TDR Targets

Basic information

Technical information

TDR Targets ID: 1536848
Name: methyl (2R)-2-[(2,6-dimethylphenyl)-(2-methox yacetyl)amino]propanoate
MW: 279.332 | Formula: C15H21NO4
H donors: 0 H acceptors: 2 LogP: 2.22 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCC(=O)N(c1c(C)cccc1C)[C@@H](C(=O)OC)C
InChi: 1S/C15H21NO4/c1-10-7-6-8-11(2)14(10)16(13(17)9-19-4)12(3)15(18)20-5/h6-8,12H,9H2,1-5H3/t12-/m1/s1
InChiKey: ZQEIXNIJLIKNTD-GFCCVEGCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R)-2-[(2,6-dimethylphenyl)-(2-methoxy-1-oxoethyl)amino]propanoic acid methyl ester
(2R)-2-[(2,6-dimethylphenyl)-(2-methoxyacetyl)amino]propionic acid methyl ester
methyl (2R)-2-[(2,6-dimethylphenyl)-(2-methoxyethanoyl)amino]propanoate
NCGC00163907-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor delta	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ecdysteroid receptor	peroxisome proliferator-activated receptor delta	441 aa	369 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0149	0.5875	0.6584
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0607	0.7652
Toxoplasma gondii	ABC1 family protein	0.0038	0.0793	1
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0793	0.4388
Entamoeba histolytica	protein kinase domain containing protein	0.0042	0.1014	0.2544
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0719	0.595
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.1233	0.1382
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0021	0.0027	0.0147
Leishmania major	DNA polymerase eta, putative	0.0033	0.0577	0.3195
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0793	0.0888
Brugia malayi	plexin A	0.0216	0.8923	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.006	0.1807	0.1807
Schistosoma mansoni	plexin	0.0183	0.74	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0793	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0719	0.0806
Onchocerca volvulus		0.0074	0.2435	0.3095
Echinococcus multilocularis	exocyst complex component 2	0.0033	0.0607	0.068
Echinococcus granulosus	plexin a4	0.0216	0.8923	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0793	0.0793
Schistosoma mansoni	hypothetical protein	0.0047	0.1233	0.1666
Schistosoma mansoni	hypothetical protein	0.0047	0.1233	0.1666
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0021	0.0027	0.0147
Loa Loa (eye worm)	plexin A	0.0216	0.8923	1
Loa Loa (eye worm)	sema domain-containing protein	0.0076	0.2559	0.2868
Brugia malayi	Sema domain containing protein	0.0076	0.2559	0.2868
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1233	0.1382
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0793	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0033	0.0607	0.7652
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.1233	0.1382
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0209	0.0525
Brugia malayi	Probable exocyst complex component Sec5	0.0033	0.0607	0.068
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0719	0.0806
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0719	0.9072
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0793	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0607	0.082
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0793	0.0888
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0607	0.7652
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0021	0.0027	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0209	0.0235
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0719	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2559	0.2868
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0033	0.0607	0.7652
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0719	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0183	0.74	0.8294
Schistosoma mansoni	hypothetical protein	0.0047	0.1233	0.1666
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0607	0.7652
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0209	0.1158
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0577	0.4775
Entamoeba histolytica	hypothetical protein	0.0108	0.3985	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.2435	0.2729
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3726	0.4176
Trypanosoma cruzi	DNA polymerase eta, putative	0.0047	0.1209	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0209	0.0235
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0149	0.5875	0.6584
Echinococcus multilocularis	transcription factor collier	0.0033	0.0607	0.068
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0793	1
Echinococcus granulosus	semaphorin 5B	0.0076	0.2559	0.2868
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2559	0.2868
Brugia malayi	hypothetical protein	0.0076	0.2559	0.2868
Echinococcus granulosus	geminin	0.015	0.5913	0.6627
Loa Loa (eye worm)	hypothetical protein	0.0106	0.3925	0.4399
Leishmania major	phosphopantetheinyl transferase-like protein	0.0021	0.0027	0.0147
Schistosoma mansoni	fibrocystin l	0.0033	0.0607	0.082
Entamoeba histolytica	hypothetical protein	0.0108	0.3985	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0033	0.0607	0.7652
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0793	0.0888
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0209	0.1158
Echinococcus granulosus	L aminoadipate semialdehyde	0.0074	0.2435	0.2729
Entamoeba histolytica	hypothetical protein	0.0033	0.0607	0.1522
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.006	0.1807	0.2025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0793	0.0888
Schistosoma mansoni	hypothetical protein	0.015	0.5913	0.799
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0793	0.1071
Trypanosoma brucei	DNA polymerase eta, putative	0.0047	0.1209	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0607	0.082
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0607	0.068
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0719	1
Leishmania major	hypothetical protein, conserved	0.0038	0.0793	0.4388
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0719	0.3981
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0793	0.0793
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0108	0.3985	0.4466
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0793	0.0793
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0209	0.0525
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.1233	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2559	0.2868
Schistosoma mansoni	hypothetical protein	0.0102	0.3726	0.5035
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.1233	0.1382
Schistosoma mansoni	hypothetical protein	0.0106	0.3925	0.5304
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0793	0.4388
Schistosoma mansoni	hypothetical protein	0.0047	0.1233	0.1666
Echinococcus granulosus	dna polymerase eta	0.0047	0.1209	0.1355
Echinococcus multilocularis	plexin a4	0.0216	0.8923	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0209	0.0525
Echinococcus multilocularis	dna polymerase eta	0.0047	0.1209	0.1355
Onchocerca volvulus		0.0038	0.0793	0.0811
Echinococcus multilocularis	hypothetical protein	0.0076	0.2559	0.2868
Echinococcus granulosus	semaphorin 1A	0.0076	0.2559	0.2868
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0209	0.0235
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0719	0.595
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.006	0.1807	1
Echinococcus granulosus	exocyst complex component 2	0.0033	0.0607	0.068
Schistosoma mansoni	semaphorin 5-related	0.0076	0.2559	0.3458
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0209	0.1158
Brugia malayi	Plexin repeat family protein	0.0183	0.74	0.8294
Echinococcus multilocularis	semaphorin 5B	0.0076	0.2559	0.2868
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0209	0.1158
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0793	0.0793
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0719	0.595
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0793	0.0793
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0209	0.0209
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0021	0.0027	0.5
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0033	0.0607	0.7652
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0607	0.068
Brugia malayi	Sema domain containing protein	0.0076	0.2559	0.2868
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0793	0.6558
Brugia malayi	beta-lactamase	0.0038	0.0793	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0209	0.0235
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0209	0.1158
Brugia malayi	ImpB/MucB/SamB family protein	0.0047	0.1209	0.1355
Entamoeba histolytica	hypothetical protein	0.0108	0.3985	1
Entamoeba histolytica	hypothetical protein	0.0033	0.0607	0.1522
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0074	0.2435	0.2729
Onchocerca volvulus		0.0038	0.0793	0.0811
Trypanosoma brucei	hypothetical protein, conserved	0.0021	0.0027	0.022
Echinococcus granulosus	GPCR family 2	0.0047	0.1233	0.1382
Entamoeba histolytica	hypothetical protein	0.0021	0.0027	0.0067
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.006	0.1807	0.2025
Brugia malayi	DNA-binding protein LAG-1	0.0033	0.0607	0.068
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0719	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0607	0.068
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.006	0.1807	0.2441
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0607	0.7652
Schistosoma mansoni	plexin	0.0106	0.3925	0.5304
Brugia malayi	IPT/TIG domain containing protein	0.0033	0.0607	0.068
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0793	1
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0793	0.6558
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.006	0.1807	1
Entamoeba histolytica	hypothetical protein	0.0108	0.3985	1
Schistosoma mansoni	hypothetical protein	0.0076	0.2559	0.3458
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0209	0.1158
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0793	0.0793
Onchocerca volvulus		0.0183	0.74	1
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0021	0.0027	0.5
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0719	0.1805
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0074	0.2435	0.329
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0149	0.5875	0.6584
Schistosoma mansoni	DNA polymerase eta	0.0047	0.1209	0.1634
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0793	0.0793
Entamoeba histolytica	cell surface protease gp63, putative	0.0033	0.0607	0.1522
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0209	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1209	0.1355
Echinococcus multilocularis	geminin	0.015	0.5913	0.6627
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.0577	0.7188
Mycobacterium ulcerans	lipase LipD	0.0038	0.0793	0.4388
Brugia malayi	hypothetical protein	0.0108	0.3985	0.4466
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0607	0.7652
Loa Loa (eye worm)	sema domain-containing protein	0.0076	0.2559	0.2868
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0607	0.7652
Brugia malayi	beta-lactamase family protein	0.0038	0.0793	0.0888
Leishmania major	DNA polymerase eta, putative	0.0047	0.1209	0.6692
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.1623	0.1819
Brugia malayi	hypothetical protein	0.0076	0.2559	0.2868
Entamoeba histolytica	hypothetical protein	0.0033	0.0607	0.1522
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0793	0.6558
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0793	0.0888
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0719	0.0806
Onchocerca volvulus		0.0076	0.2559	0.3268
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0033	0.0607	0.7652
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0793	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0719	0.0806
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0209	0.0209
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0793	0.4388
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0021	0.0027	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0793	0.1071
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0719	0.9072
Echinococcus multilocularis	GPCR, family 2	0.0047	0.1233	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2559	0.2868
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0793	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.006	0.1807	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0607	0.068
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0209	0.1158
Schistosoma mansoni	hypothetical protein	0.015	0.5913	0.799
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0793	0.0888
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0793	0.0888
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0209	0.1158
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0209	0.2385
Echinococcus granulosus	transcription factor collier	0.0033	0.0607	0.068
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0719	0.0972
Entamoeba histolytica	hypothetical protein	0.0033	0.0607	0.1522
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0793	0.0793
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0793	0.0888
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0719	0.9072
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0793	0.4388
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0793	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0793	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.1233	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0793	0.0888
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0209	0.1158
Schistosoma mansoni	transcription factor LCR-F1	0.0108	0.3985	0.5385
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0209	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0607	0.7652
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0209	0.0235
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0793	0.0888
Entamoeba histolytica	tyrosin kinase, putative	0.0042	0.1014	0.2544
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0793	0.0793
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.3726	0.4176
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0719	0.0972
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.1233	0.1382
Trichomonas vaginalis	esterase, putative	0.0038	0.0793	1
Onchocerca volvulus		0.0038	0.0793	0.0811
Schistosoma mansoni	hypothetical protein	0.0108	0.3985	0.5385
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0209	0.1158
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0719	0.0806
Brugia malayi	beta-lactamase family protein	0.0038	0.0793	0.0888
Schistosoma mansoni	hypothetical protein	0.0076	0.2559	0.3458
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0793	0.0793
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0074	0.2435	0.2729
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0108	0.3985	0.4466
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.1233	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2559	0.2868
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0209	0.2385
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0021	0.0027	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.006	0.1807	0.2025
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2559	0.2868
Loa Loa (eye worm)	hypothetical protein	0.0149	0.5875	0.6584

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1 uM	PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor delta signaling. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1905521

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1536848