Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0027 | 0.0836 | 0.076 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1741 | 0.4427 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1941 | 0.1874 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0148 | 0.0366 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0836 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2308 | 0.2192 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.4676 | 0.4596 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.045 | 0.1112 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2458 | 0.6072 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0836 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0361 | 0.0891 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2458 | 0.6072 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0836 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0361 | 0.0592 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.4049 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.2458 | 0.642 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.2458 | 0.642 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1947 | 0.1826 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0836 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0836 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.5037 | 0.4996 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0836 | 0.0698 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0611 | 0.1287 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0148 | 0.0366 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0148 | 0.0366 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0361 | 0.0592 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.2458 | 0.642 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.2458 | 0.2345 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.02 | 0.0052 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0811 | 0.0735 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3746 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0148 | 0.0366 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.2458 | 0.2396 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0836 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0611 | 0.151 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0611 | 0.1287 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1741 | 0.4427 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.045 | 0.0307 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0836 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3746 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2458 | 0.6072 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0836 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.2458 | 0.642 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.2146 | 0.2028 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.