Detailed information for compound 1540227

Basic information

Technical information
  • TDR Targets ID: 1540227
  • Name: N-(3-chloro-4-methylphenyl)-2-[6-ethoxy-3-(4- ethoxybenzoyl)-4-oxoquinolin-1-yl]acetamide
  • MW: 518.988 | Formula: C29H27ClN2O5
  • H donors: 1 H acceptors: 3 LogP: 5.82 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOc1ccc2c(c1)c(=O)c(cn2CC(=O)Nc1ccc(c(c1)Cl)C)C(=O)c1ccc(cc1)OCC
  • InChi: 1S/C29H27ClN2O5/c1-4-36-21-10-7-19(8-11-21)28(34)24-16-32(17-27(33)31-20-9-6-18(3)25(30)14-20)26-13-12-22(37-5-2)15-23(26)29(24)35/h6-16H,4-5,17H2,1-3H3,(H,31,33)
  • InChiKey: PYUZEFUSVWVLPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-chloro-4-methyl-phenyl)-2-[6-ethoxy-3-(4-ethoxybenzoyl)-4-oxo-1-quinolyl]acetamide
  • N-(3-chloro-4-methylphenyl)-2-[6-ethoxy-3-[(4-ethoxyphenyl)-oxomethyl]-4-oxo-1-quinolyl]acetamide
  • N-(3-chloro-4-methyl-phenyl)-2-[6-ethoxy-3-(4-ethoxybenzoyl)-4-keto-1-quinolyl]acetamide
  • N-(3-chloro-4-methyl-phenyl)-2-[6-ethoxy-3-(4-ethoxyphenyl)carbonyl-4-oxo-quinolin-1-yl]ethanamide
  • C647-1035
  • NCGC00111183-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.2499 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.2499 0.5045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.2499 0.6868
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.2169 0.6071
Loa Loa (eye worm) hypothetical protein 0.0011 0.1174 0.1992
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.2499 0.5426
Brugia malayi AMP-binding enzyme family protein 0.0023 0.3424 0.7823
Onchocerca volvulus 0.0023 0.3424 0.7823
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.3424 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.2371 0.5093
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.3424 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.1174 0.265
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0966 0.1455
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.2371 0.6514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0404 0.0546
Schistosoma mansoni ap endonuclease 0.0018 0.2499 0.2183
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0404 0.1111
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0404 0.0295
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.3424 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.2377 0.6531
Loa Loa (eye worm) hypothetical protein 0.0023 0.3424 0.7823
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0404 0.0546
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.3639 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.2371 0.6078
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0732 0.0789
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0404 0.0546
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.042 0.0038
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.2499 0.5
Schistosoma mansoni cpg binding protein 0.003 0.4556 0.4327
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.3639 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.2499 0.6936
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Mycobacterium ulcerans hypothetical protein 0.0023 0.3424 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.2371 0.6078
Loa Loa (eye worm) hypothetical protein 0.0021 0.2954 0.6605
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.3424 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.2371 0.6514
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.042 0.0038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.2499 0.6476
Schistosoma mansoni hypothetical protein 0.0008 0.0554 0.0156
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.2371 0.6514
Loa Loa (eye worm) hypothetical protein 0.0017 0.2344 0.5023
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0404 0.1111
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.4265 1
Schistosoma mansoni ap endonuclease 0.0018 0.2499 0.2183
Schistosoma mansoni cpg binding protein 0.0028 0.4265 0.4023
Entamoeba histolytica protein kinase rad3, putative 0.001 0.0966 0.1772
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0404 0.0546
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0732 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0966 0.2014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.2499 0.7104
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.2371 0.4735
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.2499 0.6868
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.042 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.1174 0.265
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.1163 0.1827
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.001 0.0966 0.2655
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.3424 0.941
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0966 0.2014
Brugia malayi AMP-binding enzyme family protein 0.0023 0.3424 0.7823
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0966 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.2371 0.4735
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0966 0.2014
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.2371 0.2049
Toxoplasma gondii exonuclease III APE 0.0018 0.2499 0.2483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.3424 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.2344 0.6617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0554 0.0752
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.3424 1
Echinococcus multilocularis cpg binding protein 0.003 0.4556 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0404 0.0546
Loa Loa (eye worm) hypothetical protein 0.0023 0.3424 0.7823
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.3574 0.821
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.2371 0.2049
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.2371 0.6514
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.2499 0.5426
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.2169 0.6071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.3424 0.9528
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.3639 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.2371 0.6204
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0712 0.0796
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.3424 0.9528
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0966 0.2014
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.3574 0.3303
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.2169 0.6071
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0404 0.1111
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0966 0.1353
Loa Loa (eye worm) hypothetical protein 0.0017 0.2344 0.5023
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.2371 0.6514
Brugia malayi FAT domain containing protein 0.0008 0.0554 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.3574 0.7634
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.2371 0.6204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.2344 0.5
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0404 0.1111
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.3424 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.2371 0.6078
Brugia malayi AMP-binding enzyme family protein 0.0023 0.3424 0.7823
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.042 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.2371 0.5093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.1174 0.0912
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.3424 0.941
Loa Loa (eye worm) hypothetical protein 0.0017 0.2344 0.5023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.3574 0.9821
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.001 0.0966 0.1772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0404 0.0546
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.2499 0.6609
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.3639 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.2371 0.6514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.2371 0.6514
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.8841 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.3639 0.3834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0404 0.1111
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.2371 0.4735
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.3424 1
Toxoplasma gondii FATC domain-containing protein 0.0024 0.3574 0.3757
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Loa Loa (eye worm) hypothetical protein 0.0023 0.3424 0.7823
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.2371 0.6078
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.2371 0.5093
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0966 0.1353
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0404 0.1111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.2344 0.5995
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0966 0.2014
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0732 0.0848
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.2499 0.6709
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.2371 0.6514
Brugia malayi hypothetical protein 0.0016 0.2048 0.4257
Brugia malayi hypothetical protein 0.0024 0.3639 0.8379
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.2954 0.8118
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.2371 0.6514
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0966 0.2014
Loa Loa (eye worm) hypothetical protein 0.0024 0.3639 0.8379
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0404 0.0546
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.2344 0.6421
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.2371 0.2331
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.2499 0.5045
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.2371 0.5093
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.2344 0.5995
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.2169 0.6071
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.2499 0.6476
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.3574 0.9798
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.3424 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.2499 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0007 0.0346 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Echinococcus granulosus serine protein kinase ATM 0.0024 0.3574 0.7634
Entamoeba histolytica hypothetical protein 0.0024 0.3574 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.2499 0.6709
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.1174 0.2378
Brugia malayi CXXC zinc finger family protein 0.0028 0.4265 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.3424 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0966 0.1455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0008 0.0554 0.036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.3424 0.9528
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0404 0.0546
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.2371 0.4735
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.2371 0.6078
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0008 0.0554 0.036
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.3639 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.3639 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Onchocerca volvulus 0.0028 0.4265 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.2344 0.5023
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0404 0.0546
Schistosoma mansoni cpg binding protein 0.003 0.4556 0.4327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.3574 1
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0404 0.1111
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.2371 0.6514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0404 0.0546
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0404 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.2499 0.6476
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0966 0.2014
Loa Loa (eye worm) hypothetical protein 0.0008 0.0554 0.0387
Loa Loa (eye worm) hypothetical protein 0.0017 0.2344 0.5023
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.2377 0.6531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.2371 0.6315
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.2499 0.6868
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.3424 0.941
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.042 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0346 0.0116
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.3424 1
Leishmania major hypothetical protein, conserved 0.0024 0.3639 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.1163 0.1827
Echinococcus granulosus cpg binding protein 0.003 0.4556 1
Schistosoma mansoni hypothetical protein 0.0011 0.1163 0.0791
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0404 0.0546

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.