Detailed information for compound 159773

Basic information

Technical information
  • TDR Targets ID: 159773
  • Name: N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-1H-in dole-2-carboxamide
  • MW: 333.341 | Formula: C19H15N3O3
  • H donors: 2 H acceptors: 2 LogP: 3.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1c1cnco1)NC(=O)c1cc2c([nH]1)cccc2
  • InChi: 1S/C19H15N3O3/c1-24-17-9-13(6-7-14(17)18-10-20-11-25-18)21-19(23)16-8-12-4-2-3-5-15(12)22-16/h2-11,22H,1H3,(H,21,23)
  • InChiKey: QDJAJXUIQLIIKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-methoxy-4-oxazol-5-yl-phenyl)-1H-indole-2-carboxamide
  • N-[3-methoxy-4-(5-oxazolyl)phenyl]-1H-indole-2-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.019 0.0169 0.5
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0178 0.0152 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0052 0.0689
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0163 0.013 0.0907
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0554 0.0727 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0374 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0535 0.0698 0.9572
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.019 0.0169 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.019 0.0169 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0163 0.013 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0727 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0699 0.959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0545 0.0713 0.9794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0545 0.0713 0.9794
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0163 0.013 0.7734
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0545 0.0713 0.1874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0122 0.0066 0.0205
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.05 0.0645 0.8785
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0574 0.0758 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0554 0.0727 0.0678
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0317 0.0364 0.3655
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0163 0.013 0.1146
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0403 0.0497 0.659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0342 0.4294
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.01 0.0032 0.0954
Entamoeba histolytica protein kinase rad3, putative 0.0302 0.0342 0.4294
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0222 0.0219 0.0168
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.014 0.1845
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0227 0.0226 0.2578
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0163 0.013 0.0219
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0574 0.0758 0.2104
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0574 0.0758 0.8271
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0052 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.037 0.4704
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.05 0.0645 0.1768
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0574 0.0758 0.2104
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.05 0.0645 0.8511
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0163 0.013 0.1146
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0302 0.0342 0.0291
Loa Loa (eye worm) phosphatidylinositol 3 0.0114 0.0053 0.0661
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0052 0.0646
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0554 0.0727 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.037 0.4704
Loa Loa (eye worm) hypothetical protein 0.0323 0.0374 0.4628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0545 0.0713 0.9794
Trypanosoma cruzi target of rapamycin kinase 3 0.0545 0.0713 0.1971
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0554 0.0727 0.1914
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0052 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0727 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0374 0.4939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0189 0.0169 0.1734
Trypanosoma cruzi GMP reductase 0.019 0.0169 0.035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.0342 0.4513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.0423 0.5501
Onchocerca volvulus 0.0113 0.0052 1
Schistosoma mansoni hypothetical protein 0.0222 0.0219 0.196
Schistosoma mansoni fkbp-rapamycin associated protein 0.0302 0.0342 0.3396
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0227 0.0226 0.2985
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0163 0.013 0.1177
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0574 0.0758 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.071 0.9742
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0163 0.013 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.071 0.9742
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0554 0.0727 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0113 0.0052 0.1488
Toxoplasma gondii FATC domain-containing protein 0.0317 0.0364 0.4743
Onchocerca volvulus 0.0113 0.0052 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.0053 0.0004
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0524 0.0682 0.9332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0332 0.0387 0.4962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.0696 0.9537
Loa Loa (eye worm) phosphatidylinositol kinase 0.0113 0.0052 0.0646
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.034 0.04 0.5159
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0052 0.0689
Trypanosoma brucei GMP reductase 0.019 0.0169 0.1737
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0163 0.013 0.0078
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0178 0.0152 0.8869
Leishmania major hypothetical protein, conserved 0.2417 0.3579 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0535 0.0698 0.8632
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0227 0.0226 0.2578
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0163 0.013 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0524 0.0682 0.9332
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.05 0.0645 0.8785
Entamoeba histolytica hypothetical protein 0.0317 0.0364 0.4621
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.019 0.0169 0.035
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0163 0.013 0.0231
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0317 0.0364 0.4621
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0163 0.013 0.1177
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.019 0.0169 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0524 0.0682 0.9332
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0574 0.0758 0.0709
Echinococcus granulosus serine protein kinase ATM 0.0317 0.0364 0.0313
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0178 0.0152 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0163 0.013 0.171
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.05 0.0645 0.8785
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0313 0.0358 0.4534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0545 0.0713 0.9794
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0227 0.0226 0.2578
Leishmania major phosphatidylinositol 3-kinase, putative 0.0524 0.0682 0.1786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.071 0.9742
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.05 0.0645 0.1768
Loa Loa (eye worm) IMP dehydrogenase 1 0.019 0.0169 0.2096
Leishmania major inosine-5-monophosphate dehydrogenase 0.019 0.0169 0.0332
Trypanosoma cruzi hypothetical protein, conserved 0.2304 0.3406 1
Brugia malayi FAT domain containing protein 0.0222 0.0219 0.2896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.0696 0.9537
Loa Loa (eye worm) phosphatidylinositol 3 0.0607 0.0809 1
Entamoeba histolytica hypothetical protein 0.0437 0.0548 0.7353
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0163 0.013 0.0078
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0554 0.0727 0.0678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0536 0.0699 0.959
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.019 0.0169 0.1374
Echinococcus multilocularis Zinc finger, PHD finger 0.0163 0.013 0.0078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0227 0.0226 0.2578
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.026 0.0278 0.3341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.0696 0.9538
Leishmania major guanosine monophosphate reductase 0.019 0.0169 0.0332
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.067 0.0905 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.019 0.0169 0.1737
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0052 0.23
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.019 0.0169 1
Loa Loa (eye worm) hypothetical protein 0.0177 0.015 0.1857
Giardia lamblia GTOR 0.0554 0.0727 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0335 0.0392 0.5171
Loa Loa (eye worm) hypothetical protein 0.0113 0.0052 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.0696 0.9538
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.037 0.4704
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.0169 0.1734
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0727 0.9593
Toxoplasma gondii target of rapamycin (TOR), putative 0.0543 0.071 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.019 0.0169 0.2236
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0437 0.0548 0.7353
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0163 0.013 0.0078
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0403 0.0497 0.659
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0163 0.013 0.1146
Trypanosoma cruzi GMP reductase 0.019 0.0169 0.035
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.067 0.0905 0.0858
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0204 0.0191 0.0415
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0163 0.013 0.7734
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0554 0.0727 0.1914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.071 0.9742
Echinococcus multilocularis serine protein kinase ATM 0.0317 0.0364 0.0313
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0302 0.0342 0.0864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.071 0.9742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.0373 0.4756
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0227 0.0226 0.2039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0727 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0554 0.0727 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.019 0.0169 0.0118
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0131 0.008 0.041
Loa Loa (eye worm) hypothetical protein 0.0335 0.0392 0.485
Leishmania major phosphatidylinositol kinase related protein, putative 0.0127 0.0074 0.0063
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0554 0.0727 0.2012
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0127 0.0074 0.0066
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0374 0.0324
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0222 0.0219 0.0168
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0302 0.0342 0.0291
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0176 0.0149 0.1431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0364 0.4621
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.019 0.0169 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0545 0.0713 0.9794
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0317 0.0364 0.093
Loa Loa (eye worm) hypothetical protein 0.0302 0.0342 0.4229
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0554 0.0727 0.791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.071 0.9742
Leishmania major phosphatidylinositol 3-kinase, putative 0.0163 0.013 0.0219
Loa Loa (eye worm) phosphatidylinositol 3 0.0113 0.0052 0.0646
Toxoplasma gondii IMP dehydrogenas 0.019 0.0169 0.1783
Trichomonas vaginalis PIKK family atypical protein kinase 0.0313 0.0358 0.4534
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0227 0.0226 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.071 0.9742
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0545 0.0713 0.9795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0524 0.0682 0.9332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.0696 0.9538
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0535 0.0698 0.9572
Loa Loa (eye worm) hypothetical protein 0.0204 0.0191 0.2366
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0554 0.0727 0.2012
Loa Loa (eye worm) hypothetical protein 0.0222 0.0219 0.2713
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0344 0.0406 0.5244
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.0219 0.2478
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0163 0.013 0.0907
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0227 0.0226 0.2578
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.05 0.0645 0.8785
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6613 1 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.019 0.0169 0.035
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0163 0.013 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.0696 0.9538
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0227 0.0226 0.2578
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0535 0.0698 0.1832
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0317 0.0364 0.4804
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0163 0.013 0.0231
Loa Loa (eye worm) phosphatidylinositol 3 0.0554 0.0727 0.8989
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0387 0.0472 0.6224
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.067 0.0905 0.0858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0524 0.0682 0.9332
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.0392 0.5038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0113 0.0052 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.0696 0.9537

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.11 uM Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2 ChEMBL. 12270168
IC50 (binding) = 0.11 uM Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 2 ChEMBL. 12270168
IC50 (binding) > 1 uM Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 1 ChEMBL. 12270168
IC50 (functional) < 1 uM Inhibition of human T-lymphoblast CEM cell (ATCC) proliferation; At this concentration no inhibition was observed ChEMBL. 12270168
IC50 (binding) > 1 uM Inhibitory activity of compound was evaluated against the Inosine-5'-monophosphate dehydrogenase 1 ChEMBL. 12270168
IC50 (functional) < 1 uM Inhibition of human T-lymphoblast CEM cell (ATCC) proliferation; At this concentration no inhibition was observed ChEMBL. 12270168

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12270168

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.