TDR Targets

Basic information

Technical information

TDR Targets ID: 1552692
Name: C529-0995
MW: 522.657 | Formula: C32H30N2O3S
H donors: 2 H acceptors: 3 LogP: 6.43 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccc(cc1)CCNC(=O)c1ccc2c(c1)N(Cc1cc(C)ccc1C)C(=O)c1c([S+]2[O-])cccc1
InChi: 1S/C32H30N2O3S/c1-21-9-12-24(13-10-21)16-17-33-31(35)25-14-15-30-28(19-25)34(20-26-18-22(2)8-11-23(26)3)32(36)27-6-4-5-7-29(27)38(30)37/h4-15,18-19H,16-17,20H2,1-3H3,(H,33,35)
InChiKey: MXOUFKBQHWIRSL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

NCGC00109688-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	CHD4 protein	0.0014	0.0096	0.0096
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0104	0.182	0.182
Brugia malayi	AKH receptor	0.0104	0.182	0.182
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Brugia malayi	hypothetical protein	0.0012	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0504	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus granulosus	g-protein coupled receptor	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0141	0.0141
Onchocerca volvulus		0.0104	0.182	0.8637
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0504	0.1211
Echinococcus granulosus	7tm_1 domain containing protein	0.0104	0.182	0.1818
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0713	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0104	0.182	0.1818
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0425	0.2076
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0141	0.0967
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0104	0.182	0.1799
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0713	1
Brugia malayi	G-protein coupled receptor	0.0104	0.182	0.182
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0104	0.182	0.1799
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Brugia malayi	SET domain containing protein	0.0013	0.0077	0.0077
Echinococcus multilocularis	Chromo domain	0.0012	0.0066	0.0063
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0025	0.0023
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0504	0.2473
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0063
Schistosoma mansoni	neuropeptide receptor	0.0104	0.182	0.1799
Schistosoma mansoni	adenoreceptor	0.0104	0.182	0.1799
Onchocerca volvulus	Huntingtin homolog	0.0119	0.2105	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0104	0.182	0.1818
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0025	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus granulosus	Chromo domain	0.0012	0.0066	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0104	0.182	0.1818
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.2011	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Brugia malayi	Muscleblind-like protein	0.0145	0.2603	0.2603
Trichomonas vaginalis	Heterochromatin protein, putative	0.0012	0.0066	0.0282
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0066	0.0066
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Echinococcus multilocularis	fmrfamide receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0186	0.0883
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0504	0.1211
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0141	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0063
Loa Loa (eye worm)	phosphofructokinase	0.0114	0.2011	0.2009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0.182	0.1799
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0678	0.3189
Schistosoma mansoni	hypothetical protein	0.0104	0.182	0.1799
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Mycobacterium ulcerans	lipase LipD	0.0035	0.0504	0.2473
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0066	0.0282
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0504	0.1211
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0104	0.182	0.1818
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0504	0.2473
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.123	0.1229
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0425	0.5547
Onchocerca volvulus		0.0104	0.182	0.8637
Echinococcus granulosus	neuropeptide Y receptor	0.0104	0.182	0.1818
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.2011	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0104	0.182	0.182
Brugia malayi	MH2 domain containing protein	0.001	0.0025	0.0025
Brugia malayi	MH1 domain containing protein	0.001	0.0025	0.0025
Echinococcus granulosus	neuropeptide s receptor	0.0104	0.182	0.1818
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0104	0.182	0.1818
Echinococcus granulosus	g protein coupled receptor	0.0104	0.182	0.1818
Brugia malayi	Cytochrome P450 family protein	0.0025	0.0322	0.0322
Echinococcus multilocularis	neuropeptide Y receptor	0.0104	0.182	0.1818
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.2011	0.199
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Plasmodium falciparum	glutathione reductase	0.0046	0.0713	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0063
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0066	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0618	0.3044
Loa Loa (eye worm)	Smad1	0.001	0.0025	0.0023
Echinococcus granulosus	neuropeptides capa receptor	0.0104	0.182	0.1818
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0141	0.0139
Brugia malayi	hypothetical protein	0.0119	0.2105	0.2105
Echinococcus granulosus	g protein coupled receptor	0.0104	0.182	0.1818
Onchocerca volvulus		0.0104	0.182	0.8637
Echinococcus granulosus	neuropeptides capa receptor	0.0104	0.182	0.1818
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0713	0.3059
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0104	0.182	0.8637
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.123	0.6102
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.039	0.1905
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0066	0.0282
Leishmania major	ATP-dependent phosphofructokinase	0.0114	0.2011	1
Echinococcus multilocularis	somatostatin receptor	0.0104	0.182	0.1818
Brugia malayi	putative neuropeptide receptor	0.0104	0.182	0.182
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0504	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0504	0.2473
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0104	0.182	0.1818
Schistosoma mansoni	neuropeptide receptor	0.0104	0.182	0.1799
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0504	0.2473
Echinococcus granulosus	somatostatin receptor	0.0104	0.182	0.1818
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0104	0.182	0.1818
Schistosoma mansoni	neuropeptide f receptor 76f	0.0104	0.182	0.1799
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Echinococcus multilocularis	g-protein coupled receptor	0.0104	0.182	0.1818
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0425	0.5547
Brugia malayi	6-phosphofructokinase	0.0114	0.2011	0.2011
Echinococcus multilocularis	muscleblind protein	0.0145	0.2603	0.2601
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2105	0.2104
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Schistosoma mansoni	hypothetical protein	0.0012	0.0066	0.004
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0504	0.2473
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0007
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0504	0.6774
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus granulosus	fmrfamide receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0504	0.2473
Echinococcus granulosus	neuropeptide FF receptor 2	0.0104	0.182	0.1818
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.2011	1
Brugia malayi	Sulfatase family protein	0.0009	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0504	0.048
Schistosoma mansoni	cpg binding protein	0.0029	0.04	0.0375
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0504	0.1211
Echinococcus multilocularis	dnaJ subfamily B	0.0396	0.7409	0.7409
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0141	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0.182	0.1818
Brugia malayi	Smad1	0.001	0.0025	0.0025
Echinococcus granulosus	Smad4	0.001	0.0025	0.0023
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0104	0.182	0.182
Loa Loa (eye worm)	melatonin receptor type 1A	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2105	0.2104
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0678	0.334
Brugia malayi	6-phosphofructokinase	0.0114	0.2011	0.2011
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.1834	0.4466
Echinococcus multilocularis	chromobox protein 1	0.0073	0.123	0.1229
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0.182	0.1818
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0104	0.182	0.1799
Echinococcus multilocularis	G protein coupled receptor 139	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0009	0.0007
Loa Loa (eye worm)	G-protein coupled receptor	0.0104	0.182	0.1818
Trypanosoma brucei	trypanothione reductase	0.0046	0.0713	0.3059
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0504	0.0502
Schistosoma mansoni	hypothetical protein	0.0104	0.182	0.1799
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0531	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0104	0.182	0.1799
Brugia malayi	hypothetical protein	0.0009	0.0009	0.0009
Schistosoma mansoni	neuropeptide F-like receptor	0.0104	0.182	0.1799
Echinococcus multilocularis	neuropeptide receptor A26	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0186	0.0883
Echinococcus multilocularis	neuropeptide receptor	0.0104	0.182	0.1818
Echinococcus multilocularis	fmrfamide receptor	0.0104	0.182	0.1818
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0066	0.0063
Onchocerca volvulus		0.0104	0.182	0.8637
Loa Loa (eye worm)	TYRA-2 protein	0.0104	0.182	0.1818
Brugia malayi	Heterochromatin protein 1	0.0073	0.123	0.123
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0504	0.2473
Schistosoma mansoni	hypothetical protein	0.0396	0.7409	0.7403
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.0425	0.1518
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Echinococcus granulosus	7TM GPCR rhodopsin	0.0104	0.182	0.1818
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0104	0.182	0.1818
Schistosoma mansoni	amine GPCR	0.0104	0.182	0.1799
Echinococcus multilocularis	cpg binding protein	0.0029	0.04	0.0398
Echinococcus granulosus	g protein coupled receptor	0.0104	0.182	0.1818
Echinococcus granulosus	dro:myosuppressin receptor	0.0104	0.182	0.1818
Onchocerca volvulus		0.0104	0.182	0.8637
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.4096	1
Schistosoma mansoni	chromobox protein	0.0012	0.0066	0.004
Echinococcus granulosus	sex peptide receptor	0.0104	0.182	0.1818
Schistosoma mansoni	chromobox protein	0.0073	0.123	0.1208
Leishmania major	trypanothione reductase	0.0046	0.0713	0.3059
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0504	0.048
Toxoplasma gondii	ABC1 family protein	0.0035	0.0504	0.5628
Brugia malayi	G-protein coupled receptor	0.0104	0.182	0.182
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0504	0.0502
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0104	0.182	0.1818
Onchocerca volvulus		0.0032	0.045	0.2101
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0104	0.182	0.8637
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0504	0.1942
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0141	0.0658
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0713	0.1722
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Brugia malayi	RE15519p	0.0104	0.182	0.182
Loa Loa (eye worm)	hypothetical protein	0.0145	0.2603	0.2601
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0678	0.334
Schistosoma mansoni	opsin-like receptor	0.0104	0.182	0.1799
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0104	0.182	0.1818
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Loa Loa (eye worm)	neuropeptide F receptor	0.0104	0.182	0.1818
Brugia malayi	MH2 domain containing protein	0.001	0.0025	0.0025
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0104	0.182	0.1818
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0104	0.182	0.1818
Echinococcus multilocularis	Smad4	0.001	0.0025	0.0023
Echinococcus multilocularis	chromobox protein 1	0.0073	0.123	0.1229
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0369	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0713	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0096	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0018	0.0186	0.0883
Loa Loa (eye worm)	neuropeptide F receptor	0.0104	0.182	0.1818
Schistosoma mansoni	hypothetical protein	0.0104	0.182	0.1799
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0066	0.004
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0425	0.2076
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0186	0.0883
Echinococcus granulosus	hypothetical protein	0.0104	0.182	0.1818
Echinococcus multilocularis	dro:myosuppressin receptor	0.0104	0.182	0.1818
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.2011	0.2009
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0141	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0104	0.182	0.1799
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0504	0.1211
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0066	0.004
Echinococcus multilocularis	neuropeptides capa receptor	0.0104	0.182	0.1818
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0141	0.1164
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0104	0.182	0.1799
Schistosoma mansoni	neuropeptide receptor	0.0104	0.182	0.1799
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Echinococcus multilocularis	allatostatin A receptor	0.0104	0.182	0.1818
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.2011	0.199
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0066	0.004
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0025	0.0023
Echinococcus multilocularis	serotonin receptor	0.0104	0.182	0.1818
Schistosoma mansoni	neuropeptide F-like receptor	0.0104	0.182	0.1799
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0104	0.182	0.1799
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0104	0.182	0.1818
Brugia malayi	GnHR receptor homolog	0.0104	0.182	0.182
Schistosoma mansoni	chromobox protein	0.0073	0.123	0.1208
Brugia malayi	Dopamine receptor protein 2	0.0104	0.182	0.182
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.2011	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0713	0.0711
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0425	0.2076
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0066	0.0063
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0104	0.182	0.1799
Schistosoma mansoni	opsin-like receptor	0.0104	0.182	0.1799
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0504	0.1942
Onchocerca volvulus		0.0104	0.182	0.8637
Echinococcus multilocularis	chromobox protein 2	0.0012	0.0066	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0504	0.0502
Brugia malayi	M-phase phosphoprotein, mpp8	0.0012	0.0066	0.0066
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0425	0.2076
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.1834	0.4466
Mycobacterium tuberculosis	Probable reductase	0.0104	0.1834	0.4466
Brugia malayi	Protein cec-1.	0.0012	0.0066	0.0066
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0141	0.5
Brugia malayi	Dopamine receptor	0.0104	0.182	0.182
Schistosoma mansoni	opsin-like receptor	0.0104	0.182	0.1799
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0504	0.1942
Onchocerca volvulus		0.0012	0.0066	0.0269
Schistosoma mansoni	biogenic amine receptor	0.0104	0.182	0.1799
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0066	0.0066
Echinococcus multilocularis	g protein coupled receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0186	0.0883
Schistosoma mansoni	amine GPCR	0.0104	0.182	0.1799
Schistosoma mansoni	chromobox protein	0.0012	0.0066	0.004
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.2011	1
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0025	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0032	0.045	0.0448
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0504	0.1211
Onchocerca volvulus		0.0028	0.0369	0.1718
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.006	0.006
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0618	0.2906
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0063
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0104	0.182	0.1818
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0066	0.0063
Leishmania major	hypothetical protein, conserved	0.0035	0.0504	0.1942
Schistosoma mansoni	amine GPCR	0.0104	0.182	0.1799
Brugia malayi	MH1 domain containing protein	0.001	0.0025	0.0025
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0141	0.3171
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0425	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0066	0.0282
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0531	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0104	0.182	0.1799
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0104	0.182	0.1799
Echinococcus granulosus	muscleblind protein	0.0145	0.2603	0.2601
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0141	0.1164
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0425	1
Schistosoma mansoni	amine GPCR	0.0104	0.182	0.1799
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0104	0.182	0.182
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.1834	0.4466
Brugia malayi	beta-lactamase family protein	0.0035	0.0504	0.0504
Echinococcus multilocularis	smad	0.001	0.0025	0.0023
Onchocerca volvulus		0.0104	0.182	0.8637
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.2011	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	hypothetical protein	0.0012	0.0066	0.0282
Brugia malayi	beta-lactamase	0.0035	0.0504	0.0504
Echinococcus multilocularis	neuropeptides capa receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0066	0.0282
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus multilocularis	neuropeptide s receptor	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0114	0.2011	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0369	0.0345
Echinococcus granulosus	neuropeptide receptor	0.0104	0.182	0.1818
Brugia malayi	MH2 domain containing protein	0.0144	0.2595	0.2595
Loa Loa (eye worm)	hypothetical protein	0.0332	0.618	0.6179
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0104	0.182	0.1818
Onchocerca volvulus		0.0013	0.0077	0.0324
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0425	0.4608
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0425	0.2076
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0531	1	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0114	0.2011	1
Echinococcus granulosus	neuropeptide receptor	0.0104	0.182	0.1818
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0369	0.0369
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0186	0.0883
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0104	0.182	0.1818
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0186	0.0883
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0965	0.0942
Echinococcus granulosus	dnaJ subfamily B	0.0396	0.7409	0.7409
Echinococcus granulosus	biogenic amine 5HT receptor	0.0104	0.182	0.1818
Echinococcus granulosus	smad	0.001	0.0025	0.0023
Loa Loa (eye worm)	G-protein coupled receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.013	0.0605
Schistosoma mansoni	biogenic amine receptor	0.0104	0.182	0.1799
Echinococcus granulosus	cpg binding protein	0.0029	0.04	0.0398
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0104	0.1834	0.8565
Echinococcus multilocularis	6 phosphofructokinase	0.0114	0.2011	0.2009
Loa Loa (eye worm)	helicase	0.0012	0.0066	0.0063
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0104	0.182	0.1818
Brugia malayi	Serotonin receptor	0.0104	0.182	0.182
Echinococcus multilocularis	neuropeptide Y receptor	0.0104	0.182	0.1818
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0096	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0504	0.0502
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.123	0.6102
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0425	1
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0066	0.0282
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.2057	0.5011
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0713	0.8307
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0025	0.0023
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0504	0.0502
Echinococcus granulosus	neuropeptide receptor A26	0.0104	0.182	0.1818
Onchocerca volvulus		0.0035	0.0504	0.2361
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0063
Echinococcus granulosus	chromobox protein 1	0.0073	0.123	0.1229
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.1834	0.4466
Onchocerca volvulus		0.0035	0.0504	0.2361
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0425	0.4608
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.2011	1
Onchocerca volvulus		0.0104	0.182	0.8637
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Echinococcus granulosus	biogenic amine 5HT receptor	0.0104	0.182	0.1818
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0504	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0145	0.2603	0.2601
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0141	0.0658
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0015	0.013	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0713	0.0711
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0504	0.2473
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0013	0.0077	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0618	0.3044
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.2057	1
Onchocerca volvulus		0.0104	0.182	0.8637
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0425	0.5547
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0425	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0504	0.0502
Brugia malayi	putative neuropeptide receptor NPR1	0.0104	0.182	0.182
Echinococcus granulosus	chromobox protein 1	0.0073	0.123	0.1229
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0066	0.0282
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0141	0.0139
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0104	0.182	0.1799
Echinococcus granulosus	serotonin receptor	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0618	0.0616
Echinococcus granulosus	chromobox protein 2	0.0012	0.0066	0.0063
Schistosoma mansoni	amine GPCR	0.0104	0.182	0.1799
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0425	0.2076
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0104	0.182	0.182
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0104	0.182	0.1818
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.2057	0.5011
Onchocerca volvulus		0.0104	0.182	0.8637
Schistosoma mansoni	hypothetical protein	0.0104	0.182	0.1799
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0504	0.1211
Echinococcus granulosus	orexin receptor type 2	0.0104	0.182	0.1818
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Brugia malayi	neuropeptide F receptor	0.0104	0.182	0.182
Echinococcus multilocularis	sex peptide receptor	0.0104	0.182	0.1818
Onchocerca volvulus	Huntingtin homolog	0.0119	0.2105	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0.182	0.1799
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.1834	0.4466
Brugia malayi	Thioredoxin reductase	0.0046	0.0713	0.0713
Echinococcus granulosus	G protein coupled receptor 139	0.0104	0.182	0.1818
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0.182	0.1799
Schistosoma mansoni	neuropeptide receptor	0.0104	0.182	0.1799
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.039	0.1905
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0104	0.182	0.1818
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0713	0.0711
Echinococcus granulosus	allatostatin A receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.2011	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0104	0.182	0.1799
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0141	0.1164
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0104	0.182	0.1818
Onchocerca volvulus		0.0104	0.182	0.8637
Echinococcus multilocularis	muscleblind protein 1	0.0145	0.2603	0.2601
Echinococcus granulosus	6 phosphofructokinase	0.0114	0.2011	0.2009
Onchocerca volvulus		0.0104	0.182	0.8637
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0104	0.182	0.1818
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0104	0.182	0.1799
Echinococcus multilocularis	orexin receptor type 2	0.0104	0.182	0.1818
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0104	0.182	0.1818
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0104	0.182	0.1799
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0186	0.0883
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0504	0.2473
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0066	0.0063
Brugia malayi	larval opioid receptor	0.0104	0.182	0.182
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0845	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0504	0.1211
Echinococcus multilocularis	serotonin receptor	0.0104	0.182	0.1818
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.2595	0.2593
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0504	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Onchocerca volvulus		0.0012	0.0066	0.0269
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0425	0.5547
Brugia malayi	G protein-coupled receptor F59B2.13	0.0104	0.182	0.182
Brugia malayi	Valyl-tRNA synthetase	0.0012	0.0066	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0121	0.0561
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.2011	0.2009
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0114	0.2011	0.4898
Onchocerca volvulus		0.0104	0.182	0.8637
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0141	0.1164
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0141	0.1164
Onchocerca volvulus		0.0104	0.182	0.8637
Brugia malayi	ORL1-like opioid receptor	0.0104	0.182	0.182
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0.182	0.1818
Brugia malayi	beta-lactamase family protein	0.0035	0.0504	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Echinococcus multilocularis	g protein coupled receptor	0.0104	0.182	0.1818
Schistosoma mansoni	myosin xvIII	0.0104	0.182	0.1799
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0141	0.0322
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0141	0.0116
Brugia malayi	chromobox protein homolog 3	0.0041	0.0618	0.0618
Echinococcus multilocularis	g protein coupled receptor	0.0104	0.182	0.1818
Brugia malayi	Melatonin receptor type 1A	0.0104	0.182	0.182
Schistosoma mansoni	histamine h1 receptor	0.0104	0.182	0.1799
Onchocerca volvulus		0.0104	0.182	0.8637
Brugia malayi	G protein-coupled receptor	0.0104	0.182	0.182
Brugia malayi	follicle stimulating hormone receptor	0.0104	0.182	0.182
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.2057	0.5011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0104	0.182	0.182
Echinococcus granulosus	neuropeptide Y receptor	0.0104	0.182	0.1818
Brugia malayi	Dopamine receptor protein 1	0.0104	0.182	0.182
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0025	0.0023
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0104	0.182	0.1818
Onchocerca volvulus		0.0104	0.182	0.8637
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.2011	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0104	0.182	0.1818
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0425	0.2076
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0141	0.0967
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0425	0.1846
Trichomonas vaginalis	esterase, putative	0.0035	0.0504	0.2473
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0504	0.0502
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0114	0.2011	0.9701
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0504	0.0502
Brugia malayi	neuropeptide F receptor	0.0104	0.182	0.182
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0104	0.182	0.1818
Brugia malayi	glutathione reductase	0.0046	0.0713	0.0713
Onchocerca volvulus		0.0104	0.182	0.8637
Echinococcus multilocularis	neuropeptide receptor	0.0104	0.182	0.1818
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Plasmodium falciparum	glutathione reductase	0.0016	0.0141	0.1164
Brugia malayi	hypothetical protein	0.0127	0.2271	0.2271
Schistosoma mansoni	cpg binding protein	0.0029	0.04	0.0375
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0504	0.1211
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0713	0.0711
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0096	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0104	0.182	0.1818
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.2595	0.2593
Loa Loa (eye worm)	cytochrome P450 family protein	0.0025	0.0322	0.032
Brugia malayi	hypothetical protein	0.0104	0.182	0.182
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0.182	0.1799
Brugia malayi	Serotonin receptor	0.0104	0.182	0.182
Onchocerca volvulus		0.0035	0.0504	0.2361
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0096	0.0094
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0141	0.0658
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0.182	0.1818
Schistosoma mansoni	serine/threonine protein kinase	0.0531	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0066	0.0282
Brugia malayi	phosphofructokinase	0.0114	0.2011	0.2011
Brugia malayi	sulfakinin receptor protein	0.0104	0.182	0.182
Schistosoma mansoni	biogenic amine receptor	0.0104	0.182	0.1799

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.1623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1905322

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1552692