Detailed information for compound 1538245

Basic information

Technical information
  • TDR Targets ID: 1538245
  • Name: 9-(3,5-dimethylphenyl)-7-hydroxy-1-methyl-7,8 -dihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • MW: 341.364 | Formula: C17H19N5O3
  • H donors: 2 H acceptors: 4 LogP: 1.22 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CN(c2cc(C)cc(c2)C)c2n(C1)c1c(=O)[nH]c(=O)n(c1n2)C
  • InChi: 1S/C17H19N5O3/c1-9-4-10(2)6-11(5-9)21-7-12(23)8-22-13-14(18-16(21)22)20(3)17(25)19-15(13)24/h4-6,12,23H,7-8H2,1-3H3,(H,19,24,25)
  • InChiKey: HUAMYVPEJSPZDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-(3,5-dimethylphenyl)-7-hydroxy-1-methyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone
  • STOCK4S-73220

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.296 0.3295
Plasmodium vivax glutathione reductase, putative 0.0057 0.0196 1
Echinococcus granulosus tyrosine kinase 0.0115 0.0708 0.0708
Entamoeba histolytica hypothetical protein 0.0115 0.0708 0.5
Echinococcus multilocularis nmda type glutamate receptor 0.0225 0.1672 0.1672
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.0708 0.0788
Brugia malayi Glutamate receptor 2 precursor 0.1057 0.8986 1
Schistosoma mansoni glutamate receptor NMDA 0.0724 0.6054 0.6928
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1145 0.9752 0.9752
Echinococcus multilocularis receptor type guanylyl cyclase 0.0115 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0196 1
Leishmania major extracellular receptor, putative 0.0115 0.0708 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0966 1
Brugia malayi Receptor family ligand binding region containing protein 0.0115 0.0708 0.0788
Echinococcus multilocularis glutamate receptor 2 0.1173 1 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0225 0.1672 0.1672
Schistosoma mansoni glutamate receptor AMPA 0.0608 0.504 0.5768
Onchocerca volvulus 0.0115 0.0708 0.5
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0115 0.0708 0.0788
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Schistosoma mansoni protein kinase 0.0115 0.0708 0.081
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0839 0.8342
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0674 0.5618 0.5618
Schistosoma mansoni glutamate receptor AMPA 0.0608 0.504 0.5768
Echinococcus multilocularis glutamate receptor 2 0.0948 0.8022 0.8022
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0646 0.5371 0.5371
Brugia malayi Metabotropic glutamate receptor precursor. 0.0115 0.0708 0.0788
Loa Loa (eye worm) hypothetical protein 0.0449 0.364 0.4051
Echinococcus granulosus receptor type guanylyl cyclase 0.0115 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0449 0.364 0.4051
Loa Loa (eye worm) glutamate receptor 1 0.1057 0.8986 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0115 0.0708 0.0788
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1145 0.9752 0.9752
Echinococcus multilocularis NMDA receptor 0.0646 0.5371 0.5371
Toxoplasma gondii thioredoxin reductase 0.0057 0.0196 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0115 0.0708 0.0708
Echinococcus granulosus atrial natriuretic peptide receptor 0.0115 0.0708 0.0708
Brugia malayi glutathione reductase 0.0057 0.0196 0.0218
Schistosoma mansoni ATP-binding cassette transporter 0.0608 0.504 0.5768
Loa Loa (eye worm) glutamate receptor 2 0.0608 0.504 0.5609
Echinococcus multilocularis glutamate receptor 2 0.1057 0.8986 0.8986
Schistosoma mansoni tyrosine kinase 0.0115 0.0708 0.081
Echinococcus granulosus glutamate receptor 1 0.0449 0.364 0.364
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0115 0.0708 0.0708
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0839 0.8342
Echinococcus granulosus nmda type glutamate receptor 0.0225 0.1672 0.1672
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1173 1 1
Schistosoma mansoni metabotropic glutamate receptor 0.0115 0.0708 0.081
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0225 0.1672 0.1672
Schistosoma mansoni metabotropic glutamate receptor 0.0115 0.0708 0.081
Echinococcus multilocularis tyrosine kinase 0.0115 0.0708 0.0708
Echinococcus granulosus glutamate receptor 2 0.0948 0.8022 0.8022
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1145 0.9752 0.9752
Schistosoma mansoni hypothetical protein 0.0372 0.296 0.3388
Onchocerca volvulus 0.0115 0.0708 0.5
Brugia malayi Thioredoxin reductase 0.0057 0.0196 0.0218
Schistosoma mansoni glutamate receptor kainate 0.0608 0.504 0.5768
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0646 0.5371 0.5371
Echinococcus granulosus metabotropic glutamate receptor 2 0.0115 0.0708 0.0708
Echinococcus multilocularis glutamate receptor 4 0.0449 0.364 0.364
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0961 0.1069
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.0708 0.0788
Schistosoma mansoni hypothetical protein 0.0225 0.1672 0.1914
Schistosoma mansoni tyrosine kinase 0.0115 0.0708 0.081
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0646 0.5371 0.5371
Brugia malayi Glutamate receptor 1 precursor 0.1057 0.8986 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0966 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Brugia malayi RNA, U transporter 1 0.0099 0.0564 0.0628
Brugia malayi Receptor family ligand binding region containing protein 0.0115 0.0708 0.0788
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0115 0.0708 0.0708
Schistosoma mansoni glutamate receptor NMDA 0.0608 0.504 0.5768
Loa Loa (eye worm) hypothetical protein 0.0449 0.364 0.4051
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0708 0.0708
Echinococcus granulosus glutamate receptor 4 0.0449 0.364 0.364
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0961 0.1069
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0196 0.0218
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0839 0.8342
Loa Loa (eye worm) glutamate receptor 0.0115 0.0708 0.0788
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0708 0.0708
Schistosoma mansoni glutamate receptor kainate 0.1029 0.8738 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Brugia malayi metabotropic glutamate receptor type 2 0.0115 0.0708 0.0788
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0839 0.8342
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0115 0.0708 0.0788
Loa Loa (eye worm) glutathione reductase 0.0057 0.0196 0.0218
Schistosoma mansoni glutamate receptor kainate 0.1029 0.8738 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0966 1
Echinococcus granulosus snurportin 1 0.0372 0.296 0.296
Trypanosoma cruzi extracellular receptor, putative 0.0115 0.0708 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0839 0.8342
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Plasmodium falciparum thioredoxin reductase 0.0057 0.0196 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0196 0.0196
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0966 1
Plasmodium falciparum glutathione reductase 0.0057 0.0196 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1145 0.9752 0.9752
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Echinococcus granulosus glutamate NMDA receptor subunit 0.0608 0.504 0.504
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1145 0.9752 0.9752
Loa Loa (eye worm) RGC/RGC protein kinase 0.0115 0.0708 0.0788
Echinococcus multilocularis snurportin 1 0.0372 0.296 0.296
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Echinococcus granulosus metabotropic glutamate receptor 5 0.0115 0.0708 0.0708
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0115 0.0708 0.0788
Echinococcus granulosus glutamate receptor subunit protein glur 0.0674 0.5618 0.5618
Brugia malayi hypothetical protein 0.0115 0.0708 0.0788
Mycobacterium tuberculosis Probable reductase 0.013 0.0839 0.8342
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0196 0.0196
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1173 1 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0646 0.5371 0.5371
Brugia malayi MH2 domain containing protein 0.0144 0.0961 0.1069
Brugia malayi Guanylyl cyclase protein 23 0.0115 0.0708 0.0788
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0608 0.504 0.504
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1145 0.9752 0.9752
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0115 0.0708 0.5
Loa Loa (eye worm) hypothetical protein 0.0115 0.0708 0.0788
Trypanosoma brucei trypanothione reductase 0.0057 0.0196 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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