Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0061 | 0.0232 | 0.0232 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0027 | 0.0066 | 0.0038 |
Echinococcus granulosus | neuroglian | 0.003 | 0.0078 | 0.0051 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0019 | 0.0028 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0184 | 0.0831 | 0.0806 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0019 | 0.0028 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.206 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0074 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0095 | 0.0095 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0019 | 0.0028 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0019 | 0.0028 | 0.5 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0066 | 0.0038 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.206 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0019 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0019 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0074 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0019 | 0.0028 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | kinase | 0.2004 | 0.9727 | 0.9726 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0019 | 0.0028 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0027 | 0.0066 | 0.0038 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0019 | 0.0028 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0029 | 0.0074 | 0.0047 |
Giardia lamblia | Kinase, PLK | 0.206 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0019 | 0.0028 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0019 | 0.0028 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.206 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | cytochrome P450 | 0.0019 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0184 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.206 | 1 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.206 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.206 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0027 | 0.0066 | 0.0038 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0047 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0019 | 0.0028 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.003 | 0.0078 | 0.0051 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0019 | 0.0028 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0027 | 0.0066 | 0.0038 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.206 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.206 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0019 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.003 | 0.0082 | 0.0054 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0019 | 0.0028 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0029 | 0.0074 | 0.0074 |
Echinococcus granulosus | twitchin | 0.0038 | 0.0116 | 0.0089 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0.0028 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0033 | 0.0095 | 0.0067 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0027 | 0.0066 | 0.0038 |
Schistosoma mansoni | nephrin | 0.003 | 0.0078 | 0.0051 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0019 | 0.0028 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0.0028 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0074 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Trypanosoma brucei | cytochrome P450, putative | 0.0029 | 0.0074 | 0.0047 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.206 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0061 | 0.0232 | 0.0204 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0797 | 0.383 | 0.3813 |
Echinococcus multilocularis | Immunoglobulin | 0.0027 | 0.0066 | 0.0038 |
Schistosoma mansoni | cell adhesion molecule | 0.003 | 0.0082 | 0.0054 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0027 | 0.0066 | 0.0038 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0156 | 0.0695 | 0.0027 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0019 | 0.0028 | 0.5 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0797 | 0.383 | 0.3813 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0074 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0029 | 0.0074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0082 | 0.0082 |
Echinococcus granulosus | Immunoglobulin | 0.0027 | 0.0066 | 0.0038 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0047 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0019 | 0.0028 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.206 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0027 | 0.0066 | 0.0038 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0027 | 0.0066 | 0.0038 |
Echinococcus multilocularis | roundabout 2 | 0.0033 | 0.0095 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.8 uM | Inhibitory concentration of the compound required to inhibit human T-lymphoblast Molt4 cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 6.8 uM | Antiproliferative activity against human Molt/4 cells | ChEMBL. | 17081759 |
IC50 (functional) | = 8.02 uM | Inhibitory concentration of the compound required to inhibit murine leukemia L1210 cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 8.02 uM | Antiproliferative activity against mouse L1210 cells | ChEMBL. | 17081759 |
IC50 (functional) | = 9.6 uM | Inhibitory concentration of the compound required to inhibit human T-lymphoblast CEM cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 9.6 uM | Antiproliferative activity against human CEM cells | ChEMBL. | 17081759 |
IC50 (functional) | = 27.6 uM | Inhibitory concentration of the compound required to inhibit murine mammary carcinoma FM3A cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 27.6 uM | Antiproliferative activity against mouse FM3A cells | ChEMBL. | 17081759 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.