Detailed information for compound 1613721

Basic information

Technical information
  • TDR Targets ID: 1613721
  • Name: 2-[4-[[(2S)-chroman-2-yl]methylamino]butyl]-5 ,6,7,7a-tetrahydropyrrolo[2,1-e]imidazole-1,3 -dione
  • MW: 357.447 | Formula: C20H27N3O3
  • H donors: 1 H acceptors: 2 LogP: 2.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N2CCCC2C(=O)N1CCCCNC[C@@H]1CCc2c(O1)cccc2
  • InChi: 1S/C20H27N3O3/c24-19-17-7-5-13-22(17)20(25)23(19)12-4-3-11-21-14-16-10-9-15-6-1-2-8-18(15)26-16/h1-2,6,8,16-17,21H,3-5,7,9-14H2/t16-,17?/m0/s1
  • InChiKey: IFSDSWUCBOYCCT-BHWOMJMDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[[(2S)-2-chromanyl]methylamino]butyl]-5,6,7,7a-tetrahydropyrrolo[2,1-e]imidazole-1,3-dione
  • 2-[4-[[(2S)-chroman-2-yl]methylamino]butyl]-5,6,7,7a-tetrahydropyrrolo[2,1-e]imidazole-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans sugar transporter 0.0014 0.0217 0.1918
Leishmania major hypothetical protein, conserved 0.0014 0.0217 0.303
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0045 0.0986 0.4312
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.003 0.0611 0.2648
Brugia malayi larval opioid receptor 0.0045 0.0986 0.4312
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.01 0.0373
Schistosoma mansoni myosin xvIII 0.0045 0.0986 0.4312
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Echinococcus granulosus tachykinin peptides receptor 99D 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus g-protein coupled receptor 0.0045 0.0986 0.4312
Echinococcus granulosus serotonin receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0057 0.0186
Brugia malayi AKH receptor 0.0045 0.0986 0.4312
Leishmania major glucose transporter, lmgt3 0.003 0.0621 0.868
Schistosoma mansoni lysyl-tRNA synthetase 0.0022 0.0414 0.1769
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi hypothetical protein 0.0051 0.113 0.4953
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0217 0.303
Echinococcus granulosus dro:myosuppressin receptor 0.0045 0.0986 0.4312
Schistosoma mansoni neuropeptide receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis G protein coupled receptor 139 0.0045 0.0986 0.4312
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0217 0.1918
Loa Loa (eye worm) TYRA-2 protein 0.0045 0.0986 0.4312
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0045 0.0986 0.8601
Schistosoma mansoni opsin-like receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.01 0.0373
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.01 0.0373
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0139 0.0549
Onchocerca volvulus 0.0014 0.0217 0.1137
Trypanosoma cruzi hexose transporter, putative 0.003 0.0621 0.868
Echinococcus multilocularis G-protein coupled receptor, putative 0.0045 0.0986 0.4312
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0045 0.0986 0.4312
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis g protein coupled receptor 0.0045 0.0986 0.4312
Schistosoma mansoni protein kinase 0.003 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus calcium dependent protein kinase 0.0028 0.0566 0.2448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Schistosoma mansoni adenoreceptor 0.0045 0.0986 0.4312
Echinococcus multilocularis calcium dependent protein kinase 0.0028 0.0566 0.2448
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.01 0.0373
Echinococcus granulosus 7TM GPCR rhodopsin 0.0045 0.0986 0.4312
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0611 0.2648
Entamoeba histolytica protein kinase, putative 0.003 0.0611 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni amine GPCR 0.0045 0.0986 0.4312
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.0986 0.4312
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0007 0.0044 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0045 0.0986 0.8601
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0007 0.0044 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Schistosoma mansoni biogenic amine receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0029 0.0597 0.2583
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0019 0.0348 0.1536
Echinococcus multilocularis allatostatin A receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0139 0.0549
Loa Loa (eye worm) hypothetical protein 0.0011 0.0139 0.0549
Trichomonas vaginalis sugar transporter, putative 0.003 0.0621 0.274
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0029 0.0597 0.2583
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0217 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0022 0.0414 0.366
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0044 0.0128
Trypanosoma cruzi hexose transporter, putative 0.003 0.0621 0.868
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0051 0.113 0.4953
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0014 0.0217 0.1137
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0029 0.0597 0.2583
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.077 0.3355
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Schistosoma mansoni neuropeptide receptor 0.0045 0.0986 0.4312
Brugia malayi Trypsin-like protease protein 5 0.0051 0.113 0.4953
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0097 0.2266 1
Schistosoma mansoni glucose transport protein 0.0097 0.2266 1
Schistosoma mansoni hypothetical protein 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.1137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.01 0.0373
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus multilocularis lysyl tRNA synthetase 0.0022 0.0414 0.1769
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0051 0.113 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.003 0.0612 0.0597
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0045 0.0986 0.4312
Loa Loa (eye worm) AGC/PKG protein kinase 0.0007 0.0044 0.0128
Brugia malayi Melatonin receptor type 1A 0.0045 0.0986 0.4312
Leishmania major glucose transporter, lmgt2 0.003 0.0621 0.868
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0045 0.0986 0.4312
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0217 0.0201
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0034 0.0715 0.1081
Schistosoma mansoni glucose transport protein 0.0097 0.2266 1
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0051 0.113 0.4953
Schistosoma mansoni protein kinase 0.003 0.0611 0.2648
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0045 0.0986 0.4312
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0217 0.0894
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.003 0.0611 0.2648
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0045 0.0986 0.8601
Trypanosoma brucei THT1 - hexose transporter, putative 0.003 0.0621 0.868
Schistosoma mansoni glucose transport protein 0.0097 0.2266 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0045 0.0986 0.4312
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0611 0.2648
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0044 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0611 0.2648
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0139 0.0549
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus multilocularis somatostatin receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0051 0.113 0.4953
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0097 0.2266 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0894
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0057 0.0186
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Echinococcus multilocularis neuropeptide s receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis neuropeptide receptor A26 0.0045 0.0986 0.4312
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.003 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0045 0.0986 0.8601
Brugia malayi nuclear receptor NHR-88 0.0009 0.01 0.0373
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis dro:myosuppressin receptor 0.0045 0.0986 0.4312
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.01 0.0373
Trichomonas vaginalis glucose transporter, putative 0.003 0.0621 0.274
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0852 0.3718
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0057 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.2266 1
Brugia malayi neuropeptide F receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) sugar transporter 0.0097 0.2266 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.003 0.0621 0.868
Leishmania major glucose transporter/membrane transporter D2, putative 0.003 0.0621 0.868
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.01 0.0373
Entamoeba histolytica protein kinase, putative 0.003 0.0611 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 5 0.003 0.0612 0.0597
Echinococcus multilocularis fmrfamide receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0045 0.0986 0.4312
Plasmodium falciparum proline--tRNA ligase 0.0034 0.0715 0.0701
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.0986 0.4312
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0045 0.0986 0.4312
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Toxoplasma gondii sugar transporter ST1 0.0014 0.0217 0.0327
Schistosoma mansoni amine GPCR 0.0045 0.0986 0.4312
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.01 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.01 0.0373
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.003 0.0612 0.0925
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.01 0.0373
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0018 0.0333 1
Onchocerca volvulus 0.0045 0.0986 0.8601
Brugia malayi G-protein coupled receptor 0.0045 0.0986 0.4312
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0034 0.0715 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.0986 0.4312
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0286 0.3994
Chlamydia trachomatis proline--tRNA ligase 0.001 0.0134 0.2978
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Plasmodium falciparum protein kinase 7 0.0275 0.6617 0.6612
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis serotonin receptor 0.0045 0.0986 0.4312
Brugia malayi putative neuropeptide receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0029 0.0597 0.2583
Schistosoma mansoni hypothetical protein 0.0097 0.2266 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Echinococcus granulosus General substrate transporter 0.0084 0.193 0.851
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0045 0.0986 0.4312
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0034 0.0715 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0005 0.0016 0.0218
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.01 0.0373
Onchocerca volvulus 0.0051 0.113 1
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Brugia malayi Serotonin receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0097 0.2266 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.01 0.0373
Onchocerca volvulus 0.0045 0.0986 0.8601
Schistosoma mansoni amine GPCR 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Plasmodium falciparum lysine--tRNA ligase 0.0022 0.0414 0.0399
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0045 0.0986 0.4312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Trypanosoma brucei THT1 - hexose transporter, putative 0.003 0.0621 0.868
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0217 0.1918
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0022 0.0414 0.5783
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Plasmodium falciparum cGMP-dependent protein kinase 0.0007 0.0044 0.0029
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.0057 0.0186
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0621 0.274
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.01 0.0373
Brugia malayi G protein-coupled receptor F59B2.13 0.0045 0.0986 0.4312
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.01 0.0373
Giardia lamblia Prolyl-tRNA synthetase 0.0029 0.0597 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0029 0.0597 0.2634
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0022 0.0414 0.6932
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0012 0.0175 0.0709
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Schistosoma mansoni 60S ribosomal protein L21 0.0006 0.0022 0.0027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.0986 0.4312
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0217 0.6499
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.01 0.0373
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0014 0.0217 0.1137
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0139 0.0549
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.01 0.0373
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus granulosus g protein coupled receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis enteropeptidase 0.0051 0.113 0.4953
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0045 0.0986 0.4312
Brugia malayi nuclear hormone receptor 0.0009 0.01 0.0373
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Plasmodium vivax lysine--tRNA ligase, putative 0.0022 0.0414 0.0399
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0611 0.2648
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.0057 0.0186
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0045 0.0986 0.4312
Plasmodium falciparum mitogen-activated protein kinase 2 0.0158 0.3734 0.3724
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.0986 0.4312
Schistosoma mansoni amine GPCR 0.0045 0.0986 0.4312
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.0986 0.4312
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0139 0.0549
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0097 0.2266 1
Schistosoma mansoni hypothetical protein 0.0045 0.0986 0.4312
Schistosoma mansoni biogenic amine receptor 0.0045 0.0986 0.4312
Echinococcus granulosus G protein coupled receptor 139 0.0045 0.0986 0.4312
Brugia malayi Cam kinase protein 1 0.003 0.0611 0.2648
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.003 0.0612 0.0597
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Giardia lamblia Sugar-proton symporter 0.0014 0.0217 0.346
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0621 0.274
Echinococcus granulosus alpha 1A adrenergic receptor 0.0045 0.0986 0.4312
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.0986 0.4312
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 1 0.003 0.0612 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0057 0.0186
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0217 0.0894
Schistosoma mansoni nuclear hormone receptor 0.0009 0.01 0.0373
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0057 0.0186
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.003 0.0611 0.855
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.0057 0.0186
Onchocerca volvulus 0.0014 0.0217 0.1137
Onchocerca volvulus 0.0051 0.113 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.077 0.3355
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.0057 0.0186
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0057 0.0253
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0022 0.0414 0.5783
Onchocerca volvulus 0.0014 0.0217 0.1137
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0712 0.3143
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.077 0.3355
Echinococcus granulosus sex peptide receptor 0.0045 0.0986 0.4312
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0044 0.0128
Onchocerca volvulus 0.0014 0.0217 0.1137
Schistosoma mansoni coup transcription factor 0.0009 0.01 0.0373
Trichomonas vaginalis sugar transporter, putative 0.003 0.0621 0.274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0057 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.01 0.0373
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.01 0.0373
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.01 0.0373
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0712 0.3143
Brugia malayi G protein-coupled receptor 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0014 0.0217 0.1137
Echinococcus granulosus neuropeptide receptor 0.0045 0.0986 0.4312
Brugia malayi lysyl-tRNA synthetase 0.0022 0.0414 0.1769
Loa Loa (eye worm) hypothetical protein 0.0007 0.0057 0.0186
Loa Loa (eye worm) hypothetical protein 0.0051 0.113 0.4953
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.01 0.0373
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis orexin receptor type 2 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Loa Loa (eye worm) hypothetical protein 0.003 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0158 0.3734 0.3724
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Chlamydia trachomatis lysine--tRNA ligase 0.0022 0.0414 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0005 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.01 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0611 0.2699
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0217 0.303
Brugia malayi Dopamine receptor protein 2 0.0045 0.0986 0.4312
Echinococcus granulosus Mastin 0.0051 0.113 0.4953
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0029 0.0597 0.2583
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis Mastin 0.0051 0.113 0.4953
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0057 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium ulcerans hypothetical protein 0.0051 0.113 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0139 0.0549
Onchocerca volvulus 0.0051 0.113 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.0986 0.4312
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0022 0.0027
Schistosoma mansoni hypothetical protein 0.0045 0.0986 0.4312
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0045 0.0986 0.4312
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0051 0.113 0.4953
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Echinococcus granulosus allatostatin A receptor 0.0045 0.0986 0.4312
Brugia malayi Serotonin receptor 0.0045 0.0986 0.4312
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.003 0.0612 0.0925
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.01 0.0373
Echinococcus multilocularis General substrate transporter 0.0084 0.193 0.851
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Onchocerca volvulus 0.0014 0.0217 0.1137
Echinococcus multilocularis g-protein coupled receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis neuropeptide receptor 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus granulosus 7tm_1 domain containing protein 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.1137
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Brugia malayi putative neuropeptide receptor NPR1 0.0045 0.0986 0.4312
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.01 0.0373
Echinococcus multilocularis transmembrane protease serine 3 0.0051 0.113 0.4953
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0057 0.0186
Brugia malayi RE15519p 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Giardia lamblia Lysyl-tRNA synthetase 0.0022 0.0414 0.6849
Onchocerca volvulus 0.0051 0.113 1
Echinococcus multilocularis expressed conserved protein 0.0007 0.0044 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.01 0.0373
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Brugia malayi ecdysteroid receptor 0.0009 0.01 0.0373
Schistosoma mansoni hypothetical protein 0.0045 0.0986 0.4312
Brugia malayi Dopamine receptor protein 1 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0029 0.0597 0.2583
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.01 0.0373
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0005 0.0016 0.0262
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0005 0.0016 0.0218
Echinococcus granulosus g protein coupled receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0217 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.01 0.0373
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni biogenic amine receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0414 0.1826
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.01 0.0373
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0057 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Loa Loa (eye worm) melatonin receptor type 1A 0.0045 0.0986 0.4312
Brugia malayi Sugar transporter family protein 0.0097 0.2266 1
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0045 0.0986 0.4312
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.003 0.0611 0.2648
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.1137
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.0986 0.4312
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Treponema pallidum prolyl-tRNA synthetase 0.001 0.0134 1
Plasmodium vivax sugar transporter, putative 0.0014 0.0217 0.0201
Echinococcus granulosus neuropeptide FF receptor 2 0.0045 0.0986 0.4312
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0045 0.0986 0.4312
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.0986 0.4312
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis neuropeptide FF receptor 2 0.0045 0.0986 0.4312
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0045 0.0986 0.4312
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0045 0.0986 0.4312
Schistosoma mansoni neuropeptide receptor 0.0045 0.0986 0.4312
Echinococcus granulosus somatostatin receptor 0.0045 0.0986 0.4312
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0097 0.2266 1
Toxoplasma gondii protein kinase, putative 0.0275 0.6617 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0051 0.113 0.4953
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Brugia malayi Trypsin family protein 0.0051 0.113 0.4953
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0045 0.0986 0.4312
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0005 0.0016 0.0468
Plasmodium vivax proline--tRNA ligase, putative 0.0034 0.0715 0.0701
Echinococcus multilocularis serotonin receptor 0.0045 0.0986 0.4312
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Brugia malayi Tachykinin-like peptides receptor 99D 0.0045 0.0986 0.4312
Schistosoma mansoni glucose transporter 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.1137
Schistosoma mansoni opsin-like receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.01 0.0373
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0057 0.0186
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.01 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.01 0.0373
Loa Loa (eye worm) hypothetical protein 0.0051 0.113 0.4953
Schistosoma mansoni opsin-like receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0024 0.0463 0.1987
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0005 0.0016 0.0138
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0894
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0029 0.0597 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus Putative transporter 0.0014 0.0217 0.1137
Loa Loa (eye worm) sugar transporter 0.0014 0.0217 0.0894
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.0986 0.4312
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Brugia malayi neuropeptide F receptor 0.0045 0.0986 0.4312
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0051 0.113 0.4953
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Brugia malayi follicle stimulating hormone receptor 0.0045 0.0986 0.4312
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.0057 0.0186
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Echinococcus granulosus lysyl tRNA synthetase 0.0022 0.0414 0.1769
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0217 0.6499
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0097 0.2266 1
Echinococcus granulosus transmembrane protease serine 3 0.0051 0.113 0.4953
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium vivax calcium-dependent protein kinase, putative 0.003 0.0612 0.0597
Schistosoma mansoni protein kinase 0.003 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0005 0.0016 0.0138
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0894
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.01 0.0373
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0057 0.0186
Schistosoma mansoni amine GPCR 0.0045 0.0986 0.4312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.01 0.0373
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.0986 0.4312
Leishmania major protein kinase, putative 0.0007 0.0044 0.0622
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0029 0.0597 1
Onchocerca volvulus 0.0045 0.0986 0.8601
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0045 0.0986 0.4312
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.01 0.0373
Schistosoma mansoni alpha-1 adrenergic receptor 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0045 0.0986 0.8601
Echinococcus multilocularis glycoprotein Antigen 5 0.0051 0.113 0.4953
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Schistosoma mansoni histamine h1 receptor 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0051 0.113 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0097 0.2266 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0034 0.0715 1
Brugia malayi Trypsin family protein 0.0051 0.113 0.4953
Trichomonas vaginalis sugar transporter, putative 0.003 0.0621 0.274
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0022 0.0414 0.366
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0045 0.0986 0.4312
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0018 0.0333 0.5587
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0139 0.0549
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0051 0.113 0.4953
Entamoeba histolytica hypothetical protein 0.0022 0.0414 0.6679
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0045 0.0986 0.4312
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.01 0.0373
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0005 0.0016 0.0218
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.003 0.0612 0.0597
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus neuropeptide receptor 0.0045 0.0986 0.4312
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.01 0.0373
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.0057 0.0186
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0005 0.0016 0.0069
Echinococcus granulosus cGMP dependent protein kinase 0.0007 0.0044 0.0128
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.0986 0.4312
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0057 0.0186
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Toxoplasma gondii facilitative glucose transporter GT1 0.0097 0.2266 0.3424
Echinococcus multilocularis g protein coupled receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0611 0.2648
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.01 0.0373
Onchocerca volvulus 0.0014 0.0217 0.1137
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0051 0.113 0.4953
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Echinococcus multilocularis fmrfamide receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis sex peptide receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.01 0.0373
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0057 0.0186
Leishmania major glucose transporter, lmgt1 0.003 0.0621 0.868
Schistosoma mansoni hypothetical protein 0.0051 0.113 0.4953
Echinococcus granulosus FTZ F1 alpha 0.0009 0.01 0.0373
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0217 0.1918
Echinococcus granulosus neuropeptide receptor A26 0.0045 0.0986 0.4312
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.01 0.0373
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Brugia malayi ORL1-like opioid receptor 0.0045 0.0986 0.4312
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0051 0.113 0.4953
Trypanosoma brucei glucose transporter 2A 0.003 0.0621 0.868
Plasmodium falciparum calcium-dependent protein kinase 3 0.003 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus multilocularis g protein coupled receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0045 0.0986 0.4312
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0005 0.0009 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.01 0.0373
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Trypanosoma cruzi hexose transporter 0.003 0.0621 0.868
Trypanosoma brucei glucose transporter 1E 0.003 0.0621 0.868
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.077 0.3355
Onchocerca volvulus 0.0014 0.0217 0.1137
Plasmodium falciparum calcium-dependent protein kinase 2 0.003 0.0612 0.0597
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0217 0.0327
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0097 0.2266 1
Echinococcus granulosus hypothetical protein 0.0045 0.0986 0.4312
Echinococcus granulosus cGMP dependent protein kinase 1 0.0007 0.0044 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) trypsin family protein 0.0051 0.113 0.4953
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0045 0.0986 0.4312
Toxoplasma gondii lysine-tRNA ligase 0.0022 0.0414 0.0625
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0051 0.113 0.4953
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Mycobacterium ulcerans prolyl-tRNA synthetase 0.001 0.0134 0.1187
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.01 0.0373
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.01 0.0373
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0894
Brugia malayi Egg laying defective protein 4 0.0007 0.0044 0.0128
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.003 0.0612 0.0925
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0045 0.0986 0.4312
Echinococcus granulosus g protein coupled receptor 0.0045 0.0986 0.4312
Leishmania major protein kinase, putative 0.0007 0.0044 0.0622
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0045 0.0986 0.4312
Leishmania major protein kinase, putative 0.003 0.0611 0.855
Onchocerca volvulus 0.0045 0.0986 0.8601
Trypanosoma cruzi hexose transporter, putative 0.003 0.0621 0.868
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Echinococcus granulosus fmrfamide receptor 0.0045 0.0986 0.4312
Echinococcus multilocularis neuropeptide receptor 0.0045 0.0986 0.4312
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0029 0.0597 0.2583
Leishmania major lysyl-tRNA synthetase, putative 0.0022 0.0414 0.5783
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Onchocerca volvulus Neuropeptide F receptor homolog 0.0045 0.0986 0.8601
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0005 0.0016 0.0218
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Schistosoma mansoni neuropeptide f receptor 76f 0.0045 0.0986 0.4312
Schistosoma mansoni hypothetical protein 0.0051 0.113 0.4953
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.01 0.0373
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0018 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0653 0.2833
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.003 0.0612 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.01 0.0373
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.0986 0.4312
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.0986 0.4312
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0034 0.0715 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.113 0.4953
Brugia malayi Trypsin family protein 0.0051 0.113 0.4953
Schistosoma mansoni thyroid hormone receptor 0.0009 0.01 0.0373
Brugia malayi Dopamine receptor 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni growth hormone secretagogue receptor 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0217 0.0956
Schistosoma mansoni cercarial elastase (S01 family) 0.0051 0.113 0.4953
Echinococcus granulosus orexin receptor type 2 0.0045 0.0986 0.4312
Trypanosoma brucei sugar transporter, putative 0.0014 0.0217 0.303
Onchocerca volvulus 0.0014 0.0217 0.1137
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.01 0.0373
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.0986 0.4312
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0029 0.0597 0.9752
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Plasmodium falciparum hexose transporter 0.0097 0.2266 0.2253
Trichomonas vaginalis glucose transporter, putative 0.003 0.0621 0.274
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.0986 0.4312
Leishmania major threonyl-tRNA synthetase, putative 0.0005 0.0016 0.0218
Giardia lamblia Hexose transporter 0.0014 0.0217 0.346
Brugia malayi G-protein coupled receptor 0.0045 0.0986 0.4312
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0057 0.0186
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.01 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.01 0.0373
Echinococcus granulosus cGMP dependent protein kinase 1 0.0007 0.0044 0.0128
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0034 0.0715 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Brugia malayi GnHR receptor homolog 0.0045 0.0986 0.4312
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.01 0.0373
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0217 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0009 0.01 0.0373
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0005 0.0016 0.0024
Schistosoma mansoni lysyl-tRNA synthetase 0.0022 0.0414 0.1769
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Toxoplasma gondii sugar transporter ST3 0.0014 0.0217 0.0327
Echinococcus granulosus glycoprotein Antigen 5 0.0051 0.113 0.4953
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0007 0.0044 0.0128
Onchocerca volvulus 0.0045 0.0986 0.8601
Loa Loa (eye worm) hypothetical protein 0.0022 0.0414 0.1769
Echinococcus granulosus peptide allatostatin:somatostatin 0.0045 0.0986 0.4312
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0158 0.3734 0.5643
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0057 0.0186
Brugia malayi hypothetical protein 0.0045 0.0986 0.4312
Plasmodium vivax hexose transporter 0.0097 0.2266 0.2253
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0045 0.0986 0.4312
Brugia malayi steroid hormone receptor 0.0009 0.01 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.01 0.0373
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.0986 0.4312
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.01 0.0373
Schistosoma mansoni thyroid hormone receptor 0.0009 0.01 0.0373
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0852 0.3718
Echinococcus granulosus enteropeptidase 0.0051 0.113 0.4953
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.0986 0.4312
Loa Loa (eye worm) hypothetical protein 0.0045 0.0986 0.4312
Toxoplasma gondii sugar transporter ST2 0.0014 0.0217 0.0327
Echinococcus granulosus neuropeptide s receptor 0.0045 0.0986 0.4312
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.01 0.0373
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0611 0.2648
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Brugia malayi sulfakinin receptor protein 0.0045 0.0986 0.4312
Trypanosoma brucei glucose transporter, putative 0.003 0.0621 0.868
Schistosoma mansoni neuropeptide receptor 0.0045 0.0986 0.4312
Onchocerca volvulus 0.0045 0.0986 0.8601
Brugia malayi Trypsin family protein 0.0051 0.113 0.4953
Onchocerca volvulus 0.0014 0.0217 0.1137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0986 0.4312
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.0986 0.4312

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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