0515 0.0665
Trypanosoma brucei histone deacetylase 1 0.0037 0.0669 0.2097
Echinococcus multilocularis carbonic anhydrase 0.0057 0.1176 0.152
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0138 0.0138
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0106 0.2398 0.3099
Schistosoma mansoni hypothetical protein 0.0057 0.1176 0.152
Schistosoma mansoni lamin 0.0012 0.0045 0.0059
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0137 0.3193 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0073 0.0094
Loa Loa (eye worm) hypothetical protein 0.0057 0.1176 0.1176
Giardia lamblia Histone deacetylase 0.0037 0.0669 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.022 0.022
Leishmania major glycerol uptake protein, putative 0.0031 0.0515 0.1612
Loa Loa (eye worm) TAR-binding protein 0.0044 0.0832 0.0832
Toxoplasma gondii histone deacetylase HDAC2 0.0037 0.0669 0.2097
Trichomonas vaginalis transmembrane protein nessy, putative 0.0031 0.0515 0.7089
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0031 0.0515 0.0665
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0515 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0109 0.2498 0.3228
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0031 0.0515 0.1723
Loa Loa (eye worm) hypothetical protein 0.0029 0.0467 0.0467
Loa Loa (eye worm) intermediate filament protein 0.0012 0.0045 0.0045
Loa Loa (eye worm) IMP dehydrogenase 1 0.0137 0.3193 0.3193
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0129 0.2988 0.9327
Echinococcus multilocularis GPCR, family 2 0.0013 0.0073 0.0094
Trypanosoma cruzi GUP1, putative 0.0031 0.0515 0.1612
Onchocerca volvulus 0.0407 1 1
Schistosoma mansoni lamin 0.0012 0.0045 0.0059
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0515 0.1612
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0073 0.0094
Leishmania major guanosine monophosphate reductase 0.0137 0.3193 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0073 0.0073
Brugia malayi MBOAT family protein 0.0031 0.0515 0.0515
Brugia malayi RNA recognition motif domain containing protein 0.0044 0.0832 0.0832
Echinococcus multilocularis histone deacetylase 3 0.0037 0.0669 0.0865
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0043 0.0807 0.0807
Brugia malayi histone deacetylase 3 (HD3) 0.0037 0.0669 0.0669
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0031 0.0515 0.0665
Schistosoma mansoni histone deacetylase 0.0037 0.0669 0.0865
Trichomonas vaginalis histone deacetylase, putative 0.0037 0.0669 1
Schistosoma mansoni hypothetical protein 0.0078 0.1697 0.2193
Onchocerca volvulus 0.0031 0.0515 0.0515
Trypanosoma cruzi histone deacetylase 1, putative 0.0037 0.0669 0.2097
Loa Loa (eye worm) hypothetical protein 0.0286 0.6956 0.6956
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0109 0.2498 0.3228
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0137 0.3193 1
Plasmodium falciparum carbonic anhydrase 0.0057 0.1176 0.3937
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0109 0.2498 0.3228
Echinococcus multilocularis Protein lozenge 0.0051 0.1021 0.1319
Toxoplasma gondii histone deacetylase HDAC3 0.0037 0.0669 0.2097
Trypanosoma brucei glycerol uptake protein, putative 0.0031 0.0515 0.1612
Loa Loa (eye worm) hhat protein 0.0031 0.0515 0.0515
Entamoeba histolytica histone deacetylase, putative 0.0037 0.0669 1
Loa Loa (eye worm) RNA binding protein 0.0044 0.0832 0.0832
Leishmania major glycerol uptake protein, putative 0.0031 0.0515 0.1612
Trypanosoma brucei carbonic anhydrase-like protein 0.0106 0.2398 0.7511
Loa Loa (eye worm) histone deacetylase 3 0.0037 0.0669 0.0669
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0106 0.2398 0.7511
Echinococcus multilocularis muscleblind protein 0.0128 0.2953 0.3816
Loa Loa (eye worm) hypothetical protein 0.0037 0.0669 0.0669
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0037 0.0669 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0106 0.2398 0.3099
Brugia malayi MBOAT family protein 0.0031 0.0515 0.0515
Echinococcus granulosus carbonic anhydrase II 0.0106 0.2398 0.3099
Brugia malayi intermediate filament protein 0.0012 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0031 0.0515 0.0665
Echinococcus granulosus intermediate filament protein 0.0012 0.0045 0.0059
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0031 0.0515 0.0665
Leishmania major glycerol uptake protein, putative 0.0031 0.0515 0.1612
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0515 0.0515
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0515 0.1612
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0031 0.0515 0.0665
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0138 0.0432
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0073 0.0094
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0073
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0515 0.1612
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0137 0.3193 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0515 0.0515
Trypanosoma brucei glycerol uptake protein, putative 0.0031 0.0515 0.1612
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0832 0.1075
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0832 0.1075
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0031 0.0515 0.0665
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0065 0.1376 0.4053
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.1176 0.1176
Brugia malayi Hhat protein 0.0031 0.0515 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0832 0.1075
Brugia malayi Histone deacetylase 1 0.0037 0.0669 0.0669
Schistosoma mansoni hypothetical protein 0.0013 0.0073 0.0094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0109 0.2498 0.3228
Echinococcus multilocularis muscleblind protein 1 0.0128 0.2953 0.3816
Brugia malayi RNA binding protein 0.0044 0.0832 0.0832
Brugia malayi histone deacetylase 1 (HD1) 0.0037 0.0669 0.0669
Loa Loa (eye worm) hypothetical protein 0.0056 0.1153 0.1153
Schistosoma mansoni ap endonuclease 0.0016 0.0138 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0515 0.7089
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1404 0.4143
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0515 0.0665
Loa Loa (eye worm) hypothetical protein 0.0129 0.299 0.299
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0137 0.3193 1
Loa Loa (eye worm) GMP reductase 0.0057 0.1171 0.1171
Trypanosoma brucei GMP reductase 0.0137 0.3193 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0138 0.0461
Trichomonas vaginalis histone deacetylase, putative 0.0037 0.0669 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0137 0.3193 0.3193
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0043 0.0807 0.0807
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0031 0.0515 0.0665
Onchocerca volvulus Huntingtin homolog 0.0056 0.1153 0.1153
Trypanosoma cruzi GMP reductase 0.0137 0.3193 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0072 0.155 0.4621
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0129 0.2988 1
Echinococcus multilocularis histone deacetylase 1 0.0037 0.0669 0.0865
Echinococcus multilocularis carbonic anhydrase II 0.0106 0.2398 0.3099
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1404 0.1814
Echinococcus granulosus lamin dm0 0.0012 0.0045 0.0059
Trichomonas vaginalis porcupine, putative 0.0031 0.0515 0.7089
Echinococcus multilocularis carbonic anhydrase 0.0057 0.1176 0.152
Trypanosoma cruzi GMP reductase 0.0137 0.3193 1
Toxoplasma gondii exonuclease III APE 0.0016 0.0138 0.0432
Schistosoma mansoni carbonic anhydrase-related 0.0057 0.1176 0.152
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0057 0.1176 0.1176
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0057 0.1171 0.1171
Echinococcus granulosus sterol O acyltransferase 1 0.0317 0.7738 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.1176 0.1176
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0832 0.1075
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0073 0.0073
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0057 0.1176 0.1176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1404 0.4143
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0138 0.0461
Schistosoma mansoni hypothetical protein 0.0013 0.0073 0.0094
Loa Loa (eye worm) carbonic anhydrase 3 0.0106 0.2398 0.2398
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0031 0.0515 0.0515
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0044 0.0832 0.0832
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0515 0.0665
Echinococcus granulosus lamin 0.0012 0.0045 0.0059
Loa Loa (eye worm) hypothetical protein 0.0075 0.1631 0.1631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0109 0.2498 0.3228
Onchocerca volvulus Huntingtin homolog 0.0056 0.1153 0.1153
Loa Loa (eye worm) hypothetical protein 0.0407 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0037 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0807 0.0807
Loa Loa (eye worm) hhat protein 0.0031 0.0515 0.0515
Loa Loa (eye worm) histone deacetylase 1 0.0037 0.0669 0.0669
Leishmania major glycerol uptake protein, putative 0.0031 0.0515 0.1612
Loa Loa (eye worm) hypothetical protein 0.0057 0.1176 0.1176
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0109 0.2498 0.3228
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0031 0.0515 0.0665
Brugia malayi MBOAT family protein 0.0031 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.004
Echinococcus granulosus histone deacetylase 1 0.0037 0.0669 0.0865
Loa Loa (eye worm) hypothetical protein 0.0128 0.2953 0.2953
Echinococcus multilocularis geminin 0.0078 0.1697 0.2193

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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