Detailed information for compound 1611410

Basic information

Technical information
  • TDR Targets ID: 1611410
  • Name: 2-ethoxy-6-morpholin-4-yl-4,4-bis(trifluorome thyl)-1,3,5-oxadiazine
  • MW: 349.23 | Formula: C11H13F6N3O3
  • H donors: 0 H acceptors: 0 LogP: 2.25 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC1=NC(N=C(O1)N1CCOCC1)(C(F)(F)F)C(F)(F)F
  • InChi: 1S/C11H13F6N3O3/c1-2-22-8-19-9(10(12,13)14,11(15,16)17)18-7(23-8)20-3-5-21-6-4-20/h2-6H2,1H3
  • InChiKey: IWJIUZXHKYNDEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-ethoxy-6-morpholino-4,4-bis(trifluoromethyl)-1,3,5-oxadiazine
  • 5226-19-7
  • NCI60_025597
  • 2-Ethoxy-6-(4-morpholinyl)-4,4-bis(trifluoromethyl)-4H-1,3,5-oxadiazine
  • AIDS-146121
  • AIDS146121
  • Ethyl 6-(4-morpholinyl)-4,4-bis(trifluoromethyl)-4H-1,3,5-oxadiazin-2-yl ether
  • NSC672101
  • ZINC01044115
  • STOCK1S-56353
  • SR-01000642081-1

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii FATC domain-containing protein 0.0469 0.1854 0.2416
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.016 0.0602 0.0597
Entamoeba histolytica hypothetical protein 0.016 0.0602 0.0567
Onchocerca volvulus 0.016 0.0602 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0091 0.0091
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.016 0.0602 0.0602
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0088 0.0088
Brugia malayi Protein kinase domain containing protein 0.0033 0.0088 0.0088
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0469 0.1854 0.1854
Trichomonas vaginalis PIKK family atypical protein kinase 0.1846 0.7426 0.7424
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.016 0.0602 0.0602
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0088 0.0082
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.016 0.0602 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.016 0.0602 0.0602
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.0602 0.0567
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0832 0.3323 0.3264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0469 0.1854 0.1854
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0832 0.3323 0.3298
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.016 0.0602 0.0567
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0469 0.1854 0.1823
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.016 0.0602 0.0597
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.016 0.0602 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.2482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1338 0.537 0.5368
Giardia lamblia Hypothetical protein 0.016 0.0602 0.0567
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0088 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 0.5379 0.5376
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.7945 0.7943
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.0602 0.0567
Loa Loa (eye worm) hypothetical protein 0.016 0.0602 0.0602
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.016 0.0602 0.0567
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.016 0.0602 0.0597
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.016 0.0602 0.0567
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1031 0.4127 0.4075
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0046 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.1854 0.185
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0832 0.3323 0.3323
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.016 0.0602 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0363 0.1423 0.1418
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.016 0.0602 0.0519
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.016 0.0602 0.0597
Schistosoma mansoni phosphatidylinositol 4-kinase 0.016 0.0602 0.0602
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0309 0.1206 0.1201
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.016 0.0602 0.0567
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.016 0.0602 0.0712
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0037 0.0037
Leishmania major phosphatidylinositol 3-kinase, putative 0.0832 0.3323 0.2895
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2482 1 1
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0046 0.0046
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.016 0.0602 0.0602
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.1338 0.537 0.5368
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.016 0.0602 0.0602
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.016 0.0602 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.1846 0.7426 0.7424
Trichomonas vaginalis PIKK family atypical protein kinase 0.1483 0.5957 0.5955
Trichomonas vaginalis PIKK family atypical protein kinase 0.1846 0.7426 0.7424
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.016 0.0602 0.0567
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.016 0.0602 0.0602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0602 0.0602
Entamoeba histolytica hypothetical protein 0.016 0.0602 0.0567
Toxoplasma gondii target of rapamycin (TOR), putative 0.1846 0.7426 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.016 0.0602 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.1854 0.185
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.016 0.0602 0.0597
Loa Loa (eye worm) phosphatidylinositol 3 0.0832 0.3323 0.3323
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.016 0.0602 1
Giardia lamblia GTOR 0.2482 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0309 0.1206 0.1206
Plasmodium falciparum phosphatidylinositol 4-kinase 0.016 0.0602 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0469 0.1854 0.1854
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.016 0.0602 0.0602
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.016 0.0602 0.0597
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0112 0.0112
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0037 0.0037
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.016 0.0602 0.0602
Entamoeba histolytica protein kinase, putative 0.0031 0.008 0.0042
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0046 0.0046
Echinococcus multilocularis nervana 2 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0523 0.2071 0.2071
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2482 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1976 0.7953 0.7935
Entamoeba histolytica hypothetical protein 0.016 0.0602 0.0567
Brugia malayi FAT domain containing protein 0.0363 0.1423 0.1423
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0523 0.2071 0.2711
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0088 0.0082
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2482 1 1
Echinococcus granulosus serine protein kinase ATM 0.0469 0.1854 0.1854
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0602 0.0602
Mycobacterium leprae conserved hypothetical protein 0.016 0.0602 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.016 0.0602 0.0567
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0602 0.0602
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0602 0.0602
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0046 0.0008
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.016 0.0602 0.0602
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.016 0.0602 0.0567
Loa Loa (eye worm) phosphatidylinositol 3 0.2482 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2482 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1846 0.7426 0.7424
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.016 0.0602 0.0602
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0127 0.0127
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.016 0.0602 0.0567
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.008 0.008
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0363 0.1423 0.1423
Trypanosoma cruzi target of rapamycin kinase 3 0.1976 0.7953 0.7945
Entamoeba histolytica protein kinase, putative 0.0033 0.0088 0.005
Entamoeba histolytica hypothetical protein 0.0469 0.1854 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.1665 0.6693 0.6691
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.1846 0.7426 0.7424
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.016 0.0602 0.0602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0469 0.1854 0.1854
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.0602 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.7945 0.7943
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.0602 0.0567
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0038 0.0038
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.016 0.0602 0.0602
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.016 0.0602 0.0602
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0469 0.1854 0.1854
Echinococcus multilocularis 0.016 0.0602 0.0602
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.016 0.0602 0.0602
Onchocerca volvulus 0.016 0.0602 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 0.5379 0.5376
Schistosoma mansoni fkbp-rapamycin associated protein 0.0469 0.1854 0.1854
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.016 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.1846 0.7426 0.7424
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0037 0.0037
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.008 0.008
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0112 0.0112
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2482 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.016 0.0602 0.0712
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0088 0.0082
Giardia lamblia Phosphatidylinositol 4-kinase 0.016 0.0602 0.0567
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0046 0.0046
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.016 0.0602 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.1468 0.5897 0.5895
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.016 0.0602 0.0602
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0602 0.0597
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.1338 0.537 0.5368
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0102 0.0096
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0309 0.1206 0.1173
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0602 0.0602
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.016 0.0602 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1483 0.5957 0.5955
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0363 0.1423 0.1423
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.016 0.0602 0.0597
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1976 0.7953 0.7822
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0088 0.0082
Loa Loa (eye worm) phosphatidylinositol kinase 0.016 0.0602 0.0602
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.016 0.0602 0.0519
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.016 0.0602 0.0602
Echinococcus multilocularis nervana 2 0.002 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0523 0.2071 0.2067
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2482 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0112 0.0112
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0832 0.3323 0.3323
Trichomonas vaginalis PIKK family atypical protein kinase 0.1483 0.5957 0.5955
Trichomonas vaginalis PIKK family atypical protein kinase 0.0832 0.3323 0.3319
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0046 0.0008
Entamoeba histolytica protein kinase, putative 0.0033 0.0088 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0832 0.3323 0.3319
Trichomonas vaginalis PIKK family atypical protein kinase 0.016 0.0602 0.0597
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2482 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0602 0.0602
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0469 0.1854 0.1823
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0038 0.0038
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.016 0.0602 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.7945 0.7943
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0469 0.1854 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.2482 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0832 0.3323 0.3264
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0469 0.1854 0.1782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0832 0.3323 0.3319
Entamoeba histolytica hypothetical protein 0.016 0.0602 0.0567
Plasmodium vivax hypothetical protein 0.016 0.0602 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.016 0.0602 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0832 0.3323 0.3319
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.016 0.0602 0.0602
Echinococcus granulosus nervana 2 0.002 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0832 0.3323 0.3319
Loa Loa (eye worm) hypothetical protein 0.0363 0.1423 0.1423
Trichomonas vaginalis PIKK family atypical protein kinase 0.1468 0.5897 0.5895
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.016 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.265 0.2646
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.016 0.0602 0.0602
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0088 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0309 0.1206 0.1201
Schistosoma mansoni hypothetical protein 0.016 0.0602 0.0602
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.016 0.0602 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0088 0.0082
Echinococcus granulosus nervana 2 0.002 0.0037 0.0037
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.016 0.0602 0.0597
Loa Loa (eye worm) hypothetical protein 0.0506 0.2001 0.2001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1611 0.6476 0.6474
Echinococcus multilocularis Zinc finger, PHD finger 0.016 0.0602 0.0602
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0102 0.0096
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0832 0.3323 0.2895
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.016 0.0602 0.0597
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0832 0.3323 0.3323
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2482 1 1
Echinococcus multilocularis serine protein kinase ATM 0.0469 0.1854 0.1854
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0602 0.0602
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2482 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0832 0.3323 0.3298
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.016 0.0602 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2482 1 1
Plasmodium vivax hypothetical protein, conserved 0.016 0.0602 1
Trypanosoma cruzi Protein kinase B 0.0023 0.0046 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.016 0.0602 0.0567
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.016 0.0602 0.0712
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.016 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.2119 0.8531 0.853
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.016 0.0602 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.7945 0.7943
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1174 0.4705 0.4658
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.016 0.0602 0.0712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.016 0.0602 0.0602
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.016 0.0602 0.0597
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0602 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.016 0.0602 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.1854 0.185
Loa Loa (eye worm) hypothetical protein 0.0469 0.1854 0.1854
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.016 0.0602 0.0567
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.016 0.0602 0.0712
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.016 0.0602 0.0597
Plasmodium falciparum phosphatidylinositol 3-kinase 0.016 0.0602 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2482 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.016 0.0602 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 0.5379 0.5376
Trichomonas vaginalis PIKK family atypical protein kinase 0.1846 0.7426 0.7424
Entamoeba histolytica protein kinase rad3, putative 0.0469 0.1854 0.1823
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.016 0.0602 0.0567
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0832 0.3323 0.3323
Loa Loa (eye worm) phosphatidylinositol 3 0.016 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.1974 0.7945 0.7943
Schistosoma mansoni phosphatidylinositol 4-kinase 0.016 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 0.5379 0.5376
Schistosoma mansoni hypothetical protein 0.0363 0.1423 0.1423
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0112 0.0112

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.048 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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