Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Polyketide synthase Pks13 | 0.191 | 0.7562 | 1 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0321 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.1028 | 0.3367 | 0.4452 |
Loa Loa (eye worm) | acyl carrier protein | 0.0588 | 0.127 | 0.1462 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0401 | 0.0384 | 0.0508 |
Mycobacterium ulcerans | thioesterase TesA | 0.1065 | 0.3541 | 0.4682 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0385 | 0.0306 | 0.0306 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0845 | 0.2495 | 0.3299 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0517 | 0.0933 | 0.0864 |
Onchocerca volvulus | 0.2224 | 0.9058 | 0.9285 | |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1357 | 0.4933 | 0.6522 |
Trypanosoma brucei | beta-ketoacyl-ACP synthase | 0.0321 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1357 | 0.4933 | 0.6376 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1278 | 0.4555 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1357 | 0.4933 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.2147 | 0.869 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1278 | 0.4555 | 0.6023 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1357 | 0.4933 | 0.6522 |
Brugia malayi | AMP-binding enzyme family protein | 0.1194 | 0.4155 | 0.4155 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.091 | 0.2802 | 0.5682 |
Schistosoma mansoni | methyltransferase-related | 0.0385 | 0.0306 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0918 | 0.2842 | 0.3495 |
Brugia malayi | AMP-binding enzyme family protein | 0.0393 | 0.0343 | 0.0343 |
Mycobacterium ulcerans | thioesterase | 0.1065 | 0.3541 | 0.4682 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0646 | 0.1547 | 0.3136 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1278 | 0.4555 | 0.581 |
Loa Loa (eye worm) | fatty acid synthase | 0.1261 | 0.4474 | 0.5149 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0393 | 0.0343 | 0.0052 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1278 | 0.4555 | 0.6023 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0321 | 0 | 0.5 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0321 | 0 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0829 | 0.2419 | 0.4903 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0385 | 0.0306 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1357 | 0.4933 | 0.6376 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1028 | 0.3367 | 0.4452 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1278 | 0.4555 | 0.5856 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0393 | 0.0343 | 0.0454 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.1028 | 0.3367 | 0.4155 |
Loa Loa (eye worm) | hypothetical protein | 0.0716 | 0.1881 | 0.2164 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1194 | 0.4155 | 0.5305 |
Mycobacterium ulcerans | polyketide synthase | 0.1357 | 0.4933 | 0.6522 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1239 | 0.4368 | 0.5599 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1278 | 0.4555 | 0.5856 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0726 | 0.1931 | 0.224 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0321 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.1065 | 0.3541 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1278 | 0.4555 | 0.581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1357 | 0.4933 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.191 | 0.7562 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.191 | 0.7562 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1357 | 0.4933 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.191 | 0.7562 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0401 | 0.0384 | 0.0108 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1194 | 0.4155 | 0.4782 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0321 | 0 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0439 | 0.0564 | 0.0356 |
Giardia lamblia | Methyltransferase like 2 | 0.0385 | 0.0306 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0845 | 0.2495 | 0.2941 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1357 | 0.4933 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.1278 | 0.4555 | 0.6023 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1278 | 0.4555 | 0.6023 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0321 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0385 | 0.0306 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1357 | 0.4933 | 0.6376 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0321 | 0 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.2303 | 0.9436 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.1065 | 0.3541 | 0.4459 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1278 | 0.4555 | 0.6023 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.1045 | 0.3447 | 0.4329 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0845 | 0.2495 | 0.3299 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0321 | 0 | 0.5 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1278 | 0.4555 | 0.4555 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1239 | 0.4368 | 0.5599 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.