TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 303.151 | Formula: C15H11BrO2
H donors: 0 H acceptors: 1 LogP: 3.76 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc2c(c1)C(=O)C(CO2)c1ccccc1
InChi: 1S/C15H11BrO2/c16-11-6-7-14-12(8-11)15(17)13(9-18-14)10-4-2-1-3-5-10/h1-8,13H,9H2
InChiKey: URRLNIVKMIVLSW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0158	0.0561	0.0561
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0158	0.0561	0.0538
Entamoeba histolytica	hypothetical protein	0.0158	0.0561	0.0561
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.2447	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0158	0.0561	0.0561
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0158	0.0561	0.0561
Entamoeba histolytica	protein kinase rad3, putative	0.0463	0.1819	0.1819
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0158	0.0561	0.0481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.182	0.7415	0.7415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0821	0.3294	0.3294
Loa Loa (eye worm)	phosphatidylinositol 3	0.0158	0.0561	0.0561
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	0.038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.5939	0.5939
Trichomonas vaginalis	PIKK family atypical protein kinase	0.182	0.7415	0.7415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1319	0.535	0.535
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0158	0.0561	0.0561
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.182	0.7415	0.7415
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0082	0.0082
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0057	0.0057
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0046	0.0101	0.0101
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.2447	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1949	0.7944	0.7822
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0516	0.2037	0.2575
Loa Loa (eye worm)	hypothetical protein	0.0305	0.1168	0.1168
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0158	0.0561	0.0481
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0463	0.1819	0.1819
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0158	0.0561	0.5
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0158	0.0561	0.0561
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0189	0.0189
Echinococcus multilocularis	Glutaredoxin protein 5	0.0042	0.0082	0.0082
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0158	0.0561	0.0481
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0158	0.0561	0.0561
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0158	0.0561	0.0561
Echinococcus granulosus	Glutaredoxin protein 5	0.0042	0.0082	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2447	1	1
Giardia lamblia	GTOR	0.2447	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0516	0.2037	0.2037
Schistosoma mansoni	serine/threonine-protein kinase	0.0046	0.0101	0.0101
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.2447	1	1
Entamoeba histolytica	hypothetical protein	0.0158	0.0561	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0358	0.1386	0.1386
Echinococcus multilocularis		0.0158	0.0561	0.0561
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0158	0.0561	0.0561
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0463	0.1819	0.1819
Echinococcus multilocularis	rac serine:threonine kinase	0.0046	0.0101	0.0101
Trypanosoma cruzi	target of rapamycin kinase 3	0.1949	0.7944	0.7926
Schistosoma mansoni	hypothetical protein	0.0358	0.1386	0.1386
Entamoeba histolytica	hypothetical protein	0.0158	0.0561	0.0561
Entamoeba histolytica	protein kinase, putative	0.0068	0.0189	0.0189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.182	0.7415	0.7415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1642	0.6678	0.6678
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0463	0.1819	0.1819
Entamoeba histolytica	protein kinase, putative	0.0063	0.0172	0.0172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.182	0.7415	0.7415
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0189	0.0189
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	0.0561
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0158	0.0561	0.0538
Echinococcus granulosus	serine/threonine protein kinase	0.0046	0.0101	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.182	0.7415	0.7415
Echinococcus multilocularis	serine protein kinase ATM	0.0463	0.1819	0.1819
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0158	0.0561	0.0561
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0158	0.0561	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0463	0.1819	0.1819
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0158	0.0561	0.0561
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0046	0.0101	0.0101
Trypanosoma cruzi	Protein kinase B	0.0046	0.0101	0.0017
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0158	0.0561	0.0561
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0158	0.0561	0.0561
Onchocerca volvulus		0.0158	0.0561	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0189	0.0189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2447	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1319	0.535	0.535
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0158	0.0561	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0158	0.0561	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0158	0.0561	0.0561
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0158	0.0561	0.0561
Schistosoma mansoni	serine/threonine-protein kinase	0.0046	0.0101	0.0101
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1947	0.7936	0.7936
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1321	0.5358	0.5358
Entamoeba histolytica	hypothetical protein	0.0158	0.0561	0.0561
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0821	0.3294	0.3165
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0463	0.1819	0.1819
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0158	0.0561	0.0481
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0158	0.0561	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0463	0.1819	0.1661
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0821	0.3294	0.3294
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0158	0.0561	0.0561
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0158	0.0561	0.0481
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.2447	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0158	0.0561	0.0561
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0042	0.0084	0.0084
Loa Loa (eye worm)	phosphatidylinositol 3	0.0158	0.0561	0.0561
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1016	0.4101	0.3988
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0158	0.0561	0.0561
Echinococcus granulosus	serine protein kinase ATM	0.0463	0.1819	0.1819
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0821	0.3294	0.3294
Trichomonas vaginalis	conserved hypothetical protein	0.0358	0.1386	0.1386
Schistosoma mansoni	hypothetical protein	0.0158	0.0561	0.0561
Entamoeba histolytica	protein kinase 2, putative	0.0042	0.0084	0.0084
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0042	0.0082	0.0082
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0158	0.0561	0.0481
Trichomonas vaginalis	conserved hypothetical protein	0.0305	0.1168	0.1168
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0821	0.3294	0.3165
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0057	0.0057
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.2447	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0158	0.0561	0.038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0158	0.0561	0.0561
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0189	0.0189
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0068	0.0068
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0158	0.0561	0.0561
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0158	0.0561	0.0481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1589	0.646	0.646
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0158	0.0561	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0499	0.1967	0.1967
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0305	0.1168	0.1168
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0068	0.0189	0.0189
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0821	0.3294	0.2895
Loa Loa (eye worm)	phosphatidylinositol 3	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0657	0.2618	0.2618
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1448	0.5879	0.5879
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0158	0.0561	0.0538
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0046	0.0101	0.0017
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.2447	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0158	0.0561	0.0561
Loa Loa (eye worm)	phosphatidylinositol 3	0.0158	0.0561	0.0561
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0821	0.3294	0.3294
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0017	0.0017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2447	1	1
Entamoeba histolytica	hypothetical protein	0.0463	0.1819	0.1819
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1157	0.4682	0.458
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0158	0.0561	0.0538
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1947	0.7936	0.7936
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0158	0.0561	0.0561
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0158	0.0561	0.0481
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0158	0.0561	0.0561
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0158	0.0561	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.2447	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0821	0.3294	0.3294
Plasmodium vivax	hypothetical protein	0.0158	0.0561	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2089	0.8525	0.8525
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0082	0.0082
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0158	0.0561	0.0561
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0158	0.0561	0.0561
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0158	0.0561	0.0561
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0821	0.3294	0.3237
Loa Loa (eye worm)	hypothetical protein	0.0463	0.1819	0.1819
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0158	0.0561	0.0481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1947	0.7936	0.7936
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0158	0.0561	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0561	0.0561
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0358	0.1386	0.1386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1321	0.5358	0.5358
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0189	0.0189
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0158	0.0561	0.0561
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0463	0.1819	0.1819
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0158	0.0561	0.0481
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0463	0.1819	0.1819
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.182	0.7415	0.7415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1321	0.5358	0.5358
Plasmodium vivax	hypothetical protein, conserved	0.0158	0.0561	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.2447	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0158	0.0561	0.038
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0158	0.0561	0.0561
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0463	0.1819	0.1749
Onchocerca volvulus		0.0158	0.0561	0.5
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0158	0.0561	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1321	0.5358	0.5358
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	1
Echinococcus multilocularis	nervana 2	0.0042	0.0082	0.0082
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0189	0.0189
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0158	0.0561	0.0561
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0068	0.0068
Toxoplasma gondii	target of rapamycin (TOR), putative	0.182	0.7415	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.2447	1	1
Toxoplasma gondii	FATC domain-containing protein	0.0463	0.1819	0.2274
Giardia lamblia	Hypothetical protein	0.0158	0.0561	0.0481
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0158	0.0561	0.0561
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0158	0.0561	0.0561
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0463	0.1819	0.1749
Mycobacterium leprae	conserved hypothetical protein	0.0158	0.0561	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1947	0.7936	0.7936
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0042	0.0084	0.0084
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0158	0.0561	0.0561
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0158	0.0561	0.0561
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0158	0.0561	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0358	0.1386	0.1386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.5939	0.5939
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0158	0.0561	0.0561
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0305	0.1168	0.1093
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0158	0.0561	0.0561
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1949	0.7944	0.7904
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0158	0.0561	0.0561
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0063	0.0172	0.0172
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0158	0.0561	0.0481
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1448	0.5879	0.5879
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0158	0.0561	0.0481
Echinococcus multilocularis	nervana 2	0.0042	0.0082	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1319	0.535	0.535
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0189	0.0189
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0158	0.0561	0.0561
Echinococcus multilocularis	Zinc finger, PHD finger	0.0158	0.0561	0.0561
Echinococcus granulosus	serine threonine protein kinase nrc	0.0042	0.0084	0.0084
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0189	0.0189
Echinococcus granulosus	nervana 2	0.0042	0.0082	0.0082
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0821	0.3294	0.3294
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0821	0.3294	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1462	0.5939	0.5939
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0821	0.3294	0.3294
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0158	0.0561	0.0561
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0463	0.1819	0.1819
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.2447	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0158	0.0561	0.0561
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0561	0.0561
Brugia malayi	p70 ribosomal S6 kinase beta	0.0063	0.0172	0.0172
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0158	0.0561	0.0561
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0158	0.0561	0.038
Loa Loa (eye worm)	hypothetical protein	0.0516	0.2037	0.2037
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0068	0.0068
Entamoeba histolytica	protein kinase, putative	0.0068	0.0189	0.0189
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.2447	1	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0158	0.0561	0.0538
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	0.0481
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0042	0.0082	0.0082
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0158	0.0561	0.0561
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0821	0.3294	0.3294
Brugia malayi	FAT domain containing protein	0.0358	0.1386	0.1386
Loa Loa (eye worm)	phosphatidylinositol 3	0.0821	0.3294	0.3294
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.2447	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0821	0.3294	0.3237
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0158	0.0561	0.0561
Echinococcus granulosus	nervana 2	0.0042	0.0082	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1947	0.7936	0.7936
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0463	0.1819	0.1819
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0821	0.3294	0.3294
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0158	0.0561	0.0561
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0463	0.1819	0.1819

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 29 uM	Inhibition of human recombinant aromatase expressed in baculovirus/insect cells using 7-methoxy-trifluoromethylcoumarin as substrate after 30 mins by fluorescence-based spectrophotometry	ChEMBL.	22444875
IC50 (functional)	= 100 uM	Cytotoxicity against estrogen-dependent human MCF7 cells after 72 hrs by MTT assay	ChEMBL.	24345481

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2011189

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1635403