Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0019 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0019 | 0.0028 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.206 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0074 | 0.0047 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0074 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.206 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0156 | 0.0695 | 0.0027 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0019 | 0.0028 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0019 | 0.0028 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0019 | 0.0028 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0019 | 0.0028 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0027 | 0.0066 | 0.0038 |
Echinococcus granulosus | twitchin | 0.0038 | 0.0116 | 0.0089 |
Schistosoma mansoni | kinase | 0.2004 | 0.9727 | 0.9726 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0027 | 0.0066 | 0.0038 |
Echinococcus multilocularis | roundabout 2 | 0.0033 | 0.0095 | 0.0067 |
Echinococcus granulosus | defective proboscis extension response | 0.0027 | 0.0066 | 0.0038 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0184 | 0.0831 | 0.0806 |
Trypanosoma brucei | polo-like protein kinase | 0.206 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0029 | 0.0074 | 0.0074 |
Echinococcus granulosus | neuroglian | 0.003 | 0.0078 | 0.0051 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.206 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0029 | 0.0074 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0082 | 0.0082 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0027 | 0.0066 | 0.0038 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0019 | 0.0028 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.003 | 0.0078 | 0.0051 |
Echinococcus granulosus | roundabout 2 | 0.0033 | 0.0095 | 0.0067 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0797 | 0.383 | 0.3813 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0019 | 0.0028 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0029 | 0.0074 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0047 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0019 | 0.0028 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0047 |
Brugia malayi | Cytochrome P450 family protein | 0.0061 | 0.0232 | 0.0204 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0061 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | cytochrome P450 | 0.0019 | 0.0028 | 0.0028 |
Trypanosoma brucei | cytochrome P450, putative | 0.0029 | 0.0074 | 0.0047 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0.0028 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0019 | 0.0028 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.206 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.206 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.206 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0019 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Echinococcus multilocularis | Immunoglobulin | 0.0027 | 0.0066 | 0.0038 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0027 | 0.0066 | 0.0038 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0027 | 0.0066 | 0.0038 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.003 | 0.0082 | 0.0054 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | nephrin | 0.003 | 0.0078 | 0.0051 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0019 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0095 | 0.0095 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0019 | 0.0028 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0027 | 0.0066 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0066 | 0.0038 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.206 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0019 | 0.0028 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.206 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0184 | 0.0831 | 0.0831 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0027 | 0.0066 | 0.0038 |
Schistosoma mansoni | cell adhesion molecule | 0.003 | 0.0082 | 0.0054 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0019 | 0.0028 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.206 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0.0028 | 0.5 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0797 | 0.383 | 0.3813 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0019 | 0.0028 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0027 | 0.0066 | 0.0038 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0019 | 0.0028 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.206 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0095 | 0.0095 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.206 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0074 | 0.0047 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 14.7 uM | Inhibitory concentration of the compound required to inhibit murine leukemia L1210 cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 14.7 uM | Inhibitory concentration of the compound required to inhibit human T-lymphoblast Molt4 cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 14.7 uM | Antiproliferative activity against mouse L1210 cells | ChEMBL. | 17081759 |
IC50 (functional) | = 14.7 uM | Antiproliferative activity against human Molt/4 cells | ChEMBL. | 17081759 |
IC50 (functional) | = 15.9 uM | Inhibitory concentration of the compound required to inhibit human T-lymphoblast CEM cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 15.9 uM | Antiproliferative activity against human CEM cells | ChEMBL. | 17081759 |
IC50 (functional) | = 49 uM | Inhibitory concentration of the compound required to inhibit murine mammary carcinoma FM3A cells proliferation | ChEMBL. | 15139766 |
IC50 (functional) | = 49 uM | Antiproliferative activity against mouse FM3A cells | ChEMBL. | 17081759 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.