Detailed information for compound 1588299

Basic information

Technical information
  • TDR Targets ID: 1588299
  • Name: 5-bromo-N-[2-oxo-2-(phenylmethylamino)ethyl]f uran-2-carboxamide
  • MW: 337.169 | Formula: C14H13BrN2O3
  • H donors: 2 H acceptors: 2 LogP: 2.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)c1ccc(o1)Br)NCc1ccccc1
  • InChi: 1S/C14H13BrN2O3/c15-12-7-6-11(20-12)14(19)17-9-13(18)16-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,16,18)(H,17,19)
  • InChiKey: BBEDVUIRHWLZJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-bromo-N-[2-oxo-2-(phenylmethylamino)ethyl]-2-furancarboxamide
  • N-[2-(benzylamino)-2-keto-ethyl]-5-bromo-2-furamide
  • ZINC06402001
  • T5624062

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0098 0.05 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0173 0.1006 0.1006
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0255 0.1569 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0061 0.0248 0.0248
Trichomonas vaginalis glycogen phosphorylase, putative 0.059 0.3852 1
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0061 0.0248 0.0248
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0098 0.05 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0061 0.0248 0.0248
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1493 1 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0061 0.0248 0.0248
Echinococcus granulosus glycogen phosphorylase 0.059 0.3852 0.3852
Onchocerca volvulus 0.0061 0.0248 0.0644
Entamoeba histolytica glycogen phosphorylase, putative 0.059 0.3852 1
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0061 0.0248 0.4544
Onchocerca volvulus 0.0061 0.0248 0.0644
Brugia malayi hypothetical protein 0.0061 0.0248 0.0248
Trichomonas vaginalis pten, drome, putative 0.0061 0.0248 0.0644
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Trichomonas vaginalis rotamase, putative 0.0098 0.05 0.1298
Echinococcus granulosus glycogen phosphorylase 0.059 0.3852 0.3852
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0061 0.0248 0.0248
Echinococcus granulosus acetylcholinesterase 0.0148 0.0838 0.0838
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0061 0.0248 0.4544
Echinococcus granulosus expressed protein 0.0101 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0148 0.0838 0.0838
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0173 0.1006 0.1006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus granulosus Glycosyl transferase family 35 0.059 0.3852 0.3852
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0101 0.0516 0.0516
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Echinococcus multilocularis hypothetical protein 0.0061 0.0248 0.0248
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0061 0.0248 0.0248
Brugia malayi hypothetical protein 0.0061 0.0248 0.0248
Brugia malayi hypothetical protein 0.0061 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0111 0.0587 0.0587
Entamoeba histolytica glycogen phosphorylase, putative 0.059 0.3852 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Trypanosoma brucei protein tyrosine phosphatase 1 0.0061 0.0248 0.3827
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0061 0.0248 0.0248
Leishmania major tyrosine specific protein phosphatase, putative 0.0061 0.0248 0.4544
Loa Loa (eye worm) glycogen phosphorylase 0.059 0.3852 0.3852
Onchocerca volvulus 0.0061 0.0248 0.0644
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0031 0.0038 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0061 0.0248 0.0248
Schistosoma mansoni pcd6 interacting protein-related 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Trichomonas vaginalis glycogen phosphorylase, putative 0.059 0.3852 1
Echinococcus granulosus carboxylesterase 5A 0.0148 0.0838 0.0838
Trichomonas vaginalis rotamase, putative 0.0101 0.0516 0.134
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Onchocerca volvulus 4.1 G protein, putative homolog 0.0061 0.0248 0.0644
Onchocerca volvulus Glycogen phosphorylase homolog 0.059 0.3852 1
Schistosoma mansoni glycogen phosphorylase 0.0255 0.1569 0.1569
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0061 0.0248 0.0248
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0061 0.0248 0.0248
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0061 0.0248 0.0248
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Schistosoma mansoni glycogen phosphorylase 0.059 0.3852 0.3852
Entamoeba histolytica glycogen phosphorylase, putative 0.0255 0.1569 0.3664
Schistosoma mansoni protein tyrosine phosphatase 0.0061 0.0248 0.0248
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0098 0.05 0.0699
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Giardia lamblia Glycogen phosphorylase 0.059 0.3852 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0148 0.0838 0.0838
Brugia malayi Carboxylesterase family protein 0.0148 0.0838 0.0838
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Schistosoma mansoni protein tyrosine phosphatase 0.0061 0.0248 0.0248
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0098 0.05 0.8423
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Trypanosoma brucei RNA helicase, putative 0.0111 0.0587 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Schistosoma mansoni protein tyrosine phosphatase 0.0061 0.0248 0.0248
Echinococcus multilocularis Glycosyl transferase, family 35 0.059 0.3852 0.3852
Entamoeba histolytica glycogen phosphorylase, putative 0.0255 0.1569 0.3664
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0061 0.0248 0.0248
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1493 1 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1493 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0061 0.0248 0.0248
Schistosoma mansoni glycogen phosphorylase 0.059 0.3852 0.3852
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1493 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Brugia malayi carbohydrate phosphorylase 0.059 0.3852 0.3852
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0061 0.0248 0.0248
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0061 0.0248 0.4544
Echinococcus granulosus acetylcholinesterase 0.0148 0.0838 0.0838
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Entamoeba histolytica glycogenphosphorylase, putative 0.0255 0.1569 0.3664
Loa Loa (eye worm) acetylcholinesterase 1 0.0148 0.0838 0.0838
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Toxoplasma gondii peptidylprolyl isomerase 0.0098 0.05 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Brugia malayi Carboxylesterase family protein 0.0148 0.0838 0.0838
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Chlamydia trachomatis glycogen phosphorylase 0.059 0.3852 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Brugia malayi hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein tyrosine phosphatase 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus granulosus protein tyrosine phosphatase n9 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0101 0.0516 0.0516
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0061 0.0248 0.0248
Echinococcus multilocularis acetylcholinesterase 0.0148 0.0838 0.0838
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0061 0.0248 0.4544
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0173 0.1006 0.1006
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0255 0.1569 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0173 0.1006 0.1006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0061 0.0248 0.0248
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0173 0.1006 0.1006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase 1 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0148 0.0838 0.0838
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0061 0.0248 0.0248
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0061 0.0248 0.0248
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus multilocularis acetylcholinesterase 0.0148 0.0838 0.0838
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Echinococcus multilocularis carboxylesterase 5A 0.0148 0.0838 0.0838
Echinococcus multilocularis expressed protein 0.0101 0.0516 0.0516
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus multilocularis glycogen phosphorylase 0.059 0.3852 0.3852
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0516 0.134
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0061 0.0248 0.0248
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Brugia malayi hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Onchocerca volvulus 0.0061 0.0248 0.0644
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0173 0.1006 0.1006
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Schistosoma mansoni rotamase 0.0101 0.0516 0.0516
Echinococcus multilocularis glycogen phosphorylase 0.059 0.3852 0.3852
Onchocerca volvulus 0.0061 0.0248 0.0644
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0173 0.1006 0.1006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Echinococcus multilocularis 0.0061 0.0248 0.0248
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0061 0.0248 0.0248
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0061 0.0248 0.0248
Loa Loa (eye worm) carboxylesterase 0.0148 0.0838 0.0838
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0061 0.0248 0.0248
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0098 0.05 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.9466 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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