TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.419 | Formula: C16H19N5O3S
H donors: 4 H acceptors: 4 LogP: 0.63 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccccc1OC[C@H](CNCCNC(=O)Nc1nccs1)O
InChi: 1S/C16H19N5O3S/c17-9-12-3-1-2-4-14(12)24-11-13(22)10-18-5-6-19-15(23)21-16-20-7-8-25-16/h1-4,7-8,13,18,22H,5-6,10-11H2,(H2,19,20,21,23)/t13-/m0/s1
InChiKey: GJXMMEVVMADPSO-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adrenoceptor beta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0272	0.1202	0.1202
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0047	0.0047
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0732	0.332	0.3248
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.2182	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0141	0.0598	0.0497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.0598	0.0598
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0057	0.0057
Echinococcus granulosus	nervana 2	0.0021	0.0046	0.0046
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0141	0.0598	0.0553
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0057	0.0057
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0598	0.0598
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0906	0.4124	0.4061
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0598	0.0598
Echinococcus granulosus	serine protein kinase ATM	0.0413	0.185	0.185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0732	0.332	0.332
Trichomonas vaginalis	conserved hypothetical protein	0.0319	0.1419	0.1419
Schistosoma mansoni	hypothetical protein	0.0141	0.0598	0.0598
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0141	0.0598	0.0598
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0141	0.0598	0.0553
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.2182	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0141	0.0598	0.0598
Entamoeba histolytica	hypothetical protein	0.0141	0.0598	0.0598
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0732	0.332	0.3248
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0141	0.0598	0.0553
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.185	0.185
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0141	0.0598	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0413	0.185	0.1763
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0732	0.332	0.332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2182	1	1
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0141	0.0598	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1177	0.5368	0.5368
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0141	0.0598	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0141	0.0598	0.0598
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0141	0.0598	0.0598
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0107	0.0107
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1178	0.5376	0.5376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1736	0.7944	0.7944
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0413	0.185	0.185
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0141	0.0598	0.0598
Brugia malayi	Protein kinase domain containing protein	0.0034	0.0107	0.0107
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0034	0.0107	0.0107
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0141	0.0598	0.0598
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0598	0.0598
Onchocerca volvulus		0.0141	0.0598	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0107	0.0107
Echinococcus multilocularis	nervana 2	0.0021	0.0046	0.0046
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0141	0.0598	0.0684
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0107	0.0107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1623	0.7425	0.7425
Echinococcus multilocularis	serine protein kinase ATM	0.0413	0.185	0.185
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0141	0.0598	0.0598
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0141	0.0598	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1623	0.7425	0.7425
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	0.0598
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0139	0.0139
Brugia malayi	p70 ribosomal S6 kinase beta	0.0032	0.0097	0.0097
Schistosoma mansoni	hypothetical protein	0.0319	0.1419	0.1419
Trypanosoma cruzi	target of rapamycin kinase 3	0.1738	0.7952	0.7942
Entamoeba histolytica	hypothetical protein	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1623	0.7425	0.7425
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1464	0.6691	0.6691
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0139	0.0139
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0413	0.185	0.185
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0107	0.0107
Entamoeba histolytica	protein kinase, putative	0.0034	0.0107	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.2068	0.2068
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.2182	1	1
Entamoeba histolytica	hypothetical protein	0.0141	0.0598	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0319	0.1419	0.1419
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0141	0.0598	0.0598
Echinococcus multilocularis		0.0141	0.0598	0.0598
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.185	0.185
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0141	0.0598	0.0553
Trypanosoma cruzi	Protein kinase B	0.0023	0.0057	0.001
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0598	0.0598
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2182	1	1
Giardia lamblia	GTOR	0.2182	1	1
Loa Loa (eye worm)	hypothetical protein	0.0272	0.1202	0.1202
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0141	0.0598	0.0553
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0141	0.0598	0.5
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.185	0.185
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0598	0.0598
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0123	0.0123
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0021	0.0046	0.0046
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0032	0.0097	0.0097
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.0057	0.001
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0021	0.0046	0.0046
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.2182	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1738	0.7952	0.7822
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.046	0.2068	0.2689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1623	0.7425	0.7425
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1304	0.5955	0.5955
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	0.0497
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1177	0.5368	0.5368
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0141	0.0598	0.0598
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1623	0.7425	0.7425
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0141	0.0598	0.0684
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0141	0.0598	0.0598
Entamoeba histolytica	hypothetical protein	0.0141	0.0598	0.0598
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0141	0.0598	0.0598
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.2182	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1623	0.7425	0.7425
Entamoeba histolytica	protein kinase rad3, putative	0.0413	0.185	0.185
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0141	0.0598	0.0553
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0732	0.332	0.332
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.2182	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0732	0.332	0.3288
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0598	0.0598
Echinococcus granulosus	Glutaredoxin protein 5	0.0021	0.0046	0.0046
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.185	0.185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1736	0.7944	0.7944
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0732	0.332	0.332
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	0.0598
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.185	0.185
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0141	0.0598	0.0684
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	0.0553
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0141	0.0598	0.0598
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0732	0.332	0.332
Entamoeba histolytica	protein kinase 2, putative	0.0021	0.0047	0.0047
Brugia malayi	FAT domain containing protein	0.0319	0.1419	0.1419
Loa Loa (eye worm)	phosphatidylinositol 3	0.0732	0.332	0.332
Echinococcus multilocularis	nervana 2	0.0021	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0598	0.0598
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0141	0.0598	0.0598
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0107	0.0107
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0141	0.0598	0.0497
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.046	0.2068	0.2068
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0123	0.0123
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.2182	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0057	0.0057
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0107	0.0107
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0732	0.332	0.332
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0732	0.332	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1304	0.5955	0.5955
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0732	0.332	0.332
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0598	0.0598
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0413	0.185	0.185
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0141	0.0598	0.0598
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.2182	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0141	0.0598	0.0598
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0107	0.0107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1291	0.5895	0.5895
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0057	0.0057
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0141	0.0598	0.0553
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0141	0.0598	0.0553
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1177	0.5368	0.5368
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0111	0.0111
Echinococcus multilocularis	Zinc finger, PHD finger	0.0141	0.0598	0.0598
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0598	0.0598
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0057	0.0057
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0141	0.0598	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0319	0.1419	0.1419
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1304	0.5955	0.5955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0272	0.1202	0.116
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0141	0.0598	0.0598
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0598	0.0598
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1738	0.7952	0.793
Toxoplasma gondii	FATC domain-containing protein	0.0413	0.185	0.2393
Giardia lamblia	Hypothetical protein	0.0141	0.0598	0.0553
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0141	0.0598	0.0598
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0141	0.0598	0.0598
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0413	0.185	0.1812
Mycobacterium leprae	conserved hypothetical protein	0.0141	0.0598	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1736	0.7944	0.7944
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0047	0.0047
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0141	0.0598	0.0598
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0141	0.0598	0.0598
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0413	0.185	0.1812
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0141	0.0598	0.0684
Onchocerca volvulus		0.0141	0.0598	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1178	0.5376	0.5376
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0141	0.0598	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0141	0.0598	0.0598
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1623	0.7425	1
Entamoeba histolytica	protein kinase, putative	0.0032	0.0097	0.0097
Echinococcus multilocularis	Glutaredoxin protein 5	0.0021	0.0046	0.0046
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0123	0.0123
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.2182	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0598	0.0598
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0413	0.185	0.185
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0141	0.0598	0.0553
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0413	0.185	0.185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1178	0.5376	0.5376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1623	0.7425	0.7425
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0141	0.0598	0.0598
Plasmodium vivax	hypothetical protein, conserved	0.0141	0.0598	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0141	0.0598	0.0497
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.2182	1	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0141	0.0598	0.0598
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0732	0.332	0.3288
Loa Loa (eye worm)	hypothetical protein	0.0413	0.185	0.185
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0141	0.0598	0.0553
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1178	0.5376	0.5376
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1736	0.7944	0.7944
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0598	0.0598
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0319	0.1419	0.1419
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0123	0.0123
Loa Loa (eye worm)	phosphatidylinositol 3	0.2182	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0141	0.0598	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0732	0.332	0.332
Plasmodium vivax	hypothetical protein	0.0141	0.0598	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1863	0.853	0.853
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0141	0.0598	0.0598
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0057	0.0057
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0141	0.0598	0.0598
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0141	0.0598	0.0598
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0141	0.0598	0.0684
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1032	0.4703	0.4645
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1736	0.7944	0.7944
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0141	0.0598	0.0598
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0141	0.0598	0.0553
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0141	0.0598	0.0598
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0732	0.332	0.332
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0598	0.0598
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2182	1	1
Entamoeba histolytica	hypothetical protein	0.0413	0.185	0.185
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.2182	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0586	0.2646	0.2646
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0141	0.0598	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1291	0.5895	0.5895
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0141	0.0598	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0033	0.01	0.01
Entamoeba histolytica	protein kinase, putative	0.0034	0.0107	0.0107
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0141	0.0598	0.0598
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0141	0.0598	0.0553
Echinococcus granulosus	nervana 2	0.0021	0.0046	0.0046
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1417	0.6474	0.6474
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0141	0.0598	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0445	0.1998	0.1998
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0272	0.1202	0.1202
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0111	0.0111
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0732	0.332	0.2895
Loa Loa (eye worm)	phosphatidylinositol 3	0.0141	0.0598	0.0598

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 26 nM	Displacement of [3H](-)-CGP-12177 from adrenergic beta1 receptor by cell based assay	ChEMBL.	24900360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2011229

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1635398