Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.008 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0072 | 0.8758 | 0.8758 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.8758 | 0.8758 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.8758 | 0.8758 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.008 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.8758 | 0.8758 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.008 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.008 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.8758 | 0.8758 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.008 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.008 | 1 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.008 | 1 | 0.5 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.008 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.8758 | 0.8758 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.008 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.8758 | 0.8758 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.8758 | 0.8758 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.8758 | 0.8758 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.8758 | 0.8758 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.008 | 1 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.008 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.8758 | 0.8758 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.8758 | 0.8758 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.008 | 1 | 0.5 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.008 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.8758 | 0.8758 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.008 | 1 | 1 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.008 | 1 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.008 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 43 % | Inhibition at 50 uM on cAMP production induced by 50 uM 5`-(N-ethylcarboxamido)adenosine in CHO cell line transfected with human Adenosine A2B receptor cDNA | ChEMBL. | 9667972 |
Inhibition (binding) | = 43 % | Inhibition at 50 uM on cAMP production induced by 50 uM 5`-(N-ethylcarboxamido)adenosine in CHO cell line transfected with human Adenosine A2B receptor cDNA | ChEMBL. | 9667972 |
Ki (binding) | = 23.6 nM | Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligand | ChEMBL. | 9667972 |
Ki (binding) | = 23.6 nM | Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligand | ChEMBL. | 9667972 |
Ki (binding) | = 28.3 nM | Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680 | ChEMBL. | 9667972 |
Ki (binding) | = 28.3 nM | Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680 | ChEMBL. | 9667972 |
Ki (binding) | = 45.2 nM | Binding affinity was determined in radioligand binding assay at rat brain adenosine A1 receptor vs [3H]-R-PIA | ChEMBL. | 9667972 |
Ki (binding) | = 45.2 nM | Binding affinity was determined in radioligand binding assay at rat brain adenosine A1 receptor vs [3H]-R-PIA | ChEMBL. | 9667972 |
Selectivity ratio (binding) | = 1.6 | Ratio against rat A2A receptor and Human A3 receptor | ChEMBL. | 9667972 |
Selectivity ratio (binding) | = 1.9 | Ratio against rat A1 receptor and Human A3 receptor | ChEMBL. | 9667972 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.