Detailed information for compound 154028

Basic information

Technical information
  • TDR Targets ID: 154028
  • Name: 1-[8-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-4- (2-methylanilino)quinolin-3-yl]butan-1-one
  • MW: 452.543 | Formula: C26H32N2O5
  • H donors: 2 H acceptors: 3 LogP: 4.15 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)c1cnc2c(c1Nc1ccccc1C)cccc2OCCOCCOCCO
  • InChi: 1S/C26H32N2O5/c1-3-7-23(30)21-18-27-26-20(25(21)28-22-10-5-4-8-19(22)2)9-6-11-24(26)33-17-16-32-15-14-31-13-12-29/h4-6,8-11,18,29H,3,7,12-17H2,1-2H3,(H,27,28)
  • InChiKey: MMQIHPMIJVLHMW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[8-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-4-(2-methylanilino)-3-quinolyl]butan-1-one
  • 1-[8-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-4-(2-methylanilino)-3-quinolyl]-1-butanone
  • 1-[8-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-4-[(2-methylphenyl)amino]quinolin-3-yl]butan-1-one
  • 1-[8-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-4-(o-toluidino)-3-quinolyl]butan-1-one
  • 1-[8-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-4-[(2-methylphenyl)amino]-3-quinolyl]butan-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Potassium-transporting ATPase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 265 aa 22.3 %
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Potassium-transporting ATPase   290 aa 258 aa 23.6 %
Loa Loa (eye worm) hypothetical protein Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Drosophila melanogaster nervana 1 Potassium-transporting ATPase   290 aa 305 aa 23.9 %
Onchocerca volvulus Glutamate carboxypeptidase 2 homolog Potassium-transporting ATPase   290 aa 301 aa 25.9 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 21.3 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 254 aa 23.6 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta, putative Potassium-transporting ATPase   290 aa 256 aa 25.4 %
Echinococcus granulosus nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.3 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 24.1 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Potassium-transporting ATPase   290 aa 258 aa 24.4 %
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Potassium-transporting ATPase   290 aa 306 aa 26.1 %
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 267 aa 27.3 %
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Potassium-transporting ATPase   290 aa 266 aa 25.6 %
Echinococcus multilocularis nervana 2 Potassium-transporting ATPase   290 aa 280 aa 29.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.0054 0.0534 0.2123
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0054 0.0534 0.2123
Brugia malayi Dopamine receptor protein 2 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis nervana 2 0.0026 0.018 0.018
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0074 0.0169
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0534 0.2123
Schistosoma mansoni glycogen phosphorylase 0.0093 0.101 0.4017
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0054 0.0534 0.2123
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0179 0.4141
Schistosoma mansoni glycogen phosphorylase 0.0215 0.2514 1
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0014 0.0032 0.0128
Loa Loa (eye worm) hypothetical protein 0.0035 0.0293 0.1167
Schistosoma mansoni ATPase 0.0017 0.0074 0.0294
Chlamydia trachomatis glycogen phosphorylase 0.0215 0.2514 1
Brugia malayi beta-lactamase family protein 0.0036 0.0313 0.1244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi putative neuropeptide receptor 0.0054 0.0534 0.2123
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0032 0.0128
Onchocerca volvulus 0.0054 0.0534 0.1884
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0168 0.0668
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0313 0.1131
Echinococcus multilocularis G-protein coupled receptor, putative 0.0054 0.0534 0.0534
Brugia malayi hypothetical protein 0.0017 0.0068 0.0269
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0534 0.2123
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0534 0.2123
Schistosoma mansoni neuropeptide receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0043 0.0388 0.1541
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0436 0.0436
Brugia malayi larval opioid receptor 0.0054 0.0534 0.2123
Echinococcus granulosus glycogen phosphorylase 0.0215 0.2514 1
Echinococcus granulosus dro:myosuppressin receptor 0.0054 0.0534 0.2123
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus 7tm_1 domain containing protein 0.0054 0.0534 0.2123
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0014 0.0032 0.0128
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis 0.0043 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0115 0.0458
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0534 0.2123
Echinococcus granulosus nervana 2 0.0026 0.018 0.0716
Brugia malayi hypothetical protein 0.0026 0.0179 0.0713
Brugia malayi follicle stimulating hormone receptor 0.0054 0.0534 0.2123
Echinococcus granulosus neuropeptide Y receptor 0.0054 0.0534 0.2123
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0388 1
Echinococcus granulosus g protein coupled receptor 0.0054 0.0534 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0054 0.0534 0.1884
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0436 0.1734
Trichomonas vaginalis glycogen phosphorylase, putative 0.0215 0.2514 1
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0054 0.0534 0.2123
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0534 0.0534
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0026 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis glycogen phosphorylase 0.0215 0.2514 0.2514
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0294
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0012 0.0007 0.0027
Leishmania major hypothetical protein, conserved 0.0036 0.0313 0.7899
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0534 0.2123
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0388 0.1541
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0054 0.0534 0.0534
Echinococcus granulosus alpha 1A adrenergic receptor 0.0054 0.0534 0.2123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0534 0.0534
Brugia malayi Membrane calcium atpase protein 3 0.0014 0.0032 0.0128
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis calcium transporting atpase 0.0014 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni amine GPCR 0.0054 0.0534 0.2123
Schistosoma mansoni glycogen phosphorylase 0.0215 0.2514 1
Echinococcus granulosus Na:K ATPase alpha subunit 0.0014 0.0032 0.0128
Onchocerca volvulus Neuropeptide F receptor homolog 0.0054 0.0534 0.1884
Trichomonas vaginalis esterase, putative 0.0036 0.0313 0.1131
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0067 0.0686 0.273
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0534 0.0534
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0074 0.0148
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0032 0.0128
Schistosoma mansoni histamine h1 receptor 0.0054 0.0534 0.2123
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0074 0.1178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis PHD finger protein rhinoceros 0.002 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0313 0.7899
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0388 0.1541
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0074 0.0169
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.002 0.0115 0.0458
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0067 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0054 0.0534 0.2123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Brugia malayi neuropeptide F receptor 0.0054 0.0534 0.2123
Schistosoma mansoni hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus peptide allatostatin:somatostatin 0.0054 0.0534 0.2123
Mycobacterium ulcerans lipase LipD 0.0036 0.0313 0.042
Echinococcus granulosus G protein coupled receptor 139 0.0054 0.0534 0.2123
Schistosoma mansoni growth hormone secretagogue receptor 0.0054 0.0534 0.2123
Echinococcus granulosus biogenic amine 5HT receptor 0.0054 0.0534 0.2123
Schistosoma mansoni neuropeptide F-like receptor 0.0054 0.0534 0.2123
Schistosoma mansoni transmemberane protein 0.0026 0.018 0.0716
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Schistosoma mansoni biogenic amine receptor 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0036 0.0313 0.0979
Echinococcus granulosus peregrin 0.002 0.0115 0.0458
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi MH2 domain containing protein 0.0121 0.1356 0.5395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0436 0.1734
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0014 0.0032 0.0128
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0388 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Echinococcus granulosus sex peptide receptor 0.0054 0.0534 0.2123
Echinococcus granulosus nervana 2 0.0026 0.018 0.0716
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0032 0.0128
Loa Loa (eye worm) hypothetical protein 0.0036 0.0313 0.1244
Onchocerca volvulus 0.0054 0.0534 0.1884
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0026 0.018 0.0716
Brugia malayi Bromodomain containing protein 0.002 0.0115 0.0458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Onchocerca volvulus 0.0054 0.0534 0.1884
Schistosoma mansoni amine GPCR 0.0054 0.0534 0.2123
Echinococcus granulosus nervana 2 0.0026 0.018 0.0716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0036 0.0313 0.0979
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0074 0.1492
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi jmjC domain containing protein 0.0025 0.0168 0.0668
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0294
Echinococcus granulosus neuropeptide s receptor 0.0054 0.0534 0.2123
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0534 0.2123
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0313 0.1244
Plasmodium vivax hypothetical protein, conserved 0.002 0.0115 0.1315
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0534 0.2123
Echinococcus granulosus 7TM GPCR rhodopsin 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0295 0.1171
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0534 0.0534
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0313 0.0453
Echinococcus multilocularis neuropeptide FF receptor 2 0.0054 0.0534 0.0534
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0036 0.0313 0.1244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0436 0.1734
Loa Loa (eye worm) hypothetical protein 0.0036 0.0313 0.1244
Echinococcus multilocularis neuropeptide receptor A26 0.0054 0.0534 0.0534
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0054 0.0534 0.2123
Entamoeba histolytica hypothetical protein 0.0037 0.0314 0.0862
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0179 0.3358
Mycobacterium leprae Probable lipase LipE 0.0036 0.0313 0.8039
Mycobacterium tuberculosis Conserved protein 0.0036 0.0313 0.0453
Echinococcus multilocularis geminin 0.0171 0.1976 0.1976
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) glycogen phosphorylase 0.0215 0.2514 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0314 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Echinococcus granulosus fmrfamide receptor 0.0054 0.0534 0.2123
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0179 0.4141
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0179 0.4141
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0074 0.0169
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0313 0.8039
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0074 0.1178
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0534 0.0534
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis g-protein coupled receptor 0.0054 0.0534 0.0534
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0017 0.0074 0.0092
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0032 0.0128
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0534 0.0534
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0436 0.1734
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0054 0.0534 0.2123
Plasmodium falciparum phd finger protein, putative 0.002 0.0115 0.2339
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0534 0.2123
Leishmania major hypothetical protein, conserved 0.0026 0.0179 0.4141
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0436 0.0436
Mycobacterium ulcerans beta-lactamase 0.0036 0.0313 0.042
Echinococcus granulosus somatostatin receptor 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0043 0.0388 0.1285
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0534 0.2123
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0054 0.0534 0.1884
Loa Loa (eye worm) hypothetical protein 0.0036 0.0313 0.1244
Echinococcus granulosus g protein coupled receptor 0.0054 0.0534 0.2123
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0243 0.2857 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0313 0.7899
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0014 0.0032 0.0032
Leishmania major UDP-galactopyranose mutase 0.0043 0.0388 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0313 0.1244
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0014 0.0032 0.0032
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0388 1
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus calcium transporting atpase 0.0014 0.0032 0.0128
Schistosoma mansoni amine GPCR 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0025 0.0168 0.0668
Toxoplasma gondii ABC1 family protein 0.0036 0.0313 0.7899
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0534 0.2123
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.018 0.0716
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0093 0.101 0.1483
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0054 0.0534 0.2123
Brugia malayi AKH receptor 0.0054 0.0534 0.2123
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0313 0.0453
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0382 0.1521
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0074 0.0169
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0313 0.0453
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0074 0.1492
Onchocerca volvulus Alhambra homolog 0.002 0.0115 0.0169
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis dro:myosuppressin receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) beta-lactamase 0.0036 0.0313 0.1244
Loa Loa (eye worm) neuropeptide F receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0534 0.0534
Onchocerca volvulus 0.0054 0.0534 0.1884
Entamoeba histolytica glycogenphosphorylase, putative 0.0093 0.101 0.3363
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0313 0.7618
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0035 0.0293 0.1167
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0458
Echinococcus multilocularis fmrfamide receptor 0.0054 0.0534 0.0534
Schistosoma mansoni hypothetical protein 0.0171 0.1976 0.7858
Echinococcus multilocularis g protein coupled receptor 0.0054 0.0534 0.0534
Onchocerca volvulus 0.0054 0.0534 0.1884
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.018 0.018
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0012 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni neuropeptide receptor 0.0054 0.0534 0.2123
Entamoeba histolytica hypothetical protein 0.0069 0.0716 0.2306
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0388 1
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0115 0.2339
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.018 0.0716
Echinococcus granulosus neuropeptide receptor 0.0054 0.0534 0.2123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0534 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0534 0.2123
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0388 1
Brugia malayi hypothetical protein 0.0043 0.0388 0.1541
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0074 0.0169
Echinococcus multilocularis serotonin receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0158 0.0627
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0069 0.0716 0.2306
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0054 0.0534 0.2123
Brugia malayi carbohydrate phosphorylase 0.0215 0.2514 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0168 0.0668
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0388 1
Echinococcus multilocularis nervana 2 0.0026 0.018 0.018
Echinococcus multilocularis orexin receptor type 2 0.0054 0.0534 0.0534
Brugia malayi Dopamine receptor protein 1 0.0054 0.0534 0.2123
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0388 0.0563
Giardia lamblia DNA repair protein RAD52 0.0243 0.2857 1
Echinococcus granulosus geminin 0.0171 0.1976 0.7858
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0026 0.018 0.0716
Trichomonas vaginalis glycogen phosphorylase, putative 0.0215 0.2514 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0054 0.0534 0.2123
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0054 0.0534 0.0534
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0388 1
Brugia malayi G-protein coupled receptor 0.0054 0.0534 0.2123
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0074 0.0294
Entamoeba histolytica glycogen phosphorylase, putative 0.0093 0.101 0.3363
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0014 0.0032 0.0032
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0054 0.0534 0.1884
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0017 0.0074 0.0092
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0074 0.1178
Echinococcus multilocularis serotonin receptor 0.0054 0.0534 0.0534
Schistosoma mansoni neuropeptide receptor 0.0054 0.0534 0.2123
Brugia malayi putative neuropeptide receptor NPR1 0.0054 0.0534 0.2123
Echinococcus granulosus neuropeptide FF receptor 2 0.0054 0.0534 0.2123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0054 0.0534 0.2123
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0313 0.0453
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.018 0.0716
Brugia malayi RE15519p 0.0054 0.0534 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0014 0.0032 0.0128
Brugia malayi ORL1-like opioid receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0313 0.0453
Echinococcus granulosus neuropeptide receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis glycogen phosphorylase 0.0215 0.2514 0.2514
Echinococcus granulosus PHD finger protein rhinoceros 0.002 0.0115 0.0458
Schistosoma mansoni opsin-like receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni neuropeptide f receptor 76f 0.0054 0.0534 0.2123
Echinococcus granulosus g-protein coupled receptor 0.0054 0.0534 0.2123
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0313 0.042
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.273 0.4026
Echinococcus granulosus orexin receptor type 2 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0313 0.1244
Mycobacterium ulcerans dehydrogenase 0.0043 0.0388 0.0522
Onchocerca volvulus 0.0054 0.0534 0.1884
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1356 0.5395
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0214 0.0214
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0388 0.1541
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0026 0.018 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0313 0.1131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Echinococcus granulosus lysine specific demethylase 5A 0.0025 0.0168 0.0668
Onchocerca volvulus 0.0036 0.0313 0.0979
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0054 0.0534 0.2123
Brugia malayi neuropeptide F receptor 0.0054 0.0534 0.2123
Mycobacterium tuberculosis Conserved protein 0.0036 0.0313 0.0453
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0074 0.0169
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0388 1
Schistosoma mansoni myosin xvIII 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi G-protein coupled receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0534 0.0534
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0043 0.0388 0.1541
Entamoeba histolytica glycogen phosphorylase, putative 0.0215 0.2514 0.8767
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0035 0.0293 0.1167
Echinococcus multilocularis neuropeptides capa receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0436 0.1734
Mycobacterium ulcerans oxidoreductase 0.0043 0.0388 0.0522
Echinococcus multilocularis neuropeptide s receptor 0.0054 0.0534 0.0534
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0054 0.0534 0.2123
Echinococcus granulosus glycogen phosphorylase 0.0215 0.2514 1
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0054 0.0534 0.0534
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0388 0.0563
Onchocerca volvulus 0.0054 0.0534 0.1884
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0313 0.0453
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0054 0.0534 0.2123
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Mycobacterium tuberculosis Conserved protein 0.0036 0.0313 0.0453
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0054 0.0534 0.2123
Echinococcus multilocularis nervana 2 0.0026 0.018 0.018
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0054 0.0534 0.0534
Echinococcus multilocularis rhodopsin orphan GPCR 0.0054 0.0534 0.0534
Schistosoma mansoni ATPase 0.0017 0.0074 0.0294
Echinococcus multilocularis Glycosyl transferase, family 35 0.0215 0.2514 0.2514
Entamoeba histolytica glycogen phosphorylase, putative 0.0093 0.101 0.3363
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0534 0.2123
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0026 0.018 0.0716
Brugia malayi Na,K-ATPase alpha subunit 0.0017 0.0074 0.0294
Echinococcus granulosus hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0054 0.0534 0.2123
Schistosoma mansoni biogenic amine receptor 0.0054 0.0534 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Brugia malayi jmjC domain containing protein 0.0067 0.0686 0.273
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0054 0.0534 0.2123
Echinococcus granulosus tachykinin peptides receptor 99D 0.0054 0.0534 0.2123
Echinococcus granulosus serotonin receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) melatonin receptor type 1A 0.0054 0.0534 0.2123
Brugia malayi PHD-finger family protein 0.002 0.0115 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0054 0.0534 0.0534
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0313 0.1244
Brugia malayi GnHR receptor homolog 0.0054 0.0534 0.2123
Entamoeba histolytica hypothetical protein 0.0037 0.0314 0.0862
Brugia malayi sulfakinin receptor protein 0.0054 0.0534 0.2123
Schistosoma mansoni adenoreceptor 0.0054 0.0534 0.2123
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0314 0.1249
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0517 0.2058
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0017 0.0074 0.1178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1356 0.5395
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0074 0.1178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0388 0.1541
Brugia malayi hypothetical protein 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0054 0.0534 0.1884
Entamoeba histolytica glycogen phosphorylase, putative 0.0215 0.2514 0.8767
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0054 0.0534 0.0534
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0017 0.0074 0.0294
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0313 0.1131
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0017 0.0074 0.1178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0054 0.0534 0.1884
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0388 1
Onchocerca volvulus 0.0054 0.0534 0.1884
Schistosoma mansoni hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0604 0.7295 1
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0017 0.0074 0.1178
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0388 0.0388
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0604 0.7295 1
Schistosoma mansoni opsin-like receptor 0.0054 0.0534 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0026 0.018 0.0434
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0179 0.5242
Brugia malayi beta-lactamase family protein 0.0036 0.0313 0.1244
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0313 0.1244
Brugia malayi SWIRM domain containing protein 0.0043 0.0388 0.1541
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0313 0.1131
Onchocerca volvulus 0.0054 0.0534 0.1884
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0313 0.042
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0006 0.0006
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0388 0.1541
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0388 0.0522
Echinococcus granulosus Glycosyl transferase family 35 0.0215 0.2514 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0054 0.0534 0.2123
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0179 0.4141
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0054 0.0534 0.2123
Giardia lamblia Glycogen phosphorylase 0.0215 0.2514 0.8785
Brugia malayi G protein-coupled receptor 0.0054 0.0534 0.2123
Brugia malayi Serotonin receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0054 0.0534 0.1884
Schistosoma mansoni neuropeptide receptor 0.0054 0.0534 0.2123
Echinococcus multilocularis G protein coupled receptor 139 0.0054 0.0534 0.0534
Giardia lamblia PHD finger protein 15 0.002 0.0115 0.0294
Schistosoma mansoni hypothetical protein 0.002 0.0115 0.0458
Loa Loa (eye worm) hypothetical protein 0.0043 0.0388 0.1541
Echinococcus multilocularis peregrin 0.002 0.0115 0.0115
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0017 0.0074 0.0074
Mycobacterium ulcerans hypothetical protein 0.0036 0.0313 0.042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0035 0.0293 0.1167
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0014 0.0032 0.0128
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.018 0.0716
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi Tachykinin-like peptides receptor 99D 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis neuropeptide receptor 0.0054 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0043 0.0388 0.1541
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0214 0.0849
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Brugia malayi Melatonin receptor type 1A 0.0054 0.0534 0.2123
Schistosoma mansoni hypothetical protein 0.0024 0.0158 0.0627
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0313 1
Schistosoma mansoni amine GPCR 0.0054 0.0534 0.2123
Brugia malayi Dopamine receptor 0.0054 0.0534 0.2123
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0388 1
Brugia malayi Serotonin receptor 0.0054 0.0534 0.2123
Schistosoma mansoni biogenic amine (5HT) receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0313 0.1244
Schistosoma mansoni alpha-1 adrenergic receptor 0.0054 0.0534 0.2123
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0115 0.2339
Echinococcus granulosus tm gpcr rhodopsin 0.0054 0.0534 0.2123
Echinococcus granulosus nervana 2 0.0026 0.018 0.0716
Onchocerca volvulus 0.0054 0.0534 0.1884
Loa Loa (eye worm) hypothetical protein 0.0043 0.0388 0.1541
Schistosoma mansoni amine oxidase 0.0043 0.0388 0.1541
Schistosoma mansoni hypothetical protein 0.0011 0.0006 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0179 0.4141
Schistosoma mansoni hypothetical protein 0.0037 0.0314 0.1249
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0074 0.1178
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0017 0.0074 0.0294
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0093 0.101 0.1376
Echinococcus multilocularis nervana 2 0.0026 0.018 0.018
Loa Loa (eye worm) G-protein coupled receptor 0.0054 0.0534 0.2123
Schistosoma mansoni biogenic amine receptor 0.0054 0.0534 0.2123
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0314 0.1249
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0388 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0054 0.0534 0.2123
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0017 0.0074 0.0294
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0054 0.0534 0.2123
Echinococcus multilocularis somatostatin receptor 0.0054 0.0534 0.0534
Echinococcus multilocularis allatostatin A receptor 0.0054 0.0534 0.0534
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0388 0.1541
Onchocerca volvulus Glycogen phosphorylase homolog 0.0215 0.2514 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0074 0.0169
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0026 0.018 0.0716
Leishmania major calcium-translocating P-type ATPase 0.0017 0.0074 0.1178
Onchocerca volvulus 0.0026 0.018 0.0434
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0436 0.1734
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0388 0.0388
Brugia malayi latrophilin 2 splice variant baaae 0.0024 0.0158 0.0627
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0054 0.0534 0.0534
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0313 0.0453
Schistosoma mansoni amine oxidase 0.0043 0.0388 0.1541
Schistosoma mansoni opsin-like receptor 0.0054 0.0534 0.2123
Entamoeba histolytica hypothetical protein 0.0037 0.0314 0.0862
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0313 0.1131
Brugia malayi beta-lactamase 0.0036 0.0313 0.1244
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0043 0.0388 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0074 0.0169
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0074 0.0294
Entamoeba histolytica hypothetical protein 0.0037 0.0314 0.0862
Loa Loa (eye worm) TYRA-2 protein 0.0054 0.0534 0.2123
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0074 0.1178
Echinococcus granulosus neuropeptides capa receptor 0.0054 0.0534 0.2123
Schistosoma mansoni amine GPCR 0.0054 0.0534 0.2123
Echinococcus multilocularis lysine specific demethylase 5A 0.0025 0.0168 0.0168
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0074 0.0074
Onchocerca volvulus 0.0054 0.0534 0.1884
Echinococcus multilocularis sex peptide receptor 0.0054 0.0534 0.0534
Echinococcus granulosus rhodopsin orphan GPCR 0.0054 0.0534 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0054 0.0534 0.2123
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0388 0.0522
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0074 0.0169
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0006 0.0022
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0054 0.0534 0.0534
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0074 0.1492
Loa Loa (eye worm) hypothetical protein 0.0054 0.0534 0.2123
Echinococcus granulosus neuropeptide receptor A26 0.0054 0.0534 0.2123
Schistosoma mansoni hypothetical protein 0.0171 0.1976 0.7858
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0436 0.1734
Echinococcus granulosus allatostatin A receptor 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0313 0.1244
Loa Loa (eye worm) hypothetical protein 0.0026 0.018 0.0716
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0561 0.6772 1
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0026 0.018 0.0716
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0054 0.0534 0.2123
Onchocerca volvulus 0.0054 0.0534 0.1884
Echinococcus multilocularis neuropeptide Y receptor 0.0054 0.0534 0.0534
Schistosoma mansoni hypothetical protein 0.0054 0.0534 0.2123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0179 0.0713
Brugia malayi hypothetical protein 0.0037 0.0314 0.1249

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.4 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813
IC50 (binding) = 2.4 uM Inhibition of K+ -stimulated gastric ATPase activity was measured using lyophilized gastric vesicles at pH 7 ChEMBL. 7629813
Inhibition (functional) = 20 % Mean percent peak inhibition of histamine-stimulated gastric acid secretion in the heidenhain pouch dog following a single dose of 1 umol/kg through iv administration. ChEMBL. 7629813
Inhibition (functional) = 57 % Inhibition of pentagastrin-stimulated gastric acid secretion in the anesthetized rat, ED50 (micromol/kg iv) with 95% confidence limits. ChEMBL. 7629813
Inhibition (functional) = 78 % Mean percent peak inhibition of histamine-stimulated gastric acid secretion in the heidenhain pouch dog following a single dose of 4 umol/kg through oral administration. ChEMBL. 7629813

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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