Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0358 | 0.1398 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0358 | 0.1398 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2558 | 0.2558 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.1744 | 0.1437 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1204 | 0.0878 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2558 | 0.2282 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0358 | 0.0358 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2558 | 0.2282 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2558 | 0.2282 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2558 | 0.2282 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1204 | 0.0878 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0358 | 0.0358 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1934 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.4865 | 0.4674 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0358 | 0.0358 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2558 | 0.2558 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.4865 | 0.4674 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0358 | 0.0358 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1744 | 0.6817 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1934 | 0.1635 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0358 | 0.0358 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Onchocerca volvulus | 0.0055 | 0.1744 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1934 | 0.1635 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0358 | 0.1398 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2558 | 0.2282 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.4865 | 0.4674 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0358 | 0.1398 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0358 | 0.0358 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0271 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1934 | 0.1635 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1204 | 0.4708 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.1744 | 0.6817 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2558 | 0.2282 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0271 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2239 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.