TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.806 | Formula: C18H17ClN4O2
H donors: 1 H acceptors: 4 LogP: 3.49 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)O[C@H]1C[C@H]2C[C@@H]1C[C@@H]2n1cnc2c1ncnc2Cl
InChi: 1S/C18H17ClN4O2/c19-17-16-18(21-8-20-17)23(9-22-16)14-6-11-5-10(14)7-15(11)25-13-3-1-12(24)2-4-13/h1-4,8-11,14-15,24H,5-7H2/t10-,11-,14+,15+/m1/s1
InChiKey: RPNXBCLHUQHMEB-FIXIBIHLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0356	0.1845	0.1845
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	0.0592
Echinococcus multilocularis		0.0121	0.0592	0.0592
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0121	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1414	0.1414
Entamoeba histolytica	hypothetical protein	0.0121	0.0592	0.0592
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1881	1	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.012	0.012
Trichomonas vaginalis	conserved hypothetical protein	0.0396	0.2062	0.2062
Giardia lamblia	GTOR	0.1881	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1881	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0121	0.0592	0.0592
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0121	0.0592	0.0592
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0121	0.0592	0.0592
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0064	0.0064
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0121	0.0592	0.0541
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0156	0.0156
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1399	0.7423	0.7423
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0356	0.1845	0.1845
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.012	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1261	0.6689	0.6689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1399	0.7423	0.7423
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0156	0.0156
Entamoeba histolytica	hypothetical protein	0.0121	0.0592	0.0592
Trypanosoma cruzi	target of rapamycin kinase 3	0.1497	0.7951	0.7939
Schistosoma mansoni	hypothetical protein	0.0275	0.1414	0.1414
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0109	0.0109
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1399	0.7423	0.7423
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1014	0.5365	0.5365
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1399	0.7423	0.7423
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	0.0477
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1124	0.5952	0.5952
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0631	0.3316	0.3316
Loa Loa (eye worm)	phosphatidylinositol 3	0.0121	0.0592	0.0592
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0121	0.0592	0.0541
Entamoeba histolytica	protein kinase rad3, putative	0.0356	0.1845	0.1845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1399	0.7423	0.7423
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0121	0.0592	0.0592
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0121	0.0592	0.0592
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1881	1	1
Entamoeba histolytica	hypothetical protein	0.0121	0.0592	0.0592
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0121	0.0592	0.066
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0121	0.0592	0.0592
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0054	0.0054
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0138	0.0138
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0121	0.0592	0.0592
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0121	0.0592	0.5
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0356	0.1845	0.1845
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0121	0.0592	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0234	0.1196	0.1196
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0396	0.2062	0.2671
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1497	0.7951	0.7822
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1881	1	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0109	0.0109
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0052	0.0052
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.0121	0.0592	0.0592
Trichomonas vaginalis	conserved hypothetical protein	0.0275	0.1414	0.1414
Echinococcus granulosus	serine protein kinase ATM	0.0356	0.1845	0.1845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0631	0.3316	0.3316
Loa Loa (eye worm)	phosphatidylinositol 3	0.0121	0.0592	0.0592
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0781	0.412	0.4049
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0121	0.0592	0.0592
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0064	0.0064
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0121	0.0592	0.0592
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1881	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0121	0.0592	0.0541
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0121	0.0592	0.0592
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0121	0.0592	0.0477
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1881	1	1
Echinococcus granulosus	nervana 2	0.002	0.0052	0.0052
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0631	0.3316	0.3234
Trichomonas vaginalis	conserved hypothetical protein	0.0234	0.1196	0.1196
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0121	0.0592	0.0541
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0054	0.0054
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0064	0.0064
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.012	0.012
Echinococcus multilocularis	nervana 2	0.002	0.0052	0.0052
Onchocerca volvulus		0.0121	0.0592	0.5
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0121	0.0592	0.0592
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0121	0.0592	0.0592
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.012	0.012
Brugia malayi	Protein kinase domain containing protein	0.0033	0.012	0.012
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0121	0.0592	0.0592
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0356	0.1845	0.1845
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0121	0.0592	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0121	0.0592	0.0592
Echinococcus multilocularis	serine protein kinase ATM	0.0356	0.1845	0.1845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1399	0.7423	0.7423
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.012	0.012
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0121	0.0592	0.066
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0631	0.3316	0.3316
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0356	0.1845	0.1746
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0121	0.0592	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0356	0.1845	0.1845
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0121	0.0592	0.0541
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0631	0.3316	0.3234
Entamoeba histolytica	hypothetical protein	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1015	0.5373	0.5373
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1496	0.7942	0.7942
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.012	0.012
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0121	0.0592	0.0592
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0121	0.0592	0.0592
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0121	0.0592	1
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0121	0.0592	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1014	0.5365	0.5365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1881	1	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0121	0.0592	0.0592
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0121	0.0592	0.0592
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0121	0.0592	0.0592
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0064	0.0064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1606	0.8529	0.8529
Plasmodium vivax	hypothetical protein	0.0121	0.0592	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0631	0.3316	0.3316
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0121	0.0592	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.1881	1	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0121	0.0592	0.0592
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0121	0.0592	0.0541
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0121	0.0592	0.0592
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1496	0.7942	0.7942
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0121	0.0592	0.066
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0889	0.4699	0.4635
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1881	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0121	0.0592	0.0477
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0121	0.0592	0.0592
Plasmodium vivax	hypothetical protein, conserved	0.0121	0.0592	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1399	0.7423	0.7423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1015	0.5373	0.5373
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0356	0.1845	0.1845
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0121	0.0592	0.0541
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0356	0.1845	0.1845
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0121	0.0592	0.0592
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0138	0.0138
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1015	0.5373	0.5373
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1496	0.7942	0.7942
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0121	0.0592	0.0592
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0275	0.1414	0.1414
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0121	0.0592	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0356	0.1845	0.1845
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0631	0.3316	0.328
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0113	0.0113
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1113	0.5893	0.5893
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0505	0.2641	0.2641
Loa Loa (eye worm)	phosphatidylinositol 3	0.0121	0.0592	0.0592
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0631	0.3316	0.2895
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0126	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.1196	0.1196
Loa Loa (eye worm)	hypothetical protein	0.0383	0.1992	0.1992
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1221	0.6472	0.6472
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0121	0.0592	0.0592
Entamoeba histolytica	protein kinase, putative	0.0033	0.012	0.012
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0121	0.0592	0.0541
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0052	0.0052
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0121	0.0592	0.0592
Entamoeba histolytica	hypothetical protein	0.0356	0.1845	0.1845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1881	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0011	0.0011
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0631	0.3316	0.3316
Loa Loa (eye worm)	phosphatidylinositol 3	0.0121	0.0592	0.0592
Loa Loa (eye worm)	phosphatidylinositol 3	0.0121	0.0592	0.0592
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1881	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0138	0.0138
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1881	1	1
Loa Loa (eye worm)	hypothetical protein	0.0396	0.2062	0.2062
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0052	0.0052
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0121	0.0592	0.0477
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.012	0.012
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0121	0.0592	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0592	0.0592
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0052	0.0052
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1881	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0121	0.0592	0.0592
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0356	0.1845	0.1845
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0631	0.3316	0.3316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1124	0.5952	0.5952
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0631	0.3316	0.2895
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0631	0.3316	0.3316
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.012	0.012
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0064	0.0064
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0356	0.1845	0.1845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0631	0.3316	0.3316
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1496	0.7942	0.7942
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0356	0.1845	0.1845
Entamoeba histolytica	protein kinase 2, putative	0.0021	0.0054	0.0054
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0121	0.0592	0.0592
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0631	0.3316	0.328
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1881	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0631	0.3316	0.3316
Brugia malayi	FAT domain containing protein	0.0275	0.1414	0.1414
Echinococcus granulosus	nervana 2	0.002	0.0052	0.0052
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0121	0.0592	0.0592
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0631	0.3316	0.3316
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	0.0541
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0121	0.0592	0.066
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0121	0.0592	0.0592
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0054	0.0054
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0121	0.0592	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1496	0.7942	0.7942
Mycobacterium leprae	conserved hypothetical protein	0.0121	0.0592	0.5
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0121	0.0592	0.0592
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0356	0.1845	0.1801
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0121	0.0592	0.0592
Giardia lamblia	Hypothetical protein	0.0121	0.0592	0.0541
Toxoplasma gondii	FATC domain-containing protein	0.0356	0.1845	0.2373
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1881	1	1
Echinococcus multilocularis	nervana 2	0.002	0.0052	0.0052
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0138	0.0138
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1399	0.7423	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0109	0.0109
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0121	0.0592	0.0592
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0121	0.0592	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1015	0.5373	0.5373
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0121	0.0592	0.066
Onchocerca volvulus		0.0121	0.0592	0.5
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0356	0.1845	0.1801
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.0064	0.0011
Echinococcus multilocularis	Zinc finger, PHD finger	0.0121	0.0592	0.0592
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0121	0.0592	0.0592
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0126	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1014	0.5365	0.5365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1113	0.5893	0.5893
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0121	0.0592	0.0541
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0121	0.0592	0.0541
Trypanosoma cruzi	Protein kinase B	0.0023	0.0064	0.0011
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.012	0.012
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0121	0.0592	0.0592
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1497	0.7951	0.7926
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0121	0.0592	0.0592
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0121	0.0592	0.0592
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0234	0.1196	0.1149
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1124	0.5952	0.5952
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0275	0.1414	0.1414
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0121	0.0592	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2012058

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1632769