Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0774 | 0.2125 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0774 | 0.2125 | 0.4742 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0401 | 0.104 | 0.2252 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.008 | 0.0104 | 0.0187 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.0131 | 0.0252 | 0.0443 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.1043 | 0.2908 | 0.2833 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Brugia malayi | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Echinococcus multilocularis | glycogen debranching enzyme | 0.0126 | 0.0238 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0275 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0704 | 0.1921 | 0.1921 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.0342 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.156 | 0.4416 | 0.4416 |
Echinococcus granulosus | bile acid beta glucosidase | 0.1043 | 0.2908 | 0.2833 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0401 | 0.104 | 0.4253 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0243 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.104 | 0.104 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0544 | 0.1455 | 1 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.0131 | 0.0252 | 0.0443 |
Schistosoma mansoni | alpha-glucosidase | 0.3135 | 0.9002 | 1 |
Loa Loa (eye worm) | amylo-alpha-1,6-glucosidase | 0.0061 | 0.005 | 0.005 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.3477 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0114 | 0.0114 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0744 | 0.2038 | 0.4543 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3665 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.1199 | 0.3365 | 0.4599 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.1043 | 0.2908 | 0.2833 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0275 | 0.0275 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0774 | 0.2125 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0401 | 0.104 | 0.104 |
Schistosoma mansoni | alpha glucosidase | 0.0774 | 0.2125 | 0.2271 |
Loa Loa (eye worm) | trehalase | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0401 | 0.104 | 0.2252 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0774 | 0.2125 | 0.4742 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3295 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0774 | 0.2125 | 0.4742 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0401 | 0.104 | 0.4632 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1079 | 0.3014 | 0.6781 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0126 | 0.0238 | 0.041 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.156 | 0.4416 | 0.4416 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.1043 | 0.2908 | 0.2833 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0126 | 0.0238 | 0.0238 |
Brugia malayi | Ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3365 |
Schistosoma mansoni | beta-galactosidase | 0.0139 | 0.0275 | 0.0192 |
Trypanosoma brucei | glucosidase, putative | 0.0774 | 0.2125 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3295 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0774 | 0.2125 | 0.2125 |
Echinococcus granulosus | beta galactosidase | 0.0139 | 0.0275 | 0.0172 |
Echinococcus granulosus | glycogen debranching enzyme | 0.0126 | 0.0238 | 0.0135 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Echinococcus multilocularis | beta galactosidase | 0.0139 | 0.0275 | 0.0172 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0774 | 0.2125 | 0.2042 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0774 | 0.2125 | 0.2125 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1043 | 0.2908 | 0.3151 |
Loa Loa (eye worm) | TRE-1 protein | 0.0128 | 0.0243 | 0.0243 |
Onchocerca volvulus | 0.2458 | 0.7032 | 1 | |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0774 | 0.2125 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3665 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0774 | 0.2125 | 0.2042 |
Trichomonas vaginalis | trehalase, putative | 0.0128 | 0.0243 | 0.0422 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0774 | 0.2125 | 1 |
Treponema pallidum | hypothetical protein | 0.0044 | 0 | 0.5 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0126 | 0.0238 | 0.041 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1043 | 0.2908 | 0.3151 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.1199 | 0.3365 | 0.3365 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.0136 | 0.0035 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.3477 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0401 | 0.104 | 0.2252 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.156 | 0.4416 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.3477 | 1 | 1 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0401 | 0.104 | 0.4732 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0401 | 0.104 | 0.4632 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0744 | 0.2038 | 0.954 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0401 | 0.104 | 0.2252 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0774 | 0.2125 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0238 | 0.0238 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.3477 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1079 | 0.3014 | 0.6781 |
Loa Loa (eye worm) | TRE-2 protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0243 | 0.0243 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0774 | 0.2125 | 0.4742 |
Brugia malayi | Trehalase family protein | 0.0128 | 0.0243 | 0.0243 |
Schistosoma mansoni | alpha-glucosidase | 0.3135 | 0.9002 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.1024 | 0.2853 | 0.3844 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0128 | 0.0243 | 0.0422 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0401 | 0.104 | 0.1174 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1024 | 0.2853 | 0.6413 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.532 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.434 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.427 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.363 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.304 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.043 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.