Detailed information for compound 1536960

Basic information

Technical information
  • TDR Targets ID: 1536960
  • Name: 1-cyclohexyl-4-[[1-(furan-2-ylmethyl)tetrazol -5-yl]methyl]piperazine
  • MW: 330.428 | Formula: C17H26N6O
  • H donors: 0 H acceptors: 3 LogP: 1.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)N1CCN(CC1)Cc1nnnn1Cc1ccco1
  • InChi: 1S/C17H26N6O/c1-2-5-15(6-3-1)22-10-8-21(9-11-22)14-17-18-19-20-23(17)13-16-7-4-12-24-16/h4,7,12,15H,1-3,5-6,8-11,13-14H2
  • InChiKey: MEBYOMBLIABARD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclohexyl-4-[[1-(2-furylmethyl)tetrazol-5-yl]methyl]piperazine
  • 1-cyclohexyl-4-[[1-(2-furylmethyl)-5-tetrazolyl]methyl]piperazine
  • 1-cyclohexyl-4-[[1-(furan-2-ylmethyl)-1,2,3,4-tetrazol-5-yl]methyl]piperazine
  • ASN 05557421

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glutamate receptor subunit protein glur 0.0039 0.0732 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0524 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0524 0.5
Schistosoma mansoni bromodomain containing protein 0.0062 0.1814 0.2907
Schistosoma mansoni glutamate receptor kainate 0.0106 0.3981 0.7794
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0101 0.3716 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0039 0.0732 0.0222
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0127 0.496 0.4683
Brugia malayi beta-lactamase family protein 0.0035 0.0524 0.0524
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0127 0.496 0.4683
Echinococcus multilocularis glutamate receptor 2 0.0106 0.3981 0.3651
Schistosoma mansoni glutamate receptor AMPA 0.0106 0.3981 0.7794
Trichomonas vaginalis esterase, putative 0.0035 0.0524 0.5
Mycobacterium leprae Probable lipase LipE 0.0035 0.0524 0.5
Echinococcus multilocularis NMDA receptor 0.0039 0.0732 0.0222
Brugia malayi Bromodomain containing protein 0.0073 0.2368 0.2368
Brugia malayi Bromodomain containing protein 0.0037 0.0633 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0524 0.5
Brugia malayi beta-lactamase 0.0035 0.0524 0.0524
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0127 0.496 0.4683
Echinococcus granulosus nmda type glutamate receptor 0.014 0.5625 0.5385
Schistosoma mansoni glutamate receptor kainate 0.0106 0.3981 0.7794
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0524 0.5
Echinococcus granulosus glutamate NMDA receptor subunit 0.0106 0.3981 0.3651
Loa Loa (eye worm) hypothetical protein 0.0069 0.2165 0.1732
Brugia malayi Glutamate receptor 2 precursor 0.0106 0.3981 0.3981
Echinococcus granulosus glutamate receptor 2 0.0087 0.3051 0.2669
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0524 0.0004
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0039 0.0732 0.0222
Loa Loa (eye worm) hypothetical protein 0.0231 1 1
Chlamydia trachomatis glutamine binding protein 0.0101 0.3716 0.5
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0039 0.0732 0.0222
Schistosoma mansoni hypothetical protein 0.0047 0.1102 0.1303
Schistosoma mansoni glutamate receptor kainate 0.0106 0.3981 0.7794
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0524 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0106 0.3981 0.7794
Echinococcus multilocularis glutamate receptor 2 0.0127 0.496 0.4683
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1102 0.1102
Leishmania major hypothetical protein, conserved 0.0035 0.0524 0.5
Toxoplasma gondii ABC1 family protein 0.0035 0.0524 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0127 0.496 0.4683
Schistosoma mansoni glutamate receptor NMDA 0.0127 0.496 1
Loa Loa (eye worm) glutamate receptor 2 0.0106 0.3981 0.3648
Schistosoma mansoni survival motor neuron protein 0.0047 0.1102 0.1303
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0524 0.5
Echinococcus multilocularis glutamate receptor 2 0.0087 0.3051 0.2669
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0524 0.5
Schistosoma mansoni glutamate receptor AMPA 0.0106 0.3981 0.7794
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0524 0.0524
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0039 0.0732 0.0222
Onchocerca volvulus 0.0047 0.1102 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0101 0.3716 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0524 0.0004
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0039 0.0732 0.0222
Brugia malayi Glutamate receptor 1 precursor 0.0106 0.3981 0.3981
Echinococcus multilocularis nmda type glutamate receptor 0.014 0.5625 0.5385
Loa Loa (eye worm) hypothetical protein 0.004 0.0748 0.0236
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0127 0.496 0.4683
Loa Loa (eye worm) glutamate receptor 1 0.0106 0.3981 0.3648
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0127 0.496 0.4683
Loa Loa (eye worm) hypothetical protein 0.0042 0.0838 0.0331
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0127 0.496 0.4683
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0127 0.496 0.4683
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0524 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.9695 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0636 0.0118
Schistosoma mansoni hypothetical protein 0.0039 0.0732 0.0467
Echinococcus granulosus glutamate receptor 2 0.0127 0.496 0.4683
Echinococcus multilocularis survival motor neuron protein 1 0.0231 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0524 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.1644 0.1185
Echinococcus granulosus survival motor neuron protein 1 0.0231 1 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0101 0.3716 0.5
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0106 0.3981 0.3651
Schistosoma mansoni ATP-binding cassette transporter 0.0106 0.3981 0.7794
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0039 0.0732 0.0222
Brugia malayi beta-lactamase family protein 0.0035 0.0524 0.0524
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0101 0.3716 0.348
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0524 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.1644 0.1185
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.014 0.5625 0.5385
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0101 0.3716 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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