Detailed information for compound 1533055

Basic information

Technical information
  • TDR Targets ID: 1533055
  • Name: [4-[methyl-(4-methylphenyl)sulfonylamino]phen yl] 2-(phenoxy)acetate
  • MW: 411.471 | Formula: C22H21NO5S
  • H donors: 0 H acceptors: 3 LogP: 4.44 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Oc1ccc(cc1)N(S(=O)(=O)c1ccc(cc1)C)C)COc1ccccc1
  • InChi: 1S/C22H21NO5S/c1-17-8-14-21(15-9-17)29(25,26)23(2)18-10-12-20(13-11-18)28-22(24)16-27-19-6-4-3-5-7-19/h3-15H,16H2,1-2H3
  • InChiKey: KPFUWNLWJWRNHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-[methyl-(4-methylphenyl)sulfonyl-amino]phenyl] 2-(phenoxy)acetate
  • 2-(phenoxy)acetic acid [4-[methyl-(4-methylphenyl)sulfonylamino]phenyl] ester
  • 2-(phenoxy)acetic acid [4-[methyl-(4-methylphenyl)sulfonyl-amino]phenyl] ester
  • [4-[methyl-(4-methylphenyl)sulfonyl-amino]phenyl] 2-(phenoxy)ethanoate
  • ZINC03249436
  • T0516-5899

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0154 0.0125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0769 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0295 0.0267
Loa Loa (eye worm) hypothetical protein 0.0056 0.1252 0.1878
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0493 0.6455
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0133 0.0104
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0242 0.2736
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0295 0.0406
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0029 0.0024
Schistosoma mansoni hypothetical protein 0.0018 0.0295 0.0289
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0769 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1136 0.1678
Leishmania major pyruvate kinase 0.0033 0.068 0.8315
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0154 0.0125
Mycobacterium ulcerans pyruvate kinase 0.0033 0.068 0.7643
Entamoeba histolytica hypothetical protein 0.0041 0.0885 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0014 0.000000001645
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0582 0.0554
Trypanosoma brucei pyruvate kinase 1 0.0033 0.068 0.8315
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0582 0.084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1136 0.1131
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.068 0.8837
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0769 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0295 0.0267
Plasmodium falciparum pyruvate kinase 0.0033 0.068 1
Giardia lamblia Pyruvate kinase 0.0033 0.068 1
Echinococcus multilocularis cpg binding protein 0.003 0.0605 0.0578
Echinococcus granulosus pyruvate kinase 0.0017 0.0277 0.0249
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0769 0.0742
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0277 0.2268
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0154 0.0223
Entamoeba histolytica hypothetical protein 0.0041 0.0885 1
Schistosoma mansoni pyruvate kinase 0.0017 0.0277 0.0271
Schistosoma mansoni cpg binding protein 0.003 0.0605 0.06
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0769 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0295 0.0267
Schistosoma mansoni hypothetical protein 0.0038 0.0809 0.0804
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.664 0.663
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0073 0.0101
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0478 0.4474
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0392 0.0553
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1136 0.111
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0769 0.6376
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0478 0.6158
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0478 0.6185
Schistosoma mansoni ap endonuclease 0.0021 0.0392 0.0387
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0277 0.2348
Echinococcus multilocularis pyruvate kinase 0.0026 0.0506 0.0478
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0014 0.000000001645
Schistosoma mansoni hypothetical protein 0.0018 0.0295 0.0289
Loa Loa (eye worm) hypothetical protein 0.0146 0.3525 0.5304
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0392 0.4431
Schistosoma mansoni DNA helicase recq5 0.0012 0.0154 0.0148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.1252 0.1852
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0154 0.0192
Echinococcus multilocularis pyruvate kinase 0.0033 0.068 0.0653
Leishmania major pyruvate kinase 0.0033 0.068 0.8315
Schistosoma mansoni hypothetical protein 0.0041 0.0885 0.088
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0769 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.068 0.8837
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0769 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0392 0.4533
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0133 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0392 0.5064
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.068 0.0988
Echinococcus granulosus cpg binding protein 0.003 0.0605 0.0578
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0392 0.0582
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0014 0.000000001645
Echinococcus granulosus pyruvate kinase 0.0017 0.0277 0.0249
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0242 0.3097
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.068 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.068 0.8315
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0392 0.0364
Schistosoma mansoni inositol monophosphatase 0.0036 0.0769 0.0763
Brugia malayi Inositol-1 0.0036 0.0769 0.1122
Loa Loa (eye worm) hypothetical protein 0.0023 0.043 0.0639
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0154 0.0192
Giardia lamblia Pyruvate kinase 0.0017 0.0277 0.2348
Schistosoma mansoni ap endonuclease 0.0021 0.0392 0.0387
Schistosoma mansoni pyruvate kinase 0.0033 0.068 0.0674
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0392 0.2849
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.068 0.8824
Entamoeba histolytica hypothetical protein 0.0041 0.0885 1
Schistosoma mansoni hypothetical protein 0.0018 0.0295 0.0289
Echinococcus multilocularis pyruvate kinase 0.0017 0.0277 0.0249
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0809 0.1183
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0014 0.000000001645
Schistosoma mansoni cpg binding protein 0.0028 0.0565 0.0559
Schistosoma mansoni survival motor neuron protein 0.0055 0.1237 0.1232
Schistosoma mansoni hypothetical protein 0.0403 1 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0565 0.0814
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0392 0.5012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0154 0.0223
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.007 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1136 0.1131
Loa Loa (eye worm) pyruvate kinase 0.0033 0.068 0.1016
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.043 0.0639
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0006 0.0066
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0885 0.0858
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0392 0.2849
Loa Loa (eye worm) pyruvate kinase 0.0007 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0809 0.1211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0295 0.0436
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0073 0.0044
Leishmania major hypothetical protein, conserved 0.0025 0.0478 0.4474
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0673 0.9747
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0885 0.088
Toxoplasma gondii exonuclease III APE 0.0021 0.0392 0.3229
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.043 0.4853
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0478 0.6158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0014 0.000000001645
Schistosoma mansoni DNA helicase recq1 0.0012 0.0154 0.0148
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0769 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0277 0.0249
Echinococcus multilocularis pyruvate kinase 0.0017 0.0277 0.0249
Loa Loa (eye worm) hypothetical protein 0.027 0.664 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1136 0.1704
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0014 0.000000001645
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0478 0.3944
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0769 0.0742
Echinococcus multilocularis pyruvate kinase 0.0033 0.068 0.0653
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.068 0.1713
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0769 0.8686
Brugia malayi hypothetical protein 0.0016 0.0256 0.0347
Loa Loa (eye worm) RecQ helicase 0.0029 0.0582 0.0868
Schistosoma mansoni hypothetical protein 0.0011 0.0133 0.0127
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0392 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0769 0.0763
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0014 0.000000001645
Loa Loa (eye worm) pyruvate kinase 0.0033 0.068 0.1016
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.068 0.5635
Echinococcus multilocularis pyruvate kinase 0.0017 0.0277 0.0249
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.1252 0.1852
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1136 0.111
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.068 0.1713
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1364 0.1359
Echinococcus granulosus survival motor neuron protein 1 0.027 0.664 0.663
Loa Loa (eye worm) hypothetical protein 0.0018 0.0295 0.0436
Brugia malayi hypothetical protein 0.027 0.664 1
Onchocerca volvulus 0.0055 0.1237 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.068 0.8824
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0103 0.0115
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1136 0.111
Echinococcus granulosus pyruvate kinase 0.0033 0.068 0.0653
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.068 0.1713
Loa Loa (eye worm) hypothetical protein 0.0025 0.0478 0.0711
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0392 0.4533
Loa Loa (eye worm) inositol-1 0.0036 0.0769 0.115
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0295 0.0267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1136 0.1131
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0242 0.3025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0885 0.0858
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.068 0.0988
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0769 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.068 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0014 0.000000001645
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0154 0.0125
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.068 1
Schistosoma mansoni hypothetical protein 0.0018 0.0295 0.0289
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0582 0.7526
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0154 0.1234
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0154 0.1234
Entamoeba histolytica hypothetical protein 0.0041 0.0885 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0346 0.5083
Loa Loa (eye worm) hypothetical protein 0.0033 0.068 0.1016
Schistosoma mansoni pyruvate kinase 0.0033 0.068 0.0674
Schistosoma mansoni cpg binding protein 0.003 0.0605 0.06
Brugia malayi hypothetical protein 0.0025 0.0478 0.0682
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0295 0.0406
Echinococcus granulosus GPCR family 2 0.0018 0.0295 0.0267
Chlamydia trachomatis pyruvate kinase 0.0033 0.068 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.034 0.2791
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1136 0.111
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0428 0.0423
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0154 0.0125
Loa Loa (eye worm) pyruvate kinase 0.0033 0.068 0.1016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.1252 0.1878
Echinococcus granulosus pyruvate kinase 0.0033 0.068 0.0653
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0392 0.5064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0392 0.0364
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0277 0.4076
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0478 0.7025
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.1237 0.183
Echinococcus granulosus bloom syndrome protein 0.0029 0.0582 0.0554
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0769 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0295 0.0267
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0565 0.0843
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0392 0.5012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0073 0.0044
Brugia malayi hypothetical protein 0.0041 0.0885 0.1298
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0582 0.7526
Schistosoma mansoni hypothetical protein 0.0055 0.1237 0.1232
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0478 0.6185
Echinococcus multilocularis dnaJ subfamily B 0.0403 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1202 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0392 0.5767

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 70 uM PubChem BioAssay. Cytotoxicity (24 hours) Measured in Cell-Based System Using Plate Reader - 2137-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6294 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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