Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0158 | 0.1644 | 0.2199 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0295 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0259 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0269 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0269 | 0.4168 | 0.5576 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1592 | 0.0823 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0223 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0223 | 0.3131 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0278 | 0.4361 | 0.581 |
Mycobacterium ulcerans | thioesterase TesA | 0.0231 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0227 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0184 | 0.2228 | 0.2981 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.05 | 0.9416 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0295 | 0.4752 | 0.6357 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.018 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | thioesterase | 0.0231 | 0.3311 | 0.443 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0278 | 0.4361 | 0.4361 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0278 | 0.4361 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0112 | 0.061 | 0.0817 |
Loa Loa (eye worm) | fatty acid synthase | 0.0274 | 0.4277 | 0.4318 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0198 | 0.2547 | 0.3708 |
Brugia malayi | AMP-binding enzyme family protein | 0.0259 | 0.3948 | 0.3948 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0087 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0199 | 0.2588 | 0.3461 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0184 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0278 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | hypothetical protein | 0.0466 | 0.8643 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0295 | 0.4752 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase | 0.0295 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0295 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0259 | 0.3948 | 0.3889 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0087 | 0.0042 | 0.0056 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0184 | 0.2228 | 0.2941 |
Onchocerca volvulus | 0.0483 | 0.9025 | 0.9285 | |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0295 | 0.4752 | 0.6337 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0415 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0415 | 0.7476 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0295 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0231 | 0.3311 | 0.443 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0415 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0223 | 0.3131 | 0.4155 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0095 | 0.0229 | 0.0306 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0278 | 0.4361 | 0.5834 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0231 | 0.3311 | 0.4398 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0415 | 0.7476 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.