Detailed information for compound 1632163

Basic information

Technical information
  • TDR Targets ID: 1632163
  • Name: N-[9-(3-morpholin-4-ylpropylamino)acridin-1-y l]-N-oxidohydroxylamine
  • MW: 366.414 | Formula: C20H22N4O3
  • H donors: 1 H acceptors: 3 LogP: 3.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc2c1c(NCCCN1CCOCC1)c1c(n2)cccc1
  • InChi: 1S/C20H22N4O3/c25-24(26)18-8-3-7-17-19(18)20(15-5-1-2-6-16(15)22-17)21-9-4-10-23-11-13-27-14-12-23/h1-3,5-8H,4,9-14H2,(H,21,22)
  • InChiKey: VWWYFEVGXLCSTR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-morpholin-4-ylpropyl)-1-nitroacridin-9-amine
  • N-[9-(3-morpholinopropylamino)acridin-1-yl]-N-oxido-hydroxylamine
  • N-(3-morpholinopropyl)-1-nitro-acridin-9-amine
  • N-[9-(3-morpholinopropylamino)-1-acridinyl]-N-oxidohydroxylamine
  • N-(3-morpholinopropyl)-1-nitro-9-acridinamine
  • 3-morpholinopropyl-(1-nitroacridin-9-yl)amine
  • N-[9-(3-morpholin-4-ylpropylamino)acridin-1-yl]-N-oxido-hydroxylamine
  • N-(3-morpholin-4-ylpropyl)-1-nitro-acridin-9-amine
  • NCI60_023301

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi leucyl aminopeptidase 0.0185 0.131 0.131
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0254 0.0254
Onchocerca volvulus 0.0158 0.107 0.1069
Loa Loa (eye worm) hypothetical protein 0.1165 1 1
Onchocerca volvulus Fxna peptidase homolog 0.0185 0.131 0.131
Mycobacterium ulcerans hypothetical protein 0.0185 0.131 1
Leishmania major hypothetical protein, conserved 0.0185 0.131 1
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.1165 1 1
Brugia malayi hypothetical protein 0.0158 0.107 0.107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.023 0.1753
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.023 0.023
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0254 0.0254
Leishmania major glutaminyl cyclase, putative 0.0185 0.131 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.023 0.1274
Onchocerca volvulus Glutaminyl cyclase homolog 0.1165 1 1
Schistosoma mansoni nicalin (M28 family) 0.0185 0.131 0.131
Brugia malayi RNA binding protein 0.0066 0.0254 0.0254
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.1165 1 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0185 0.131 0.131
Brugia malayi nicalin 0.0185 0.131 0.131
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0185 0.131 0.131
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0185 0.131 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.0804 0.0804
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0185 0.131 0.131
Brugia malayi MH2 domain containing protein 0.0125 0.0775 0.0775
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0185 0.131 0.131
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0185 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0128 0.0804 0.0804
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.023 0.023
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0254 0.0254
Entamoeba histolytica hypothetical protein 0.0038 0 0.5
Trypanosoma cruzi glutaminyl cyclase, putative 0.0185 0.131 1
Mycobacterium leprae conserved hypothetical protein 0.0038 0 0.5
Brugia malayi hypothetical protein 0.0128 0.0804 0.0804
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.131 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.023 0.023
Onchocerca volvulus Fxna peptidase homolog 0.0185 0.131 0.131
Entamoeba histolytica hypothetical protein 0.0038 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.131 1
Schistosoma mansoni Fxna peptidase (M28 family) 0.0185 0.131 0.131
Mycobacterium tuberculosis Conserved protein 0.0185 0.131 0.7267
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.023 0.023
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0185 0.131 0.131
Loa Loa (eye worm) hypothetical protein 0.0128 0.0804 0.0804
Loa Loa (eye worm) leucyl aminopeptidase 0.0185 0.131 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0185 0.131 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.0804 0.0804
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0254 0.0254
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.023 0.1753
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0775 0.0775
Onchocerca volvulus 0.0185 0.131 0.131
Mycobacterium leprae Probable lipase LipE 0.0038 0 0.5
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0185 0.131 1
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0185 0.131 0.131
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0185 0.131 0.7267
Loa Loa (eye worm) hypothetical protein 0.0185 0.131 0.131
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0254 0.0254
Toxoplasma gondii peptidase, M28 family protein 0.0185 0.131 1
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.1165 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.1803 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0254 0.0254
Brugia malayi TAR-binding protein 0.0066 0.0254 0.0254
Onchocerca volvulus Fxna peptidase homolog 0.0185 0.131 0.131
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0254 0.0254
Toxoplasma gondii hypothetical protein 0.0185 0.131 1
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.0185 0.131 0.131
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0185 0.131 0.131
Brugia malayi FXNA 0.0185 0.131 0.131
Plasmodium vivax hypothetical protein, conserved 0.0038 0 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.023 0.1753
Trypanosoma cruzi glutaminyl cyclase, putative 0.0185 0.131 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0254 0.0254
Entamoeba histolytica hypothetical protein 0.0038 0 0.5
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0185 0.131 0.131
Trypanosoma brucei glutaminyl cyclase, putative 0.0185 0.131 1
Entamoeba histolytica hypothetical protein 0.0038 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0066 0.0254 0.0254
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.023 0.1753
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.023 0.1753
Loa Loa (eye worm) hypothetical protein 0.0158 0.107 0.1069

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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