Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bradykinin receptor B1 | Starlite/ChEMBL | References |
Rattus norvegicus | Bradykinin B1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 306 aa | 19.6 % | |
Loa Loa (eye worm) | hypothetical protein | Bradykinin B1 receptor | 337 aa | 290 aa | 23.1 % |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 276 aa | 21.7 % | |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Bradykinin B1 receptor | 337 aa | 339 aa | 20.4 % |
Schistosoma mansoni | neuropeptide receptor | Bradykinin B1 receptor | 337 aa | 310 aa | 23.2 % |
Loa Loa (eye worm) | neuropeptide F receptor | Bradykinin B1 receptor | 337 aa | 304 aa | 27.0 % |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 341 aa | 21.1 % | |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Bradykinin B1 receptor | 337 aa | 333 aa | 21.9 % |
Schistosoma japonicum | Rhodopsin, putative | Bradykinin B1 receptor | 337 aa | 275 aa | 22.9 % |
Schistosoma mansoni | opsin-like receptor | Bradykinin B1 receptor | 337 aa | 322 aa | 24.8 % |
Brugia malayi | putative neuropeptide receptor NPR1 | Bradykinin B1 receptor | 337 aa | 290 aa | 23.4 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Bradykinin B1 receptor | 337 aa | 351 aa | 23.4 % |
Schistosoma japonicum | Alpha-1A adrenergic receptor, putative | Bradykinin B1 receptor | 337 aa | 382 aa | 21.5 % |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 318 aa | 25.5 % | |
Schistosoma mansoni | adenoreceptor | Bradykinin B1 receptor | 337 aa | 285 aa | 23.5 % |
Onchocerca volvulus | Bradykinin B1 receptor | 337 aa | 308 aa | 22.4 % | |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Bradykinin B1 receptor | 337 aa | 323 aa | 21.4 % |
Echinococcus granulosus | tachykinin peptides receptor 99D | Bradykinin B1 receptor | 337 aa | 291 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0203 | 0.1644 | 0.2199 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0357 | 0.4361 | 0.581 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0643 | 0.9416 | 1 |
Onchocerca volvulus | 0.0621 | 0.9025 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0379 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase | 0.0379 | 0.4752 | 0.6357 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1592 | 0.0823 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0144 | 0.061 | 0.0817 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0297 | 0.3311 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0287 | 0.3131 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0357 | 0.4361 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0287 | 0.3131 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0236 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0297 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0379 | 0.4752 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0599 | 0.8643 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0352 | 0.4277 | 0.4318 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0379 | 0.4752 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0533 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0256 | 0.2588 | 0.3461 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0379 | 0.4752 | 0.6357 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0254 | 0.2547 | 0.3708 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0357 | 0.4361 | 0.5834 |
Brugia malayi | AMP-binding enzyme family protein | 0.0333 | 0.3948 | 0.3948 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0112 | 0.0042 | 0.0056 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0379 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | thioesterase | 0.0297 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0346 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0346 | 0.4168 | 0.5576 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0123 | 0.0229 | 0.0306 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0231 | 0.2149 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0287 | 0.3131 | 0.4188 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0333 | 0.3948 | 0.3889 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | thioesterase TesA | 0.0297 | 0.3311 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0379 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0357 | 0.4361 | 0.5834 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0333 | 0.3948 | 0.528 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0533 | 0.7476 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0357 | 0.4361 | 0.4361 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0533 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0292 | 0.3214 | 0.4299 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0236 | 0.2228 | 0.2981 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0112 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0533 | 0.7476 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0236 | 0.2228 | 0.2941 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 5.8 % | Antagonist activity at human bradykinin B2 receptor at 1 uM | ChEMBL. | 22483585 |
IC50 (functional) | = 43 nM | Antagonist activity at rat bradykinin B1 receptor | ChEMBL. | 22483585 |
Ki (binding) | = 8.9 nM | Binding affinity to human bradykinin B1 receptor | ChEMBL. | 22483585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.