Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0236 | 0.0683 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0236 | 0.0683 | 0.1039 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.0219 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0236 | 0.0683 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0219 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0219 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0236 | 0.0683 | 0.0474 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0236 | 0.0683 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0236 | 0.0683 | 0.1039 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0236 | 0.0683 | 0.1039 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0236 | 0.0683 | 0.1039 |
Onchocerca volvulus | 0.0236 | 0.0683 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0219 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0334 | 0.0117 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0236 | 0.0683 | 0.1039 |
Schistosoma mansoni | choline o-acyltransferase | 0.0236 | 0.0683 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0236 | 0.0683 | 0.1039 |
Onchocerca volvulus | 0.0236 | 0.0683 | 1 | |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0236 | 0.0683 | 0.1039 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0236 | 0.0683 | 0.1039 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.0219 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0236 | 0.0683 | 0.1039 |
Loa Loa (eye worm) | hypothetical protein | 0.2683 | 1 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0236 | 0.0683 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0236 | 0.0683 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0219 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0236 | 0.0683 | 0.0474 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0236 | 0.0683 | 0.1039 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1285 | 0.4679 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0334 | 0.0117 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0236 | 0.0683 | 0.1039 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0236 | 0.0683 | 0.0474 |
Onchocerca volvulus | 0.0236 | 0.0683 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0236 | 0.0683 | 0.1039 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0236 | 0.0683 | 0.1039 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0334 | 0.0117 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1285 | 0.4679 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0219 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0236 | 0.0683 | 0.0474 |
Brugia malayi | Choline O-acetyltransferase | 0.0236 | 0.0683 | 0.0474 |
Onchocerca volvulus | 0.0236 | 0.0683 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0236 | 0.0683 | 0.1039 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.0219 | 0.3156 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0683 | 0.0474 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0236 | 0.0683 | 0.1039 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0236 | 0.0683 | 0.0474 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0219 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0236 | 0.0683 | 0.0474 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0236 | 0.0683 | 0.1039 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0236 | 0.0683 | 0.1039 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1285 | 0.4679 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.0219 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0236 | 0.0683 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1285 | 0.4679 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1285 | 0.4679 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3934 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.6213 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.