Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | fatty acid synthase | 0.0152 | 0.4474 | 0.5149 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0039 | 0 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0154 | 0.4555 | 0.6023 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1881 | 0.2164 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0149 | 0.4368 | 0.5599 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0154 | 0.4555 | 0.581 |
Trypanosoma brucei | RNA helicase, putative | 0.0226 | 0.7382 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0164 | 0.4933 | 0.6522 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0149 | 0.4368 | 0.5599 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0154 | 0.4555 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0164 | 0.4933 | 0.6337 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.023 | 0.7562 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0053 | 0.0564 | 0.0356 |
Brugia malayi | AMP-binding enzyme family protein | 0.0144 | 0.4155 | 0.4155 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0102 | 0.2495 | 0.3299 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.023 | 0.7562 | 1 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative | 0.0039 | 0 | 0.5 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0078 | 0.1547 | 0.3136 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0048 | 0.0384 | 0.0108 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0154 | 0.4555 | 0.6023 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0164 | 0.4933 | 0.6522 |
Mycobacterium ulcerans | thioesterase TesA | 0.0128 | 0.3541 | 0.4682 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0088 | 0.1931 | 0.224 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0047 | 0.0343 | 0.0052 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0278 | 0.9436 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0164 | 0.4933 | 0.6337 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0046 | 0.0306 | 0.0306 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0164 | 0.4933 | 0.6376 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0128 | 0.3541 | 0.4459 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0154 | 0.4555 | 0.5856 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0126 | 0.3447 | 0.4329 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0124 | 0.3367 | 0.4452 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0154 | 0.4555 | 0.5856 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0164 | 0.4933 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.023 | 0.7562 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0226 | 0.7382 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0154 | 0.4555 | 0.6023 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0048 | 0.0384 | 0.0508 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0144 | 0.4155 | 0.4782 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0102 | 0.2495 | 0.2941 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0128 | 0.3541 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0154 | 0.4555 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0124 | 0.3367 | 0.4155 |
Loa Loa (eye worm) | acyl carrier protein | 0.0071 | 0.127 | 0.1462 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0062 | 0.0933 | 0.0864 |
Mycobacterium ulcerans | polyketide synthase | 0.0154 | 0.4555 | 0.6023 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein synthase | 0.0039 | 0 | 0.5 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0144 | 0.4155 | 0.5305 |
Plasmodium falciparum | 3-oxoacyl-acyl-carrier protein synthase I/II | 0.0039 | 0 | 0.5 |
Giardia lamblia | Methyltransferase like 2 | 0.0046 | 0.0306 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl (acyl carrier protein) synthase | 0.0039 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0111 | 0.2842 | 0.3495 |
Trypanosoma cruzi | beta-ketoacyl synthase family protein, putative | 0.0039 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0164 | 0.4933 | 0.6376 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.023 | 0.7562 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0128 | 0.3541 | 0.4682 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0306 | 0.5 |
Mycobacterium ulcerans | polyketide synthase MbtD | 0.0047 | 0.0343 | 0.0454 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.01 | 0.2419 | 0.4903 |
Onchocerca volvulus | 0.0268 | 0.9058 | 0.9285 | |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0102 | 0.2495 | 0.3299 |
Schistosoma mansoni | methyltransferase-related | 0.0046 | 0.0306 | 0.0414 |
Leishmania major | hypothetical protein, conserved | 0.0046 | 0.0306 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0039 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0047 | 0.0343 | 0.0343 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.011 | 0.2802 | 0.5682 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0154 | 0.4555 | 0.4555 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0164 | 0.4933 | 0.6376 |
Mycobacterium ulcerans | polyketide synthase | 0.0164 | 0.4933 | 0.6522 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.869 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0164 | 0.4933 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0154 | 0.4555 | 0.6023 |
Chlamydia trachomatis | 3-oxoacyl-ACP synthase | 0.0039 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0124 | 0.3367 | 0.4452 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.832 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.78 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.76 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.76 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.756 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.727 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.718 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.688 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.642 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.