Detailed information for compound 1536867

Basic information

Technical information
  • TDR Targets ID: 1536867
  • Name: [4-acetyloxy-2,5-bis(acetyloxymethyl)-2-(4-me thylphenyl)oxolan-3-yl] acetate
  • MW: 422.426 | Formula: C21H26O9
  • H donors: 0 H acceptors: 4 LogP: 1.33 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OCC1(OC(C(C1OC(=O)C)OC(=O)C)COC(=O)C)c1ccc(cc1)C
  • InChi: 1S/C21H26O9/c1-12-6-8-17(9-7-12)21(11-27-14(3)23)20(29-16(5)25)19(28-15(4)24)18(30-21)10-26-13(2)22/h6-9,18-20H,10-11H2,1-5H3
  • InChiKey: RPTVMNJMFOWKKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-acetoxy-2,5-bis(acetoxymethyl)-2-(4-methylphenyl)tetrahydrofuran-3-yl] acetate
  • acetic acid [4-acetoxy-2,5-bis(acetoxymethyl)-2-(4-methylphenyl)-3-tetrahydrofuranyl] ester
  • acetic acid [4-acetoxy-2,5-bis(acetoxymethyl)-2-(4-methylphenyl)tetrahydrofuran-3-yl] ester
  • [4-acetyloxy-2,5-bis(acetyloxymethyl)-2-(4-methylphenyl)oxolan-3-yl] ethanoate
  • NSC105584

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0168 0.3609 0.5279
Echinococcus granulosus General substrate transporter 0.0089 0.1752 0.2563
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0568
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.6378 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0245 0.481
Schistosoma mansoni hypothetical protein 0.0029 0.0328 0.0479
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0152 0.2987
Plasmodium vivax CDK-related protein kinase 6, putative 0.044 1 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0404 0.0404
Onchocerca volvulus Alhambra homolog 0.0029 0.0328 0.4191
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.3595 0.3595
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0751
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0469 0.0686
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0485 0.165
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.6378 1
Brugia malayi hypothetical protein 0.0025 0.0245 0.0474
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0318
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0568
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0294
Loa Loa (eye worm) hypothetical protein 0.0025 0.0251 0.0368
Toxoplasma gondii protein kinase, putative 0.0293 0.6542 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.033 0.647
Schistosoma mansoni protein kinase 0.0032 0.0404 0.059
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.033 0.647
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.033 0.0504
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0568
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0648
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0404 0.0617
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0328 0.0479
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0037
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0648
Brugia malayi RNA, U transporter 1 0.0081 0.1569 0.3035
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0245 0.0245
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0485 0.0761
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0485 0.071
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0152
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0485 0.0981
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0485 0.0761
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0485 0.0938
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Trypanosoma brucei glucose transporter 1E 0.0032 0.0413 0.8107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0328 0.0479
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0404 0.0404
Schistosoma mansoni hypothetical protein 0.0168 0.3609 0.5279
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0316
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0245 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0648
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0485 0.0981
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0404 0.0404
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0485 0.0761
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0152 0.2987
Echinococcus granulosus geminin 0.0168 0.3609 0.5279
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0328 0.0479
Brugia malayi Bromodomain containing protein 0.0029 0.0328 0.0634
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0404 0.0404
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0485 0.0981
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 0.0404
Plasmodium vivax hexose transporter 0.0104 0.2094 0.2094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0025 0.0037
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0404 0.0404
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0404 0.059
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1402 0.2051
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0404 0.0404
Brugia malayi Cam kinase protein 1 0.0032 0.0404 0.078
Onchocerca volvulus 0.0048 0.0782 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0485 0.0742
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0404 0.0617
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium vivax importin-beta 2, putative 0.0029 0.033 0.033
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Leishmania major hypothetical protein, conserved 0.0035 0.0485 0.9522
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.0482
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0037
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0388 0.0954
Brugia malayi hypothetical protein 0.0234 0.5171 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0404 0.059
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0485 0.9522
Echinococcus multilocularis GPCR, family 2 0.0016 0.0025 0.0037
Leishmania major protein kinase, putative 0.0032 0.0404 0.7919
Schistosoma mansoni hypothetical protein 0.0034 0.0452 0.0661
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Schistosoma mansoni protein kinase 0.0032 0.0404 0.059
Schistosoma mansoni hypothetical protein 0.0168 0.3609 0.5279
Leishmania major glucose transporter, lmgt1 0.0032 0.0413 0.8107
Leishmania major glucose transporter, lmgt2 0.0032 0.0413 0.8107
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0404 0.0404
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0203 0.3975
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.3595 0.3595
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0025 0.0049
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.6835 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0485 0.0761
Echinococcus granulosus snurportin 1 0.0305 0.6835 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0245 0.481
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0203 0.0318
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0357 0.0523
Schistosoma mansoni glucose transport protein 0.0104 0.2094 0.3064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0485 0.071
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Schistosoma mansoni hypothetical protein 0.0305 0.6835 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0413 0.8107
Plasmodium falciparum proline--tRNA ligase 0.0036 0.051 0.051
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0294
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.051 0.0779
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0328 0.0479
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0152 0.2987
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0152 0.0152
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Schistosoma mansoni ran 0.0021 0.0152 0.0223
Brugia malayi Sugar transporter family protein 0.0104 0.2094 0.405
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0469 0.0686
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0119 0.0241
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1042 0.1524
Loa Loa (eye worm) sugar transporter 0.0104 0.2094 0.3064
Mycobacterium leprae Probable lipase LipE 0.0035 0.0485 0.1297
Brugia malayi jmjC domain containing protein 0.0034 0.0469 0.0907
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0294
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.294 1
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.0079
Onchocerca volvulus 0.0035 0.0485 0.6205
Leishmania major glucose transporter, lmgt3 0.0032 0.0413 0.8107
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0404 0.0633
Brugia malayi Importin beta-1 subunit 0.0029 0.033 0.0638
Schistosoma mansoni ran 0.0021 0.0152 0.0223
Loa Loa (eye worm) hypothetical protein 0.0025 0.0245 0.0359
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0568
Schistosoma mansoni hypothetical protein 0.0104 0.2094 0.3064
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0485 0.0981
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0245 0.481
Echinococcus multilocularis jumonji domain containing protein 0.004 0.059 0.0864
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0568
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.082 0.1585
Brugia malayi beta-lactamase 0.0035 0.0485 0.0938
Trypanosoma cruzi hexose transporter, putative 0.0018 0.007 0.1383
Brugia malayi beta-lactamase family protein 0.0035 0.0485 0.0938
Leishmania major importin beta-1 subunit, putative 0.0023 0.0203 0.3975
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0485 0.0981
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0328 0.0328
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0201
Leishmania major GTP-binding protein, putative 0.0021 0.0152 0.2987
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0357 0.0523
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0025 0.0037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0152 0.0223
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Echinococcus multilocularis General substrate transporter 0.0089 0.1752 0.2563
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0328 0.0501
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.0291
Brugia malayi jmjC domain containing protein 0.0093 0.1853 0.3583
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Entamoeba histolytica hypothetical protein 0.0023 0.0203 0.0081
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0469 0.0686
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0201
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0485 0.0761
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0328 0.0479
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0469 0.0686
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 0.0404
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.0316
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0648
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0751
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1853 0.2711
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0485 0.0981
Brugia malayi hypothetical protein 0.0016 0.0037 0.0071
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.2094 0.3064
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.4947 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.2094 0.3201
Loa Loa (eye worm) hypothetical protein 0.0032 0.0404 0.059
Brugia malayi beta-lactamase family protein 0.0035 0.0485 0.0938
Mycobacterium ulcerans beta-lactamase 0.0035 0.0485 0.165
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0134 0.021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Mycobacterium tuberculosis Conserved protein 0.0035 0.0485 0.0981
Loa Loa (eye worm) hypothetical protein 0.0034 0.0452 0.0661
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0328 0.0501
Onchocerca volvulus 0.0035 0.0485 0.6205
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0685
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0469 0.0686
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0648
Plasmodium falciparum hexose transporter 0.0104 0.2094 0.2094
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0685
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.082 0.1585
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0294
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Trichomonas vaginalis esterase, putative 0.0035 0.0485 0.0761
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Plasmodium falciparum importin beta, putative 0.0029 0.033 0.033
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0388 0.0609
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0404 0.078
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0404 0.059
Giardia lamblia PHD finger protein 15 0.0029 0.0328 0.0514
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0404 0.0404
Echinococcus granulosus GPCR family 2 0.0016 0.0025 0.0037
Mycobacterium ulcerans lipase LipD 0.0035 0.0485 0.165
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0485 0.0981
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0648
Schistosoma mansoni importin beta-1 0.0029 0.033 0.0482
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0485 0.165
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.082 0.1199
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0308
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0152 0.0223
Echinococcus multilocularis peregrin 0.0029 0.0328 0.0479
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.294 0.5944
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0404 0.059
Schistosoma mansoni protein kinase 0.0032 0.0404 0.059
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 0.5
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0404 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.2094 0.3284
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0203 0.0318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.5171 0.7566
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0782 0.1512
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0037
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.395
Schistosoma mansoni glucose transport protein 0.0104 0.2094 0.3064
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1853 0.2711
Schistosoma mansoni glucose transport protein 0.0104 0.2094 0.3064
Echinococcus multilocularis snurportin 1 0.0305 0.6835 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0388 0.0609
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0388 0.0379
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.6378 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0782 0.1144
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0485 0.9522
Plasmodium falciparum phd finger protein, putative 0.0029 0.0328 0.0328
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0245 0.0245
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0648
Echinococcus granulosus peregrin 0.0029 0.0328 0.0479
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.8107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0119 0.0241
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.051 0.051
Schistosoma mansoni hypothetical protein 0.0048 0.0782 0.1144
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Echinococcus granulosus importin subunit beta 1 0.0029 0.033 0.0482
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0452 0.0874
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0404 0.7919
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.6378 1
Trypanosoma cruzi hexose transporter 0.0032 0.0413 0.8107
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0389
Loa Loa (eye worm) beta-lactamase 0.0035 0.0485 0.071
Loa Loa (eye worm) hypothetical protein 0.0049 0.082 0.1199
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0485 0.9522
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0152 0.0233
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.5171 0.7566
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0025 0.0049
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.6378 1
Leishmania major hypothetical protein, conserved 0.0025 0.0245 0.481
Trypanosoma brucei glucose transporter 2A 0.0032 0.0413 0.8107
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0294
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0485 0.1297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0485 0.071
Trichomonas vaginalis ran, putative 0.0021 0.0152 0.0239
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0404 0.0617
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0245 0.0375
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0294
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0485 0.071
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.2094 0.3064
Plasmodium falciparum protein kinase 7 0.0293 0.6542 0.6542
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0485 0.071
Mycobacterium ulcerans hypothetical protein 0.0035 0.0485 0.165
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.3595 0.5495
Loa Loa (eye worm) hypothetical protein 0.0049 0.0807 0.118
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0485 0.071
Mycobacterium tuberculosis Conserved protein 0.0035 0.0485 0.0981
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.059
Echinococcus multilocularis importin subunit beta 1 0.0029 0.033 0.0482
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.8107
Brugia malayi PHD-finger family protein 0.0029 0.0328 0.0634
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.294 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0152 0.0223
Onchocerca volvulus 0.0035 0.0485 0.6205
Mycobacterium tuberculosis Conserved protein 0.0035 0.0485 0.0981
Loa Loa (eye worm) hypothetical protein 0.0234 0.5171 0.7566
Echinococcus granulosus jumonji domain containing protein 0.004 0.059 0.0864

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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