pI: 4.5647 |
Length (AA): 519 |
MW (Da): 56709 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 300 | 4g3c (B) | 347 | 651 | 26.00 | 0 | 1 | 0.849754 | -0.03 |
4 | 333 | 4aw2 (A) | 7 | 393 | 29.00 | 0 | 1 | 0.782238 | 0.66 |
14 | 353 | 4lqq (A) | 321 | 714 | 23.00 | 0 | 1 | 0.661606 | 1.38 |
18 | 335 | 1kob (A) | 24 | 337 | 25.00 | 0 | 1 | 0.922217 | -0.15 |
33 | 321 | 1u5q (A) | 13 | 298 | 36.00 | 0 | 1 | 1.00934 | -0.58 |
34 | 323 | 4usf (A) | 22 | 310 | 51.00 | 0 | 1 | 1.14827 | -0.65 |
34 | 323 | 4equ (A) | 24 | 313 | 52.00 | 0 | 1 | 1.10727 | -0.14 |
35 | 324 | 3a7i (A) | 13 | 295 | 39.00 | 0 | 1 | 1.06727 | -0.84 |
38 | 480 | 3mwu (A) | 0 | 533 | 24.00 | 0 | 1 | 1.00806 | 0.6 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130670)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_26435 | Protein kinase domain containing protein |
Caenorhabditis elegans | CELE_C04A11.3 | Protein GCK-4 |
Dictyostelium discoideum | DDB_G0267730 | STE20 family protein kinase |
Drosophila melanogaster | Dmel_CG4527 | Sterile20-like kinase |
Echinococcus granulosus | EgrG_001193000 | STE20 serine:threonine protein kinase |
Echinococcus multilocularis | EmuJ_001193000 | STE20 serine:threonine protein kinase |
Homo sapiens | ENSG00000072786 | serine/threonine kinase 10 |
Homo sapiens | ENSG00000065613 | STE20-like kinase |
Loa Loa (eye worm) | LOAG_06240 | STE/STE20/SLK protein kinase |
Loa Loa (eye worm) | LOAG_04738 | hypothetical protein |
Mus musculus | ENSMUSG00000025060 | STE20-like kinase |
Mus musculus | ENSMUSG00000020272 | serine/threonine kinase 10 |
Schistosoma japonicum | Sjp_0065920 | ko:K08837 serine/threonine kinase 10, putative |
Schistosoma japonicum | Sjp_0105200 | expressed protein |
Schistosoma mansoni | Smp_150260 | protein kinase |
Schmidtea mediterranea | mk4.001249.06 | Protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C04A11.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C04A11.3 | Caenorhabditis elegans | slow growth | wormbase |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | STE20-like kinase | Compounds | References |
Homo sapiens | serine/threonine kinase 10 | Compounds | References |
Homo sapiens | STE20-like kinase | Compounds | References |