TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.447 | Formula: C20H27N3O3
H donors: 1 H acceptors: 2 LogP: 2.25 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N2CCCC2C(=O)N1CCCCNCC1CCc2c(O1)cccc2
InChi: 1S/C20H27N3O3/c24-19-17-7-5-13-22(17)20(25)23(19)12-4-3-11-21-14-16-10-9-15-6-1-2-8-18(15)26-16/h1-2,6,8,16-17,21H,3-5,7,9-14H2
InChiKey: IFSDSWUCBOYCCT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0158	0.3734	0.3724
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	orexin receptor type 2	0.0045	0.0986	0.4312
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.003	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	neuropeptide receptor	0.0045	0.0986	0.4312
Brugia malayi	lysyl-tRNA synthetase	0.0022	0.0414	0.1769
Brugia malayi	G protein-coupled receptor	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0014	0.0217	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0057	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0051	0.113	0.4953
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0057	0.0186
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0621	0.274
Echinococcus granulosus	ecdysone induced protein 78C	0.0009	0.01	0.0373
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.01	0.0373
Schistosoma mansoni	retinoic acid receptor RXR	0.0009	0.01	0.0373
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0712	0.3143
Echinococcus multilocularis	Mastin	0.0051	0.113	0.4953
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0057	0.0186
Mycobacterium ulcerans	hypothetical protein	0.0051	0.113	1
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0029	0.0597	0.2583
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0009	0.01	0.0373
Trichomonas vaginalis	CAMK family protein kinase	0.003	0.0611	0.2699
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0217	0.303
Brugia malayi	Dopamine receptor protein 2	0.0045	0.0986	0.4312
Echinococcus granulosus	Mastin	0.0051	0.113	0.4953
Chlamydia trachomatis	lysine--tRNA ligase	0.0022	0.0414	1
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Toxoplasma gondii	glycyl-tRNA synthetase	0.0005	0.0016	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Giardia lamblia	Sugar-proton symporter	0.0014	0.0217	0.346
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.003	0.0612	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0621	0.274
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Brugia malayi	Sugar transporter family protein	0.0014	0.0217	0.0894
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.0986	0.4312
Plasmodium falciparum	calcium-dependent protein kinase 1	0.003	0.0612	0.0597
Schistosoma mansoni	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0986	0.4312
Brugia malayi	Cam kinase protein 1	0.003	0.0611	0.2648
Echinococcus granulosus	G protein coupled receptor 139	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0139	0.0549
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0097	0.2266	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.0986	0.4312
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0158	0.3734	0.3724
Schistosoma mansoni	amine GPCR	0.0045	0.0986	0.4312
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0712	0.3143
Echinococcus granulosus	sex peptide receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.077	0.3355
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0044	0.0128
Onchocerca volvulus		0.0014	0.0217	0.1137
Schistosoma mansoni	coup transcription factor	0.0009	0.01	0.0373
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0007	0.0057	0.0253
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0022	0.0414	0.5783
Onchocerca volvulus		0.0014	0.0217	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0057	0.0186
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.003	0.0611	0.855
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.01	0.0373
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0057	0.0186
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.077	0.3355
Onchocerca volvulus		0.0051	0.113	1
Onchocerca volvulus		0.0014	0.0217	0.1137
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0007	0.0057	0.0186
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0217	0.0894
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0057	0.0186
Onchocerca volvulus		0.0045	0.0986	0.8601
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0217	0.6499
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Schistosoma mansoni	60S ribosomal protein L21	0.0006	0.0022	0.0027
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.0986	0.4312
Giardia lamblia	Prolyl-tRNA synthetase	0.0029	0.0597	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0029	0.0597	0.2634
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0012	0.0175	0.0709
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0022	0.0414	0.6932
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0057	0.0186
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0621	0.274
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.0986	0.4312
Brugia malayi	G protein-coupled receptor F59B2.13	0.0045	0.0986	0.4312
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.01	0.0373
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0007	0.0057	0.0186
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0611	0.2648
Plasmodium vivax	lysine--tRNA ligase, putative	0.0022	0.0414	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.0986	0.4312
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0009	0.01	0.0373
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0045	0.0986	0.4312
Brugia malayi	nuclear hormone receptor	0.0009	0.01	0.0373
Echinococcus multilocularis	enteropeptidase	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0014	0.0217	0.1137
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0139	0.0549
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.01	0.0373
Echinococcus granulosus	General substrate transporter	0.0084	0.193	0.851
Brugia malayi	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0611	0.2648
Plasmodium falciparum	protein kinase 7	0.0275	0.6617	0.6612
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	serotonin receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	hypothetical protein	0.0097	0.2266	1
Brugia malayi	putative neuropeptide receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0597	0.2583
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0986	0.4312
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0286	0.3994
Chlamydia trachomatis	proline--tRNA ligase	0.001	0.0134	0.2978
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0018	0.0333	1
Onchocerca volvulus		0.0045	0.0986	0.8601
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.003	0.0612	0.0925
Echinococcus multilocularis	FTZ F1 alpha	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Brugia malayi	G-protein coupled receptor	0.0045	0.0986	0.4312
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0034	0.0715	1
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0217	0.1918
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0022	0.0414	0.5783
Plasmodium falciparum	cGMP-dependent protein kinase	0.0007	0.0044	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	amine GPCR	0.0045	0.0986	0.4312
Plasmodium falciparum	lysine--tRNA ligase	0.0022	0.0414	0.0399
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0045	0.0986	0.4312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Trypanosoma brucei	THT1 - hexose transporter, putative	0.003	0.0621	0.868
Brugia malayi	Serotonin receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0045	0.0986	0.8601
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.01	0.0373
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0097	0.2266	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0034	0.0715	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0045	0.0986	0.4312
Loa Loa (eye worm)	steroid hormone receptor	0.0009	0.01	0.0373
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0005	0.0016	0.0218
Onchocerca volvulus		0.0051	0.113	1
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.2266	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0007	0.0057	0.0253
Brugia malayi	neuropeptide F receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	sugar transporter	0.0097	0.2266	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	dro:myosuppressin receptor	0.0045	0.0986	0.4312
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0852	0.3718
Trichomonas vaginalis	glucose transporter, putative	0.003	0.0621	0.274
Brugia malayi	Steroid receptor seven-up type 2	0.0009	0.01	0.0373
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.003	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Brugia malayi	nuclear receptor NHR-88	0.0009	0.01	0.0373
Onchocerca volvulus		0.0045	0.0986	0.8601
Echinococcus multilocularis	neuropeptide s receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Echinococcus multilocularis	neuropeptide receptor A26	0.0045	0.0986	0.4312
Schistosoma mansoni	amine GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0894
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0009	0.01	0.0373
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.01	0.0373
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0045	0.0986	0.4312
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0217	0.0327
Plasmodium falciparum	proline--tRNA ligase	0.0034	0.0715	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0045	0.0986	0.4312
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0986	0.4312
Trypanosoma brucei	THT1 - hexose transporter, putative	0.003	0.0621	0.868
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0009	0.01	0.0373
Leishmania major	glucose transporter/membrane transporter D2, putative	0.003	0.0621	0.868
Entamoeba histolytica	protein kinase, putative	0.003	0.0611	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.0986	0.4312
Plasmodium falciparum	calcium-dependent protein kinase 5	0.003	0.0612	0.0597
Leishmania major	glucose transporter, lmgt2	0.003	0.0621	0.868
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0045	0.0986	0.4312
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0217	0.0201
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0034	0.0715	0.1081
Schistosoma mansoni	glucose transport protein	0.0097	0.2266	1
Onchocerca volvulus		0.0014	0.0217	0.1137
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	lysyl tRNA synthetase	0.0022	0.0414	0.1769
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0009	0.01	0.0373
Onchocerca volvulus		0.0045	0.0986	0.8601
Plasmodium falciparum	calcium-dependent protein kinase 4	0.003	0.0612	0.0597
Onchocerca volvulus		0.0051	0.113	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Brugia malayi	Melatonin receptor type 1A	0.0045	0.0986	0.4312
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0007	0.0044	0.0128
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0045	0.0986	0.4312
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.077	0.3355
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0097	0.2266	1
Schistosoma mansoni	glucose transport protein	0.0097	0.2266	1
Brugia malayi	Trypsin-like protease protein 5	0.0051	0.113	0.4953
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Schistosoma mansoni	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0014	0.0217	0.1137
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0029	0.0597	0.2583
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0051	0.113	0.4953
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0097	0.2266	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0217	0.0894
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0057	0.0186
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0044	0.0128
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	serine/threonine protein kinase	0.003	0.0611	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Onchocerca volvulus		0.0045	0.0986	0.8601
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0139	0.0549
Echinococcus multilocularis	somatostatin receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	glucose transport protein	0.0097	0.2266	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0045	0.0986	0.4312
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.003	0.0611	0.2648
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0051	0.113	0.4953
Schistosoma mansoni	protein kinase	0.003	0.0611	0.2648
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0217	0.0894
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0045	0.0986	0.4312
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0045	0.0986	0.8601
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.003	0.0611	0.2648
Trypanosoma brucei	THT1 - hexose transporter, putative	0.003	0.0621	0.868
Schistosoma mansoni	amine GPCR	0.0045	0.0986	0.4312
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0986	0.4312
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0007	0.0044	0.0067
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0009	0.01	0.0373
Echinococcus granulosus	7TM GPCR rhodopsin	0.0045	0.0986	0.4312
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Entamoeba histolytica	protein kinase, putative	0.003	0.0611	1
Schistosoma mansoni	protein kinase	0.003	0.0611	0.2648
Echinococcus granulosus	calcium dependent protein kinase	0.0028	0.0566	0.2448
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	calcium dependent protein kinase	0.0028	0.0566	0.2448
Schistosoma mansoni	adenoreceptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0986	0.4312
Trypanosoma cruzi	hexose transporter, putative	0.003	0.0621	0.868
Onchocerca volvulus		0.0045	0.0986	0.8601
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0051	0.113	0.4953
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0139	0.0549
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0621	0.274
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0139	0.0549
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0029	0.0597	0.2583
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0217	0.0894
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0044	0.0128
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0022	0.0414	0.366
Schistosoma mansoni	sugar transporter	0.0014	0.0217	0.0894
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0029	0.0597	0.2583
Echinococcus multilocularis	allatostatin A receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0019	0.0348	0.1536
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0007	0.0044	0.0128
Onchocerca volvulus		0.0045	0.0986	0.8601
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	serotonin receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	g-protein coupled receptor	0.0045	0.0986	0.4312
Brugia malayi	AKH receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	voltage-gated potassium channel	0.0007	0.0057	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0022	0.0414	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Leishmania major	glucose transporter, lmgt3	0.003	0.0621	0.868
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0045	0.0986	0.4312
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.003	0.0611	0.2648
Brugia malayi	larval opioid receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	myosin xvIII	0.0045	0.0986	0.4312
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0009	0.01	0.0373
Mycobacterium ulcerans	sugar transporter	0.0014	0.0217	0.1918
Leishmania major	hypothetical protein, conserved	0.0014	0.0217	0.303
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0045	0.0986	0.4312
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0009	0.01	0.0373
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0139	0.0549
Trypanosoma cruzi	hexose transporter, putative	0.003	0.0621	0.868
Onchocerca volvulus		0.0014	0.0217	0.1137
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0045	0.0986	0.4312
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0045	0.0986	0.4312
Schistosoma mansoni	opsin-like receptor	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0045	0.0986	0.8601
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0217	0.1918
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	TYRA-2 protein	0.0045	0.0986	0.4312
Brugia malayi	hypothetical protein	0.0051	0.113	0.4953
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0217	0.303
Echinococcus granulosus	dro:myosuppressin receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953
Echinococcus multilocularis	G protein coupled receptor 139	0.0045	0.0986	0.4312
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0852	0.3718
Echinococcus granulosus	enteropeptidase	0.0051	0.113	0.4953
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.0986	0.4312
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0045	0.0986	0.4312
Brugia malayi	steroid hormone receptor	0.0009	0.01	0.0373
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0986	0.4312
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0009	0.01	0.0373
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Plasmodium vivax	hexose transporter	0.0097	0.2266	0.2253
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0014	0.0217	0.1137
Brugia malayi	Trypsin family protein	0.0051	0.113	0.4953
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0986	0.4312
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0045	0.0986	0.8601
Echinococcus granulosus	neuropeptide s receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.003	0.0611	0.2648
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0009	0.01	0.0373
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Brugia malayi	sulfakinin receptor protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0217	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Plasmodium falciparum	hexose transporter	0.0097	0.2266	0.2253
Trichomonas vaginalis	glucose transporter, putative	0.003	0.0621	0.274
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0014	0.0217	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.01	0.0373
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0029	0.0597	0.9752
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	growth hormone secretagogue receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	orexin receptor type 2	0.0045	0.0986	0.4312
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0051	0.113	0.4953
Brugia malayi	Trypsin family protein	0.0051	0.113	0.4953
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.01	0.0373
Brugia malayi	Dopamine receptor	0.0045	0.0986	0.4312
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0158	0.3734	0.5643
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0057	0.0186
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0005	0.0016	0.0024
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0217	0.0327
Echinococcus granulosus	glycoprotein Antigen 5	0.0051	0.113	0.4953
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0217	0.303
Schistosoma mansoni	lysyl-tRNA synthetase	0.0022	0.0414	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0414	0.1769
Onchocerca volvulus		0.0045	0.0986	0.8601
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0007	0.0044	0.0128
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0045	0.0986	0.4312
Brugia malayi	GnHR receptor homolog	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0009	0.01	0.0373
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Giardia lamblia	Hexose transporter	0.0014	0.0217	0.346
Brugia malayi	G-protein coupled receptor	0.0045	0.0986	0.4312
Leishmania major	threonyl-tRNA synthetase, putative	0.0005	0.0016	0.0218
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0009	0.01	0.0373
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0057	0.0186
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0034	0.0715	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0007	0.0044	0.0128
Brugia malayi	major facilitator superfamily protein	0.0014	0.0217	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.003	0.0612	0.0925
Brugia malayi	Egg laying defective protein 4	0.0007	0.0044	0.0128
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0045	0.0986	0.4312
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.001	0.0134	0.1187
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0009	0.01	0.0373
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Loa Loa (eye worm)	trypsin family protein	0.0051	0.113	0.4953
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0045	0.0986	0.4312
Toxoplasma gondii	lysine-tRNA ligase	0.0022	0.0414	0.0625
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0653	0.2833
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.003	0.0612	0.0597
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0018	0.0333	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0009	0.01	0.0373
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0034	0.0715	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.0986	0.4312
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Brugia malayi	hypothetical protein	0.0014	0.0217	0.0894
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0005	0.0016	0.0218
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0045	0.0986	0.8601
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Schistosoma mansoni	neuropeptide f receptor 76f	0.0045	0.0986	0.4312
Schistosoma mansoni	hypothetical protein	0.0051	0.113	0.4953
Trypanosoma cruzi	hexose transporter, putative	0.003	0.0621	0.868
Echinococcus granulosus	fmrfamide receptor	0.0045	0.0986	0.4312
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.0986	0.4312
Leishmania major	lysyl-tRNA synthetase, putative	0.0022	0.0414	0.5783
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0029	0.0597	0.2583
Echinococcus granulosus	solute carrier family 22	0.0014	0.0217	0.0894
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0045	0.0986	0.4312
Leishmania major	protein kinase, putative	0.0007	0.0044	0.0622
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0986	0.4312
Leishmania major	protein kinase, putative	0.003	0.0611	0.855
Onchocerca volvulus		0.0045	0.0986	0.8601
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0057	0.0186
Schistosoma mansoni	hypothetical protein	0.0051	0.113	0.4953
Leishmania major	glucose transporter, lmgt1	0.003	0.0621	0.868
Echinococcus granulosus	FTZ F1 alpha	0.0009	0.01	0.0373
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0217	0.1918
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	sex peptide receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0009	0.01	0.0373
Onchocerca volvulus		0.0014	0.0217	0.1137
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.003	0.0611	0.2648
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0986	0.4312
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	cGMP dependent protein kinase	0.0007	0.0044	0.0128
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0005	0.0016	0.0069
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0057	0.0186
Toxoplasma gondii	facilitative glucose transporter GT1	0.0097	0.2266	0.3424
Plasmodium falciparum	calcium-dependent protein kinase 2	0.003	0.0612	0.0597
Onchocerca volvulus		0.0014	0.0217	0.1137
Echinococcus granulosus	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0097	0.2266	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0007	0.0044	0.0128
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0217	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.01	0.0373
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Trypanosoma cruzi	hexose transporter	0.003	0.0621	0.868
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.077	0.3355
Trypanosoma brucei	glucose transporter 1E	0.003	0.0621	0.868
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0005	0.0009	0.0122
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.01	0.0373
Echinococcus granulosus	neuropeptide receptor A26	0.0045	0.0986	0.4312
Trypanosoma brucei	glucose transporter 2A	0.003	0.0621	0.868
Brugia malayi	ORL1-like opioid receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Plasmodium falciparum	calcium-dependent protein kinase 3	0.003	0.0612	0.0597
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0045	0.0986	0.8601
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0045	0.0986	0.8601
Schistosoma mansoni	histamine h1 receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	glycoprotein Antigen 5	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Leishmania major	protein kinase, putative	0.0007	0.0044	0.0622
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0045	0.0986	0.8601
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0029	0.0597	1
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0057	0.0186
Brugia malayi	photoreceptor-specific nuclear receptor	0.0009	0.01	0.0373
Schistosoma mansoni	amine GPCR	0.0045	0.0986	0.4312
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0009	0.01	0.0373
Echinococcus granulosus	transmembrane protease serine 3	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0097	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Schistosoma mansoni	protein kinase	0.003	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Plasmodium vivax	calcium-dependent protein kinase, putative	0.003	0.0612	0.0597
Brugia malayi	Sugar transporter family protein	0.0014	0.0217	0.0894
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0005	0.0016	0.0138
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0009	0.01	0.0373
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0986	0.4312
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.003	0.0612	0.0597
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0005	0.0016	0.0218
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	neuropeptide receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0007	0.0057	0.0186
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0139	0.0549
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0045	0.0986	0.4312
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0018	0.0333	0.5587
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0051	0.113	0.4953
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0045	0.0986	0.4312
Entamoeba histolytica	hypothetical protein	0.0022	0.0414	0.6679
Brugia malayi	Trypsin family protein	0.0051	0.113	0.4953
Trichomonas vaginalis	sugar transporter, putative	0.003	0.0621	0.274
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0022	0.0414	0.366
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0097	0.2266	1
Onchocerca volvulus		0.0051	0.113	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0217	0.0956
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0034	0.0715	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0009	0.01	0.0373
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0057	0.0186
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0009	0.01	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0051	0.113	0.4953
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Schistosoma mansoni	opsin-like receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	glucose transporter	0.0014	0.0217	0.0894
Onchocerca volvulus		0.0014	0.0217	0.1137
Schistosoma mansoni	opsin-like receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0009	0.01	0.0373
Plasmodium vivax	proline--tRNA ligase, putative	0.0034	0.0715	0.0701
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0005	0.0016	0.0468
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0045	0.0986	0.4312
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0045	0.0986	0.4312
Echinococcus multilocularis	serotonin receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	somatostatin receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0051	0.113	0.4953
Toxoplasma gondii	protein kinase, putative	0.0275	0.6617	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0097	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Brugia malayi	Trypsin family protein	0.0051	0.113	0.4953
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Echinococcus granulosus	lysyl tRNA synthetase	0.0022	0.0414	0.1769
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0217	0.6499
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.003	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0051	0.113	0.4953
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Brugia malayi	follicle stimulating hormone receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0007	0.0057	0.0186
Brugia malayi	major facilitator superfamily protein	0.0014	0.0217	0.0894
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0005	0.0016	0.0138
Onchocerca volvulus	Putative transporter	0.0014	0.0217	0.1137
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0029	0.0597	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Brugia malayi	neuropeptide F receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	sugar transporter	0.0014	0.0217	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0463	0.1987
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	ecdysone induced protein 78C	0.0009	0.01	0.0373
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0414	0.1826
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0986	0.4312
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0009	0.01	0.0373
Trypanosoma brucei	glucose transporter, putative	0.003	0.0621	0.868
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0217	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.01	0.0373
Brugia malayi	ecdysteroid receptor	0.0009	0.01	0.0373
Schistosoma mansoni	hypothetical protein	0.0045	0.0986	0.4312
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.01	0.0373
Brugia malayi	Dopamine receptor protein 1	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0597	0.2583
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0005	0.0016	0.0262
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0986	0.4312
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0005	0.0016	0.0218
Schistosoma mansoni	cercarial elastase (S01 family)	0.0051	0.113	0.4953
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0986	0.4312
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0045	0.0986	0.4312
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0045	0.0986	0.4312
Plasmodium vivax	sugar transporter, putative	0.0014	0.0217	0.0201
Echinococcus granulosus	neuropeptide FF receptor 2	0.0045	0.0986	0.4312
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Treponema pallidum	prolyl-tRNA synthetase	0.001	0.0134	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0045	0.0986	0.4312
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.0986	0.4312
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Brugia malayi	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0014	0.0217	0.1137
Loa Loa (eye worm)	melatonin receptor type 1A	0.0045	0.0986	0.4312
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0057	0.0186
Brugia malayi	Sugar transporter family protein	0.0097	0.2266	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0217	0.0894
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.003	0.0611	0.2648
Onchocerca volvulus		0.0045	0.0986	0.8601
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0986	0.4312
Echinococcus granulosus	allatostatin A receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953
Brugia malayi	Serotonin receptor	0.0045	0.0986	0.4312
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0051	0.113	0.4953
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0894
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0986	0.4312
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.0986	0.4312
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0045	0.0986	0.4312
Schistosoma mansoni	hypothetical protein	0.0045	0.0986	0.4312
Schistosoma mansoni	voltage-gated potassium channel	0.0006	0.0022	0.0027
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0139	0.0549
Onchocerca volvulus		0.0051	0.113	1
Echinococcus multilocularis	expressed conserved protein	0.0007	0.0044	0.0128
Onchocerca volvulus		0.0051	0.113	1
Brugia malayi	RE15519p	0.0045	0.0986	0.4312
Giardia lamblia	Lysyl-tRNA synthetase	0.0022	0.0414	0.6849
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0009	0.01	0.0373
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0217	0.0956
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0009	0.01	0.0373
Brugia malayi	putative neuropeptide receptor NPR1	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0014	0.0217	0.1137
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0057	0.0186
Brugia malayi	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	transmembrane protease serine 3	0.0051	0.113	0.4953
Onchocerca volvulus		0.0014	0.0217	0.1137
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	g-protein coupled receptor	0.0045	0.0986	0.4312
Onchocerca volvulus		0.0045	0.0986	0.8601
Echinococcus granulosus	7tm_1 domain containing protein	0.0045	0.0986	0.4312
Echinococcus multilocularis	General substrate transporter	0.0084	0.193	0.851
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0009	0.01	0.0373
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.003	0.0612	0.0925
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0051	0.113	0.4953

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1962486

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1620477