Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0777 | 0.0777 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.3784 | 0.3784 |
Loa Loa (eye worm) | hypothetical protein | 0.1188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1182 | 0.9948 | 0.9948 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.0777 | 0.0777 |
Plasmodium vivax | amine transporter, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0777 | 0.0777 |
Toxoplasma gondii | hypothetical protein | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | transporter, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0461 | 0.3784 | 0.3784 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.0777 | 0.0777 |
Schistosoma mansoni | tyrosine kinase | 0.0461 | 0.3784 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.0777 | 0.0777 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.0777 | 0.2054 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.1188 | 1 | 1 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.1188 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.3732 | 0.3732 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.3732 | 0.3732 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.1188 | 1 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0019 | 0 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | protein KINase family member (kin 25) | 0.0461 | 0.3784 | 0.3784 |
Echinococcus multilocularis | transfer RNA-Thr | 0.1188 | 1 | 1 |
Onchocerca volvulus | 0.0109 | 0.0777 | 1 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.0777 | 0.2054 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0777 | 0.0777 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.0777 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.15 | Displacement of [3H]WIN35428 from rat cloned striatal DAT receptor | ChEMBL. | 22300887 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.