TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.369 | Formula: C15H24N3O4+
H donors: 1 H acceptors: 1 LogP: 1.17 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(/C=N\NC(=O)C[N+](C)(C)C)cc(c1OC)OC
InChi: 1S/C15H23N3O4/c1-18(2,3)10-14(19)17-16-9-11-7-12(20-4)15(22-6)13(8-11)21-5/h7-9H,10H2,1-6H3/p+1/b16-9-
InChiKey: BQQTYFYHEDLIFO-SXGWCWSVSA-O

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1266	0.7421	0.7419
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.011	0.0587	0.0587
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0174	0.0174
Entamoeba histolytica	protein kinase, putative	0.0031	0.0119	0.0061
Trypanosoma cruzi	target of rapamycin kinase 3	0.1355	0.7949	0.7937
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0249	0.1409	0.1409
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1266	0.7421	0.7419
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1141	0.6687	0.6683
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0174	0.0174
Entamoeba histolytica	hypothetical protein	0.0322	0.1841	0.1793
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0131	0.0119
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0359	0.2058	0.2655
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0131	0.0131
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1702	1	1
Entamoeba histolytica	hypothetical protein	0.011	0.0587	0.0532
Brugia malayi	FAT domain containing protein	0.0249	0.1409	0.1409
Mycobacterium leprae	conserved hypothetical protein	0.011	0.0587	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0587	0.0587
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.011	0.0587	0.0532
Echinococcus granulosus	serine protein kinase ATM	0.0322	0.1841	0.1841
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.011	0.0587	0.0532
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0587	0.0587
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.007	0.007
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0587	0.0587
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.011	0.0587	0.0587
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1702	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.1702	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1191	0.1191
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.011	0.0587	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.011	0.0587	0.0576
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0322	0.1841	0.1841
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0587	0.0587
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0587	0.0587
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0154	0.0154
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0057	0.0057
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.007	0.0012
Echinococcus multilocularis	nervana 2	0.002	0.0057	0.0057
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0119	0.0119
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1702	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1355	0.7949	0.7922
Loa Loa (eye worm)	hypothetical protein	0.0359	0.2058	0.2058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1266	0.7421	0.7419
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.011	0.0587	0.0462
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1017	0.595	0.5945
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0917	0.5363	0.5357
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.011	0.0587	0.0587
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1266	0.7421	0.7419
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0587	0.0587
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.011	0.0587	0.0587
Entamoeba histolytica	hypothetical protein	0.011	0.0587	0.0532
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0587	0.0587
Giardia lamblia	GTOR	0.1702	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.011	0.0587	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1266	0.7421	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0322	0.1841	0.1831
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.011	0.0587	0.0462
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.011	0.0587	0.0576
Loa Loa (eye worm)	phosphatidylinositol 3	0.0571	0.3312	0.3312
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0212	0.1191	0.1181
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.002	0.0058	0.0058
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0571	0.3312	0.2895
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1702	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.011	0.0587	0.0532
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.011	0.0587	0.064
Trypanosoma cruzi	Protein kinase B	0.0022	0.007	0.0012
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.002	0.0058	0.0058
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.011	0.0587	0.0587
Echinococcus granulosus	serine/threonine protein kinase	0.0022	0.007	0.007
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0707	0.4117	0.4039
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0587	0.0576
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0322	0.1841	0.1831
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0571	0.3312	0.3312
Trichomonas vaginalis	conserved hypothetical protein	0.0249	0.1409	0.1399
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.011	0.0587	0.0587
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.011	0.0587	0.0462
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0587	0.0576
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1702	1	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.011	0.0587	0.0587
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0587	0.0532
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0571	0.3312	0.3223
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011	0.0587	0.0532
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0322	0.1841	0.1793
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0587	0.0576
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0322	0.1841	0.1841
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0571	0.3312	0.3273
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1702	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0917	0.5363	0.5357
Giardia lamblia	Hypothetical protein	0.011	0.0587	0.0532
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.011	0.0587	0.0532
Loa Loa (eye worm)	hypothetical protein	0.011	0.0587	0.0587
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.011	0.0587	0.0532
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0131	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1354	0.7941	0.7939
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0919	0.5371	0.5365
Toxoplasma gondii	FATC domain-containing protein	0.0322	0.1841	0.2358
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0587	0.0587
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0131	0.0119
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0131	0.0119
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.011	0.0587	0.0576
Entamoeba histolytica	hypothetical protein	0.011	0.0587	0.0532
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0131	0.0119
Onchocerca volvulus		0.011	0.0587	0.5
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.011	0.0587	0.0587
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0131	0.0119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1266	0.7421	0.7419
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0322	0.1841	0.1841
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.011	0.0587	0.0587
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.011	0.0587	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0322	0.1841	0.1831
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.011	0.0587	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0322	0.1841	0.1841
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1266	0.7421	0.7419
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0919	0.5371	0.5365
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.011	0.0587	0.0576
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.011	0.0587	0.064
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.011	0.0587	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.011	0.0587	0.0576
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1702	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0571	0.3312	0.3312
Entamoeba histolytica	protein kinase rad3, putative	0.0322	0.1841	0.1793
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0919	0.5371	0.5365
Schistosoma mansoni	hypothetical protein	0.0249	0.1409	0.1409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1354	0.7941	0.7939
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0587	0.0587
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.011	0.0587	0.0587
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0154	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1702	1	1
Plasmodium vivax	hypothetical protein, conserved	0.011	0.0587	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0571	0.3312	0.3273
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.011	0.0587	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1453	0.8529	0.8527
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0587	0.0532
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.007	0.007
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.011	0.0587	0.064
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.011	0.0587	0.0587
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.011	0.0587	0.064
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0805	0.4696	0.4626
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1354	0.7941	0.7939
Mycobacterium tuberculosis	Conserved hypothetical protein	0.011	0.0587	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0587	0.0587
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.011	0.0587	0.0576
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0571	0.3312	0.3312
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.011	0.0587	0.0576
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1702	1	1
Echinococcus multilocularis	serine protein kinase ATM	0.0322	0.1841	0.1841
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1702	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0587	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0457	0.2637	0.2629
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.011	0.0587	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1007	0.589	0.5886
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.011	0.0587	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0125	0.0125
Schistosoma mansoni	hypothetical protein	0.011	0.0587	0.0587
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.011	0.0587	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0131	0.0119
Echinococcus granulosus	nervana 2	0.002	0.0057	0.0057
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.011	0.0587	0.0576
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1105	0.647	0.6466
Loa Loa (eye worm)	hypothetical protein	0.0347	0.1988	0.1988
Trichomonas vaginalis	conserved hypothetical protein	0.0212	0.1191	0.1181
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0139	0.0128
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0571	0.3312	0.2895
Echinococcus multilocularis	Zinc finger, PHD finger	0.011	0.0587	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1702	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0571	0.3312	0.3223
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.011	0.0587	0.0532
Echinococcus granulosus	nervana 2	0.002	0.0057	0.0057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1354	0.7941	0.7939
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0322	0.1841	0.1793
Entamoeba histolytica	hypothetical protein	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0571	0.3312	0.3304
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0322	0.1841	0.1732
Plasmodium vivax	hypothetical protein	0.011	0.0587	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0571	0.3312	0.3304
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.011	0.0587	0.0576
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.011	0.0587	0.0587
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0249	0.1409	0.1409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0571	0.3312	0.3304
Echinococcus granulosus	serine threonine protein kinase nrc	0.002	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.011	0.0587	0.0587
Loa Loa (eye worm)	phosphatidylinositol kinase	0.011	0.0587	0.0587
Entamoeba histolytica	protein kinase, putative	0.0033	0.0131	0.0073
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.011	0.0587	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0359	0.2058	0.2049
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0057	0.0057
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0154	0.0154
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1702	1	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0131	0.0073
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.007	0.0012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0571	0.3312	0.3304
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0571	0.3312	0.3312
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1017	0.595	0.5945
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0571	0.3312	0.3304
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0587	0.0587
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0322	0.1841	0.1793
Trichomonas vaginalis	PIKK family atypical protein kinase	0.011	0.0587	0.0576
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1702	1	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.011	0.0587	0.0587
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0131	0.0119
Echinococcus multilocularis	rac serine:threonine kinase	0.0022	0.007	0.007
Giardia lamblia	Phosphatidylinositol 4-kinase	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1007	0.589	0.5886
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.011	0.0587	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0917	0.5363	0.5357
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0139	0.0128
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0587	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.011	0.0587	0.0576
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.007	0.0012
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.011	0.0587	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0249	0.1409	0.1409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1017	0.595	0.5945
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0212	0.1191	0.114
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0587	0.0587
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.0587	0.0576
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1355	0.7949	0.7822
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0322	0.1841	0.1841
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0587	0.0532
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.011	0.0587	0.0587
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.011	0.0587	0.0587
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0322	0.1841	0.1841
Echinococcus multilocularis		0.011	0.0587	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1354	0.7941	0.7939
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0057	0.0057
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.0587	0.0532
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0587	0.0587
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0322	0.1841	0.1841
Onchocerca volvulus		0.011	0.0587	0.5
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.011	0.0587	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0919	0.5371	0.5365
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.011	0.0587	0.064
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0154	0.0154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1266	0.7421	0.7419
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0119	0.0119
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.011	0.0587	0.0587
Echinococcus multilocularis	nervana 2	0.002	0.0057	0.0057
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1702	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2008247

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1632787