Detailed information for compound 1570216

Basic information

Technical information
  • TDR Targets ID: 1570216
  • Name: 2-[[(Z)-[7-[(8Z)-1,6-dihydroxy-3-methyl-7-oxo -5-propan-2-yl-8-[(2-sulfoethylamino)methylid ene]naphthalen-2-yl]-3,8-dihydroxy-6-methyl-2 -oxo-4-propan-2-ylnaphthalen-1-ylidene]methyl ]amino]ethanesulfonic acid
  • MW: 732.818 | Formula: C34H40N2O12S2
  • H donors: 8 H acceptors: 12 LogP: 3.93 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC(C1=C(O)C(=O)/C(=C\NCCS(=O)(=O)O)/c2c1cc(C)c(c2O)c1c(C)cc2c(c1O)/C(=C/NCCS(=O)(=O)O)/C(=O)C(=C2C(C)C)O)C
  • InChi: 1S/C34H40N2O12S2/c1-15(2)23-19-11-17(5)25(31(39)27(19)21(29(37)33(23)41)13-35-7-9-49(43,44)45)26-18(6)12-20-24(16(3)4)34(42)30(38)22(28(20)32(26)40)14-36-8-10-50(46,47)48/h11-16,35-36,39-42H,7-10H2,1-6H3,(H,43,44,45)(H,46,47,48)/b21-13-,22-14-
  • InChiKey: JXLMYTURVBELLL-JZTLMNBPSA-N  

Network

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Synonyms

  • 2-[[(Z)-[7-[(8Z)-1,6-dihydroxy-5-isopropyl-3-methyl-7-oxo-8-[(2-sulfoethylamino)methylene]-2-naphthyl]-3,8-dihydroxy-4-isopropyl-6-methyl-2-oxo-1-naphthylidene]methyl]amino]ethanesulfonic acid
  • 2-[[(Z)-[7-[(8Z)-1,6-dihydroxy-5-isopropyl-7-keto-3-methyl-8-[(2-sulfoethylamino)methylene]-2-naphthyl]-3,8-dihydroxy-4-isopropyl-2-keto-6-methyl-1-naphthylidene]methyl]amino]ethanesulfonic acid
  • 2-[[(Z)-[7-[(8Z)-1,6-dihydroxy-3-methyl-7-oxo-5-propan-2-yl-8-[(2-sulfoethylamino)methylidene]naphthalen-2-yl]-3,8-dihydroxy-6-methyl-2-oxo-4-propan-2-yl-naphthalen-1-ylidene]methyl]amino]ethanesulfonic acid
  • 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-8,8'-bis[[(2-hydroxysulfonyl)ethyl]iminomethyl][2,2'-binaphthalene]
  • AIDS-005279
  • AIDS005279
  • Glossypol di-OHSO2EtNCH deriv.

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0002 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.2184 0.6104
Schistosoma mansoni alpha-glucosidase 0.014 0.2133 0.5959
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0407 0.1138
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0002 0.0006
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0226 0.3579 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0012 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0018 0.0103 0.0287
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0407 0.1132
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0407 0.0895
Echinococcus multilocularis muscleblind protein 1 0.015 0.2301 0.6431
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0114 0.0313
Onchocerca volvulus 0.0283 0.4525 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0103 0.0103
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0407 0.0895
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0407 0.1132
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0235
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0114 0.0248
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0407 0.0895
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0002 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.2051 0.4531
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0114 0.0313
Plasmodium falciparum glutathione reductase 0.0053 0.0692 0.193
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0063
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.074 0.074
Plasmodium falciparum MO15-related protein kinase 0.0119 0.1797 0.5018
Trypanosoma brucei trypanothione reductase 0.0053 0.0692 0.1865
Echinococcus granulosus geminin 0.0171 0.2659 0.7429
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.2184 0.2183
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0283 0.4525 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0235
Leishmania major trypanothione reductase 0.0053 0.0692 0.193
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0283 0.4525 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0226 0.3579 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0114 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.2184 0.6104
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0002 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0114 0.0235
Loa Loa (eye worm) hypothetical protein 0.0056 0.074 0.074
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.251 0.251
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.074 0.0739
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0407 0.0895
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0002 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0445 0.0443
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0114 0.0235
Toxoplasma gondii thioredoxin reductase 0.0053 0.0692 0.193
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0283 0.4525 1
Loa Loa (eye worm) hypothetical protein 0.015 0.2301 0.2301
Brugia malayi Thioredoxin reductase 0.0053 0.0692 0.069
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0063
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0283 0.4525 0.4525
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0031 0.0063
Treponema pallidum NADH oxidase 0.0018 0.0114 0.5
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0692 0.0692
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2184 0.6101
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0114 0.0235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0235
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0033 0.0031
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0407 0.0405
Brugia malayi glutathione reductase 0.0053 0.0692 0.069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0103 0.0287
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0692 0.1865
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.2184 0.2184
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0114 0.0313
Echinococcus multilocularis muscleblind protein 0.015 0.2301 0.6431
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0226 0.3579 0.7908
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0283 0.4525 0.4524
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0407 0.0895
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.2051 0.4531
Mycobacterium tuberculosis Probable reductase 0.0121 0.1826 0.4033
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0407 0.0895
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0002 0.0006
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0407 0.0407
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0319
Echinococcus multilocularis GPCR, family 2 0.0018 0.0103 0.0287
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0033 0.0031
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0063
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.1826 0.4033
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0226 0.3579 1
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0226 0.3579 1
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0114 0.0313
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0114 0.0248
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0407 0.0895
Loa Loa (eye worm) glutathione reductase 0.0053 0.0692 0.0692
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0002 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0235
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0063
Plasmodium falciparum thioredoxin reductase 0.0053 0.0692 0.193
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0283 0.4525 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2184 0.6101
Schistosoma mansoni hypothetical protein 0.0171 0.2659 0.7428
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0283 0.4525 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.2051 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0313
Echinococcus multilocularis geminin 0.0171 0.2659 0.7429
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0283 0.4525 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.2051 0.4531
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0226 0.3579 0.3579
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0407 0.0895
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0407 0.1061
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0002 0.0006
Schistosoma mansoni alpha glucosidase 0.0036 0.0407 0.1132
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0226 0.3579 0.3577
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.1826 0.4033
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0031 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0313
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0002 0.0006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0407 0.0895
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0226 0.3579 0.3579
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0692 0.193
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0283 0.4525 1
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0114 0.0248
Brugia malayi Muscleblind-like protein 0.015 0.2301 0.23
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0063
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.251 0.7013
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0226 0.3579 0.7908
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0235
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0612 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.2184 0.6104
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0103 0.0101
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0002 0.0006
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0283 0.4525 1
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0002 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0235
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0114 0.0235
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.074 0.0739
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0103 0.0287
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0283 0.4525 1
Echinococcus granulosus muscleblind protein 0.015 0.2301 0.6431
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0283 0.4525 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0407 0.0895
Schistosoma mansoni hypothetical protein 0.0171 0.2659 0.7428
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0114 0.0313
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0226 0.3579 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0407 0.1138
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0114 0.5
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0114 0.0235
Schistosoma mansoni alpha-glucosidase 0.014 0.2133 0.5959
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0114 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0114 0.0235
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0226 0.3579 1
Loa Loa (eye worm) hypothetical protein 0.015 0.2301 0.2301
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0407 0.0895
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0031
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0226 0.3579 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0283 0.4525 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.2184 0.6104
Plasmodium vivax glutathione reductase, putative 0.0053 0.0692 0.193
Schistosoma mansoni hypothetical protein 0.0038 0.0445 0.1239
Plasmodium falciparum thioredoxin reductase 0.0018 0.0114 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.2184 0.6101
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0692 0.1935
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0031 0.0063
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0002 0.0006
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.1826 0.4033
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0114 0.0112
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0012 0.0002 0.0002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.251 0.2508
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0103 0.0287
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0235
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0692 0.1935
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0103 0.0101
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0226 0.3579 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0407 0.1061
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.251 0.7013
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0114 0.0313
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0114 0.0313
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0063
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0692 0.1526
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0031 0.0063
Trypanosoma brucei glucosidase, putative 0.0036 0.0407 0.1061
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0226 0.3579 1
Schistosoma mansoni hypothetical protein 0.0018 0.0103 0.0281
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.251 0.7013
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0226 0.3579 1
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0119 0.1797 0.5018
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0114 0.0319
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0111 0.1666 0.4652
Onchocerca volvulus 0.0094 0.137 0.3025
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0226 0.3579 0.7908
Loa Loa (eye worm) hypothetical protein 0.0038 0.0445 0.0445
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0103 0.0287
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.1826 0.4033
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0002 0.0006
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0226 0.3579 0.3577
Plasmodium falciparum glutathione reductase 0.0018 0.0114 0.0313
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.1826 0.4033
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0031 0.008
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0114 0.0313

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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