Detailed information for compound 1635439

Basic information

Technical information
  • TDR Targets ID: 1635439
  • Name: 2-(phenyl-sulfanylphosphinothioyl)acetic acid
  • MW: 232.26 | Formula: C8H9O2PS2
  • H donors: 1 H acceptors: 2 LogP: 2.74 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CP(=S)(c1ccccc1)S
  • InChi: 1S/C8H9O2PS2/c9-8(10)6-11(12,13)7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)(H,12,13)
  • InChiKey: RMXLGVUDWFUVEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(phenyl-sulfanyl-phosphinothioyl)acetic acid
  • 2-(mercapto-phenylphosphinothioyl)acetic acid
  • 2-(mercapto-phenyl-thiophosphoryl)acetic acid
  • 2-(phenyl-sulfanyl-phosphinothioyl)ethanoic acid
  • AIDS157057
  • NSC634091 (SODIUM SALT)
  • [Mercapto(phenyl)phosphorothioyl]acetic acid
  • NCI60_011341
  • AIDS-157057

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0121 0.0535 0.0535
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0248 0.0248
Leishmania major phosphatidylinositol 3-related kinase, putative 0.063 0.3276 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0234 0.1143 0.1143
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0121 0.0535 0.043
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0248 0.0248
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0121 0.0535 0.0535
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0383 0.1944 0.1944
Trichomonas vaginalis PIKK family atypical protein kinase 0.1219 0.6451 0.6451
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0121 0.0535 0.0535
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0133 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.1111 0.5868 0.5868
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0504 0.2597 0.2597
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0121 0.0535 0.0535
Loa Loa (eye worm) phosphatidylinositol 3 0.0121 0.0535 0.0535
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1877 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1877 1 1
Entamoeba histolytica hypothetical protein 0.0355 0.1796 0.1796
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0023 0.0023
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.063 0.3276 0.3276
Loa Loa (eye worm) phosphatidylinositol 3 0.0121 0.0535 0.0535
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0121 0.0535 0.043
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0121 0.0535 0.0535
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0121 0.0535 0.0535
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.793 0.793
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0888 0.4667 0.4532
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0121 0.0535 0.0432
Entamoeba histolytica protein kinase 2, putative 0.0042 0.011 0.011
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0121 0.0535 0.0535
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0121 0.0535 0.0535
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.1603 0.8521 0.8521
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.3276 0.3276
Plasmodium vivax hypothetical protein 0.0121 0.0535 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0121 0.0535 1
Loa Loa (eye worm) phosphatidylinositol 3 0.1877 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1014 0.5346 0.5346
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0275 0.1362 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.793 0.793
Loa Loa (eye worm) hypothetical protein 0.0121 0.0535 0.0535
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0121 0.0535 0.0535
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0355 0.1796 0.1796
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0121 0.0535 0.043
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.063 0.3276 0.3201
Plasmodium vivax hypothetical protein, conserved 0.0121 0.0535 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1877 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0121 0.0535 0.0295
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.1396 0.7407 0.7407
Trichomonas vaginalis PIKK family atypical protein kinase 0.1014 0.5346 0.5346
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0121 0.0535 0.0535
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0121 0.0535 0.043
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0355 0.1796 0.1796
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0355 0.1796 0.1796
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0121 0.0535 0.0535
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0076 0.0076
Echinococcus multilocularis nervana 2 0.0042 0.0108 0.0108
Toxoplasma gondii target of rapamycin (TOR), putative 0.1396 0.7407 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0121 0.0535 0.0535
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0248 0.0248
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1877 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0121 0.0535 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0121 0.0535 0.0535
Onchocerca volvulus 0.0121 0.0535 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1014 0.5346 0.5346
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0355 0.1796 0.1705
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.793 0.793
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0121 0.0535 0.0432
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.011 0.011
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0121 0.0535 0.0535
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0121 0.0535 0.0535
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0355 0.1796 0.1705
Mycobacterium leprae conserved hypothetical protein 0.0121 0.0535 0.5
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0121 0.0535 0.0535
Toxoplasma gondii FATC domain-containing protein 0.0355 0.1796 0.2187
Giardia lamblia Hypothetical protein 0.0121 0.0535 0.043
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0121 0.0535 0.0535
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1495 0.7938 0.7886
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0234 0.1143 0.1045
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0121 0.0535 0.0535
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0121 0.0535 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0275 0.1362 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.1122 0.5928 0.5928
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0121 0.0535 0.0535
Echinococcus multilocularis Zinc finger, PHD finger 0.0121 0.0535 0.0535
Echinococcus granulosus nervana 2 0.0042 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.5337 0.5337
Brugia malayi Protein kinase domain containing protein 0.0068 0.0248 0.0248
Entamoeba histolytica protein kinase, putative 0.0064 0.0225 0.0225
Echinococcus multilocularis nervana 2 0.0042 0.0108 0.0108
Giardia lamblia Phosphatidylinositol 4-kinase 0.0121 0.0535 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.1111 0.5868 0.5868
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0121 0.0535 0.043
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0121 0.0535 0.0535
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1877 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0121 0.0535 0.0535
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0121 0.0535 0.0535
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0355 0.1796 0.1796
Trichomonas vaginalis PIKK family atypical protein kinase 0.1122 0.5928 0.5928
Leishmania major phosphatidylinositol 3-kinase, putative 0.063 0.3276 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.3276 0.3276
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0042 0.0108 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0248 0.0248
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.063 0.3276 0.3276
Loa Loa (eye worm) hypothetical protein 0.0396 0.2015 0.2015
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0076 0.0076
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1877 1 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0248 0.0248
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0064 0.0225 0.0225
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0121 0.0535 0.0535
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0121 0.0535 0.0295
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0121 0.0535 0.0535
Loa Loa (eye worm) phosphatidylinositol 3 0.063 0.3276 0.3276
Brugia malayi FAT domain containing protein 0.0275 0.1362 0.1362
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0121 0.0535 0.0432
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0094 0.0094
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0121 0.0535 0.043
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.063 0.3276 0.3276
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0121 0.0535 0.0535
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0355 0.1796 0.1796
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.3276 0.3276
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0121 0.0535 0.0535
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0121 0.0535 0.0535
Echinococcus granulosus nervana 2 0.0042 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.793 0.793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.1796 0.1796
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1877 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.063 0.3276 0.3201
Trichomonas vaginalis PIKK family atypical protein kinase 0.1396 0.7407 0.7407
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0121 0.0535 0.043
Entamoeba histolytica protein kinase rad3, putative 0.0355 0.1796 0.1796
Loa Loa (eye worm) phosphatidylinositol 3 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.3276 0.3276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0121 0.0535 0.0535
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1877 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0121 0.0535 0.0535
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0121 0.0535 0.0535
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0121 0.0535 0.0432
Entamoeba histolytica hypothetical protein 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.1396 0.7407 0.7407
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0121 0.0535 0.0535
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.5337 0.5337
Trichomonas vaginalis PIKK family atypical protein kinase 0.1122 0.5928 0.5928
Trichomonas vaginalis PIKK family atypical protein kinase 0.1396 0.7407 0.7407
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0121 0.0535 0.0295
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0396 0.2015 0.2492
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1877 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1495 0.7938 0.7822
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.011 0.011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0063 0.0063
Echinococcus multilocularis rac serine:threonine kinase 0.0046 0.0133 0.0133
Entamoeba histolytica protein kinase, putative 0.0068 0.0248 0.0248
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0094 0.0094
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0121 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0234 0.1143 0.1143
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0121 0.0535 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.1796 0.1796
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0121 0.0535 0.0535
Mycobacterium tuberculosis Conserved hypothetical protein 0.0121 0.0535 0.5
Giardia lamblia GTOR 0.1877 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1877 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0121 0.0535 0.0535
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0121 0.0535 0.0535
Echinococcus granulosus Glutaredoxin protein 5 0.0042 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0535 0.0535
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0121 0.0535 0.043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.1796 0.1796
Echinococcus multilocularis 0.0121 0.0535 0.0535
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0121 0.0535 0.0535
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0121 0.0535 0.0535
Entamoeba histolytica hypothetical protein 0.0121 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0275 0.1362 0.1362
Trichomonas vaginalis conserved hypothetical protein 0.0396 0.2015 0.2015
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0133 0.0133
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1877 1 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0355 0.1796 0.1796
Brugia malayi p70 ribosomal S6 kinase beta 0.0064 0.0225 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.1396 0.7407 0.7407
Trichomonas vaginalis PIKK family atypical protein kinase 0.1259 0.6669 0.6669
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0248 0.0248
Entamoeba histolytica hypothetical protein 0.0121 0.0535 0.0535
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0133 0.0133
Trypanosoma cruzi target of rapamycin kinase 3 0.1495 0.7938 0.7915
Schistosoma mansoni hypothetical protein 0.0275 0.1362 0.1362
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0121 0.0535 0.0535
Entamoeba histolytica protein kinase, putative 0.0068 0.0248 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.1396 0.7407 0.7407
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0121 0.0535 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.1396 0.7407 0.7407
Echinococcus multilocularis serine protein kinase ATM 0.0355 0.1796 0.1796
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0121 0.0535 0.0432
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0133 0.0133
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0121 0.0535 0.0535
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0121 0.0535 0.0535
Onchocerca volvulus 0.0121 0.0535 0.5
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0121 0.0535 0.0535
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0133 0.0023
Echinococcus granulosus serine/threonine protein kinase 0.0046 0.0133 0.0133
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0355 0.1796 0.1796
Trypanosoma cruzi Protein kinase B 0.0046 0.0133 0.0023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.793 0.793
Trichomonas vaginalis PIKK family atypical protein kinase 0.1014 0.5346 0.5346
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0121 0.0535 0.0535
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0121 0.0535 0.0535
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0121 0.0535 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1877 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0121 0.0535 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1012 0.5337 0.5337
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0355 0.1796 0.1588
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.063 0.3276 0.3276
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0121 0.0535 0.043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0355 0.1796 0.1796
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0121 0.0535 1
Entamoeba histolytica hypothetical protein 0.0121 0.0535 0.0535
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.063 0.3276 0.3105
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0121 0.0535 0.0535
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1877 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0121 0.0535 0.043
Loa Loa (eye worm) phosphatidylinositol kinase 0.0121 0.0535 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.063 0.3276 0.3276
Echinococcus granulosus serine protein kinase ATM 0.0355 0.1796 0.1796
Schistosoma mansoni hypothetical protein 0.0121 0.0535 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0275 0.1362 0.1362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0121 0.0535 0.0535
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.078 0.4085 0.3935
Loa Loa (eye worm) phosphatidylinositol 3 0.0121 0.0535 0.0535
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0042 0.0108 0.0108
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0121 0.0535 0.043
Echinococcus multilocularis Glutaredoxin protein 5 0.0042 0.0108 0.0108
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.011 0.011
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0121 0.0535 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0121 0.0535 0.0535
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0063 0.0063
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.063 0.3276 0.3105
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1877 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0234 0.1143 0.1143

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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