Detailed information for compound 1617244

Basic information

Technical information
  • TDR Targets ID: 1617244
  • Name: 4-(1,8-dioxo-3,4,5,6,7,9-hexahydro-2H-acridin -10-yl)-N-hydroxybenzeneamine oxide
  • MW: 338.357 | Formula: C19H18N2O4
  • H donors: 0 H acceptors: 4 LogP: 2.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCCC2=C1CC1=C(N2c2ccc(cc2)[N+](=O)[O-])CCCC1=O
  • InChi: 1S/C19H18N2O4/c22-18-5-1-3-16-14(18)11-15-17(4-2-6-19(15)23)20(16)12-7-9-13(10-8-12)21(24)25/h7-10H,1-6,11H2
  • InChiKey: SOOVJBNIZSFYKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 10-(4-nitrophenyl)-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-dione
  • 10-[4-(hydroxy-oxidoamino)phenyl]-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-dione
  • 4-(1,8-dioxo-3,4,5,6,7,9-hexahydro-2H-acridin-10-yl)-N-hydroxy-benzeneamine oxide
  • 10-[4-(hydroxy-oxido-amino)phenyl]-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-dione
  • 4-(1,8-diketo-3,4,5,6,7,9-hexahydro-2H-acridin-10-yl)-N-hydroxy-benzeneamine oxide
  • 10-(4-nitrophenyl)-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-quinone
  • 10-[4-(hydroxy-oxido-amino)phenyl]-3,4,5,6,7,9-hexahydro-2H-acridine-1,8-quinone
  • NCI60_022477
  • 10-(4-(Hydroxy(oxido)amino)phenyl)-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione
  • AIDS-143752
  • AIDS143752
  • NSC665136

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.0011
Brugia malayi conserved hypotetical protein 0.001 0.0007 0.0007
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0056 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0059 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0755 0.3308 0.3308
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0007 0.0007
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0012 0.0013 0.002
Echinococcus granulosus twitchin 0.002 0.0052 0.0077
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0021 0.0056 0.5
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0755 0.3308 0.4952
Schistosoma mansoni DNA ligase IV 0.0021 0.0056 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0068 0.1159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0416 0.1806 0.2704
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0059 0.0059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0068 0.1159
Brugia malayi steroid hormone receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0007 0.0007
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0013 0.0019
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0755 0.3308 0.3308
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0068 0.1159
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0059 0.0059
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0059 0.0088
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0059 0.3301
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0272 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0059 0.0088
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0068 0.1159
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0755 0.3308 0.4952
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0034 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi hypothetical protein 0.0021 0.0056 0.0056
Brugia malayi Kinase associated domain 1 family protein 0.0749 0.3283 0.3283
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0048
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0007 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0068 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0013 0.0013
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0007 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0059 0.0088
Echinococcus multilocularis nibrin 0.0021 0.0056 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0166 0.0249
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0013
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0068 0.1159
Schistosoma mansoni coup transcription factor 0.0022 0.0059 0.0059
Brugia malayi hypothetical protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0056 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0059 0.0059
Echinococcus multilocularis Immunoglobulin 0.0012 0.0013 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0068 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0013 0.0013
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0068 1
Echinococcus granulosus neuroglian 0.0015 0.0026 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi nuclear receptor NHR-67 0.001 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0059 0.0088
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0059 0.0088
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0007 0.0416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0166 0.0166
Brugia malayi topoisomerase 0.0021 0.0056 0.0056
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0749 0.3283 0.3283
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0059 0.0059
Echinococcus multilocularis neuroglian 0.0015 0.0026 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0059 0.0059
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0755 0.3308 0.4952
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0056 0.0655
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0007 0.0007
Echinococcus multilocularis calcium activated potassium channel 0.0755 0.3308 0.4952
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.0011
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0272 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0272 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0059 0.0088
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0032 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Schistosoma mansoni topbp1 0.0021 0.0056 0.0056
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0011
Echinococcus granulosus defective proboscis extension response 0.0012 0.0013 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0166 0.0249
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0059 0.0088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0056 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0068 1
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0059 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0755 0.3308 0.3308
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Onchocerca volvulus 0.001 0.0007 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0059 0.0059
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Brugia malayi nuclear receptor NHR-88 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi nuclear receptor RXR 0.001 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0059 0.0059
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0059 0.0059
Onchocerca volvulus 0.0021 0.0056 0.316
Echinococcus granulosus nibrin 0.0021 0.0056 0.0084
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.1516 0.6679 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0059 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.1516 0.6679 0.666
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0068 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0013 0.0013
Brugia malayi Fibronectin type III domain containing protein 0.0012 0.0013 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0114 0.0114
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0059 0.0088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0272 0.0272
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0749 0.3283 0.3283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0059 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0068 0.0068
Onchocerca volvulus 0.0049 0.0178 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0059 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0068 0.1321
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0059 0.0059
Echinococcus granulosus roundabout 2 0.0015 0.0026 0.0039
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0059 0.0059
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0166 0.0166
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0068 0.1159
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0272 1
Brugia malayi hypothetical protein 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi hypothetical protein 0.001 0.0007 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0023 0.0023
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0007
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0059 0.0059
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0013 0.002
Mycobacterium ulcerans hypothetical protein 0.0024 0.0068 0.1159
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0059 0.0088
Echinococcus granulosus Immunoglobulin 0.0012 0.0013 0.002
Brugia malayi ecdysteroid receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0068
Echinococcus granulosus calcium activated potassium channel 0.0755 0.3308 0.4952
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0272 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0114 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Schistosoma mansoni zinc finger protein 0.001 0.0007 0.0007
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0014 0.0023 0.0023
Schistosoma mansoni topbp1 0.0021 0.0056 0.0056
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0059 0.0059
Schistosoma mansoni survival motor neuron protein 0.0049 0.0178 0.0178
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0032
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0007 0.0007
Schistosoma mansoni vesicular amine transporter 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0056 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0059 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.1516 0.6679 0.666
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0059 0.3301
Giardia lamblia Replication factor C, subunit 1 0.0021 0.0056 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0272 0.0408
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi hypothetical protein 0.001 0.0007 0.0007
Echinococcus granulosus GPCR family 2 0.0016 0.0032 0.0048
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0007 0.0011
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0012 0.0013 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0032 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0049 0.0178 0.0178
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0068 0.1159
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0059 0.0088
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0032 0.0032
Echinococcus multilocularis GPCR, family 2 0.0016 0.0032 0.0048
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.0011
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0007 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0059 0.0059
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0059 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0059 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0755 0.3308 0.3308
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0059 0.0059
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0007 0.0007
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0056 0.0056
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0056 0.00000012515
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0056 0.0001
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0032
Brugia malayi tailless protein 0.001 0.0007 0.0007
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0059 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0059 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0166 0.0249
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0178 0.0178
Brugia malayi hypothetical protein 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0239 0.102 0.102
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0059 0.0088
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0755 0.3308 0.3308
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0059 0.0059
Echinococcus multilocularis roundabout 2 0.0015 0.0026 0.0039
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0056 0.00000012515
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0007 0.0416
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.102 0.1527
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0819 0.3592 0.5377
Onchocerca volvulus 0.001 0.0007 0.0416
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0059 0.0088
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.1516 0.6679 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0059 0.0088
Echinococcus multilocularis hypothetical protein 0.0749 0.3283 0.4915
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0007 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0059 0.0059
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0056 0.0084
Loa Loa (eye worm) hypothetical protein 0.005 0.0185 0.0185
Brugia malayi hypothetical protein 0.0239 0.102 0.102
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0007 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0059 0.0059
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0166 0.0249
Onchocerca volvulus 0.0022 0.0059 0.3301
Schistosoma mansoni nephrin 0.0015 0.0026 0.0026
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0755 0.3308 0.4952
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0032
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.102 0.1527
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0059 0.3301
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0041 0.0184
Brugia malayi ecdysone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0059 0.0059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0185 0.0185
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0021 0.0056 0.5
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0056 0.0084
Brugia malayi DKFZp564C0469 protein 0.0021 0.0056 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0068 1
Treponema pallidum DNA ligase (lig) 0.0021 0.0056 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0166 0.0166
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0059 0.0059
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0059
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0056 0.00000012515
Brugia malayi nuclear receptor NHR-88 0.0022 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0059 0.0059
Chlamydia trachomatis DNA ligase 0.0021 0.0056 1
Brugia malayi nuclear hormone receptor 0.0022 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0272 0.0272
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0059 0.0088
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0048
Loa Loa (eye worm) DR-78 0.001 0.0007 0.0007
Brugia malayi hypothetical protein 0.0012 0.0013 0.0013
Brugia malayi nuclear hormone receptor 0.001 0.0007 0.0007
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0013 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0272 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0068 0.1321
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0272 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0059 0.0059
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0007 0.0011
Onchocerca volvulus 0.0024 0.0068 0.3817
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0056 0.0000057527
Echinococcus multilocularis Immunoglobulin 0.0012 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0749 0.3283 0.3283
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0166 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0059 0.0059
Brugia malayi nuclear receptor RXR 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Trypanosoma cruzi FHA domain containing protein, putative 0.0021 0.0056 0.5
Schistosoma mansoni cell adhesion molecule 0.0012 0.0013 0.0013

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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