Detailed information for compound 1632778

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 296.359 | Formula: C16H24O5
  • H donors: 3 H acceptors: 5 LogP: 1.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C[C@H]1C(=C)[C@@H](O)C[C@@H]2[C@]1(C)CCC[C@]2(C)C(=O)O
  • InChi: 1S/C16H24O5/c1-9-10(7-13(18)19)15(2)5-4-6-16(3,14(20)21)12(15)8-11(9)17/h10-12,17H,1,4-8H2,2-3H3,(H,18,19)(H,20,21)/t10-,11-,12+,15+,16-/m0/s1
  • InChiKey: ZVBBGMJUCZRFPO-KSMPYDNASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0359 0.0359
Schistosoma mansoni serine/threonine-protein kinase 0.0047 0.0346 0.0346
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0048 0.0359 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0645 0.0645
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0139 0.1643 0.1396
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.1335 0.8749
Loa Loa (eye worm) hypothetical protein 0.0037 0.0213 0.0213
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.0359
Mycobacterium ulcerans hypothetical protein 0.0026 0.0055 0.5
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0047 0.0346 0.006
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0048 0.0359 0.0359
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0139 0.1643 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.7359 0.7359
Schistosoma mansoni hypothetical protein 0.0108 0.1201 0.1201
Brugia malayi Thioredoxin reductase 0.0051 0.0413 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.1643 0.1643
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0645 0.0645
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0359 0.0074
Brugia malayi Protein kinase domain containing protein 0.0068 0.0645 0.0645
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.5251 0.5251
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0359 0.0359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0359 0.0359
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.0074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0398 0.5259 0.5259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.7891 0.7891
Echinococcus multilocularis serine protein kinase ATM 0.0139 0.1643 0.1643
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0247 0.315 0.315
Entamoeba histolytica hypothetical protein 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0737 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0055 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1866 0.1866
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0048 0.0359 0.0359
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.1518 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0092 0.0978 0.0978
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0359 0.5696
Entamoeba histolytica protein kinase rad3, putative 0.0139 0.1643 0.1643
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.1518 1
Leishmania major hypothetical protein, conserved 0.0048 0.0359 0.0306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.7359 0.7359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0494 0.6607 0.6607
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0359 0.0074
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0359 0.0359
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0048 0.0359 0.0359
Plasmodium vivax glutathione reductase, putative 0.0051 0.0413 1
Schistosoma mansoni hypothetical protein 0.0048 0.0359 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.7359 0.7359
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.7359 0.7359
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.0287 0.0287
Leishmania major phosphatidylinositol kinase related protein, putative 0.0048 0.0359 0.0306
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0359 0.5696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.7359 0.7359
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.0359
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0737 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0155 0.1866 0.2153
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0978 0.0978
Echinococcus multilocularis Glutaredoxin protein 5 0.0042 0.0281 0.0281
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0359 0.0359
Schistosoma mansoni serine/threonine-protein kinase 0.0047 0.0346 0.0346
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.0645 0.0645
Leishmania major phosphatidylinositol 4-kinase, putative 0.0048 0.0359 0.0306
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0359 0.0359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.5852 0.5852
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0247 0.315 0.2895
Loa Loa (eye worm) hypothetical protein 0.0054 0.0452 0.0452
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0452 0.0452
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0737 1 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0645 0.0645
Entamoeba histolytica hypothetical protein 0.0038 0.0225 0.0225
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0359 0.0359
Leishmania major phosphatidylinositol kinase, putative 0.0048 0.0359 0.0306
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0737 1 1
Echinococcus granulosus nervana 2 0.0042 0.0281 0.0281
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0413 0.0413
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0359 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0645 0.0645
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0247 0.315 0.315
Entamoeba histolytica hypothetical protein 0.0038 0.0225 0.0225
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0247 0.315 0.315
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0247 0.315 0.2948
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.7891 0.7891
Echinococcus granulosus nervana 2 0.0042 0.0281 0.0281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0359 0.0359
Toxoplasma gondii thioredoxin reductase 0.0051 0.0413 0.0077
Trypanosoma brucei rac serine-threonine kinase, putative 0.0068 0.0645 0.0297
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.0359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.1643 0.1643
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0359 0.0359
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0139 0.1643 0.1643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.7891 0.7891
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0359 0.5696
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0413 0.013
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0042 0.0281 0.0281
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0587 0.79 0.7822
Schistosoma mansoni hypothetical protein 0.0037 0.0213 0.0213
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0359 0.0074
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0359 0.0359
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0413 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0349 0.4568 0.4366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.7891 0.7891
Echinococcus multilocularis rac serine:threonine kinase 0.0047 0.0346 0.0346
Echinococcus multilocularis nervana 2 0.0042 0.0281 0.0281
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0645 0.0645
Schistosoma mansoni hypothetical protein 0.0038 0.0225 0.0225
Entamoeba histolytica hypothetical protein 0.0038 0.0225 0.0225
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0247 0.315 0.2948
Echinococcus granulosus serine protein kinase ATM 0.0139 0.1643 0.1643
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0359 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0055 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0398 0.5259 0.5259
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0359 0.208
Onchocerca volvulus 0.0048 0.0359 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0139 0.1643 0.1643
Loa Loa (eye worm) glutathione reductase 0.0051 0.0413 0.0413
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0452 0.0452
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0737 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0359 0.0359
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0048 0.0359 0.0074
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0048 0.0359 0.0074
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0478 0.6384 0.6384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.315 0.315
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0225 0.0225
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0359 0.0359
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0048 0.0359 0.0359
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0737 1 1
Entamoeba histolytica protein kinase 2, putative 0.0042 0.0287 0.0287
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0247 0.315 0.315
Toxoplasma gondii AGC kinase 0.0064 0.0587 0.0325
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.0359
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0737 1 1
Brugia malayi hypothetical protein 0.0038 0.0225 0.0225
Plasmodium falciparum thioredoxin reductase 0.0051 0.0413 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0737 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0055
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0359 0.0359
Entamoeba histolytica hypothetical protein 0.0038 0.0225 0.0225
Echinococcus multilocularis 0.0048 0.0359 0.0359
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0306 0.3975 0.375
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0247 0.315 0.3113
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0359 0.0359
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.0287 0.0287
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0048 0.0359 0.0359
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0048 0.0359 0.0359
Mycobacterium tuberculosis Probable reductase 0.0117 0.1335 0.8749
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.315 0.315
Giardia lamblia Phosphatidylinositol 4-kinase 0.0048 0.0359 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0737 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0413 0.2451
Loa Loa (eye worm) phosphatidylinositol kinase 0.0048 0.0359 0.0359
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0055 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0359 0.0074
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0055 0.5
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0048 0.0359 0.5696
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0359 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.1201 0.1201
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0359 0.0074
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0737 1 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0359 0.0359
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.1335 0.8749
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0055 0.0055
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.5696
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0247 0.315 0.2895
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.1643 0.1643
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0359 0.0359
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0359 0.0359
Echinococcus multilocularis nervana 2 0.0042 0.0281 0.0281
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0359 0.0359
Brugia malayi p70 ribosomal S6 kinase beta 0.0064 0.0587 0.0587
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0645 0.0645
Giardia lamblia GTOR 0.0737 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0055 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0359 0.0074
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0737 1 1
Entamoeba histolytica hypothetical protein 0.0048 0.0359 0.0359
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0587 0.79 0.7888
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0048 0.0359 0.0359
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.0287 0.0287
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0042 0.0281 0.0281
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0139 0.1643 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.7359 0.7359
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.0306
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0413 0.0413
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0359 0.0359
Loa Loa (eye worm) phosphatidylinositol 3 0.0737 1 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1643 0.1643
Loa Loa (eye worm) phosphatidylinositol 3 0.0247 0.315 0.315
Leishmania major trypanothione reductase 0.0051 0.0413 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.5852 0.5852
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.5251 0.5251
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0359 0.0359
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0048 0.0359 0.0359
Trypanosoma cruzi target of rapamycin kinase 3 0.0587 0.79 0.7838
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0359 0.0359
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.1335 0.8749
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0139 0.1643 0.1643
Entamoeba histolytica hypothetical protein 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.315 0.315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.315 0.315
Echinococcus granulosus serine/threonine protein kinase 0.0047 0.0346 0.0346
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0139 0.1643 0.1643
Trypanosoma cruzi Protein kinase B 0.0047 0.0346 0.006
Giardia lamblia Hypothetical protein 0.0048 0.0359 0.0074
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0225 0.0225
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0359 0.5696
Entamoeba histolytica protein kinase, putative 0.0064 0.0587 0.0587
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0359 0.0359
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0155 0.1866 0.1866
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0055
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0359 0.0359
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.1335 0.8749
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0737 1 1
Entamoeba histolytica hypothetical protein 0.0048 0.0359 0.0359
Entamoeba histolytica hypothetical protein 0.0139 0.1643 0.1643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0247 0.315 0.315
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0359 0.0074
Toxoplasma gondii FATC domain-containing protein 0.0139 0.1643 0.1835
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.1643 0.1643
Brugia malayi FAT domain containing protein 0.0108 0.1201 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0398 0.5259 0.5259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.7359 0.7359
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0048 0.0359 0.0074
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0359 0.0306
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0737 1 1
Plasmodium vivax hypothetical protein 0.0048 0.0359 0.5696
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0064 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0978 0.0978
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0346 0.0346
Echinococcus granulosus Glutaredoxin protein 5 0.0042 0.0281 0.0281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0359 0.0359
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0359 0.0359
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.1518 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.044 0.5852 0.5852
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.1335 0.8749
Onchocerca volvulus 0.0048 0.0359 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0055 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0092 0.0978 0.0712
Trypanosoma brucei trypanothione reductase 0.0051 0.0413 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.5791 0.5791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0359 0.0359
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0397 0.5251 0.5251
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0048 0.0359 0.5696
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0108 0.1201 0.1201
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0645 0.0645
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0048 0.0359 0.0359
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0359 0.0359
Entamoeba histolytica protein kinase, putative 0.0068 0.0645 0.0645
Echinococcus multilocularis Zinc finger, PHD finger 0.0048 0.0359 0.0359
Brugia malayi glutathione reductase 0.0051 0.0413 0.0413
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0737 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0247 0.315 0.3113
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0413 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0629 0.8493 0.8493
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0048 0.0359 0.0359
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0359 0.5696
Loa Loa (eye worm) hypothetical protein 0.0048 0.0359 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0359 0.0359
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0359 0.208
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1518 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.7891 0.7891
Leishmania major hypothetical protein, unknown function 0.0048 0.0359 0.0306
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0139 0.1643 0.1643
Loa Loa (eye worm) hypothetical protein 0.0108 0.1201 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0398 0.5259 0.5259
Toxoplasma gondii target of rapamycin (TOR), putative 0.0548 0.7359 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.015 0.1794 0.1794
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0108 0.1201 0.1201
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.1335 0.8749
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0048 0.0359 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0055 0.5
Entamoeba histolytica protein kinase, putative 0.0068 0.0645 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0198 0.2459 0.2459
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0055 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.5791 0.5791
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0213 0.0213
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0048 0.0359 0.0359
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0059 0.0059
Plasmodium falciparum glutathione reductase 0.0051 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.1643 0.1643
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0055 0.5

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) Antifungal activity against Candida albicans after 18 hrs by broth microdilution method ChEMBL. 22283451

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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