Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Bradykinin B1 receptor | Starlite/ChEMBL | References |
Homo sapiens | bradykinin receptor B1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 318 aa | 25.5 % | |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Bradykinin B1 receptor | 337 aa | 351 aa | 23.4 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Bradykinin B1 receptor | 337 aa | 339 aa | 20.4 % |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 341 aa | 21.1 % | |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Bradykinin B1 receptor | 337 aa | 323 aa | 21.4 % |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Bradykinin B1 receptor | 337 aa | 333 aa | 21.9 % |
Schistosoma mansoni | adenoreceptor | Bradykinin B1 receptor | 337 aa | 285 aa | 23.5 % |
Schistosoma japonicum | Rhodopsin, putative | Bradykinin B1 receptor | 337 aa | 275 aa | 22.9 % |
Schistosoma japonicum | Alpha-1A adrenergic receptor, putative | Bradykinin B1 receptor | 337 aa | 382 aa | 21.5 % |
Loa Loa (eye worm) | hypothetical protein | Bradykinin B1 receptor | 337 aa | 290 aa | 23.1 % |
Echinococcus granulosus | tachykinin peptides receptor 99D | Bradykinin B1 receptor | 337 aa | 291 aa | 24.7 % |
Loa Loa (eye worm) | neuropeptide F receptor | Bradykinin B1 receptor | 337 aa | 304 aa | 27.0 % |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 306 aa | 19.6 % | |
Brugia malayi | putative neuropeptide receptor NPR1 | Bradykinin B1 receptor | 337 aa | 290 aa | 23.4 % |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 308 aa | 22.4 % | |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 276 aa | 21.7 % | |
Schistosoma mansoni | neuropeptide receptor | Bradykinin B1 receptor | 337 aa | 310 aa | 23.2 % |
Schistosoma mansoni | opsin-like receptor | Bradykinin B1 receptor | 337 aa | 322 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0346 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0346 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0287 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0533 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0287 | 0.3131 | 0.4155 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0254 | 0.2547 | 0.3708 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0236 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0256 | 0.2588 | 0.3461 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0123 | 0.0229 | 0.0306 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0144 | 0.061 | 0.0817 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0379 | 0.4752 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase | 0.0379 | 0.4752 | 0.6357 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0643 | 0.9416 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0379 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0112 | 0.0042 | 0.0056 |
Loa Loa (eye worm) | fatty acid synthase | 0.0352 | 0.4277 | 0.4318 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0297 | 0.3311 | 0.4398 |
Mycobacterium ulcerans | thioesterase TesA | 0.0297 | 0.3311 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0236 | 0.2228 | 0.2981 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0379 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0112 | 0.0042 | 0.0056 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0357 | 0.4361 | 0.581 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0357 | 0.4361 | 0.4361 |
Onchocerca volvulus | 0.0621 | 0.9025 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0292 | 0.3214 | 0.4299 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0379 | 0.4752 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0236 | 0.2228 | 0.2941 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0357 | 0.4361 | 0.581 |
Mycobacterium ulcerans | polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0231 | 0.2149 | 0.2574 |
Loa Loa (eye worm) | hypothetical protein | 0.0599 | 0.8643 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0203 | 0.1644 | 0.2199 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0287 | 0.3131 | 0.4188 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0379 | 0.4752 | 0.6357 |
Brugia malayi | AMP-binding enzyme family protein | 0.0333 | 0.3948 | 0.3948 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | thioesterase | 0.0297 | 0.3311 | 0.443 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0533 | 0.7476 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0357 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0333 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0333 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1592 | 0.0823 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0533 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0297 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0533 | 0.7476 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0357 | 0.4361 | 0.5834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5.8 % | Antagonist activity at human bradykinin B2 receptor at 1 uM | ChEMBL. | 22483585 |
IC50 (functional) | = 43 nM | Antagonist activity at rat bradykinin B1 receptor | ChEMBL. | 22483585 |
Ki (binding) | = 8.9 nM | Binding affinity to human bradykinin B1 receptor | ChEMBL. | 22483585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.