Detailed information for compound 159231

Basic information

Technical information
  • TDR Targets ID: 159231
  • Name: 8-chloro-2-(4-methoxyphenyl)-5H-[1,2,4]triazo lo[1,5-a]quinoxalin-4-one
  • MW: 326.737 | Formula: C16H11ClN4O2
  • H donors: 1 H acceptors: 4 LogP: 3.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nn2c(n1)c(O)nc1c2cc(Cl)cc1
  • InChi: 1S/C16H11ClN4O2/c1-23-11-5-2-9(3-6-11)14-19-15-16(22)18-12-7-4-10(17)8-13(12)21(15)20-14/h2-8H,1H3,(H,18,22)
  • InChiKey: CRNSVOSEEIHNQB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-chloro-2-(4-methoxyphenyl)-5H-[1,2,4]triazolo[5,1-c]quinoxalin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Bos taurus GABA-A receptor; anion channel Starlite/ChEMBL References
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Adenosine A1 receptor   326 aa 331 aa 25.7 %
Onchocerca volvulus GABA-A receptor; anion channel   555 aa 516 aa 25.4 %
Echinococcus granulosus allatostatin A receptor Adenosine A1 receptor   326 aa 304 aa 25.3 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A1 receptor   326 aa 318 aa 22.3 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 277 aa 23.8 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 315 aa 23.8 %
Onchocerca volvulus Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog Adenosine A1 receptor   326 aa 286 aa 22.7 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 311 aa 21.9 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 326 aa 20.2 %
Echinococcus multilocularis Cys loop ligand gated ion channel subunit GABA-A receptor; anion channel   555 aa 583 aa 25.4 %
Onchocerca volvulus Adenosine A1 receptor   326 aa 307 aa 21.2 %
Onchocerca volvulus GABA-A receptor; anion channel   555 aa 466 aa 31.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Adenosine A1 receptor   326 aa 312 aa 24.0 %
Schistosoma japonicum 5-hydroxytryptamine receptor 4, putative Adenosine A1 receptor   326 aa 301 aa 25.6 %
Echinococcus multilocularis allatostatin A receptor Adenosine A1 receptor   326 aa 306 aa 26.1 %
Brugia malayi hypothetical protein Adenosine A1 receptor   326 aa 311 aa 21.9 %
Loa Loa (eye worm) neuropeptide F receptor Adenosine A1 receptor   326 aa 316 aa 19.3 %
Schistosoma mansoni neuropeptide receptor Adenosine A1 receptor   326 aa 314 aa 21.7 %
Schistosoma mansoni opsin-like receptor Adenosine A1 receptor   326 aa 312 aa 22.1 %
Loa Loa (eye worm) hypothetical protein Adenosine A1 receptor   326 aa 296 aa 22.6 %
Echinococcus granulosus Cys loop ligand gated ion channel subunit GABA-A receptor; anion channel   555 aa 578 aa 25.8 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.1084 0.0289
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 0.3202 0.2827
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0062 0.9979 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.311 0.273
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Schistosoma mansoni ap endonuclease 0.0019 0.2586 0.2586
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.1084 0.1084
Schistosoma mansoni ap endonuclease 0.0019 0.2586 0.2586
Echinococcus multilocularis cpg binding protein 0.0031 0.4619 0.4327
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 0.3202 0.2601
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.2586 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0062 0.9979 1
Onchocerca volvulus 0.001 0.1086 0.0003
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.001 0.1086 0.0588
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Brugia malayi hypothetical protein 0.0012 0.1301 0.0526
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.2586 0.5
Onchocerca volvulus 0.0023 0.3202 0.2381
Brugia malayi Dopamine receptor protein 1 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.3202 0.2827
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.311 0.2485
Onchocerca volvulus 0.0012 0.139 0.0344
Echinococcus multilocularis nAChR subunit 0.0023 0.3202 0.2827
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0062 0.9979 1
Brugia malayi putative neuropeptide receptor NPR1 0.0062 0.9979 1
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.9979 1
Echinococcus multilocularis sex peptide receptor 0.0062 0.9979 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 0.3202 0.3202
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.3202 0.2827
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.3202 0.2827
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) ACC-1 protein 0.0023 0.3202 0.2585
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.9979 0.9979
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.9979 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.001 0.1086 0.0588
Onchocerca volvulus 0.0062 0.9979 1
Schistosoma mansoni hypothetical protein 0.0062 0.9979 0.9979
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.1084 0.0585
Echinococcus granulosus sex peptide receptor 0.0062 0.9979 1
Brugia malayi nuclear receptor NHR-67 0.001 0.1084 0.0289
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.1301 0.0815
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.9979 0.9979
Brugia malayi G-protein coupled receptor 0.0062 0.9979 1
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.311 0.273
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.311 0.311
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.1086 0.1086
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.2586 0.1929
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.311 0.311
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis g protein coupled receptor 0.0062 0.9979 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.2586 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.1084 0.0585
Onchocerca volvulus 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.1301 0.1301
Schistosoma mansoni nuclear hormone receptor 0.001 0.1084 0.1084
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.9979 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0012 0.139 0.139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.2586 0.2175
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.001 0.1086 0.0292
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.3202 0.2827
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.1086 0.0292
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.3202 0.2827
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.311 0.311
Loa Loa (eye worm) acetylcholine receptor protein 0.001 0.1086 0.027
Schistosoma mansoni nAChR subunit 0.0023 0.3202 0.3202
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485
Schistosoma mansoni nAChR subunit 0.0023 0.3202 0.3202
Onchocerca volvulus 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.1301 0.0526
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.311 0.273
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis G protein coupled receptor 139 0.0062 0.9979 1
Brugia malayi G protein-coupled receptor 0.0062 0.9979 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0062 0.9979 1
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.1084 0.0585
Brugia malayi Cation transporter family protein 0.0023 0.3202 0.2601
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.311 0.311
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Brugia malayi conserved hypotetical protein 0.001 0.1084 0.0289
Echinococcus multilocularis fmrfamide receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni nAChR subunit 0.0023 0.3202 0.3202
Schistosoma mansoni opsin-like receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Schistosoma mansoni amine GPCR 0.0062 0.9979 0.9979
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0839 0.0326
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.311 0.311
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.311 0.2501
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.311 0.273
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.311 0.2485
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.2586 0.5
Schistosoma mansoni biogenic amine receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.3202 0.2827
Echinococcus granulosus g protein coupled receptor 0.0062 0.9979 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 0.3202 0.2827
Brugia malayi Dopamine receptor protein 2 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.1084 0.0289
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.311 0.2501
Onchocerca volvulus 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.311 0.2501
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.311 0.2485
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0062 0.9979 0.9979
Schistosoma mansoni nAChR subunit 0.0023 0.3202 0.3202
Schistosoma mansoni amine GPCR 0.0062 0.9979 0.9979
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 0.3202 0.2827
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.001 0.1086 0.0588
Onchocerca volvulus 0.0062 0.9979 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.311 0.2485
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.2586 0.5
Brugia malayi sulfakinin receptor protein 0.0062 0.9979 1
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.9979 1
Brugia malayi nuclear hormone receptor 0.0022 0.311 0.2501
Onchocerca volvulus 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 0.3202 0.2827
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0062 0.9979 1
Brugia malayi GnHR receptor homolog 0.0062 0.9979 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.1084 0.0585
Schistosoma mansoni neuropeptide f receptor 76f 0.0062 0.9979 0.9979
Brugia malayi hypothetical protein 0.0062 0.9979 1
Brugia malayi hypothetical protein 0.001 0.1084 0.0289
Brugia malayi AKH receptor 0.0062 0.9979 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0062 0.9979 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0062 0.9979 0.9979
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.3202 0.2601
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.3202 0.2827
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni amine GPCR 0.0062 0.9979 0.9979
Echinococcus multilocularis g-protein coupled receptor 0.0062 0.9979 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0012 0.139 0.0624
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.2586 0.1911
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.311 0.2501
Brugia malayi RE15519p 0.0062 0.9979 1
Schistosoma mansoni neuropeptide receptor 0.0062 0.9979 0.9979
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.311 0.273
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.3202 0.3202
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0062 0.9979 1
Echinococcus multilocularis allatostatin A receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.2586 0.2175
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.311 0.273
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.3202 0.2827
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.9979 0.9979
Onchocerca volvulus 0.0062 0.9979 1
Onchocerca volvulus Putative nachr subunit 0.0023 0.3202 0.2381
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.311 0.311
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0012 0.139 0.139
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.311 0.273
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Onchocerca volvulus 0.0062 0.9979 1
Echinococcus multilocularis fmrfamide receptor 0.0062 0.9979 1
Schistosoma mansoni nAChR subunit 0.001 0.1086 0.1086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Schistosoma mansoni myosin xvIII 0.0062 0.9979 0.9979
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.9979 0.9979
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.1086 0.1086
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.1084 0.0585
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 0.3202 0.2601
Echinococcus multilocularis serotonin receptor 0.0062 0.9979 1
Brugia malayi hypothetical protein 0.0062 0.9979 1
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.311 0.2278
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Echinococcus granulosus nAChR subunit 0.0012 0.139 0.091
Onchocerca volvulus 0.0062 0.9979 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0062 0.9979 0.9979
Echinococcus granulosus fmrfamide receptor 0.0062 0.9979 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Echinococcus granulosus G protein coupled receptor 139 0.0062 0.9979 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.4331 0.3834
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.311 0.2501
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.311 0.273
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0062 0.9979 0.9979
Schistosoma mansoni acetylcholine receptor-related 0.001 0.1086 0.1086
Schistosoma mansoni nAChR subunit 0.0023 0.3202 0.3202
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0839 0.0326
Loa Loa (eye worm) hypothetical protein 0.0012 0.1301 0.0505
Onchocerca volvulus 0.0023 0.3202 0.2381
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.9979 1
Onchocerca volvulus 0.0023 0.3202 0.2381
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.1084 0.0585
Schistosoma mansoni nuclear receptor 0.001 0.1084 0.1084
Schistosoma mansoni cpg binding protein 0.0031 0.4619 0.4619
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.9979 1
Schistosoma mansoni hypothetical protein 0.0062 0.9979 0.9979
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0062 0.9979 1
Echinococcus granulosus nAChR subunit 0.0023 0.3202 0.2827
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.311 0.273
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0062 0.9979 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.9979 1
Loa Loa (eye worm) TYRA-2 protein 0.0062 0.9979 1
Echinococcus granulosus somatostatin receptor 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.311 0.2501
Echinococcus multilocularis nAChR subunit 0.0012 0.139 0.091
Brugia malayi nuclear receptor NHR-88 0.001 0.1084 0.0289
Brugia malayi hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni nuclear receptor 0.001 0.1084 0.1084
Echinococcus granulosus 7tm_1 domain containing protein 0.0062 0.9979 1
Brugia malayi hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.1084 0.1084
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.311 0.273
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.2586 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0012 0.1301 0.0505
Brugia malayi G protein-coupled receptor F59B2.13 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.311 0.2501
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.9979 0.9979
Onchocerca volvulus 0.001 0.1086 0.0003
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 0.3202 0.2601
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Brugia malayi hypothetical protein 0.0062 0.9979 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.311 0.2501
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0062 0.9979 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.3202 0.2827
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Onchocerca volvulus 0.0062 0.9979 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.311 0.311
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.001 0.1086 0.0292
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Schistosoma mansoni nAChR subunit 0.0023 0.3202 0.3202
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.9979 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Onchocerca volvulus 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485
Schistosoma mansoni nAChR subunit 0.0023 0.3202 0.3202
Brugia malayi steroid hormone receptor 0.0022 0.311 0.2501
Schistosoma mansoni zinc finger protein 0.001 0.1084 0.1084
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus granulosus neuropeptide s receptor 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.311 0.2501
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.311 0.2501
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.311 0.311
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.311 0.311
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.311 0.2278
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.9979 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0062 0.9979 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0062 0.9979 1
Brugia malayi Cation transporter family protein 0.0023 0.3202 0.2601
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.3202 0.2827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.311 0.2485
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.9979 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.139 0.0624
Schistosoma mansoni nAChR subunit 0.001 0.1086 0.1086
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.9979 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Loa Loa (eye worm) melatonin receptor type 1A 0.0062 0.9979 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.9979 1
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.9979 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.3202 0.2601
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.1084 0.1084
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.9979 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 0.3202 0.2601
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0062 0.9979 1
Schistosoma mansoni coup transcription factor 0.0022 0.311 0.311
Schistosoma mansoni biogenic amine receptor 0.0062 0.9979 0.9979
Onchocerca volvulus 0.0012 0.139 0.0344
Echinococcus granulosus neuropeptide receptor 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.311 0.2501
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 0.3202 0.2585
Onchocerca volvulus 0.0023 0.3202 0.2381
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.139 0.0624
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.311 0.273
Brugia malayi hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.9979 0.9979
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0062 0.9979 1
Echinococcus multilocularis g protein coupled receptor 0.0062 0.9979 1
Brugia malayi hypothetical protein 0.001 0.1086 0.0292
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Brugia malayi hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0062 0.9979 0.9979
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0062 0.9979 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.311 0.273
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.1084 0.0268
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Schistosoma mansoni amine GPCR 0.0062 0.9979 0.9979
Brugia malayi nuclear hormone receptor 0.001 0.1084 0.0289
Schistosoma mansoni hypothetical protein 0.0062 0.9979 0.9979
Echinococcus granulosus g protein coupled receptor 0.0062 0.9979 1
Echinococcus multilocularis neuropeptide s receptor 0.0062 0.9979 1
Onchocerca volvulus 0.0062 0.9979 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Onchocerca volvulus 0.0029 0.4331 0.3651
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0062 0.9979 0.9979
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.001 0.1086 0.0588
Echinococcus multilocularis neuropeptide receptor 0.0062 0.9979 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 0.3202 0.2827
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.3202 0.2827
Brugia malayi hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni neuropeptide receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.1301 0.0526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.311 0.2485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Onchocerca volvulus 0.0062 0.9979 1
Brugia malayi hypothetical protein 0.001 0.1084 0.0289
Echinococcus granulosus alpha 1A adrenergic receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.311 0.2501
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.311 0.273
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0012 0.139 0.139
Brugia malayi putative neuropeptide receptor 0.0062 0.9979 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0062 0.9979 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.2586 1
Schistosoma mansoni opsin-like receptor 0.0062 0.9979 0.9979
Schistosoma mansoni opsin-like receptor 0.0062 0.9979 0.9979
Echinococcus granulosus neuropeptide receptor 0.0062 0.9979 1
Echinococcus granulosus dro:myosuppressin receptor 0.0062 0.9979 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.2586 0.5
Onchocerca volvulus 0.0062 0.9979 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.001 0.1086 0.0588
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Brugia malayi nuclear receptor RXR 0.0012 0.1301 0.0526
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0062 0.9979 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.311 0.273
Loa Loa (eye worm) hypothetical protein 0.0012 0.1301 0.0505
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.9979 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.3202 0.2601
Echinococcus multilocularis neuropeptide receptor A26 0.0062 0.9979 1
Echinococcus multilocularis serotonin receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Onchocerca volvulus 0.001 0.1086 0.0003
Echinococcus granulosus cpg binding protein 0.0031 0.4619 0.4327
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.311 0.2501
Brugia malayi Nuclear hormone receptor E75 0.001 0.1084 0.0289
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.3202 0.2601
Echinococcus multilocularis g protein coupled receptor 0.0062 0.9979 1
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.9979 1
Echinococcus granulosus hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0062 0.9979 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.139 0.0624
Onchocerca volvulus 0.0062 0.9979 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Echinococcus multilocularis orexin receptor type 2 0.0062 0.9979 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0062 0.9979 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.3202 0.2601
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Brugia malayi Dopamine receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485
Schistosoma mansoni hypothetical protein 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Schistosoma mansoni cpg binding protein 0.0029 0.4331 0.4331
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Brugia malayi excitatory GABA receptor EXP-1A 0.0023 0.3202 0.2601
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 0.3202 0.2827
Echinococcus granulosus neuropeptide receptor A26 0.0062 0.9979 1
Brugia malayi Serotonin receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Brugia malayi larval opioid receptor 0.0062 0.9979 1
Brugia malayi Serotonin receptor 0.0062 0.9979 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.3202 0.2585
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.1084 0.1084
Onchocerca volvulus 0.0023 0.3202 0.2381
Onchocerca volvulus Neuropeptide F receptor homolog 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Brugia malayi Cation transporter family protein 0.0023 0.3202 0.2601
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.3202 0.2827
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.3202 0.2601
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.1301 0.0815
Brugia malayi tailless protein 0.001 0.1084 0.0289
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.3202 0.3202
Schistosoma mansoni thyroid hormone receptor 0.0022 0.311 0.311
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 0.3202 0.2585
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.9979 0.9979
Brugia malayi hypothetical protein 0.001 0.1086 0.0292
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.3202 0.2827
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.1301 0.0505
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.3202 0.2827
Brugia malayi follicle stimulating hormone receptor 0.0062 0.9979 1
Brugia malayi hypothetical protein 0.001 0.1086 0.0292
Brugia malayi neuropeptide F receptor 0.0062 0.9979 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 0.3202 0.2827
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.311 0.311
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Brugia malayi nuclear receptor RXR 0.001 0.1084 0.0289
Loa Loa (eye worm) ACC-1 protein 0.0023 0.3202 0.2585
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.9979 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.9979 1
Brugia malayi Melatonin receptor type 1A 0.0062 0.9979 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.2586 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.311 0.273
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.1084 0.0585
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.9979 1
Brugia malayi ecdysteroid receptor 0.0022 0.311 0.2501
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.311 0.273
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.2586 0.5
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.1084 0.0268
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus granulosus orexin receptor type 2 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni amine GPCR 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Brugia malayi ORL1-like opioid receptor 0.0062 0.9979 1
Loa Loa (eye worm) GABA receptor subunit 0.0012 0.139 0.0603
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.3202 0.2601
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.8854 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.311 0.2501
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.2586 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.2586 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.3202 0.2601
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.9979 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.311 0.2501
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.1086 0.0292
Onchocerca volvulus 0.0022 0.311 0.2278
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.4331 0.3821
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0062 0.9979 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.311 0.2501
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.311 0.2485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Schistosoma mansoni biogenic amine receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.9979 0.9979
Echinococcus granulosus g protein coupled receptor 0.0062 0.9979 1
Echinococcus granulosus allatostatin A receptor 0.0062 0.9979 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.2586 0.5
Echinococcus multilocularis somatostatin receptor 0.0062 0.9979 1
Brugia malayi hypothetical protein 0.001 0.1086 0.0292
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.3202 0.3202
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 0.3202 0.3202
Brugia malayi hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni neuropeptide receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.311 0.2485
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0062 0.9979 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.9979 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.3202 0.2601
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.311 0.2501
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.9979 1
Echinococcus multilocularis neuropeptide receptor 0.0062 0.9979 1
Loa Loa (eye worm) LGC-31 protein 0.0023 0.3202 0.2585
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.1084 0.0268
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.2586 0.5
Schistosoma mansoni cpg binding protein 0.0031 0.4619 0.4619
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.311 0.273
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.001 0.1086 0.027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.311 0.2278
Schistosoma mansoni adenoreceptor 0.0062 0.9979 0.9979
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0062 0.9979 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0531 0.0531
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.9979 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.1084 0.0289
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 0.3202 0.2585
Loa Loa (eye worm) hypothetical protein 0.0012 0.1301 0.0505
Schistosoma mansoni neuropeptide receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.1084 0.0585
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.001 0.1086 0.027
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485
Echinococcus granulosus serotonin receptor 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.311 0.273
Brugia malayi neuropeptide F receptor 0.0062 0.9979 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 0.3202 0.2827
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 0.3202 0.2601
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 0.3202 0.2827
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.1084 0.0585
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0062 0.9979 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.1084 0.0585
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.3202 0.2827
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.1084 0.0289
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.1086 0.0292
Loa Loa (eye worm) hypothetical protein 0.001 0.1086 0.027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0062 0.9979 1
Brugia malayi G-protein coupled receptor 0.0062 0.9979 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.9979 0.9979
Brugia malayi hypothetical protein 0.001 0.1086 0.0292
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.9979 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.9979 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 0.3202 0.3202
Brugia malayi hypothetical protein 0.0012 0.1301 0.0526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.1084 0.0585
Echinococcus granulosus g-protein coupled receptor 0.0062 0.9979 1
Loa Loa (eye worm) DR-78 0.001 0.1084 0.0268
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.1084 0.0585
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.9979 1
Onchocerca volvulus 0.0023 0.3202 0.2381
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.3202 0.2601
Loa Loa (eye worm) hypothetical protein 0.001 0.1084 0.0268
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 0.3202 0.2601
Schistosoma mansoni thyroid hormone receptor 0.0022 0.311 0.311
Brugia malayi ecdysone receptor 0.001 0.1084 0.0289
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 0.3202 0.2585
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.1084 0.0289
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.3202 0.2827
Schistosoma mansoni acetylcholine receptor subunit beta 0.001 0.1086 0.1086
Loa Loa (eye worm) hypothetical protein 0.0012 0.139 0.0603
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.1301 0.0505
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Onchocerca volvulus 0.0062 0.9979 1
Schistosoma mansoni histamine h1 receptor 0.0062 0.9979 0.9979
Schistosoma mansoni alpha-1 adrenergic receptor 0.0062 0.9979 0.9979
Echinococcus granulosus neuropeptide FF receptor 2 0.0062 0.9979 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 0.3202 0.2585
Brugia malayi hypothetical protein 0.0062 0.9979 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.1301 0.1301
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.001 0.1086 0.0292
Onchocerca volvulus 0.0062 0.9979 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.9979 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0062 0.9979 1
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.9979 0.9979
Loa Loa (eye worm) hypothetical protein 0.0023 0.3202 0.2585
Loa Loa (eye worm) hypothetical protein 0.0022 0.311 0.2485

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 12.1 % Percentage inhibition of [3H]CGS 21680 binding to adenosine A2A receptor in bovine striatal membranes at 34 uM ChEMBL. 16335918
Inhibition (binding) = 12.1 % Percentage inhibition of [3H]CGS 21680 binding to adenosine A2A receptor in bovine striatal membranes at 34 uM ChEMBL. 16335918
Kd (functional) = 1.8 nM Displacement of [3H]-flunitrazepam from bovine brain membranes at 0.2 nM. ChEMBL. 8071933
Kd (functional) = 1.8 nM Displacement of [3H]-flunitrazepam from bovine brain membranes at 0.2 nM. ChEMBL. 8071933
Ki (binding) = 3.29 nM Displacement of [3H]CHA from cloned human adenosine A1 receptor expressed in CHO cells ChEMBL. 16335918
Ki (binding) = 3.29 nM Displacement of [3H]CHA from cloned human adenosine A1 receptor expressed in CHO cells ChEMBL. 16335918
Ki (binding) = 5.4 nM Binding affinity to BZR receptor on bovine cerebral cortex by [3H]-flunitrazepam displacement. ChEMBL. 8071933
Ki (binding) = 5.4 nM Binding affinity to BZR receptor on bovine cerebral cortex by [3H]-flunitrazepam displacement. ChEMBL. 8071933
Ki (binding) = 25.8 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 16335918
Ki (binding) = 25.8 nM Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 16335918
Ki (binding) = 1060 nM Displacement of [3H]CHA from adenosine A1 receptor in bovine cerebral cortical membranes ChEMBL. 16335918
Ki (binding) = 1060 nM Displacement of [3H]CHA from adenosine A1 receptor in bovine cerebral cortical membranes ChEMBL. 16335918
Ratio (binding) = 1.03 GABA ratio is measured by IC50 (compound)/IC50 (compound at 10 microM GABA ChEMBL. 8071933
Ratio (binding) = 1.03 GABA ratio is measured by IC50 (compound)/IC50 (compound at 10 microM GABA ChEMBL. 8071933
Ratio Ki (binding) = 0.13 Selectivity for human adenosine A3 receptor over human adenosine A1 receptor ChEMBL. 16335918

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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