TDR Targets

Basic information

Technical information

TDR Targets ID: 1585646
Name: N-[2-(cyclopentylamino)-1-(4-dimethylaminophe nyl)-2-oxoethyl]-N-cyclopropylthiadiazole-4-c arboxamide
MW: 413.536 | Formula: C21H27N5O2S
H donors: 1 H acceptors: 4 LogP: 3.22 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(N(C(=O)c1csnn1)C1CC1)c1ccc(cc1)N(C)C)NC1CCCC1
InChi: 1S/C21H27N5O2S/c1-25(2)16-9-7-14(8-10-16)19(20(27)22-15-5-3-4-6-15)26(17-11-12-17)21(28)18-13-29-24-23-18/h7-10,13,15,17,19H,3-6,11-12H2,1-2H3,(H,22,27)
InChiKey: MYAFZVGVKIARIQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(cyclopentylamino)-1-(4-dimethylaminophenyl)-2-oxo-ethyl]-N-cyclopropyl-thiadiazole-4-carboxamide
N-[2-(cyclopentylamino)-1-(4-dimethylaminophenyl)-2-oxoethyl]-N-cyclopropyl-4-thiadiazolecarboxamide
N-[2-(cyclopentylamino)-1-(4-dimethylaminophenyl)-2-keto-ethyl]-N-cyclopropyl-thiadiazole-4-carboxamide
N-[2-(cyclopentylamino)-1-(4-dimethylaminophenyl)-2-oxo-ethyl]-N-cyclopropyl-1,2,3-thiadiazole-4-carboxamide
ASN 06567345

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0097	0.0785	0.078
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0036	0.0112	0.0107
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0135	0.1209	0.1204
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0389	0.4014	0.4011
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0293	0.2954	0.295
Loa Loa (eye worm)	MBCTL1	0.0097	0.0785	0.078
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0395	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0121	0.0115
Onchocerca volvulus		0.0293	0.2954	0.295
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0277	0.0272
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.0331	0.3371	0.3367
Onchocerca volvulus		0.0094	0.075	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0931	1	1
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0027	0.0016	0.0012
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0121	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0646	0.2396
Schistosoma mansoni	chromobox protein	0.0199	0.1916	0.2047
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0293	0.2954	0.295
Echinococcus granulosus	nAChR subunit	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0293	0.2954	0.3159
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0121	1
Loa Loa (eye worm)	hypothetical protein	0.0576	0.6082	0.608
Echinococcus multilocularis	serotonin receptor	0.0134	0.119	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Leishmania major	trypanothione reductase	0.0037	0.0123	0.0379
Onchocerca volvulus		0.0576	0.6082	0.608
Echinococcus granulosus	glycine receptor subunit beta	0.0293	0.2954	0.295
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1209	0.1289
Onchocerca volvulus		0.0158	0.146	0.1455
Schistosoma mansoni	nAChR subunit	0.0293	0.2954	0.3159
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0121	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Brugia malayi	Cation transporter family protein	0.0293	0.2954	0.295
Brugia malayi	Muscleblind-like protein	0.0149	0.1357	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0395	0.039
Loa Loa (eye worm)	hypothetical protein	0.0419	0.4344	0.4341
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0277	0.0272
Echinococcus granulosus	neutral alpha glucosidase AB	0.0036	0.0112	0.0107
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0646	0.2396
Onchocerca volvulus		0.0135	0.1209	0.1204
Loa Loa (eye worm)	CHromoDomain protein family member	0.0027	0.0016	0.0011
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0395	1
Brugia malayi	hypothetical protein	0.0135	0.1209	0.1204
Brugia malayi	hypothetical protein	0.0135	0.1209	0.1204
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.075	0.2871
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0646	0.2396
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0121	0.0115
Trichomonas vaginalis	esterase, putative	0.0037	0.0121	1
Schistosoma mansoni	phd finger protein	0.0041	0.0169	0.0176
Trypanosoma brucei	trypanothione reductase	0.0037	0.0123	1
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0036	0.0112	0.2826
Echinococcus granulosus	biogenic amine 5HT receptor	0.0134	0.119	0.1185
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0121	0.978
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Schistosoma mansoni	sex comb on midleg homolog	0.0269	0.2683	0.2869
Echinococcus granulosus	geminin	0.0166	0.1543	0.1539
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0293	0.2954	0.295
Brugia malayi	Thioredoxin reductase	0.0037	0.0123	0.0117
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0931	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0395	0.0418
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0931	1	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0931	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0099	0.0094
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0121	0.8297
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0646	0.2396
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Echinococcus multilocularis	lysine specific demethylase 5A	0.0078	0.058	0.0575
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0931	1	1
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0123	1
Brugia malayi	beta-lactamase family protein	0.0037	0.0121	0.0115
Entamoeba histolytica	hypothetical protein	0.0158	0.146	1
Onchocerca volvulus		0.0576	0.6082	0.608
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0293	0.2954	0.295
Onchocerca volvulus		0.0305	0.3086	0.3082
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0931	1	1
Schistosoma mansoni	nAChR subunit	0.0293	0.2954	0.3159
Echinococcus granulosus	histone acetyltransferase MYST2	0.0097	0.0785	0.078
Echinococcus granulosus	SAM and MBT domain containing protein	0.0389	0.4014	0.4011
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1357	0.1352
Schistosoma mansoni	nAChR subunit	0.0293	0.2954	0.3159
Onchocerca volvulus	Putative nachr subunit	0.0931	1	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0462	0.4822	0.4819
Schistosoma mansoni	hypothetical protein	0.0331	0.3371	0.3606
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Echinococcus multilocularis	nAChR subunit	0.0158	0.146	0.1455
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0036	0.0112	0.0107
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.075	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0277	0.0272
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0135	0.1209	0.1204
Toxoplasma gondii	ABC1 family protein	0.0037	0.0121	0.3051
Schistosoma mansoni	nAChR subunit	0.0293	0.2954	0.3159
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0135	0.1209	0.1204
Schistosoma mansoni	hypothetical protein	0.0166	0.1543	0.1648
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0293	0.2954	0.295
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.0646	0.8347
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0121	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Echinococcus multilocularis	nAChR subunit	0.0293	0.2954	0.295
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.075	0.2871
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0293	0.2954	0.295
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1209	0.1204
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.2311	1
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0123	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0293	0.2954	0.295
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0158	0.146	0.1558
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0158	0.146	0.1558
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0441	0.4588	0.4585
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0135	0.1209	0.1204
Echinococcus multilocularis	glycine receptor subunit beta	0.0293	0.2954	0.295
Schistosoma mansoni	nAChR subunit	0.0293	0.2954	0.3159
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Echinococcus multilocularis	histone acetyltransferase myst3	0.0041	0.0169	0.0164
Onchocerca volvulus		0.0037	0.0121	0.0115
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0293	0.2954	0.295
Loa Loa (eye worm)	GABA receptor subunit	0.0158	0.146	0.1455
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0293	0.2954	0.295
Brugia malayi	excitatory GABA receptor EXP-1A	0.0293	0.2954	0.295
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0121	0.0124
Schistosoma mansoni	neurotransmitter gated ion channel	0.0135	0.1209	0.1289
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0931	1	1
Onchocerca volvulus		0.0576	0.6082	0.608
Schistosoma mansoni	nAChR subunit	0.0135	0.1209	0.1289
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0135	0.1209	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0115	0.0989	0.0984
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0097	0.0785	0.078
Echinococcus granulosus	histone acetyltransferase myst3	0.0041	0.0169	0.0164
Onchocerca volvulus		0.0158	0.146	0.1455
Onchocerca volvulus		0.0293	0.2954	0.295
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0646	0.2396
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.0331	0.3371	0.3367
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0036	0.0112	0.0107
Echinococcus granulosus	lysine specific demethylase 5A	0.0094	0.0754	0.0749
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0293	0.2954	0.295
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0099	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0576	0.6082	0.608
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Onchocerca volvulus		0.0037	0.0121	0.0115
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0135	0.1209	0.1204
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0293	0.2954	0.295
Loa Loa (eye worm)	LGC-31 protein	0.0293	0.2954	0.295
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.1506	0.1501
Echinococcus granulosus	glycine receptor subunit beta	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0135	0.1209	0.1204
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0395	0.039
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0785	0.078
Echinococcus multilocularis	polycomb protein SCMH1	0.0269	0.2683	0.2679
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0293	0.2954	0.295
Loa Loa (eye worm)	mbt repeat family protein	0.028	0.2804	0.28
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0121	0.0124
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0293	0.2954	0.3159
Schistosoma mansoni	alpha glucosidase	0.0036	0.0112	0.0114
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0293	0.2954	0.3159
Plasmodium falciparum	glutathione reductase	0.0037	0.0123	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1209	0.1204
Echinococcus granulosus	chromobox protein 2	0.0199	0.1916	0.1912
Echinococcus granulosus	muscleblind protein	0.0149	0.1357	0.1352
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0293	0.2954	0.295
Loa Loa (eye worm)	ACC-1 protein	0.0293	0.2954	0.295
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.075	0.2871
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0094	0.0754	0.0802
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0135	0.1209	0.1204
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0097	0.0785	0.078
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0162	0.1506	0.1501
Echinococcus multilocularis	chromobox protein 2	0.0199	0.1916	0.1912
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0123	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Schistosoma mansoni	hypothetical protein	0.0166	0.1543	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0121	0.0115
Onchocerca volvulus		0.0037	0.0121	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Echinococcus multilocularis	muscleblind protein 1	0.0149	0.1357	0.1352
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0293	0.2954	0.295
Brugia malayi	glutathione reductase	0.0037	0.0123	0.0117
Brugia malayi	hypothetical protein	0.0135	0.1209	0.1204
Leishmania major	hypothetical protein, conserved	0.0037	0.0121	0.0314
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0097	0.0785	0.078
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0293	0.2954	0.295
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0531	0.5581	0.5579
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1357	0.1352
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0931	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0395	0.0418
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0531	0.5581	0.5579
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0121	0.0115
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0115	0.0989	0.0984
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0121	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0128	0.0123
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0576	0.6082	0.6511
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0293	0.2954	0.3159
Schistosoma mansoni	hypothetical protein	0.0035	0.0099	0.01
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0162	0.1506	0.1501
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0094	0.0754	0.0802
Schistosoma mansoni	hypothetical protein	0.0871	0.9339	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0158	0.146	0.1455
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1209	0.1289
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0576	0.6082	0.6511
Schistosoma mansoni	nAChR subunit	0.0135	0.1209	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0462	0.4822	0.4819
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1209	0.1289
Loa Loa (eye worm)	jmjC domain-containing protein	0.0139	0.1245	0.124
Schistosoma mansoni	alpha-glucosidase	0.014	0.1256	0.134
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0121	0.0115
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0293	0.2954	0.295
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0135	0.1209	0.1204
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0121	0.8297
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0121	0.0115
Brugia malayi	hypothetical protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Echinococcus granulosus	polycomb protein SCMH1	0.0269	0.2683	0.2679
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0158	0.146	0.1455
Schistosoma mansoni	sex comb on midleg homolog	0.0269	0.2683	0.2869
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0121	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0134	0.119	0.1269
Brugia malayi	beta-lactamase	0.0037	0.0121	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0121	0.0115
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	acetylcholine receptor protein	0.0135	0.1209	0.1204
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0293	0.2954	0.295
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0293	0.2954	0.295
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0395	0.1254
Brugia malayi	Cation transporter family protein	0.0293	0.2954	0.295
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0135	0.1209	0.1204
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0293	0.2954	0.295
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0123	0.3098
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0395	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0121	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0128	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Schistosoma mansoni	neurotransmitter gated ion channel	0.0135	0.1209	0.1289
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1209	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0293	0.2954	0.295
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0389	0.4014	0.4295
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0293	0.2954	0.295
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0121	0.8297
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0293	0.2954	0.295
Brugia malayi	Cation transporter family protein	0.0576	0.6082	0.608
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0121	0.0115
Brugia malayi	mbt repeat family protein	0.0462	0.4822	0.4819
Schistosoma mansoni	microtubule-associated protein tau	0.0674	0.7163	0.7669
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0135	0.1209	0.1204
Brugia malayi	CHD4 protein	0.0027	0.0016	0.0011
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0033	0.0076	0.1915
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0277	0.0272
Schistosoma mansoni	nAChR subunit	0.0293	0.2954	0.3159
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0121	0.0115
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0293	0.2954	0.295
Echinococcus granulosus	microtubule associated protein 2	0.0674	0.7163	0.7162
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0162	0.1506	0.1501
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1209	0.1204
Brugia malayi	beta-lactamase family protein	0.0037	0.0121	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Onchocerca volvulus		0.0135	0.1209	0.1204
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0135	0.1209	0.1204
Brugia malayi	mbt repeat family protein	0.028	0.2804	0.28
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0646	0.2396
Echinococcus multilocularis	muscleblind protein	0.0149	0.1357	0.1352
Echinococcus granulosus	lysosomal alpha glucosidase	0.0162	0.1506	0.1501
Echinococcus multilocularis	microtubule associated protein 2	0.0674	0.7163	0.7162
Toxoplasma gondii	PLU-1 family protein	0.0044	0.0205	0.5184
Echinococcus multilocularis	geminin	0.0166	0.1543	0.1539
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0123	0.0117
Schistosoma mansoni	neurotransmitter gated ion channel	0.0158	0.146	0.1558
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0293	0.2954	0.295
Schistosoma mansoni	acetylcholine receptor-related	0.0135	0.1209	0.1289
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0158	0.146	0.1455
Brugia malayi	jmjC domain containing protein	0.0139	0.1245	0.124
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0293	0.2954	0.295
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0123	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0097	0.0785	0.0835
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0158	0.146	0.1455
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0158	0.146	0.1455
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0293	0.2954	0.295
Loa Loa (eye worm)	hypothetical protein	0.0134	0.119	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0134	0.119	0.1185
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0135	0.1209	0.1289
Brugia malayi	hypothetical protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	ACC-1 protein	0.0293	0.2954	0.295
Schistosoma mansoni	nAChR subunit	0.0293	0.2954	0.3159
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0293	0.2954	0.295
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0395	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0293	0.2954	0.295
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0293	0.2954	0.295
Onchocerca volvulus		0.0135	0.1209	0.1204
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0135	0.1209	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0419	0.4344	0.4341
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0123	0.0117
Onchocerca volvulus		0.0293	0.2954	0.295
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0027	0.0016	0.0011
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0027	0.0016	0.0011
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0123	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1209	0.1204
Schistosoma mansoni	alpha-glucosidase	0.014	0.1256	0.134
Echinococcus granulosus	nAChR subunit	0.0158	0.146	0.1455
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0293	0.2954	0.295
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0395	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0293	0.2954	0.295
Echinococcus multilocularis	serotonin receptor	0.0134	0.119	0.1185

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.2589 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1887989

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1585646