Detailed information for compound 1537945

Basic information

Technical information
  • TDR Targets ID: 1537945
  • Name: 4-[5-(morpholin-4-ylmethyl)tetrazol-1-yl]-N-( 1-thiophen-2-ylpropan-2-yl)butanamide
  • MW: 378.492 | Formula: C17H26N6O2S
  • H donors: 1 H acceptors: 4 LogP: 0.71 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cc1cccs1)NC(=O)CCCn1nnnc1CN1CCOCC1
  • InChi: 1S/C17H26N6O2S/c1-14(12-15-4-3-11-26-15)18-17(24)5-2-6-23-16(19-20-21-23)13-22-7-9-25-10-8-22/h3-4,11,14H,2,5-10,12-13H2,1H3,(H,18,24)
  • InChiKey: FOLJCGBQBAGYDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-methyl-2-(2-thienyl)ethyl]-4-[5-(morpholinomethyl)tetrazol-1-yl]butanamide
  • N-[1-methyl-2-(2-thienyl)ethyl]-4-[5-(morpholinomethyl)-1-tetrazolyl]butanamide
  • N-[1-methyl-2-(2-thienyl)ethyl]-4-[5-(morpholinomethyl)tetrazol-1-yl]butyramide
  • 4-[5-(morpholin-4-ylmethyl)-1,2,3,4-tetrazol-1-yl]-N-(1-thiophen-2-ylpropan-2-yl)butanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ran 0.0022 0.0116 0.0334
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0553 0.1083
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0583 0.1676
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0161 0.0459
Schistosoma mansoni hypothetical protein 0.0051 0.0434 0.1245
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0163 0.0245
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Leishmania major glucose transporter, lmgt1 0.0066 0.0608 0.8651
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0203 0.6328
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.04 0.6849
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0608 0.8651
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0228 0.0855
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1172
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Brugia malayi Cam kinase protein 1 0.0066 0.0598 0.2258
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0608 0.269
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.04 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0398
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.04 0.1769
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0206 0.0587
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.032 0.5469
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0608 0.8651
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2644 0.518
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Schistosoma mansoni protein kinase 0.0066 0.0598 0.1718
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0142 0.0622
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0116 0.0174
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.04 0.6849
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus GPCR family 2 0.0032 0.0228 0.0446
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.1006 0.2886
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0203 0.0398
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) hypothetical protein 0.0066 0.0598 0.1715
Echinococcus granulosus importin subunit beta 1 0.003 0.0206 0.0403
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0163 0.0162
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0583 0.1143
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0203 0.0398
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0583 1
Schistosoma mansoni ran 0.0022 0.0116 0.0334
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0203 0.0894
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0398
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0203 0.6328
Plasmodium falciparum hexose transporter 0.0214 0.2255 0.2253
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0435
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Echinococcus granulosus geminin 0.0179 0.1857 0.3638
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0599 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Brugia malayi hypothetical protein 0.003 0.0203 0.0762
Schistosoma mansoni importin beta-1 0.003 0.0206 0.0591
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0598 0.1715
Leishmania major glucose transporter, lmgt2 0.0066 0.0608 0.8651
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus sodium channel protein 0.0037 0.0276 0.054
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0037 0.0276 0.3913
Leishmania major GTP-binding protein, putative 0.0022 0.0116 0.164
Giardia lamblia Hexose transporter 0.003 0.0203 0.346
Loa Loa (eye worm) hypothetical protein 0.0052 0.0449 0.1286
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.04 1
Trypanosoma cruzi hexose transporter, putative 0.003 0.0203 0.2874
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Loa Loa (eye worm) hypothetical protein 0.0102 0.1006 0.2886
Loa Loa (eye worm) sugar transporter 0.0214 0.2255 0.6474
Brugia malayi Importin beta-1 subunit 0.003 0.0206 0.0773
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0702 1
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0608 0.8651
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0163 0.0162
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0702 1
Trypanosoma cruzi glucose transporter, putative 0.003 0.0203 0.2874
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0228 0.0446
Loa Loa (eye worm) hypothetical protein 0.007 0.0646 0.1851
Plasmodium vivax importin-beta 2, putative 0.003 0.0206 0.0204
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0206 0.2916
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0206 0.0309
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0583 0.2583
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0228 0.0446
Plasmodium vivax sugar transporter, putative 0.003 0.0203 0.0201
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0702 0.0701
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Giardia lamblia Sugar-proton symporter 0.003 0.0203 0.346
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0228 0.0446
Brugia malayi Sugar transporter family protein 0.003 0.0203 0.0762
Echinococcus multilocularis neuropeptide s receptor 0.047 0.5105 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.1006 0.3801
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0608 0.269
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.2255 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0163 0.2308
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4417
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0142 0.0622
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0702 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0334 0.1477
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0608 0.269
Leishmania major glucose transporter, lmgt3 0.0066 0.0608 0.8651
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0583 0.2202
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0398
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Loa Loa (eye worm) hypothetical protein 0.0032 0.0228 0.0649
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0203 0.5052
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Leishmania major hypothetical protein, conserved 0.003 0.0203 0.2874
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0002 0.0003
Schistosoma mansoni glucose transport protein 0.0214 0.2255 0.6476
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.04 0.5689
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Entamoeba histolytica protein kinase, putative 0.0066 0.0598 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0115
Brugia malayi Sugar transporter family protein 0.0214 0.2255 0.8527
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0599 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1172
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0002 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0608 0.269
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0599 0.0597
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0608 0.269
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0599 0.0903
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0608 0.269
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1172
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4417
Brugia malayi hypothetical protein 0.0027 0.0163 0.0612
Toxoplasma gondii sugar transporter ST2 0.003 0.0203 0.0305
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0179 0.1857 0.5333
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0608 0.8651
Loa Loa (eye worm) hypothetical protein 0.0027 0.0163 0.0465
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0346 0.3725 0.5632
Toxoplasma gondii facilitative glucose transporter GT1 0.0214 0.2255 0.3408
Leishmania major hypothetical protein, conserved 0.0027 0.0163 0.2308
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0203 0.0579
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus General substrate transporter 0.0184 0.1919 0.3759
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Entamoeba histolytica Ran family GTPase 0.0022 0.0116 0.1925
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0346 0.3725 0.3724
Toxoplasma gondii protein kinase, putative 0.0606 0.6612 1
Brugia malayi RNA, U transporter 1 0.0086 0.083 0.3136
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0702 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.1006 0.3801
Toxoplasma gondii sugar transporter ST3 0.003 0.0203 0.0305
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1172
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.3482 1
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0608 0.8651
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.012 0.2978
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0203 0.0398
Brugia malayi major facilitator superfamily protein 0.003 0.0203 0.0762
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0434 0.1635
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4417
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0203 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2644 0.518
Loa Loa (eye worm) hypothetical protein 0.0048 0.04 0.1145
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0583 0.1143
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0599 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Brugia malayi major facilitator superfamily protein 0.003 0.0203 0.0762
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0599 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.04 0.5689
Leishmania major protein kinase, putative 0.0066 0.0598 0.8517
Entamoeba histolytica protein kinase, putative 0.0066 0.0598 1
Schistosoma mansoni hypothetical protein 0.0325 0.3482 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0116 0.0228
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0599 0.0597
Brugia malayi lysyl-tRNA synthetase 0.0048 0.04 0.1508
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0398
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.04 0.1149
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0598 0.2648
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4417
Schistosoma mansoni survival motor neuron protein 0.0051 0.0434 0.1245
Schistosoma mansoni glucose transport protein 0.0214 0.2255 0.6476
Echinococcus multilocularis importin subunit beta 1 0.003 0.0206 0.0403
Brugia malayi hypothetical protein 0.003 0.0203 0.0762
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1172
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0203 0.0579
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0203 0.5052
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0608 0.269
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0598 0.8517
Schistosoma mansoni protein kinase 0.0066 0.0598 0.1718
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0398
Schistosoma mansoni protein kinase 0.0066 0.0598 0.1718
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0203 0.0201
Trypanosoma brucei sugar transporter, putative 0.003 0.0203 0.2874
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0583 0.1676
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0599 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0598 0.1172
Trypanosoma cruzi hexose transporter 0.0066 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.04 1
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.012 0.2978
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0598 0.1715
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0002 0.0004
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0203 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.04 0.0784
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Brugia malayi Sugar transporter family protein 0.003 0.0203 0.0762
Trichomonas vaginalis glucose transporter, putative 0.003 0.0203 0.0894
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0702 0.0701
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0228 0.0446
Trypanosoma cruzi sugar transporter, putative 0.003 0.0203 0.2874
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0702 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0583 0.9752
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0598 0.2258
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0203 0.5052
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Brugia malayi hypothetical protein 0.003 0.0203 0.0762
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0398
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0203 0.0583
Echinococcus granulosus snurportin 1 0.0325 0.3482 0.6821
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4417
Schistosoma mansoni hypothetical protein 0.007 0.0646 0.1855
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4417
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0203 0.2874
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0228 0.0855
Plasmodium vivax CDK-related protein kinase 6, putative 0.091 1 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Echinococcus multilocularis snurportin 1 0.0325 0.3482 0.6821
Loa Loa (eye worm) sugar transporter 0.003 0.0203 0.0579
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0228 0.0649
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0142 0.2002
Loa Loa (eye worm) hypothetical protein 0.0249 0.2644 0.7593
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0142 0.0622
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0599 0.0597
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0203 0.0762
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Plasmodium falciparum importin beta, putative 0.003 0.0206 0.0204
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0646 0.2438
Echinococcus multilocularis sodium channel protein 0.0037 0.0276 0.054
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0163 0.2308
Trypanosoma brucei glucose transporter 1E 0.0066 0.0608 0.8651
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0163 0.2308
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.04 0.0784
Echinococcus granulosus neuropeptide receptor A26 0.047 0.5105 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0203 0.0398
Leishmania major importin beta-1 subunit, putative 0.0025 0.0142 0.2002
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.032 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.04 0.1149
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Mycobacterium ulcerans sugar transporter 0.003 0.0203 0.5052
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Trichomonas vaginalis ran, putative 0.0022 0.0116 0.051
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Toxoplasma gondii sugar transporter ST1 0.003 0.0203 0.0305
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0206 0.2916
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Brugia malayi hypothetical protein 0.0249 0.2644 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.04 0.0399
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0116 0.0115
Echinococcus granulosus neuropeptide s receptor 0.047 0.5105 1
Trypanosoma brucei glucose transporter 2A 0.0066 0.0608 0.8651
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0702 0.106
Schistosoma mansoni hypothetical protein 0.0179 0.1857 0.5333
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Onchocerca volvulus 0.0051 0.0434 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0599 0.0903
Echinococcus multilocularis GPCR, family 2 0.0032 0.0228 0.0446
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0599 0.0597
Schistosoma mansoni glucose transporter 0.003 0.0203 0.0583
Schistosoma mansoni glucose transport protein 0.0214 0.2255 0.6476
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0203 0.0762
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0272 0.386
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.032 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0214 0.2255 0.4417
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0598 0.1718
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0553 0.1083
Echinococcus multilocularis General substrate transporter 0.0184 0.1919 0.3759
Loa Loa (eye worm) hypothetical protein 0.0064 0.0583 0.1672
Loa Loa (eye worm) hypothetical protein 0.0064 0.0583 0.1672
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0116 0.0228
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.012 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0037 0.0276 0.054
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.04 0.5689
Plasmodium vivax hexose transporter 0.0214 0.2255 0.2253
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Plasmodium falciparum mitogen-activated protein kinase 2 0.0346 0.3725 0.3724
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0599 0.0597
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0214 0.2255 0.4417
Echinococcus multilocularis neuropeptide receptor A26 0.047 0.5105 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1172
Schistosoma mansoni sugar transporter 0.003 0.0203 0.0583
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579
Entamoeba histolytica hypothetical protein 0.0048 0.04 0.6679
Trichomonas vaginalis sugar transporter, putative 0.003 0.0203 0.0894
Schistosoma mansoni hypothetical protein 0.0214 0.2255 0.6476
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0203 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0203 0.2874
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0583 1
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.04 0.0399
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0163 0.0162
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0583 0.2202
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0203 0.0762
Echinococcus granulosus solute carrier family 22 0.003 0.0203 0.0398
Schistosoma mansoni hypothetical protein 0.0032 0.0228 0.0654
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0598 0.1172
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.1974
Entamoeba histolytica hypothetical protein 0.0025 0.0142 0.235
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0002 0.0003
Plasmodium falciparum protein kinase 7 0.0606 0.6612 0.6612
Brugia malayi hypothetical protein 0.0017 0.0058 0.0215
Trypanosoma brucei glucose transporter, putative 0.0066 0.0608 0.8651
Echinococcus multilocularis geminin 0.0179 0.1857 0.3638
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.04 0.0603
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0203 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0203 0.0579

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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