Detailed information for compound 1568091

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 621.997 | Formula: C28H38BrClN6O3
  • H donors: 3 H acceptors: 3 LogP: 5.8 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)CCC[N+](CCCc1ccc(cc1)OC)(CCNC(=O)c1nc(Cl)c(nc1N)N)C.[Br-]
  • InChi: 1S/C28H37ClN6O3.BrH/c1-35(17-4-6-20-8-12-22(37-2)13-9-20,18-5-7-21-10-14-23(38-3)15-11-21)19-16-32-28(36)24-26(30)34-27(31)25(29)33-24;/h8-15H,4-7,16-19H2,1-3H3,(H4-,30,31,32,34,36);1H
  • InChiKey: WJAQDFBBJFNPLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.006 0.0158 0.2469
Brugia malayi Sema domain containing protein 0.0061 0.0164 0.0309
Echinococcus multilocularis tyrosine protein kinase HCK 0.0091 0.0443 0.094
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0504 0.1121
Brugia malayi Immunoglobulin I-set domain containing protein 0.0422 0.3486 0.8249
Loa Loa (eye worm) hypothetical protein 0.0151 0.0996 0.236
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0504 1
Schistosoma mansoni tyrosine kinase 0.0502 0.4218 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0504 1
Schistosoma mansoni plexin 0.0072 0.0269 0.0561
Schistosoma mansoni cell adhesion molecule 0.0048 0.0045 0.0024
Loa Loa (eye worm) hypothetical protein 0.0115 0.0665 0.1576
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.0374 0.034
Echinococcus granulosus tyrosine protein kinase Blk 0.0117 0.0682 0.0649
Schistosoma mansoni tyrosine kinase 0.0367 0.2978 0.7035
Schistosoma mansoni tyrosine kinase 0.019 0.1355 0.3156
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0138 0.0871 0.1928
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0045 0.0023
Echinococcus multilocularis mitogen activated protein kinase 11 0.0129 0.0788 0.1736
Echinococcus multilocularis epidermal growth factor receptor 0.04 0.3286 0.7496
Trypanosoma brucei polo-like protein kinase 0.0098 0.0504 0.6183
Echinococcus granulosus aurora kinase A 0.006 0.0158 0.0124
Echinococcus granulosus tyrosine kinase 0.006 0.0154 0.0119
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0082 0.0821
Echinococcus multilocularis roundabout 2 0.0048 0.0045 0.0023
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0211 0.1544 0.348
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0052 0.0082 0.0508
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0138 0.0871 0.1928
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0114 0.0657 0.0624
Schistosoma mansoni protein kinase 0.006 0.0158 0.0295
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0082 0.0821
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0129 0.0788 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.006 0.0158 0.0124
Echinococcus granulosus tyrosine kinase 0.0117 0.0682 0.0649
Echinococcus granulosus tyrosine protein kinase Fyn 0.0138 0.0871 0.0839
Trypanosoma brucei protein kinase, putative 0.0052 0.0082 0.0508
Giardia lamblia Kinase, CMGC GSK 0.0052 0.0082 0.0821
Echinococcus granulosus tyrosine protein kinase Src64B 0.0138 0.0871 0.0839
Echinococcus granulosus cyclin dependent kinase 0.0048 0.0045 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.0055 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0504 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0138 0.0871 0.0839
Schistosoma mansoni titin 0.0053 0.0091 0.0133
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0045 0.0023
Loa Loa (eye worm) hypothetical protein 0.0099 0.0512 0.1213
Brugia malayi serine/threonine-protein kinase 6 0.006 0.0158 0.0295
Schistosoma mansoni tyrosine kinase 0.008 0.0343 0.0736
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.006 0.0158 0.0284
Onchocerca volvulus 0.006 0.0154 0.0265
Echinococcus granulosus hemicentin 1 0.0053 0.0091 0.0056
Echinococcus multilocularis tyrosine protein kinase shark 0.006 0.0154 0.0274
Brugia malayi SRC-1 0.0138 0.0871 0.1998
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0138 0.0871 0.1928
Onchocerca volvulus 0.006 0.0154 0.0265
Schistosoma mansoni protein kinase 0.0162 0.1091 0.2525
Schistosoma mansoni cell adhesion molecule 0.0048 0.0045 0.0024
Loa Loa (eye worm) hypothetical protein 0.0133 0.0827 0.196
Schistosoma mansoni hypothetical protein 0.0061 0.0164 0.0309
Loa Loa (eye worm) plexin A 0.0159 0.1071 0.2539
Trichomonas vaginalis AGC family protein kinase 0.006 0.0158 0.2469
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0138 0.0871 0.1928
Loa Loa (eye worm) TK/INSR protein kinase 0.0502 0.4218 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0049 0.0055 0.002
Brugia malayi P38 map kinase family protein 2 0.0129 0.0788 0.1799
Plasmodium falciparum glycogen synthase kinase 3 0.0052 0.0082 0.3325
Loa Loa (eye worm) hypothetical protein 0.0061 0.0164 0.0389
Loa Loa (eye worm) hypothetical protein 0.0054 0.0101 0.0239
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Trichomonas vaginalis AGC family protein kinase 0.006 0.0158 0.2469
Echinococcus multilocularis Immunoglobulin 0.0099 0.0512 0.11
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0117 0.0682 0.1492
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Onchocerca volvulus 0.0061 0.0164 0.0303
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0362 0.2933 0.6953
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0158 0.0295
Entamoeba histolytica tyrosin kinase, putative 0.006 0.0159 0.2485
Brugia malayi cell division control protein 2 homolog 0.0048 0.0045 0.0023
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0457 0.3807 0.8698
Echinococcus multilocularis cyclin dependent kinase 0.0048 0.0045 0.0023
Echinococcus multilocularis tyrosine protein kinase Srms 0.0117 0.0682 0.1492
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0162 0.1091 0.2434
Schistosoma mansoni cell adhesion molecule 0.0131 0.081 0.1852
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0117 0.0682 0.0649
Brugia malayi Fibronectin type III domain containing protein 0.0115 0.0665 0.1506
Trichomonas vaginalis AGC family protein kinase 0.006 0.0158 0.2469
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0162 0.1091 0.2586
Loa Loa (eye worm) TK/ABL protein kinase 0.006 0.0154 0.0365
Loa Loa (eye worm) hypothetical protein 0.0061 0.0164 0.0389
Echinococcus multilocularis 0.021 0.154 0.3471
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.006 0.0158 0.2469
Loa Loa (eye worm) hypothetical protein 0.0099 0.0512 0.1213
Loa Loa (eye worm) hypothetical protein 0.0115 0.0665 0.1576
Schistosoma mansoni ephrin receptor 0.005 0.0068 0.0079
Echinococcus granulosus tyrosine protein kinase HCK 0.0091 0.0443 0.0409
Echinococcus multilocularis mitogen activated protein kinase 14 0.0129 0.0788 0.1736
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0211 0.1544 0.1514
Echinococcus granulosus mitogen activated protein kinase 14 0.0129 0.0788 0.0755
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0048 0.0045 0.0023
Schistosoma mansoni nephrin 0.0048 0.0045 0.0024
Brugia malayi Protein kinase domain containing protein 0.006 0.0154 0.0284
Loa Loa (eye worm) TK/EGFR protein kinase 0.0468 0.3911 0.9271
Schistosoma mansoni tyrosine kinase 0.0468 0.3911 0.9265
Schistosoma mansoni kinase 0.0052 0.0083 0.0116
Echinococcus granulosus Immunoglobulin 0.0099 0.0512 0.0479
Schistosoma mansoni ephrin receptor 0.0087 0.0409 0.0894
Loa Loa (eye worm) TK/EPH protein kinase 0.0102 0.0544 0.129
Loa Loa (eye worm) hypothetical protein 0.0061 0.0164 0.0389
Entamoeba histolytica protein kinase , putative 0.006 0.0158 0.2469
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Schistosoma mansoni tyrosine kinase 0.0367 0.2978 0.7035
Loa Loa (eye worm) hypothetical protein 0.0047 0.0035 0.0083
Onchocerca volvulus 0.0054 0.0099 0.0062
Schistosoma mansoni hypothetical protein 0.0054 0.0099 0.0153
Schistosoma mansoni nephrin 0.013 0.0805 0.1841
Brugia malayi hypothetical protein 0.0061 0.0164 0.0309
Trypanosoma brucei aurora B kinase 0.006 0.0158 0.1527
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0422 0.3486 0.8263
Echinococcus multilocularis neuroglian 0.0048 0.0045 0.0023
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0162 0.1091 0.2585
Brugia malayi Protein kinase domain containing protein 0.0247 0.1876 0.4402
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.008 0.0343 0.0736
Echinococcus multilocularis mitogen activated protein kinase 14 0.0129 0.0788 0.1736
Brugia malayi Protein kinase domain containing protein 0.0162 0.1091 0.2525
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0504 0.6183
Schistosoma mansoni tyrosine kinase 0.0065 0.02 0.0394
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0504 0.1566
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0457 0.3807 0.3785
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.0045 0.0023
Echinococcus multilocularis cyclin dependent kinase 1 0.0048 0.0045 0.0023
Loa Loa (eye worm) hypothetical protein 0.0061 0.0164 0.0389
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0129 0.0788 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0138 0.0871 0.0839
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0412 0.3394 0.8046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0106
Brugia malayi Protein kinase domain containing protein 0.006 0.0154 0.0284
Loa Loa (eye worm) hypothetical protein 0.006 0.0154 0.0365
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Echinococcus granulosus tyrosine protein kinase Src42A 0.0138 0.0871 0.0839
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0504 0.1121
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0162 0.1091 0.2523
Echinococcus multilocularis semaphorin 5B 0.0061 0.0164 0.0298
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0504 0.1082
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0052 0.0082 0.3325
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0519 0.4371 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0052 0.0082 0.3325
Schistosoma mansoni vesicular amine transporter 0.0099 0.0512 0.114
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0504 0.6183
Trypanosoma cruzi aurora B kinase, putative 0.006 0.0158 0.1527
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0072 0.0596
Schistosoma mansoni tyrosine kinase 0.0138 0.0871 0.1998
Echinococcus multilocularis epidermal growth factor receptor 0.0468 0.3911 0.8937
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0048 0.0045 0.0023
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0129 0.0788 1
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0045 0.0023
Echinococcus granulosus contactin 0.0069 0.0244 0.021
Onchocerca volvulus 0.006 0.0154 0.0265
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0049 0.0055 0.0046
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0048 0.0045 0.001
Brugia malayi Protein kinase domain containing protein 0.0048 0.0045 0.0023
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Loa Loa (eye worm) TK protein kinase 0.0117 0.0682 0.1617
Plasmodium vivax serine/threonine protein kinase 6, putative 0.006 0.0158 1
Loa Loa (eye worm) AUR protein kinase 0.006 0.0158 0.0375
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0082 0.0821
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0045 0.0024
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0504 0.1195
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0082 0.0821
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0048 0.0045 0.0106
Loa Loa (eye worm) AUR protein kinase 0.006 0.0158 0.0375
Brugia malayi serine/threonine kinase 12 0.006 0.0158 0.0295
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.0871 0.1928
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.006 0.0154 0.0274
Echinococcus granulosus semaphorin 5B 0.0061 0.0164 0.013
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0045 0.0024
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0138 0.0871 0.1928
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0048 0.0045 0.0023
Echinococcus granulosus twitchin 0.0119 0.0697 0.0664
Echinococcus granulosus protein kinase shaggy 0.0052 0.0082 0.0048
Entamoeba histolytica protein kinase, putative 0.0052 0.0082 0.0821
Schistosoma mansoni hypothetical protein 0.0072 0.0269 0.0561
Echinococcus granulosus insulin receptor 0.0502 0.4218 0.4198
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0082 0.0195
Leishmania major protein kinase, putative 0.006 0.0158 0.1527
Echinococcus granulosus neuroglian 0.0114 0.0652 0.0619
Brugia malayi hypothetical protein 0.006 0.0154 0.0284
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.04 0.3286 0.3262
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0504 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0162 0.1091 0.3744
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0504 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.008 0.0343 0.071
Echinococcus multilocularis Immunoglobulin 0.0099 0.0512 0.11
Brugia malayi Protein kinase domain containing protein 0.0502 0.4218 1
Echinococcus granulosus c src tyrosine kinase 0.008 0.0343 0.0309
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.0871 0.1928
Loa Loa (eye worm) sema domain-containing protein 0.0061 0.0164 0.0389
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0162 0.1091 0.2585
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0099 0.0512 0.114
Brugia malayi Plexin repeat family protein 0.0133 0.0827 0.1893
Loa Loa (eye worm) AUR protein kinase 0.006 0.0158 0.0375
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0082 0.0821
Echinococcus multilocularis hemicentin 1 0.0053 0.0091 0.0128
Echinococcus granulosus roundabout 2 0.0146 0.095 0.0918
Echinococcus granulosus tyrosine protein kinase ABL1 0.006 0.0154 0.0119
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0504 0.0471
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0052 0.0082 0.0508
Echinococcus multilocularis roundabout 2 0.0048 0.0045 0.0023
Echinococcus granulosus tyrosine protein kinase Lyn 0.0142 0.0916 0.0884
Entamoeba histolytica protein kinase, putative 0.0091 0.0443 0.8665
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Toxoplasma gondii aurora kinase 0.006 0.0158 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0269 0.0639
Loa Loa (eye worm) TK protein kinase 0.0049 0.0055 0.013
Onchocerca volvulus 0.0274 0.2128 0.7597
Echinococcus multilocularis insulin receptor 0.0502 0.4218 0.9647
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0052 0.0082 0.0195
Echinococcus granulosus tyrosine protein kinase Fps85D 0.006 0.0154 0.0119
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0099 0.0512 0.11
Brugia malayi plexin A 0.0159 0.1071 0.2477
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0158 0.2469
Schistosoma mansoni tyrosine kinase 0.0502 0.4218 1
Giardia lamblia Aurora kinase 0.006 0.0158 0.2469
Echinococcus granulosus roundabout 2 0.0048 0.0045 0.001
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0519 0.4371 0.4352
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0053 0.0091 0.003
Loa Loa (eye worm) TK/ROR protein kinase 0.0049 0.0055 0.013
Loa Loa (eye worm) hypothetical protein 0.0114 0.0657 0.1556
Loa Loa (eye worm) hypothetical protein 0.0452 0.3762 0.8918
Loa Loa (eye worm) hypothetical protein 0.0099 0.0514 0.1218
Echinococcus granulosus defective proboscis extension response 0.0099 0.0512 0.0479
Loa Loa (eye worm) hypothetical protein 0.0214 0.1569 0.3719
Echinococcus multilocularis plexin a4 0.0159 0.1071 0.2389
Brugia malayi Protein kinase domain containing protein 0.006 0.0154 0.0284
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.0374 0.0782
Echinococcus granulosus epidermal growth factor receptor 0.04 0.3286 0.3262
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0138 0.0871 0.1928
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1091 0.2523
Brugia malayi intracellular kinase 0.0052 0.0082 0.0114
Giardia lamblia Kinase, PLK 0.0098 0.0504 1
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Echinococcus granulosus ephrin type A receptor 4 A 0.01 0.0527 0.0493
Echinococcus granulosus plexin a4 0.0159 0.1071 0.104
Plasmodium falciparum serine/threonine protein kinase, putative 0.006 0.0158 1
Schistosoma mansoni tyrosine kinase 0.04 0.3286 0.7771
Schistosoma mansoni hypothetical protein 0.0061 0.0164 0.0309
Loa Loa (eye worm) hypothetical protein 0.013 0.0797 0.1889
Loa Loa (eye worm) hypothetical protein 0.0061 0.0164 0.0389
Schistosoma mansoni plexin 0.0133 0.0827 0.1893
Loa Loa (eye worm) hypothetical protein 0.0115 0.0665 0.1576
Entamoeba histolytica protein kinase, putative 0.006 0.0158 0.2469
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0504 1
Brugia malayi Protein kinase domain containing protein 0.006 0.0154 0.0284
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0053 0.0089 0.0212
Echinococcus granulosus roundabout 2 0.0048 0.0045 0.001
Echinococcus granulosus tyrosine protein kinase Srms 0.006 0.0154 0.0119
Echinococcus granulosus tyrosine protein kinase shark 0.006 0.0154 0.0119
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0052 0.0082 0.011
Brugia malayi Protein kinase domain containing protein 0.0412 0.3394 0.803
Echinococcus granulosus cyclin dependent kinase 5 0.0048 0.0045 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0104 0.0164
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0504 0.6183
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0138 0.0871 0.0839
Loa Loa (eye worm) hypothetical protein 0.0061 0.0164 0.0389
Brugia malayi Immunoglobulin I-set domain containing protein 0.0115 0.0665 0.1506
Brugia malayi hypothetical protein 0.0061 0.0164 0.0309
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0129 0.0788 1
Loa Loa (eye worm) SRC-1 0.0138 0.0871 0.2064
Echinococcus multilocularis protein kinase shaggy 0.0052 0.0082 0.011
Echinococcus granulosus neuroglian 0.0048 0.0045 0.001
Brugia malayi Furin-like cysteine rich region family protein 0.0468 0.3911 0.9265
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0159 0.2485
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0154 0.0365
Brugia malayi SH2 domain containing protein 0.006 0.0154 0.0284
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0362 0.2933 0.2908
Onchocerca volvulus Tyrosine kinase homolog 0.0345 0.2775 1
Brugia malayi Protein kinase domain containing protein 0.006 0.0154 0.0284
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0129 0.0788 0.1867
Schistosoma mansoni serine/threonine protein kinase 0.0362 0.2933 0.6927
Echinococcus granulosus semaphorin 1A 0.0061 0.0164 0.013
Onchocerca volvulus 0.0054 0.0101 0.0069
Brugia malayi SH2 domain containing protein 0.006 0.0154 0.0284
Brugia malayi map kinase activated protein kinase protein 2 0.0362 0.2933 0.6927
Brugia malayi Tyrosine-protein kinase abl-1 0.008 0.0343 0.0736
Schistosoma mansoni tyrosine kinase 0.0367 0.2978 0.7035
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.0035 0.0083
Loa Loa (eye worm) TK protein kinase 0.0091 0.0443 0.1049
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0504 1
Schistosoma mansoni semaphorin 5-related 0.0061 0.0164 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0072 0.0596
Echinococcus multilocularis tyrosine protein kinase ABL1 0.006 0.0154 0.0274
Trichomonas vaginalis AGC family protein kinase 0.006 0.0158 0.2469
Brugia malayi hypothetical protein 0.0115 0.0665 0.1506
Entamoeba histolytica SH2-protein kinase domain containing protein 0.006 0.0154 0.2376
Echinococcus multilocularis cyclin dependent kinase 5 0.0048 0.0045 0.0023
Echinococcus multilocularis tyrosine protein kinase Blk 0.0117 0.0682 0.1492
Brugia malayi ephrin receptor 1 precursor 0.0059 0.0148 0.0269
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.006 0.0158 0.2469
Schistosoma mansoni tyrosine kinase 0.0138 0.0871 0.1998
Echinococcus granulosus epidermal growth factor receptor 0.0468 0.3911 0.3889
Onchocerca volvulus 0.006 0.0154 0.0265
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0048 0.0045 0.001
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0138 0.0871 0.1928
Echinococcus granulosus mitogen activated protein kinase 11 0.0129 0.0788 0.0755
Echinococcus multilocularis neuroglian 0.0114 0.0652 0.1423
Onchocerca volvulus 0.006 0.0154 0.0265
Onchocerca volvulus 0.006 0.0154 0.0265
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0048 0.0045 0.0106
Echinococcus multilocularis c src tyrosine kinase 0.008 0.0343 0.071
Schistosoma mansoni tyrosine kinase 0.008 0.0343 0.0736
Echinococcus multilocularis aurora kinase A 0.006 0.0158 0.0284
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0045 0.0024
Entamoeba histolytica protein kinase, putative 0.006 0.0158 0.2469
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0052 0.0082 0.0114
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0052 0.0082 0.0048
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0099 0.0512 0.114
Brugia malayi serine/threonine protein kinase 6 0.006 0.0158 0.0295
Echinococcus multilocularis ephrin type A receptor 4 A 0.01 0.0527 0.1134
Schistosoma mansoni tyrosine kinase 0.006 0.0154 0.0284
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0138 0.0871 0.0839
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0504 1
Echinococcus granulosus cyclin dependent kinase 1 0.0048 0.0045 0.001
Brugia malayi protein-tyrosine kinase 0.0117 0.0682 0.1547
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0047 0.0035 0.0083
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0362 0.2933 0.6683
Echinococcus multilocularis mitogen activated protein kinase 11 0.0129 0.0788 0.1736
Onchocerca volvulus 0.0133 0.0827 0.2764
Schistosoma mansoni neuroglian 0.0048 0.0045 0.0024
Echinococcus multilocularis roundabout 2 0.0146 0.095 0.211
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0048 0.0045 0.0024
Echinococcus multilocularis tyrosine kinase 0.006 0.0154 0.0274
Schistosoma mansoni tyrosine kinase 0.04 0.3286 0.7771
Brugia malayi Sema domain containing protein 0.0061 0.0164 0.0309
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.0045 0.0106
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0162 0.1091 0.1059
Loa Loa (eye worm) sema domain-containing protein 0.0061 0.0164 0.0389
Brugia malayi Protein kinase domain containing protein 0.0162 0.1091 0.2523
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0048 0.0045 0.0106
Echinococcus multilocularis hypothetical protein 0.0061 0.0164 0.0298

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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