TDR Targets

Basic information

Technical information

TDR Targets ID: 1537943
Name: N-cycloheptyl-2-propan-2-ylquinoline-4-carbox amide
MW: 310.433 | Formula: C20H26N2O
H donors: 1 H acceptors: 2 LogP: 4.98 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc(nc2c1cccc2)C(C)C)NC1CCCCCC1
InChi: 1S/C20H26N2O/c1-14(2)19-13-17(16-11-7-8-12-18(16)22-19)20(23)21-15-9-5-3-4-6-10-15/h7-8,11-15H,3-6,9-10H2,1-2H3,(H,21,23)
InChiKey: WWLYYJRTBIYCHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cycloheptyl-2-isopropyl-quinoline-4-carboxamide
N-cycloheptyl-2-isopropyl-4-quinolinecarboxamide
N-cycloheptyl-2-isopropyl-cinchoninamide
N-cycloheptyl-2-propan-2-yl-quinoline-4-carboxamide
T5408050
ZINC07002311

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0594	0.1104
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0401	0.1216
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0064	0.0594	0.1104
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0064	0.0595	0.0553
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0064	0.0595	0.0553
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0064	0.0595	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0044	0.0133
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0199	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Loa Loa (eye worm)	sugar transporter	0.0209	0.2251	0.6834
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0199	0.0156
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0316	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0047	0.0396	0.0354
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0604	0.8555
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0432	0.0592
Plasmodium falciparum	hexose transporter	0.0209	0.2251	0.2217
Schistosoma mansoni	sugar transporter	0.0029	0.0199	0.0604
Brugia malayi	Sugar transporter family protein	0.0029	0.0199	0.0796
Leishmania major	glucose transporter, lmgt3	0.0065	0.0604	0.8555
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0038	0.0294	0.3817
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0404	0.075
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0073	0.0698	0.0997
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.1032	0.4128
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0404	0.1226
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.01	0.0056
Brugia malayi	hypothetical protein	0.005	0.0432	0.173
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.01	0.0056
Onchocerca volvulus		0.0029	0.0199	0.4963
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0064	0.0595	0.0553
Brugia malayi	Sugar transporter family protein	0.0029	0.0199	0.0796
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0185	0.0343
Leishmania major	protein kinase, putative	0.0064	0.0594	0.8412
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0064	0.0595	0.0553
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0199	0.0461
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0047	0.0396	0.5384
Brugia malayi	hypothetical protein	0.0029	0.0199	0.0796
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0199	0.0796
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0604	0.8555
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.058	0.1759
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0889	1	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0401	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0199	0.0796
Toxoplasma gondii	facilitative glucose transporter GT1	0.0209	0.2251	0.3362
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.3295	1
Onchocerca volvulus		0.0029	0.0199	0.4963
Onchocerca volvulus		0.0029	0.0199	0.4963
Schistosoma mansoni	sugar transporter	0.0029	0.0199	0.0604
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0698	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2251	0.4181
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0199	0.2954
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0199	0.0236
Brugia malayi	major facilitator superfamily protein	0.0029	0.0199	0.0796
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0199	0.0461
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0044	0.0133
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0199	0.5702
Echinococcus multilocularis	snurportin 1	0.0301	0.3295	0.6118
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.01	0.0185
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0063	0.058	0.2319
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0064	0.0595	0.0553
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0199	0.2954
Schistosoma mansoni	hypothetical protein	0.0047	0.0404	0.1226
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0404	0.1616
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0118	0.022
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0044	0.0081
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0044	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Onchocerca volvulus		0.0029	0.0199	0.4963
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0432	0.039
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0199	0.237
Echinococcus multilocularis	neuropeptide s receptor	0.0484	0.5385	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0044	0.0081
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0199	0.0369
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0698	1
Leishmania major	GTP-binding protein, putative	0.0021	0.01	0.0854
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Schistosoma mansoni	protein kinase	0.0064	0.0594	0.1804
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0199	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0047	0.0396	0.1378
Onchocerca volvulus		0.0029	0.0199	0.4963
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.2499	0.4641
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0396	1
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0199	0.237
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0432	0.5937
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0396	0.1202
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Echinococcus granulosus	neuropeptide s receptor	0.0484	0.5385	1
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0124	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Brugia malayi	RNA, U transporter 1	0.008	0.0777	0.311
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Schistosoma mansoni	hypothetical protein	0.0166	0.1752	0.5318
Loa Loa (eye worm)	hypothetical protein	0.0231	0.2499	0.7586
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0044	0.0081
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Plasmodium falciparum	lysine--tRNA ligase	0.0047	0.0396	0.0354
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.01	0.0854
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0124	0.0112
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus granulosus	solute carrier family 22	0.0029	0.0199	0.0369
Trypanosoma cruzi	hexose transporter	0.0065	0.0604	0.8555
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0063	0.058	0.1759
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0063	0.058	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0185	0.215
Leishmania major	glucose transporter, lmgt2	0.0065	0.0604	0.8555
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2251	0.4181
Echinococcus granulosus	General substrate transporter	0.018	0.1916	0.3557
Echinococcus granulosus	calcium dependent protein kinase	0.006	0.0549	0.102
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0047	0.0396	0.3046
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0199	0.0236
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0404	0.1616
Entamoeba histolytica	protein kinase, putative	0.0064	0.0594	1
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0044	0.0175
Echinococcus granulosus	solute carrier family 22	0.0029	0.0199	0.0369
Plasmodium vivax	hexose transporter	0.0209	0.2251	0.2217
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus granulosus	GPCR family 2	0.0047	0.0404	0.075
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0063	0.058	0.2319
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Giardia lamblia	Prolyl-tRNA synthetase	0.0063	0.058	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Schistosoma mansoni	glucose transport protein	0.0209	0.2251	0.6834
Mycobacterium ulcerans	sugar transporter	0.0029	0.0199	0.2954
Schistosoma mansoni	hypothetical protein	0.0047	0.0404	0.1226
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0199	0.0604
Plasmodium vivax	sugar transporter, putative	0.0029	0.0199	0.0156
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0594	0.1804
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0604	0.8555
Echinococcus multilocularis	neuropeptide receptor A26	0.0484	0.5385	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Schistosoma mansoni	glucose transport protein	0.0209	0.2251	0.6834
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0038	0.0294	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.2251	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0185	0.0141
Echinococcus granulosus	lysyl tRNA synthetase	0.0047	0.0396	0.0736
Schistosoma mansoni	hypothetical protein	0.0047	0.0404	0.1226
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0041	0.033	0.1073
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0338	0.3722	0.3695
Schistosoma mansoni	hypothetical protein	0.0166	0.1752	0.5318
Brugia malayi	hypothetical protein	0.0032	0.0231	0.0923
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0432	0.5937
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0199	0.0369
Schistosoma mansoni	hypothetical protein	0.0022	0.0118	0.0359
Trypanosoma brucei	glucose transporter 1E	0.0065	0.0604	0.8555
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.01	0.0399
Toxoplasma gondii	protein kinase, putative	0.0592	0.6611	1
Schistosoma mansoni	sugar transporter	0.0029	0.0199	0.0604
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.01	0.0185
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0199	0.0461
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0404	0.075
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0116	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0604	0.8555
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0396	1
Schistosoma mansoni	protein kinase	0.0064	0.0594	0.1804
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0064	0.0594	0.2378
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0199	0.0461
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0594	0.1104
Leishmania major	hypothetical protein, conserved	0.005	0.0432	0.5937
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0199	0.0461
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0199	0.0461
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0432	0.039
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0064	0.0595	0.0553
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0199	0.0369
Schistosoma mansoni	importin beta-1	0.0028	0.0185	0.056
Echinococcus multilocularis	calcium dependent protein kinase	0.006	0.0549	0.102
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.058	0.1759
Loa Loa (eye worm)	sugar transporter	0.0029	0.0199	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Schistosoma mansoni	glucose transporter	0.0029	0.0199	0.0604
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0594	0.1804
Giardia lamblia	Lysyl-tRNA synthetase	0.0047	0.0396	0.6178
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Brugia malayi	Importin beta-1 subunit	0.0028	0.0185	0.0738
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0199	0.5702
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0396	0.1202
Loa Loa (eye worm)	hypothetical protein	0.015	0.1573	0.4773
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0199	0.237
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0604	0.2343
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.2499	0.4641
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0404	0.1226
Onchocerca volvulus		0.0029	0.0199	0.4963
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0064	0.0594	0.1804
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0199	0.237
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0404	0.075
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0047	0.0396	0.5384
Brugia malayi	hypothetical protein	0.0029	0.0199	0.0796
Echinococcus multilocularis	sodium channel protein	0.0038	0.0294	0.0545
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0594	0.1104
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0604	0.2343
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0065	0.0604	0.8555
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0268	0.3425
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Echinococcus granulosus	geminin	0.0166	0.1752	0.3254
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0064	0.0594	0.8412
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0185	0.0343
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Onchocerca volvulus		0.0029	0.0199	0.4963
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2251	0.4181
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0063	0.058	0.1076
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.0157	0.0477
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0063	0.058	0.223
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Brugia malayi	lysyl-tRNA synthetase	0.0047	0.0396	0.1585
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0063	0.058	0.9701
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0199	0.237
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0199	0.237
Leishmania major	hypothetical protein, conserved	0.0029	0.0199	0.237
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0698	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0404	0.075
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0698	1
Onchocerca volvulus		0.0029	0.0199	0.4963
Echinococcus granulosus	solute carrier family 22	0.0029	0.0199	0.0369
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0199	0.0461
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0199	0.0236
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2251	0.4181
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0044	0.0081
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.015	0.1573	0.4773
Plasmodium vivax	proline--tRNA ligase, putative	0.0073	0.0698	0.0657
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0064	0.0595	0.0839
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0698	1
Echinococcus granulosus	sodium channel protein	0.0038	0.0294	0.0545
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0199	0.0604
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0604	0.2343
Onchocerca volvulus		0.0029	0.0199	0.4963
Entamoeba histolytica	hypothetical protein	0.0047	0.0396	0.5993
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0445	0.1351
Onchocerca volvulus		0.0029	0.0199	0.4963
Entamoeba histolytica	hypothetical protein	0.0023	0.0124	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0396	0.1202
Chlamydia trachomatis	lysine--tRNA ligase	0.0047	0.0396	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0063	0.058	0.1076
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0594	0.1104
Onchocerca volvulus		0.0029	0.0199	0.4963
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0124	0.1222
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0404	0.075
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2251	0.4181
Giardia lamblia	Hexose transporter	0.0029	0.0199	0.2068
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Brugia malayi	Sugar transporter family protein	0.0209	0.2251	0.9009
Plasmodium falciparum	importin beta, putative	0.0028	0.0185	0.0141
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0594	0.1104
Schistosoma mansoni	hypothetical protein	0.0102	0.1032	0.3131
Schistosoma mansoni	hypothetical protein	0.0047	0.0404	0.1226
Schistosoma mansoni	sugar transporter	0.0029	0.0199	0.0604
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0594	0.1104
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.01	0.0085
Schistosoma mansoni	ran	0.0021	0.01	0.0302
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.015	0.1573	0.6292
Echinococcus granulosus	neuropeptide receptor A26	0.0484	0.5385	1
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0199	0.0369
Echinococcus multilocularis	lysyl tRNA synthetase	0.0047	0.0396	0.0736
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0199	0.5
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0199	0.0369
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2251	0.4181
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0604	0.2343
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0604	0.8555
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0064	0.0595	0.0553
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0064	0.0595	0.0839
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0594	0.2299
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0064	0.0595	0.0553
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0064	0.0595	0.0553
Schistosoma mansoni	hypothetical protein	0.0209	0.2251	0.6834
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0185	0.215
Leishmania major	glucose transporter, lmgt1	0.0065	0.0604	0.8555
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.01	0.0302
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0594	0.1104
Entamoeba histolytica	protein kinase, putative	0.0064	0.0594	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0199	0.0604
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2251	0.4181
Schistosoma mansoni	ran	0.0021	0.01	0.0302
Giardia lamblia	Sugar-proton symporter	0.0029	0.0199	0.2068
Toxoplasma gondii	lysine-tRNA ligase	0.0047	0.0396	0.0537
Onchocerca volvulus		0.0029	0.0199	0.4963
Loa Loa (eye worm)	hypothetical protein	0.005	0.0432	0.1312
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0044	0.0081
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.004	0.0316	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0185	0.0214
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0199	0.0604
Onchocerca volvulus		0.0029	0.0199	0.4963
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0044	0.0081
Schistosoma mansoni	glucose transport protein	0.0209	0.2251	0.6834
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0432	0.5937
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0199	0.0369
Schistosoma mansoni	hypothetical protein	0.0301	0.3295	1
Brugia malayi	Cam kinase protein 1	0.0064	0.0594	0.2378
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.01	0.0854
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0604	0.8555
Brugia malayi	major facilitator superfamily protein	0.0029	0.0199	0.0796
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0124	0.1222
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0199	0.2954
Brugia malayi	Calcitonin receptor-like protein seb-1	0.015	0.1573	0.6292
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0124	0.0112
Plasmodium falciparum	proline--tRNA ligase	0.0073	0.0698	0.0657
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1032	0.3131
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0338	0.3722	0.3695
Plasmodium falciparum	protein kinase 7	0.0592	0.6611	0.6596
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.01	0.0854
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0118	0.022
Echinococcus granulosus	solute carrier family 22	0.0029	0.0199	0.0369
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0199	0.0796
Echinococcus multilocularis	General substrate transporter	0.018	0.1916	0.3557
Onchocerca volvulus		0.0029	0.0199	0.4963
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0338	0.3722	0.5602
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0209	0.2251	0.4181
Echinococcus multilocularis	geminin	0.0166	0.1752	0.3254
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0604	0.2343
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0199	0.0236
Leishmania major	lysyl-tRNA synthetase, putative	0.0047	0.0396	0.5384
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0199	0.0461
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0604	0.2343
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0064	0.0594	0.1804
Onchocerca volvulus	Putative transporter	0.0029	0.0199	0.4963
Onchocerca volvulus		0.0029	0.0199	0.4963
Onchocerca volvulus		0.0047	0.0401	1
Echinococcus granulosus	snurportin 1	0.0301	0.3295	0.6118
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0604	0.8555
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0185	0.056
Schistosoma mansoni	protein kinase	0.0064	0.0594	0.1804
Trypanosoma brucei	glucose transporter 2A	0.0065	0.0604	0.8555
Schistosoma mansoni	hypothetical protein	0.0047	0.0401	0.1216
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0199	0.0369
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0432	0.039
Brugia malayi	hypothetical protein	0.0231	0.2499	1
Brugia malayi	hypothetical protein	0.0029	0.0199	0.0796
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0604	0.2343
Onchocerca volvulus		0.0029	0.0199	0.4963
Loa Loa (eye worm)	hypothetical protein	0.0063	0.058	0.1759

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1891115

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1537943