Detailed information for compound 1560971

Basic information

Technical information
  • TDR Targets ID: 1560971
  • Name: N-(2-diethylaminoethyl)-4-dimethylamino-2-met hoxy-5-nitrobenzamide
  • MW: 338.402 | Formula: C16H26N4O4
  • H donors: 1 H acceptors: 3 LogP: 1.89 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)c1cc([N+](=O)[O-])c(cc1OC)N(C)C)CC
  • InChi: 1S/C16H26N4O4/c1-6-19(7-2)9-8-17-16(21)12-10-14(20(22)23)13(18(3)4)11-15(12)24-5/h10-11H,6-9H2,1-5H3,(H,17,21)
  • InChiKey: FGTQEICFEHSKTB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-diethylaminoethyl)-4-dimethylamino-2-methoxy-5-nitro-benzamide
  • CBDivE_015814
  • Benzamide, N-(2-diethylaminoethyl)-4-dimethylamino-2-methoxy-5-nitro-
  • A1089/0051128
  • BAS 00253646
  • N-(2-Diethylamino-ethyl)-4-dimethylamino-2-methoxy-5-nitro-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.0722 0.5655
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0411
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0019 0.0126
Echinococcus granulosus intermediate filament protein 0.003 0.0082 0.0094
Brugia malayi amine oxidase, flavin-containing family protein 0.0312 0.1276 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0146 0.1143
Loa Loa (eye worm) RecQ helicase 0.0021 0.0045 0.0356
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0018 0.0141
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0135 0.1038
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.003 0.0111
Echinococcus granulosus microtubule associated protein 2 0.0693 0.2891 0.3331
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0722 0.0722
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.124 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0045 0.1548
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0019 0.0019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.003 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0312 0.1276 1
Loa Loa (eye worm) intermediate filament protein 0.003 0.0082 0.0639
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0018 0.0545
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0123
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0023 0.0177
Toxoplasma gondii hypothetical protein 0.0049 0.0162 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0125 0.853
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0097 0.0647
Loa Loa (eye worm) hypothetical protein 0.0076 0.0276 0.2164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Plasmodium falciparum protoporphyrinogen oxidase 0.0312 0.1276 1
Onchocerca volvulus 0.005 0.0165 0.1293
Trypanosoma brucei glucosidase, putative 0.004 0.0125 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0068 0.2366
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0146 0.1154
Echinococcus granulosus lamin 0.003 0.0082 0.0094
Onchocerca volvulus 0.0024 0.0055 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0079 0.2769
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0312 0.1276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0146 0.5225
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0106
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0016 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0276 0.0276
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0016 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0026
Onchocerca volvulus 0.0105 0.0398 0.3121
Schistosoma mansoni lamin 0.003 0.0082 0.0082
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0722 0.0722
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0055 0.367
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0125 0.853
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0034 0.0035
Echinococcus granulosus lysine specific histone demethylase 1A 0.0312 0.1276 0.1471
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0435
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0125 0.0978
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.124 0.9711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Schistosoma mansoni amine oxidase 0.0312 0.1276 0.1276
Leishmania major UDP-galactopyranose mutase 0.0312 0.1276 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0146 0.1154
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0146 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0125 0.0956
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0312 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Schistosoma mansoni alpha-glucosidase 0.0156 0.0615 0.0615
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0055 0.0034
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0055 0.367
Loa Loa (eye worm) hypothetical protein 0.005 0.0165 0.1293
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0123
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0146 0.1121
Toxoplasma gondii histone lysine-specific demethylase 0.0312 0.1276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0146 0.5225
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0141
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0055 0.0026
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0125 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0083 0.292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0435
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0034 0.025
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0082 0.0639
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.0722 0.0832
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0019 0.0147
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0076 0.0276 0.0276
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0107 0.0815
Echinococcus granulosus tumor protein p63 0.0339 0.1392 0.1604
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0125 0.0956
Echinococcus multilocularis musashi 0.003 0.0082 0.0082
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0435
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0339
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0146 0.1121
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.0722 0.5655
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.2407
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0082 0.0639
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0312 0.1276 0.125
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0175 0.1348
Schistosoma mansoni lamin 0.003 0.0082 0.0082
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0125 0.4457
Brugia malayi intermediate filament protein 0.003 0.0082 0.0639
Onchocerca volvulus 0.0312 0.1276 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0125 0.0978
Giardia lamblia GTOR 0.0045 0.0146 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0055 0.0026
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0312 0.1276 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0146 0.0168
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0018 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.1999
Echinococcus multilocularis 0.0312 0.1276 0.1276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0411
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0146 0.1121
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0045 0.1548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0023 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.124 0.9711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.2407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0068 0.2366
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0055 0.367
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0125 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.1999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0118 0.4202
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0055 0.0026
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0018 0.0117
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0212
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0045 0.0356
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0165 0.0165
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.124 0.9711
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0107 0.0839
Onchocerca volvulus 0.003 0.0082 0.0639
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0146 0.1121
Mycobacterium ulcerans oxidoreductase 0.0312 0.1276 0.125
Schistosoma mansoni amine oxidase 0.0312 0.1276 0.1276
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0055 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Echinococcus granulosus bloom syndrome protein 0.0021 0.0045 0.0052
Echinococcus multilocularis tumor protein p63 0.0339 0.1392 0.1392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0018 0.0141
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0312 0.1276 0.125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.1999
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0135 0.1069
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0018 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0563 0.4395
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0312 0.1276 0.1445
Echinococcus granulosus protoporphyrinogen oxidase 0.2058 0.8678 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0146 0.5225
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.237 1 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0312 0.1276 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0312 0.1276 0.1471
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0125
Schistosoma mansoni alpha-glucosidase 0.0156 0.0615 0.0615
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0621
Plasmodium vivax hypothetical protein, conserved 0.0312 0.1276 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0055 0.0034
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0125 0.0956
Echinococcus multilocularis lamin 0.003 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0106
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.2891 0.2891
Echinococcus multilocularis protoporphyrinogen oxidase 0.237 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0055 0.0026
Mycobacterium ulcerans protoporphyrinogen oxidase 0.237 1 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0563 0.4395
Brugia malayi hypothetical protein 0.0312 0.1276 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0019 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.2407
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0107 0.0815
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0125 0.4457
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0123
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0135 0.1038
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.2891 0.2891
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0018 0.0545
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0019 0.0126
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0045 0.0045
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0018 0.1044
Brugia malayi Melibiase family protein 0.0076 0.0276 0.2164
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0019 0.0147
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0125 0.0144
Echinococcus multilocularis lamin dm0 0.003 0.0082 0.0082
Mycobacterium ulcerans dehydrogenase 0.0312 0.1276 0.125
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0135 0.1038
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0125 0.0125
Schistosoma mansoni alpha glucosidase 0.004 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0024 0.0055 0.0435
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0312 0.1276 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0146 0.1143
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0125 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0018 0.0545
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0146 0.0146
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0076 0.0276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.2004
Mycobacterium ulcerans hypothetical protein 0.0024 0.0055 0.0026
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0312 0.1276 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0312 0.1276 0.1276
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0312 0.1276 0.1276
Toxoplasma gondii melibiase subfamily protein 0.0114 0.0437 0.3343
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0055 0.0435
Mycobacterium tuberculosis Conserved hypothetical protein 0.0312 0.1276 0.1445
Schistosoma mansoni intermediate filament proteins 0.003 0.0082 0.0082
Mycobacterium ulcerans monoamine oxidase 0.0312 0.1276 0.125
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0018 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0019 0.0572
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0114 0.0437 0.0503
Trypanosoma cruzi UDP-galactopyranose mutase 0.0312 0.1276 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0019 0.0123
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0114 0.0437 0.0437
Brugia malayi SWIRM domain containing protein 0.0312 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0023 0.0177
Loa Loa (eye worm) hypothetical protein 0.0312 0.1276 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0082 0.0639
Mycobacterium ulcerans hypothetical protein 0.016 0.0631 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0006 0.0102
Echinococcus granulosus lamin dm0 0.003 0.0082 0.0094
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.237 1 1
Onchocerca volvulus 0.003 0.0082 0.0639
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0018 0.0545
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0055 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0097 0.3431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0107 0.3793
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0019 0.0022
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.2058 0.8678 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0563 0.4526
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0114 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0235
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0631 0.07
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0125 0.0869
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0114 0.0437 0.0437

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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