Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | multidrug resistance protein 1 | 0.0012 | 0.0002 | 0.0006 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0143 | 0.2184 | 0.6104 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.2133 | 0.5959 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0407 | 0.1138 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0012 | 0.0002 | 0.0006 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0226 | 0.3579 | 1 |
Loa Loa (eye worm) | multidrug resistance protein 3 | 0.0012 | 0.0002 | 0.0002 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0103 | 0.0287 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0407 | 0.1132 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0407 | 0.0895 |
Echinococcus multilocularis | muscleblind protein 1 | 0.015 | 0.2301 | 0.6431 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0114 | 0.0313 |
Onchocerca volvulus | 0.0283 | 0.4525 | 1 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0103 | 0.0103 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0407 | 0.0895 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0407 | 0.1132 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0018 | 0.0114 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0407 | 0.0895 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0103 | 0.0281 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0012 | 0.0002 | 0.0006 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0135 | 0.2051 | 0.4531 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0018 | 0.0114 | 0.0313 |
Plasmodium falciparum | glutathione reductase | 0.0053 | 0.0692 | 0.193 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0031 | 0.0063 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.074 | 0.074 |
Plasmodium falciparum | MO15-related protein kinase | 0.0119 | 0.1797 | 0.5018 |
Trypanosoma brucei | trypanothione reductase | 0.0053 | 0.0692 | 0.1865 |
Echinococcus granulosus | geminin | 0.0171 | 0.2659 | 0.7429 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0143 | 0.2184 | 0.2183 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0283 | 0.4525 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Leishmania major | trypanothione reductase | 0.0053 | 0.0692 | 0.193 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0283 | 0.4525 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0226 | 0.3579 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0114 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0143 | 0.2184 | 0.6104 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0012 | 0.0002 | 0.0006 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.074 | 0.074 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0162 | 0.251 | 0.251 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.074 | 0.0739 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0407 | 0.0895 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0012 | 0.0002 | 0.0006 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0445 | 0.0443 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0018 | 0.0114 | 0.0235 |
Toxoplasma gondii | thioredoxin reductase | 0.0053 | 0.0692 | 0.193 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0283 | 0.4525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.2301 | 0.2301 |
Brugia malayi | Thioredoxin reductase | 0.0053 | 0.0692 | 0.069 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0031 | 0.0063 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0283 | 0.4525 | 0.4525 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0013 | 0.0031 | 0.0063 |
Treponema pallidum | NADH oxidase | 0.0018 | 0.0114 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053 | 0.0692 | 0.0692 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0031 | 0.0063 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.2184 | 0.6101 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0014 | 0.0033 | 0.0031 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0407 | 0.0405 |
Brugia malayi | glutathione reductase | 0.0053 | 0.0692 | 0.069 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0103 | 0.0287 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053 | 0.0692 | 0.1865 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0143 | 0.2184 | 0.2184 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0018 | 0.0114 | 0.0313 |
Echinococcus multilocularis | muscleblind protein | 0.015 | 0.2301 | 0.6431 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0226 | 0.3579 | 0.7908 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0283 | 0.4525 | 0.4524 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0407 | 0.0895 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0135 | 0.2051 | 0.4531 |
Mycobacterium tuberculosis | Probable reductase | 0.0121 | 0.1826 | 0.4033 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0407 | 0.0895 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0012 | 0.0002 | 0.0006 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0407 | 0.0407 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0114 | 0.0319 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0103 | 0.0287 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0103 | 0.0281 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0014 | 0.0033 | 0.0031 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0031 | 0.0063 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0121 | 0.1826 | 0.4033 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0226 | 0.3579 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0226 | 0.3579 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0018 | 0.0114 | 0.0313 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0114 | 0.0248 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0407 | 0.0895 |
Loa Loa (eye worm) | glutathione reductase | 0.0053 | 0.0692 | 0.0692 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0012 | 0.0002 | 0.0006 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0031 | 0.0063 |
Plasmodium falciparum | thioredoxin reductase | 0.0053 | 0.0692 | 0.193 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0283 | 0.4525 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.2184 | 0.6101 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2659 | 0.7428 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0283 | 0.4525 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0135 | 0.2051 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0313 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2659 | 0.7429 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0283 | 0.4525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0103 | 0.0103 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0135 | 0.2051 | 0.4531 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0226 | 0.3579 | 0.3579 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0407 | 0.0895 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0407 | 0.1061 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0012 | 0.0002 | 0.0006 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0407 | 0.1132 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0226 | 0.3579 | 0.3577 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0121 | 0.1826 | 0.4033 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0013 | 0.0031 | 0.0029 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0313 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0012 | 0.0002 | 0.0006 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0407 | 0.0895 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0226 | 0.3579 | 0.3579 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053 | 0.0692 | 0.193 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0283 | 0.4525 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0114 | 0.0248 |
Brugia malayi | Muscleblind-like protein | 0.015 | 0.2301 | 0.23 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0031 | 0.0063 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.251 | 0.7013 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0226 | 0.3579 | 0.7908 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0114 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0103 | 0.0281 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0612 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0143 | 0.2184 | 0.6104 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0103 | 0.0101 |
Echinococcus multilocularis | ATP binding cassette subfamily B (MDR:TAP) | 0.0012 | 0.0002 | 0.0006 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0283 | 0.4525 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0012 | 0.0002 | 0.0006 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0114 | 0.0235 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.074 | 0.0739 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0103 | 0.0287 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0283 | 0.4525 | 1 |
Echinococcus granulosus | muscleblind protein | 0.015 | 0.2301 | 0.6431 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0283 | 0.4525 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0407 | 0.0895 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2659 | 0.7428 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0018 | 0.0114 | 0.0313 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0226 | 0.3579 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0407 | 0.1138 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0018 | 0.0114 | 0.5 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0114 | 0.0235 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.2133 | 0.5959 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0.0114 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0114 | 0.0313 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0114 | 0.0235 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0226 | 0.3579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.2301 | 0.2301 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0407 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0031 | 0.0031 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0226 | 0.3579 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0283 | 0.4525 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0143 | 0.2184 | 0.6104 |
Plasmodium vivax | glutathione reductase, putative | 0.0053 | 0.0692 | 0.193 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0445 | 0.1239 |
Plasmodium falciparum | thioredoxin reductase | 0.0018 | 0.0114 | 0.0313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.2184 | 0.6101 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053 | 0.0692 | 0.1935 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0013 | 0.0031 | 0.0063 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0012 | 0.0002 | 0.0006 |
Echinococcus granulosus | ATP binding cassette subfamily B MDR:TAP | 0.0012 | 0.0002 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0121 | 0.1826 | 0.4033 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0114 | 0.0112 |
Loa Loa (eye worm) | ATP-binding cassette sub-family B member 2 | 0.0012 | 0.0002 | 0.0002 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0162 | 0.251 | 0.2508 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0103 | 0.0287 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0114 | 0.0235 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053 | 0.0692 | 0.1935 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0103 | 0.0101 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0226 | 0.3579 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0407 | 0.1061 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.251 | 0.7013 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0018 | 0.0114 | 0.0313 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0018 | 0.0114 | 0.0313 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0031 | 0.0063 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053 | 0.0692 | 0.1526 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0013 | 0.0031 | 0.0063 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0407 | 0.1061 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0226 | 0.3579 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0103 | 0.0281 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0162 | 0.251 | 0.7013 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0226 | 0.3579 | 1 |
Plasmodium vivax | cyclin dependent kinase 7 (cdk7), putative | 0.0119 | 0.1797 | 0.5018 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0114 | 0.0319 |
Toxoplasma gondii | cell-cycle-associated protein kinase, putative | 0.0111 | 0.1666 | 0.4652 |
Onchocerca volvulus | 0.0094 | 0.137 | 0.3025 | |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0226 | 0.3579 | 0.7908 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0445 | 0.0445 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0103 | 0.0287 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0121 | 0.1826 | 0.4033 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0012 | 0.0002 | 0.0006 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0226 | 0.3579 | 0.3577 |
Plasmodium falciparum | glutathione reductase | 0.0018 | 0.0114 | 0.0313 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0121 | 0.1826 | 0.4033 |
Leishmania major | glycosyl hydrolase-like protein | 0.0013 | 0.0031 | 0.008 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0114 | 0.0313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.