Detailed information for compound 162655

Basic information

Technical information
  • TDR Targets ID: 162655
  • Name: (2R,3R,4S,5R)-2-(4-chloro-5-iodopyrrolo[2,3-d ]pyrimidin-7-yl)-5-(methoxymethyl)oxolane-3,4 -diol
  • MW: 425.607 | Formula: C12H13ClIN3O4
  • H donors: 2 H acceptors: 4 LogP: 0.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2Cl)I
  • InChi: 1S/C12H13ClIN3O4/c1-20-3-6-8(18)9(19)12(21-6)17-2-5(14)7-10(13)15-4-16-11(7)17/h2,4,6,8-9,12,18-19H,3H2,1H3/t6-,8-,9-,12-/m1/s1
  • InChiKey: ARLVVNDAGKSXKV-WOUKDFQISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R,4S,5R)-2-(4-chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(methoxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-chloro-5-iodo-7-pyrrolo[2,3-d]pyrimidinyl)-5-(methoxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(methoxymethyl)oxolane-3,4-diol
  • (2R,3R,4S,5R)-2-(4-chloro-5-iodopyrrolo[3,2-e]pyrimidin-7-yl)-5-(methoxymethyl)oxolane-3,4-diol
  • (2R,3R,4S,5R)-2-(4-chloro-5-iodo-pyrrolo[3,2-e]pyrimidin-7-yl)-5-(methoxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-chloro-5-iodo-7-pyrrolo[3,2-e]pyrimidinyl)-5-(methoxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-chloro-5-iodo-pyrrolo[3,2-e]pyrimidin-7-yl)-5-(methoxymethyl)oxolane-3,4-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania braziliensis adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Cryptosporidium parvum adenosine kinase like ribokinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania infantum adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma japonicum ko:K00856 adenosine kinase [EC2.7.1.20], putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania mexicana adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus multilocularis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Onchocerca volvulus Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Neospora caninum GG10762, related Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans putative adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Brugia malayi Adenosine kinase-like Get druggable targets OG5_128398 All targets in OG5_128398
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania major adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma congolense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Babesia bovis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus granulosus adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Toxoplasma gondii kinase, pfkB family protein Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania donovani adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi adenosine kinase, putative adenosine kinase 345 aa 337 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta tubulin 0.1454 0.5544 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0184 0.0603 0.1088
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis neuropeptide FF receptor 2 0.124 0.4714 0.8502
Loa Loa (eye worm) beta-tubulin 0.1454 0.5544 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.014 0.0221
Echinococcus multilocularis c src tyrosine kinase 0.0057 0.011 0.0198
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0794 0.2977 0.5369
Brugia malayi Tubulin beta-1 chain 0.1454 0.5544 0.5544
Onchocerca volvulus 0.0794 0.2977 0.6507
Brugia malayi celfurPC protein 0.0115 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0018
Onchocerca volvulus 0.0251 0.0862 0.1869
Brugia malayi endoprotease bli-4 precursor 0.0142 0.0441 0.0441
Echinococcus granulosus dnaJ subfamily B 0.1254 0.4768 0.86
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0064
Schistosoma mansoni hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0026 0.0047
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus multilocularis Tubulin beta 2C chain 0.1454 0.5544 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0794 0.2977 0.5369
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0224 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0087 0.0224 0.0404
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0016 0.0029
Schistosoma mansoni biogenic amine receptor 0.0794 0.2977 0.5369
Trichomonas vaginalis tubulin alpha chain, putative 0.1454 0.5544 1
Brugia malayi G-protein coupled receptor 0.0794 0.2977 0.2977
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0098 0.0176
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Loa Loa (eye worm) G-protein coupled receptor 0.0794 0.2977 0.5369
Trypanosoma brucei beta tubulin 0.1454 0.5544 1
Loa Loa (eye worm) BEN-1 protein 0.1454 0.5544 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.01 0.018
Echinococcus multilocularis serotonin receptor 0.0794 0.2977 0.5369
Brugia malayi polk-prov protein 0.004 0.0043 0.0043
Echinococcus multilocularis neuropeptide s receptor 0.0794 0.2977 0.5369
Brugia malayi beta-lactamase family protein 0.0038 0.0036 0.0036
Loa Loa (eye worm) TK/CSK protein kinase 0.0036 0.0026 0.0047
Echinococcus granulosus serotonin receptor 0.0794 0.2977 0.5369
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0794 0.2977 0.2977
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus biogenic amine 5HT receptor 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0794 0.2977 0.6507
Loa Loa (eye worm) neuropeptide F receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Brugia malayi Pre-SET motif family protein 0.0032 0.001 0.001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0794 0.2977 0.5369
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0036 0.0028 0.005
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Leishmania major beta tubulin 0.1454 0.5544 1
Echinococcus granulosus adenosine kinase 0.0105 0.0296 0.0535
Echinococcus granulosus furin 0.0142 0.0441 0.0796
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0794 0.2977 0.5369
Brugia malayi RE15519p 0.0794 0.2977 0.2977
Echinococcus multilocularis tar DNA binding protein 0.0054 0.0098 0.0176
Echinococcus granulosus tubulin beta 4A class IVa 0.1454 0.5544 1
Echinococcus granulosus c src tyrosine kinase 0.0057 0.011 0.0198
Toxoplasma gondii ABC1 family protein 0.0038 0.0036 0.0046
Brugia malayi beta-lactamase family protein 0.0038 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0036 0.0014
Echinococcus multilocularis 0.0115 0.0334 0.0603
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0123 0.1186
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0794 0.2977 0.6507
Brugia malayi Dopamine receptor protein 2 0.0794 0.2977 0.2977
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0036 0.0095
Giardia lamblia Beta tubulin 0.1454 0.5544 1
Echinococcus multilocularis fmrfamide receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.004 0.0043 0.0078
Onchocerca volvulus 0.0047 0.0068 0.0128
Leishmania major beta tubulin 0.1454 0.5544 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.001 0.0018
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0054 0.0097 0.0176
Brugia malayi Pre-SET motif family protein 0.022 0.0744 0.0744
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0219 0.0395
Loa Loa (eye worm) G-protein coupled receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Schistosoma mansoni opsin-like receptor 0.0794 0.2977 0.5369
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0091 0.0243 0.0243
Echinococcus multilocularis g protein coupled receptor 0.0794 0.2977 0.5369
Schistosoma mansoni opsin-like receptor 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0038 0.0036 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.014 0.0231
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0353 0.0636
Loa Loa (eye worm) SH2 domain-containing protein 0.0043 0.0057 0.0102
Brugia malayi protein-tyrosine kinase 0.0044 0.0058 0.0058
Echinococcus granulosus neuropeptide Y receptor 0.0794 0.2977 0.5369
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0123 0.1736
Leishmania major beta tubulin 0.1454 0.5544 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.0398 0.0398
Loa Loa (eye worm) tubulin beta-4 chain 0.1454 0.5544 1
Brugia malayi SRC-1 0.0055 0.01 0.01
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis Tubulin beta 2C chain 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase Abl 0.0106 0.0299 0.0539
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0794 0.2977 0.6507
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0047 0.0084
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0794 0.2977 0.2977
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0794 0.2977 0.2977
Mycobacterium tuberculosis Conserved protein 0.0038 0.0036 0.0095
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0794 0.2977 0.5369
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0098 0.0176
Schistosoma mansoni adenoreceptor 0.0794 0.2977 0.5369
Echinococcus granulosus alpha 1A adrenergic receptor 0.0794 0.2977 0.5369
Trypanosoma brucei beta tubulin 0.1454 0.5544 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0219 0.0395
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.014 0.0231
Trypanosoma cruzi calpain cysteine peptidase, putative 0.011 0.0316 0.0522
Echinococcus multilocularis allatostatin A receptor 0.1203 0.4569 0.8241
Leishmania major beta tubulin 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0794 0.2977 0.5369
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0098 0.0176
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Plasmodium falciparum tubulin beta chain 0.1454 0.5544 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.001 0.0018
Trypanosoma brucei calpain-like protein, putative 0.011 0.0316 0.0549
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.0316 0.0522
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0142 0.0441 0.0796
Brugia malayi Tyrosine-protein kinase abl-1 0.0106 0.0299 0.0299
Echinococcus granulosus 7tm_1 domain containing protein 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi Calcitonin receptor-like protein seb-1 0.0091 0.0243 0.0243
Schistosoma mansoni opsin-like receptor 0.0794 0.2977 0.5369
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.0542 0.6378
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0794 0.2977 0.5369
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0054 0.0097 0.0176
Schistosoma mansoni amine GPCR 0.0794 0.2977 0.5369
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.014 0.0203
Echinococcus granulosus Tubulin beta 2C chain 0.1454 0.5544 1
Schistosoma mansoni neuropeptide F-like receptor 0.0794 0.2977 0.5369
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0224 0.0372
Echinococcus granulosus G protein coupled receptor 139 0.0794 0.2977 0.5369
Echinococcus granulosus neuropeptides capa receptor 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0062 0.009
Schistosoma mansoni hypothetical protein 0.1254 0.4768 0.86
Echinococcus multilocularis g-protein coupled receptor 0.0794 0.2977 0.5369
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0062 0.0062
Leishmania major DNA polymerase kappa, putative 0.0043 0.0056 0.005
Schistosoma mansoni neuropeptide receptor 0.0794 0.2977 0.5369
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0085 0.0219 0.0219
Leishmania major beta tubulin 0.1454 0.5544 1
Echinococcus granulosus dro:myosuppressin receptor 0.0794 0.2977 0.5369
Echinococcus granulosus rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Brugia malayi map kinase activated protein kinase protein 2 0.0184 0.0603 0.0603
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0036 0.0095
Mycobacterium tuberculosis Conserved protein 0.0038 0.0036 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0794 0.2977 0.5369
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0476 0.0812
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0036 0.5
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0098 0.0176
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.0316 0.0522
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0055 0.01 0.018
Echinococcus granulosus hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0794 0.2977 0.5369
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0123 0.0223
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0353 0.403
Onchocerca volvulus 0.0794 0.2977 0.6507
Giardia lamblia High cysteine membrane protein Group 2 0.0053 0.0093 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.113 0.1998
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0026 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0353 0.6262
Schistosoma mansoni hypothetical protein 0.0054 0.0097 0.0176
Trichomonas vaginalis esterase, putative 0.0038 0.0036 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0159 0.0287
Onchocerca volvulus 0.0153 0.0482 0.1035
Schistosoma mansoni tyrosine kinase 0.0055 0.01 0.018
Schistosoma mansoni apoptosis regulator bax 0.0054 0.0097 0.0176
Schistosoma mansoni hypothetical protein 0.0063 0.0131 0.0236
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.01 0.0131
Brugia malayi RNA binding protein 0.0054 0.0098 0.0098
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0794 0.2977 0.5369
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0036 0.0064
Schistosoma mansoni neuropeptide f receptor 76f 0.0794 0.2977 0.5369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0085 0.0219 0.0395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0085 0.0219 0.0395
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0316 0.0549
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0123 0.0223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.001 0.0018
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0058 0.0105
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0794 0.2977 0.2977
Loa Loa (eye worm) BEN-1 protein 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi follicle stimulating hormone receptor 0.0794 0.2977 0.2977
Echinococcus granulosus tyrosine protein kinase Lyn 0.0055 0.0101 0.0183
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0353 0.0636
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0036 0.0064
Trichomonas vaginalis tubulin gamma chain, putative 0.1454 0.5544 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis orexin receptor type 2 0.0794 0.2977 0.5369
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0159 0.0258
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0036 0.0064
Brugia malayi putative neuropeptide receptor 0.0794 0.2977 0.2977
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.014 0.0203
Schistosoma mansoni tubulin subunit beta 0.1454 0.5544 1
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.011 0.0316 0.0549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0085 0.0219 0.0395
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0056 0.0345
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0353 0.0636
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0159 0.0287
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.014 0.2064
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus Tubulin beta 2C chain 0.1454 0.5544 1
Echinococcus granulosus dna polymerase kappa 0.0065 0.014 0.0253
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0036 0.0064
Loa Loa (eye worm) TAR-binding protein 0.0054 0.0098 0.0176
Echinococcus granulosus Furin 1 0.0034 0.0018 0.0033
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Loa Loa (eye worm) TK protein kinase 0.0044 0.0058 0.0105
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0159 0.0238
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0123 0.0223
Loa Loa (eye worm) tubulin beta chain 0.1454 0.5544 1
Echinococcus multilocularis neuropeptide receptor 0.0794 0.2977 0.5369
Echinococcus granulosus tm gpcr rhodopsin 0.0794 0.2977 0.5369
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.0834 1
Brugia malayi G protein-coupled receptor 0.0794 0.2977 0.2977
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Echinococcus granulosus rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0064
Echinococcus multilocularis g protein coupled receptor 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0043 0.0056
Echinococcus granulosus g protein coupled receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0058 0.0105
Echinococcus multilocularis Tubulin beta 2C chain 0.1454 0.5544 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0054 0.0097 0.0176
Schistosoma mansoni amine GPCR 0.0794 0.2977 0.5369
Schistosoma mansoni biogenic amine receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Leishmania major beta tubulin 0.1454 0.5544 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0062 0.0062
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0353 0.0636
Schistosoma mansoni amine GPCR 0.0794 0.2977 0.5369
Brugia malayi putative neuropeptide receptor NPR1 0.0794 0.2977 0.2977
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi TAR-binding protein 0.0054 0.0098 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0054 0.0098 0.0176
Entamoeba histolytica tubulin family protein 0.1454 0.5544 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.1454 0.5544 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Echinococcus granulosus neuropeptide s receptor 0.0794 0.2977 0.5369
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0036 0.0031
Brugia malayi neuroendocrine convertase 1 precursor 0.0089 0.0235 0.0235
Echinococcus multilocularis tubulin subunit beta 0.1454 0.5544 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.0316 0.0522
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0353 0.6262
Echinococcus multilocularis neuroendocrine convertase 2 0.0089 0.0235 0.0425
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0064
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0055 0.01 0.018
Brugia malayi Dopamine receptor 0.0794 0.2977 0.2977
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0184 0.0603 0.1088
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0055 0.01 0.018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0056 0.005
Loa Loa (eye worm) endoprotease bli-4 0.0142 0.0441 0.0796
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.001 0.0018
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.113 0.2021
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0034 0.0018 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0085 0.0219 0.0395
Loa Loa (eye worm) TK/ABL protein kinase 0.0226 0.0768 0.1386
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0296 0.0514
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0123 0.0123
Onchocerca volvulus 0.0794 0.2977 0.6507
Brugia malayi proprotein convertase 2 0.0089 0.0235 0.0235
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Trypanosoma brucei beta tubulin 0.1454 0.5544 1
Leishmania major beta tubulin 0.1454 0.5544 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0676 0.2519 0.4543
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0085 0.0219 0.0395
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.01 0.018
Trichomonas vaginalis set domain proteins, putative 0.0251 0.0862 0.1527
Leishmania major beta tubulin 0.1454 0.5544 1
Leishmania major beta tubulin 0.1454 0.5544 1
Echinococcus multilocularis g protein coupled receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0159 0.0287
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.0316 0.0522
Echinococcus granulosus neuropeptide Y receptor 0.0794 0.2977 0.5369
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0794 0.2977 0.5369
Echinococcus granulosus sex peptide receptor 0.0794 0.2977 0.5369
Schistosoma mansoni amine GPCR 0.0794 0.2977 0.5369
Leishmania major adenosine kinase, putative 0.0105 0.0296 0.0487
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0159 0.0238
Giardia lamblia Beta tubulin 0.1454 0.5544 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0794 0.2977 0.5369
Schistosoma mansoni tyrosine kinase 0.0216 0.0726 0.131
Brugia malayi Tachykinin-like peptides receptor 99D 0.124 0.4714 0.4714
Schistosoma mansoni tubulin subunit beta 0.1454 0.5544 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.01 0.018
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0026 0.0047
Brugia malayi RNA recognition motif domain containing protein 0.0054 0.0098 0.0098
Leishmania major beta tubulin 0.1454 0.5544 1
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0296 0.0514
Echinococcus granulosus biogenic amine 5HT receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Schistosoma mansoni adenosine kinase 0.0105 0.0296 0.0535
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.011 0.0316 0.0522
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0056 0.0105 0.0189
Loa Loa (eye worm) melatonin receptor type 1A 0.0794 0.2977 0.5369
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0794 0.2977 0.5369
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0084 0.0215 0.0389
Brugia malayi Dopamine receptor protein 1 0.0794 0.2977 0.2977
Trypanosoma cruzi beta tubulin, putative 0.1454 0.5544 1
Echinococcus granulosus beta tubulin 0.1454 0.5544 1
Schistosoma mansoni histamine h1 receptor 0.0794 0.2977 0.5369
Echinococcus granulosus peptide allatostatin:somatostatin 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0142 0.0441 0.0796
Loa Loa (eye worm) hypothetical protein 0.124 0.4714 0.8502
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus multilocularis Tubulin beta 2C chain 0.1454 0.5544 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Schistosoma mansoni neuropeptide receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis adenosine kinase 0.0105 0.0296 0.0535
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0055 0.01 0.018
Schistosoma mansoni tubulin subunit beta 0.1454 0.5544 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.011 0.0316 0.0522
Schistosoma mansoni hypothetical protein 0.0794 0.2977 0.5369
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0316 0.0549
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0036 0.0028 0.005
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0296 0.0487
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0316 0.0549
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0159 0.0287
Echinococcus granulosus tyrosine kinase 0.0044 0.0058 0.0105
Echinococcus granulosus tachykinin peptides receptor 99D 0.0794 0.2977 0.5369
Echinococcus granulosus rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0038 0.0036 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0056 0.0079
Brugia malayi beta-tubulin, identical 0.1454 0.5544 0.5544
Schistosoma mansoni tubulin subunit beta 0.1454 0.5544 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.01 0.018
Echinococcus multilocularis dro:myosuppressin receptor 0.0794 0.2977 0.5369
Brugia malayi ORL1-like opioid receptor 0.0794 0.2977 0.2977
Brugia malayi G-protein coupled receptor 0.0794 0.2977 0.2977
Leishmania major beta tubulin 0.1454 0.5544 1
Trypanosoma brucei calpain, putative 0.011 0.0316 0.0549
Loa Loa (eye worm) neuropeptide F receptor 0.0794 0.2977 0.5369
Toxoplasma gondii hypothetical protein 0.0052 0.0088 0.014
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0028 0.0028
Schistosoma mansoni neuropeptide F-like receptor 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0794 0.2977 0.6507
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.014 0.2064
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0062 0.0062
Echinococcus granulosus tar DNA binding protein 0.0054 0.0098 0.0176
Echinococcus granulosus g protein coupled receptor 0.0794 0.2977 0.5369
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.0296 0.0517
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0794 0.2977 0.5369
Loa Loa (eye worm) proprotein convertase 2 0.0034 0.0018 0.0033
Leishmania major beta tubulin 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0064
Echinococcus granulosus neuroendocrine convertase 2 0.0089 0.0235 0.0425
Onchocerca volvulus Neuropeptide F receptor homolog 0.0794 0.2977 0.6507
Schistosoma mansoni DNA polymerase eta 0.0036 0.0028 0.005
Echinococcus granulosus neuropeptide receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) TYRA-2 protein 0.0794 0.2977 0.5369
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0794 0.2977 0.5369
Loa Loa (eye worm) tubulin beta-2A chain 0.1454 0.5544 1
Trypanosoma brucei DNA polymerase eta, putative 0.0036 0.0028 0.0029
Echinococcus granulosus allatostatin A receptor 0.1203 0.4569 0.8241
Echinococcus granulosus tyrosine protein kinase Src64B 0.0055 0.01 0.018
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.014 0.0221
Echinococcus multilocularis fmrfamide receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0744 0.1342
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.113 0.1998
Echinococcus multilocularis somatostatin receptor 0.0794 0.2977 0.5369
Leishmania major beta tubulin 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0036 0.0028 0.005
Echinococcus granulosus tyrosine protein kinase ABL1 0.0226 0.0768 0.1386
Echinococcus granulosus rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0091 0.0243 0.0439
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0316 0.0549
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0794 0.2977 0.5369
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0036 0.0095
Brugia malayi larval opioid receptor 0.0794 0.2977 0.2977
Mycobacterium ulcerans hypothetical protein 0.0168 0.0542 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0058 0.0105
Schistosoma mansoni terminal deoxycytidyl transferase 0.0036 0.0028 0.005
Echinococcus multilocularis Furin 1 0.0034 0.0018 0.0033
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0794 0.2977 0.5369
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0036 0.0095
Echinococcus multilocularis beta tubulin 0.1454 0.5544 1
Brugia malayi hypothetical protein 0.0153 0.0482 0.0482
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0036 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0036 0.0031
Echinococcus multilocularis serotonin receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0794 0.2977 0.5369
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0794 0.2977 0.5369
Loa Loa (eye worm) beta-lactamase 0.0038 0.0036 0.0064
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0055 0.01 0.018
Toxoplasma gondii beta tubulin 0.1454 0.5544 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.01 0.018
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Leishmania major beta tubulin 0.1454 0.5544 1
Brugia malayi Adenosine kinase-like 0.0105 0.0296 0.0296
Mycobacterium tuberculosis Conserved protein 0.0038 0.0036 0.0095
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.01 0.018
Schistosoma mansoni tubulin subunit beta 0.1454 0.5544 1
Echinococcus granulosus tm gpcr rhodopsin 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0026 0.0047
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0058 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.005
Schistosoma mansoni myosin xvIII 0.0794 0.2977 0.5369
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.113 0.1998
Loa Loa (eye worm) hypothetical protein 0.0054 0.0097 0.0176
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0087 0.0224 0.0404
Brugia malayi G protein-coupled receptor F59B2.13 0.0794 0.2977 0.2977
Brugia malayi AKH receptor 0.0794 0.2977 0.2977
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0036 0.0046
Trichomonas vaginalis tubulin, putative 0.1454 0.5544 1
Echinococcus multilocularis neuropeptide receptor 0.0794 0.2977 0.5369
Echinococcus granulosus rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0128 0.0231
Onchocerca volvulus 0.0038 0.0036 0.0056
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0123 0.0173
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Toxoplasma gondii beta-1 tubulin, putative 0.1454 0.5544 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1203 0.4569 0.8241
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0794 0.2977 0.5369
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0045 0.0081
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0112 0.0181
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Schistosoma mansoni adenosine kinase 0.0105 0.0296 0.0535
Echinococcus granulosus tubulin subunit beta 0.1454 0.5544 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0794 0.2977 0.5369
Toxoplasma gondii beta-tubulin, putative 0.1454 0.5544 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0036 0.0031
Leishmania major hypothetical protein, conserved 0.0038 0.0036 0.0014
Loa Loa (eye worm) tubulin beta-1 chain 0.1454 0.5544 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0794 0.2977 0.5369
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0047 0.0084
Echinococcus granulosus g protein coupled receptor 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0043 0.0056
Brugia malayi beta-lactamase 0.0038 0.0036 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0036 0.0042
Leishmania major beta tubulin 0.1454 0.5544 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0036 0.0095
Mycobacterium leprae Probable lipase LipE 0.0038 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0353 0.0589
Echinococcus multilocularis tubulin beta 1 chain 0.1454 0.5544 1
Echinococcus multilocularis neuropeptide receptor A26 0.0794 0.2977 0.5369
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0054 0.0097 0.0097
Leishmania major beta tubulin 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Loa Loa (eye worm) SRC-1 0.0055 0.01 0.018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.014 0.0203
Trypanosoma brucei beta tubulin 0.1454 0.5544 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0036 0.0028 0.0021
Echinococcus multilocularis neuropeptide Y receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis neuropeptides capa receptor 0.0794 0.2977 0.5369
Trichomonas vaginalis tubulin epsilon chain, putative 0.1454 0.5544 1
Echinococcus granulosus Tubulin beta 2C chain 0.1454 0.5544 1
Onchocerca volvulus 0.0794 0.2977 0.6507
Leishmania major beta tubulin 0.1454 0.5544 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Giardia lamblia Beta tubulin 0.1454 0.5544 1
Schistosoma mansoni hypothetical protein 0.0794 0.2977 0.5369
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0353 0.0619
Echinococcus granulosus neuropeptide FF receptor 2 0.124 0.4714 0.8502
Trypanosoma brucei unspecified product 0.0058 0.0112 0.0181
Schistosoma mansoni tyrosine kinase 0.0057 0.011 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Echinococcus granulosus tubulin beta 1 chain 0.1454 0.5544 1
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0085 0.0219 0.0395
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0055 0.01 0.018
Echinococcus granulosus rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Schistosoma mansoni hypothetical protein 0.0054 0.0097 0.0176
Schistosoma mansoni alpha-1 adrenergic receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0091 0.0243 0.0439
Brugia malayi sulfakinin receptor protein 0.0794 0.2977 0.2977
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0353 0.6262
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.001 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Brugia malayi latrophilin 2 splice variant baaae 0.0063 0.0131 0.0131
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0159 0.0238
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Echinococcus multilocularis dnaJ subfamily B 0.1254 0.4768 0.86
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Echinococcus multilocularis neuropeptide Y receptor 0.0794 0.2977 0.5369
Echinococcus granulosus neuropeptides capa receptor 0.0794 0.2977 0.5369
Echinococcus granulosus Tubulin beta 2C chain 0.1454 0.5544 1
Echinococcus granulosus fmrfamide receptor 0.0794 0.2977 0.5369
Brugia malayi SH2 domain containing protein 0.0047 0.0068 0.0068
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.001 0.0018
Echinococcus multilocularis G-protein coupled receptor, putative 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0038 0.0036 0.0064
Onchocerca volvulus 0.0794 0.2977 0.6507
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.014 0.0203
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0055 0.01 0.018
Loa Loa (eye worm) hypothetical protein 0.0105 0.0296 0.0535
Brugia malayi hypothetical protein 0.0794 0.2977 0.2977
Schistosoma mansoni biogenic amine (5HT) receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0058 0.0105
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Schistosoma mansoni hypothetical protein 0.0054 0.0097 0.0176
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Onchocerca volvulus 0.0093 0.025 0.0525
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0028 0.005
Loa Loa (eye worm) TK protein kinase 0.0033 0.0016 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0036 0.0014
Echinococcus granulosus dna polymerase eta 0.0036 0.0028 0.005
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Leishmania major beta tubulin 0.1454 0.5544 1
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0296 0.0487
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.014 0.0231
Schistosoma mansoni tubulin subunit beta 0.1454 0.5544 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase csk 0.0036 0.0026 0.0047
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.0476 0.0838
Loa Loa (eye worm) RNA binding protein 0.0054 0.0098 0.0176
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0226 0.0768 0.1386
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0036 0.0095
Echinococcus multilocularis Tubulin beta 2C chain 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.1203 0.4569 0.8241
Brugia malayi neuropeptide F receptor 0.0794 0.2977 0.2977
Echinococcus granulosus orexin receptor type 2 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0153 0.0482 0.087
Echinococcus multilocularis sex peptide receptor 0.0794 0.2977 0.5369
Echinococcus granulosus neuropeptide receptor A26 0.0794 0.2977 0.5369
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0123 0.1736
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0028 0.0028
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0054 0.0098 0.0176
Brugia malayi neuropeptide F receptor 0.0794 0.2977 0.2977
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.0476 0.0812
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0036 0.0095
Trypanosoma brucei hypothetical protein 0.011 0.0316 0.0549
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0794 0.2977 0.5369
Echinococcus granulosus Tubulin beta 2C chain 0.1454 0.5544 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.001 0.0018
Echinococcus multilocularis dna polymerase kappa 0.0065 0.014 0.0253
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus multilocularis neuropeptides capa receptor 0.0794 0.2977 0.5369
Schistosoma mansoni neuropeptide receptor 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0184 0.0603 0.1088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus granulosus beta tubulin 0.1454 0.5544 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0036 0.0064
Onchocerca volvulus 0.0794 0.2977 0.6507
Echinococcus multilocularis dna polymerase eta 0.0036 0.0028 0.005
Brugia malayi Serotonin receptor 0.0794 0.2977 0.2977
Schistosoma mansoni biogenic amine receptor 0.0794 0.2977 0.5369
Echinococcus granulosus neuropeptide receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0063 0.0131 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.011 0.0316 0.0549
Echinococcus multilocularis G protein coupled receptor 139 0.0794 0.2977 0.5369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Echinococcus granulosus tyrosine protein kinase csk 0.0036 0.0026 0.0047
Schistosoma mansoni tyrosine kinase 0.0055 0.01 0.018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0794 0.2977 0.5369
Echinococcus granulosus somatostatin receptor 0.0794 0.2977 0.5369
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.01 0.018
Plasmodium vivax tubulin beta chain, putative 0.1454 0.5544 1
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Echinococcus granulosus g-protein coupled receptor 0.0794 0.2977 0.5369
Onchocerca volvulus 0.1203 0.4569 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0794 0.2977 0.5369
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0036 0.0031
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.011 0.0316 0.0549
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0159 0.0266
Loa Loa (eye worm) apoptosis regulator protein 0.0054 0.0097 0.0176
Schistosoma mansoni amine GPCR 0.0794 0.2977 0.5369
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0108 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0794 0.2977 0.5369
Loa Loa (eye worm) hypothetical protein 0.0794 0.2977 0.5369
Entamoeba histolytica tubulin family protein 0.1454 0.5544 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0794 0.2977 0.2977
Echinococcus granulosus transcription factor Dp 1 0.004 0.0045 0.0081
Echinococcus granulosus tyrosine protein kinase Fyn 0.0055 0.01 0.018
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.0603 0.1088
Schistosoma mansoni neuropeptide receptor 0.0794 0.2977 0.5369
Brugia malayi Melatonin receptor type 1A 0.0794 0.2977 0.2977
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.011 0.0316 0.0522
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0676 0.2519 0.4543
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0006 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0036 0.0031
Trichomonas vaginalis tubulin beta chain, putative 0.1454 0.5544 1
Brugia malayi Serotonin receptor 0.0794 0.2977 0.2977

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.35 Concentration required for 50% inhibition of the adenosine kinase (AK) activity. ChEMBL. 15149648
IC50 (binding) = 0.45 uM Inhibition of human adenosine kinase activity ChEMBL. 11958989
IC50 (binding) = 0.45 uM Inhibition of recombinant human adenosine kinase ChEMBL. 10956196
IC50 (binding) = 0.45 uM Inhibition of human adenosine kinase activity ChEMBL. 11958989
IC50 (binding) = 0.45 uM Inhibition of recombinant human adenosine kinase ChEMBL. 10956196
log(10'3/IC50) (binding) = 3.35 Inhibition of adenosine kinase ChEMBL. 18359230
logIC50 (binding) = -0.8239 Inhibition of adenosine kinase (unknown origin) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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