Detailed information for compound 15707

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.4 | Formula: C19H23F2N3O4
  • H donors: 3 H acceptors: 4 LogP: 0.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNCC1CCN(C1)c1c(F)c(O)c2c(c1F)n(CC)cc(c2=O)C(=O)O
  • InChi: 1S/C19H23F2N3O4/c1-3-22-7-10-5-6-24(8-10)16-13(20)15-12(18(26)14(16)21)17(25)11(19(27)28)9-23(15)4-2/h9-10,22,26H,3-8H2,1-2H3,(H,27,28)
  • InChiKey: PNHCXCTWESNAEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0076 0.0721 0.1211
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0314 0.0985
Entamoeba histolytica cyclin family protein 0.0018 0.007 0.0221
Onchocerca volvulus 0.0022 0.0109 0.05
Onchocerca volvulus Troponin I homolog 0.0112 0.1125 0.6768
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0314 0.321
Echinococcus multilocularis caspase 2 0.0092 0.0901 0.0862
Brugia malayi DnaJ domain containing protein 0.0062 0.056 0.2835
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.0979 0.5869
Schistosoma mansoni rab6-interacting 0.0022 0.0109 0.0344
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0126 0.1284 0.2217
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.0979 0.0941
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0109 0.0119
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0325 0.0814
Brugia malayi hypothetical protein 0.0022 0.0109 0.0418
Echinococcus granulosus tyrosine protein kinase Blk 0.0076 0.0721 0.1211
Echinococcus multilocularis cyclins 0.0018 0.007 0.0028
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.04 0.6547
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0096
Brugia malayi Sex muscle abnormal protein 5 0.0017 0.005 0.0104
Entamoeba histolytica cyclin, putative 0.0018 0.007 0.0221
Echinococcus granulosus oncosphere protein Tso22e 0.0138 0.1429 0.2476
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0979 0.3068
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0084 0.0813 0.0774
Schistosoma mansoni polycystin 1-related 0.0022 0.0109 0.0344
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0325 0.1017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0076 0.0721 0.0681
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.0979 0.5078
Echinococcus granulosus geminin 0.0187 0.1981 0.3461
Echinococcus granulosus tyrosine protein kinase Src42A 0.0073 0.0694 0.1164
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0217 0.0901
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1489 0.1482
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.3193 1
Echinococcus multilocularis cyclins 0.0018 0.007 0.0028
Brugia malayi Troponin family protein 0.0112 0.1125 0.5858
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0073 0.0685 0.1147
Brugia malayi PHD-finger family protein 0.0031 0.0217 0.0996
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0096
Trichomonas vaginalis cyclin B, putative 0.0018 0.007 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0979 0.3068
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0979 0.3068
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0314 0.1532
Leishmania major cyclin 0.0018 0.007 0.0418
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.1989
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0979 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0031 0.0018
Brugia malayi SRC-1 0.0084 0.0813 0.4189
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0314 0.0273
Trypanosoma cruzi metacaspase, putative 0.0047 0.04 0.4085
Onchocerca volvulus 0.0018 0.007 0.0263
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0291 0.1408
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.043 0.2152
Trypanosoma cruzi metacaspase, putative 0.0047 0.04 0.4085
Echinococcus multilocularis caspase 3 0.0078 0.0746 0.0707
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0291 0.0445
Echinococcus granulosus cyclins 0.0018 0.007 0.005
Brugia malayi hypothetical protein 0.0073 0.0685 0.35
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.0077 0.0179
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0109 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.007 0.0221
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0325 0.1017
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0325 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.04 0.1253
Schistosoma mansoni tsg101-related 0.006 0.0547 0.2605
Brugia malayi Doublecortin family protein 0.0022 0.0109 0.0418
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0594 0.3026
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0109 0.1167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0314 0.0985
Echinococcus multilocularis cyclins 0.0018 0.007 0.0028
Trypanosoma brucei Metacaspase-4 0.0047 0.04 0.4085
Trypanosoma cruzi cyclin, putative 0.0018 0.007 0.0719
Trypanosoma brucei polo-like protein kinase 0.0099 0.0979 1
Echinococcus multilocularis neuropeptide receptor A26 0.0511 0.5644 0.5625
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0251 0.1177
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0291 0.025
Echinococcus multilocularis tyrosine protein kinase Blk 0.0076 0.0721 0.0681
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0016
Trypanosoma brucei mitotic cyclin 6 0.0018 0.007 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.04 0.1253
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.04 0.6547
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0325 0.3315
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0031 0.0096
Schistosoma mansoni kinase 0.005 0.043 0.2001
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.043 0.2139
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.007 0.0212
Brugia malayi hypothetical protein 0.0158 0.1649 0.8663
Trichomonas vaginalis cyclins, putative 0.0018 0.007 0.0221
Loa Loa (eye worm) hypothetical protein 0.0158 0.1649 0.8665
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0031 0.0096
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0109 0.0434
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0553 0.0513
Schistosoma mansoni tsg101-related 0.0049 0.0422 0.1958
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0049 0.0422 0.1321
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0073 0.0685 0.0645
Trypanosoma cruzi cyclin, putative 0.0018 0.007 0.0719
Schistosoma mansoni tsg101-related 0.006 0.0547 0.2605
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.0077 0.0062
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0047 0.04 0.1977
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.0813 0.0774
Onchocerca volvulus 0.0104 0.104 0.6245
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.0813 0.0774
Echinococcus granulosus troponin i 0.0112 0.1125 0.1934
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.06 0.288
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0017 0.005 0.0042
Schistosoma mansoni tyrosine kinase 0.0019 0.0077 0.0179
Brugia malayi Variant SH3 domain containing protein 0.0017 0.005 0.0104
Schistosoma mansoni cyclins 0.0018 0.007 0.0146
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0042 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0415 0.1301
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.056 0.2846
Echinococcus multilocularis peregrin 0.0031 0.0217 0.0175
Echinococcus multilocularis troponin i 0.0112 0.1125 0.1088
Entamoeba histolytica cyclin, putative 0.0018 0.007 0.0221
Loa Loa (eye worm) TK protein kinase 0.0076 0.0721 0.3702
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0228
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1489 0.1482
Echinococcus granulosus neuropeptide receptor A26 0.0511 0.5644 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0325 0.1017
Trypanosoma cruzi cyclin 6, putative 0.0018 0.007 0.0719
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0325 0.0504
Trichomonas vaginalis cyclin B, putative 0.0018 0.007 0.0221
Onchocerca volvulus 0.0022 0.0109 0.05
Echinococcus granulosus neuropeptide s receptor 0.0511 0.5644 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0067 0.0626 0.0586
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0018 0.007 0.0028
Trichomonas vaginalis cyclin B, putative 0.0018 0.007 0.0221
Loa Loa (eye worm) troponin T 0.0066 0.0612 0.3119
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0031 0.0314
Schistosoma mansoni rab6-interacting 0.0022 0.0109 0.0344
Trypanosoma cruzi CYC2-like cyclin, putative 0.0018 0.007 0.0719
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0138 0.1429 0.1393
Schistosoma mansoni lipoxygenase 0.0022 0.0109 0.0344
Entamoeba histolytica cyclin family protein 0.0018 0.007 0.0221
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.0077 0.0035
Echinococcus multilocularis NCK adaptor protein 0.0017 0.005 0.0008
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0553 0.0911
Plasmodium falciparum metacaspase 1 0.0047 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0314 0.0985
Echinococcus granulosus cyclin b3 0.0018 0.007 0.005
Trypanosoma brucei metacaspase MCA2 0.0047 0.04 0.4085
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.04 0.1253
Brugia malayi hypothetical protein 0.0066 0.0612 0.3108
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.1899 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.0979 0.3068
Schistosoma mansoni hypothetical protein 0.0187 0.1981 1
Schistosoma mansoni hypothetical protein 0.0031 0.0217 0.0901
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.0813 0.1377
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0084 0.0813 0.1377
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0047 0.04 0.1846
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Schistosoma mansoni tyrosine kinase 0.0084 0.0813 0.3978
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0109 0.0119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0314 0.0985
Schistosoma mansoni adapter molecule crk 0.0017 0.005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0112 0.1125 0.5864
Schistosoma mansoni cyclin B3 0.0018 0.007 0.0146
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.056 0.0925
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0066 0.0612 0.36
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0031 0.0096
Giardia lamblia Kinase, PLK 0.0099 0.0979 0.2911
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.1899 0.3315
Leishmania major hypothetical protein, conserved 0.0023 0.0125 0.0998
Brugia malayi Bromodomain containing protein 0.0031 0.0217 0.0996
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0979 0.3068
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0217 0.3387
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0314 0.0985
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.1899 0.1865
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Schistosoma mansoni lipoxygenase 0.0061 0.0553 0.2633
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0356 0.0559
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0314 0.0486
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.0979 0.5085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0363 0.1792
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.043 0.2139
Trichomonas vaginalis cyclin A, putative 0.0018 0.007 0.0221
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.06 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0901 0.4665
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.06 0.6005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0291 0.1285
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0325 0.3315
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0363 0.0573
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.04 0.4085
Trichomonas vaginalis cyclins, putative 0.0018 0.007 0.0221
Echinococcus granulosus cyclins 0.0018 0.007 0.005
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.0979 0.1673
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0217 0.3704
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0031 0.0314
Schistosoma mansoni hypothetical protein 0.0034 0.0251 0.1076
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.056 0.052
Loa Loa (eye worm) hypothetical protein 0.0112 0.1125 0.5864
Trichomonas vaginalis cyclin B3, putative 0.0018 0.007 0.0221
Schistosoma mansoni troponin I 0.0112 0.1125 0.5587
Brugia malayi jmjC domain containing protein 0.0038 0.0291 0.1395
Brugia malayi Tyrosine-protein kinase abl-1 0.0019 0.0077 0.0247
Schistosoma mansoni caspase-3 (C14 family) 0.0126 0.1284 0.6406
Onchocerca volvulus 0.0158 0.1649 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.06 0.288
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0109 0.0434
Echinococcus granulosus RUN 0.0022 0.0109 0.0119
Echinococcus multilocularis caspase 8 0.0047 0.04 0.0359
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0325 0.1458
Loa Loa (eye worm) cyclin domain-containing protein 0.0018 0.007 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0325 0.3315
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.007 0.0212
Echinococcus multilocularis neuropeptide s receptor 0.0511 0.5644 0.5625
Echinococcus multilocularis cyclins 0.0018 0.007 0.0028
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0084 0.0813 0.0774
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0325 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0979 0.3068
Leishmania major metacaspase, putative 0.0047 0.04 0.3893
Trypanosoma cruzi metacaspase, putative 0.0047 0.04 0.4085
Loa Loa (eye worm) troponin I 0.0112 0.1125 0.5864
Trichomonas vaginalis cyclin B, putative 0.0018 0.007 0.0221
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0595 0.6599 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0314 0.0985
Schistosoma mansoni hypothetical protein 0.0022 0.0109 0.0344
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.0979 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0217 0.0175
Echinococcus multilocularis cyclin B3 1 0.0018 0.007 0.0028
Loa Loa (eye worm) hypothetical protein 0.005 0.043 0.2152
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0109 0.0067
Schistosoma mansoni troponin I 0.0112 0.1125 0.5587
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0018 0.007 0.005
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.007 0.0212
Brugia malayi Troponin T 0.0066 0.0612 0.3108
Echinococcus multilocularis tyrosine protein kinase Srms 0.0076 0.0721 0.0681
Echinococcus granulosus tyrosine protein kinase Src64B 0.0084 0.0813 0.1377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Schistosoma mansoni loxhd1 0.0022 0.0109 0.0344
Brugia malayi Troponin T 0.0066 0.0612 0.3108
Loa Loa (eye worm) SRC-1 0.0084 0.0813 0.4198
Echinococcus granulosus caspase 0.0126 0.1284 0.2217
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0314 0.0985
Brugia malayi protein-tyrosine kinase 0.0076 0.0721 0.3692
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0084 0.0813 0.0774
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Trichomonas vaginalis hypothetical protein 0.0035 0.0263 0.0824
Echinococcus multilocularis cyclins 0.0018 0.007 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0047 0.04 1
Brugia malayi Troponin I 0.0112 0.1125 0.5858
Schistosoma mansoni troponin I 0.0112 0.1125 0.5587
Giardia lamblia PHD finger protein 15 0.0031 0.0217 0.0469
Trichomonas vaginalis cyclins, putative 0.0018 0.007 0.0221
Echinococcus granulosus cyclins 0.0018 0.007 0.005
Schistosoma mansoni alpha-glucosidase 0.0155 0.1616 0.8116
Trypanosoma brucei metacaspase 5, putative 0.0047 0.04 0.4085
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0595 0.6599 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0217 0.101
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0217 0.0312
Schistosoma mansoni troponin I 0.0112 0.1125 0.5587
Schistosoma mansoni nck2/grb4 0.0017 0.005 0.0042
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0217 0.3387
Schistosoma mansoni hypothetical protein 0.0112 0.1125 0.5587
Plasmodium falciparum phd finger protein, putative 0.0031 0.0217 0.4439
Schistosoma mansoni troponin t invertebrate 0.0138 0.1429 0.7154
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.005 0.0042
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0325 0.0504
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.005 0.012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0109 0.0067
Trichomonas vaginalis cyclin B, putative 0.0018 0.007 0.0221
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0325 0.1458
Trypanosoma brucei metacaspase MCA3 0.0047 0.04 0.4085
Schistosoma mansoni tyrosine kinase 0.0019 0.0077 0.0179
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0031 0.0314
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0325 0.1017
Brugia malayi Cell death protein 3 precursor 0.0092 0.0901 0.4657
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0125 0.1281
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.0813 0.0774
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1023 0.1751
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0077
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0018 0.007 0.0418
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0096
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.012
Brugia malayi Variant SH3 domain containing protein 0.0017 0.005 0.0104
Plasmodium falciparum metacaspase-like protein 0.0047 0.04 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0084 0.0813 0.0774
Echinococcus multilocularis cyclin b3 0.0018 0.007 0.0028
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0325 0.1573
Brugia malayi jmjC domain containing protein 0.0102 0.1023 0.531
Schistosoma mansoni alpha-glucosidase 0.0155 0.1616 0.8116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.3193 1
Echinococcus multilocularis cyclin B 0.0018 0.007 0.0028
Echinococcus granulosus cyclins 0.0018 0.007 0.005
Schistosoma mansoni caspase-7 (C14 family) 0.0126 0.1284 0.6406
Schistosoma mansoni caspase-7 (C14 family) 0.0092 0.0901 0.4429
Schistosoma mansoni hypothetical protein 0.0062 0.056 0.2673
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.0813 0.1377
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.0813 0.1377
Loa Loa (eye worm) hypothetical protein 0.0073 0.0685 0.3511
Trypanosoma brucei metacaspase 0.0047 0.04 0.4085
Echinococcus multilocularis tyrosine protein kinase Abl 0.0019 0.0077 0.0035
Echinococcus granulosus growth factor receptor bound protein 2 0.0017 0.005 0.0014
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0314 0.1518
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.06 0.0561
Loa Loa (eye worm) hypothetical protein 0.0066 0.0612 0.3119
Echinococcus granulosus NCK adaptor protein 0.0017 0.005 0.0014
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0325 0.3099
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0314 0.0985
Echinococcus granulosus tyrosine protein kinase Lyn 0.0084 0.0817 0.1383
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.1899 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0291 0.1285
Loa Loa (eye worm) TK protein kinase 0.0067 0.0626 0.3194
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0784 0.3829
Onchocerca volvulus Alhambra homolog 0.0031 0.0217 0.1165
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0314 0.0985
Brugia malayi hypothetical protein 0.0044 0.0363 0.1779
Schistosoma mansoni cyclin B 0.0018 0.007 0.0146
Echinococcus multilocularis caspase 0.0126 0.1284 0.1247
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0096
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0979 0.3068
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0031 0.0096
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0073 0.0694 0.0655
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Plasmodium vivax metacaspase 1, putative 0.0047 0.04 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0067 0.0626 0.1042
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0126 0.1284 0.1247
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0042 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0325 0.1587
Loa Loa (eye worm) hypothetical protein 0.0054 0.047 0.2363
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0595 0.6599 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.1899 0.1865
Brugia malayi Troponin T 0.0066 0.0612 0.3108
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0109 0.0119
Echinococcus granulosus c src tyrosine kinase 0.0019 0.0077 0.0062
Loa Loa (eye worm) hypothetical protein 0.0034 0.0251 0.1191
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0217 0.101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.3193 1
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1313 0.687
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0325 0.0284
Echinococcus granulosus cyclin B3 1 0.0018 0.007 0.005
Onchocerca volvulus Cell death protein 3 homolog 0.0092 0.0901 0.5384
Trypanosoma cruzi metacaspase, putative 0.0047 0.04 0.4085
Echinococcus granulosus tyrosine protein kinase Fyn 0.0084 0.0813 0.1377
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0125 0.1281
Echinococcus granulosus peregrin 0.0031 0.0217 0.0312
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0314 0.0985
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.04 0.6547
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.0077 0.0035
Echinococcus multilocularis cyclins 0.0018 0.007 0.0028
Schistosoma mansoni hypothetical protein 0.0044 0.0363 0.1656
Entamoeba histolytica protein kinase, putative 0.0067 0.0626 0.1959
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.04 0.1253
Trichomonas vaginalis cyclin D, putative 0.0018 0.007 0.0221
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1023 0.0985
Echinococcus multilocularis geminin 0.0187 0.1981 0.1947
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.04 0.4085
Schistosoma mansoni alpha glucosidase 0.004 0.0314 0.1404
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0363 0.0322
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0314 0.0985
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0356 0.0315
Echinococcus granulosus cyclins 0.0018 0.007 0.005
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0314 0.299
Schistosoma mansoni tyrosine kinase 0.0084 0.0813 0.3978
Echinococcus multilocularis RUN 0.0022 0.0109 0.0067
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.056 0.1755
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0314 0.321
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0979 0.4835
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.0979 0.3068
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.06 0.0997
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1313 0.687
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0031 0.0096
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0325 0.0504
Echinococcus granulosus caspase 3 0.0078 0.0746 0.1257
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Trichomonas vaginalis cyclins, putative 0.0018 0.007 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.04 0.1253
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0415 0.1301
Trypanosoma brucei glucosidase, putative 0.004 0.0314 0.321
Echinococcus multilocularis cyclins 0.0018 0.007 0.0028
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0084 0.0813 0.1377
Schistosoma mansoni hypothetical protein 0.0187 0.1981 1
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0138 0.1429 0.8641
Loa Loa (eye worm) troponin 0.0066 0.0612 0.3119
Trichomonas vaginalis cyclins, putative 0.0018 0.007 0.0221
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0017 0.005 0.012
Trichomonas vaginalis cyclin D, putative 0.0018 0.007 0.0221
Onchocerca volvulus 0.0044 0.0363 0.2068
Brugia malayi MH2 domain containing protein 0.0128 0.1313 0.6865
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0314 0.507
Brugia malayi hypothetical protein 0.0022 0.0109 0.0418
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Loa Loa (eye worm) hypothetical protein 0.0022 0.0109 0.0434
Echinococcus granulosus cyclin B 0.0018 0.007 0.005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Echinococcus granulosus tyrosine kinase 0.0076 0.0721 0.1211
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0042 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.04 0.1253
Echinococcus multilocularis growth factor receptor bound protein 2 0.0017 0.005 0.0008
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.0979 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0084 0.0813 0.0774
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.3193 1
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.3193 0.5
Echinococcus granulosus caspase 2 0.0092 0.0901 0.1533
Echinococcus granulosus caspase 8 0.0047 0.04 0.0639
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.04 0.1253
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0084 0.0813 0.0774

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.05 ug ml-1 Antibacterial activity was determined against gram positive organism, S. aureus UC76 ChEMBL. 1848296
MIC (functional) = 0.2 ug ml-1 Antibacterial activity was determined against gram positive organism, S. pneumonia SV-1 ChEMBL. 1848296
MIC (functional) = 0.2 ug ml-1 Antibacterial activity was determined against gram positive organism, S. pyogenes C203 ChEMBL. 1848296
MIC (functional) = 0.4 ug ml-1 Antibacterial activity was determined against gram negative organism, E. cloacae MA2646 ChEMBL. 1848296
MIC (functional) = 0.4 ug ml-1 Antibacterial activity was determined against gram negative organism, E. coli vogel ChEMBL. 1848296
MIC (functional) = 0.4 ug ml-1 Antibacterial activity was determined against gram positive organism, S. auerus H228 ChEMBL. 1848296
MIC (functional) = 0.4 ug ml-1 Antibacterial activity was determined against gram positive organism, S. faecalis MGH-2 ChEMBL. 1848296
MIC (functional) = 0.4 ug ml-1 Antibacterial activity was determined against gram negative organism, E. coli vogel ChEMBL. 1848296
MIC (functional) = 0.8 ug ml-1 Antibacterial activity was determined against gram negative organism, K. pneumonia MGH-2 ChEMBL. 1848296
MIC (functional) = 2.5 ug ml-1 Minimum inhibitory concentration against E. coli DNA-gyrase in supercoiling assay ChEMBL. 1848296
MIC (functional) = 2.5 ug ml-1 Minimum inhibitory concentration against E. coli DNA-gyrase in supercoiling assay ChEMBL. 1848296
MIC (functional) = 3.1 ug ml-1 Antibacterial activity was determined against gram negative organism, P. rettgeri. M1771 ChEMBL. 1848296
MIC (functional) = 12.5 ug ml-1 Antibacterial activity was determined against gram negative organism, P. aeruginosa UI-18 ChEMBL. 1848296
Ratio (functional) = 0.2 MIC ratio measured as the mean MICs of gram-positive bacteria ChEMBL. 1848296
Ratio (functional) = 1.38 MIC ratio measured as the mean MICs of gram-negative bacteria ChEMBL. 1848296

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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