Detailed information for compound 1635444

Basic information

Technical information
  • TDR Targets ID: 1635444
  • Name: 2-(2-amino-3,4-dibromophenyl)-N-methyl-N-[(1S ,2S)-2-pyrrolidin-1-ylcyclohexyl]acetamide
  • MW: 473.245 | Formula: C19H27Br2N3O
  • H donors: 1 H acceptors: 1 LogP: 3.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N([C@H]1CCCC[C@@H]1N1CCCC1)C)Cc1ccc(c(c1N)Br)Br
  • InChi: 1S/C19H27Br2N3O/c1-23(15-6-2-3-7-16(15)24-10-4-5-11-24)17(25)12-13-8-9-14(20)18(21)19(13)22/h8-9,15-16H,2-7,10-12,22H2,1H3/t15-,16-/m0/s1
  • InChiKey: YPSYVLXJCIRFDK-HOTGVXAUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-amino-3,4-dibromo-phenyl)-N-methyl-N-[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]acetamide
  • 2-(2-amino-3,4-dibromophenyl)-N-methyl-N-[(1S,2S)-2-1-pyrrolidinylcyclohexyl]acetamide
  • 2-(2-amino-3,4-dibromo-phenyl)-N-methyl-N-[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]ethanamide
  • NCI60_038352

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0813 0.4663 0.4519
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0111 0.0529 0.0529
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0416
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0111 0.0529 0.0529
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0111 0.0529 1
Loa Loa (eye worm) phosphatidylinositol 3 0.172 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Plasmodium vivax hypothetical protein 0.0111 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.852 0.852
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0529
Entamoeba histolytica protein kinase 2, putative 0.0041 0.0117 0.0117
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0111 0.0529 0.0529
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0111 0.0529 0.0529
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.3191
Loa Loa (eye worm) hypothetical protein 0.0325 0.179 0.179
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0111 0.0529 0.0416
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0252 0.1356 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Loa Loa (eye worm) hypothetical protein 0.0111 0.0529 0.0529
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.0529 0.0416
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0325 0.179 0.179
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0325 0.179 0.179
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0529 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.172 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0529 0.0273
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0111 0.0529 0.0529
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0111 0.0529 0.0416
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0111 0.0529 0.0529
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0351 0.1939 0.1939
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1117 0.6448 0.6448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.1137 0.1137
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.2895
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.2592 0.2592
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.5865 0.5865
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0141 0.0141
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.172 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0577 0.3271 0.3271
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.172 1 1
Entamoeba histolytica hypothetical protein 0.0325 0.179 0.179
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0114 0.0114
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0577 0.3271 0.3271
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.5925 0.5925
Leishmania major phosphatidylinositol 3-kinase, putative 0.0577 0.3271 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0325 0.179 0.179
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0111 0.0529 0.0529
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.172 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0111 0.0529 0.0529
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0111 0.0529 0.0529
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0062 0.0239 0.0239
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0111 0.0529 0.0273
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0363 0.2009 0.2009
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.172 1 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0529
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0577 0.3271 0.3271
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0109 0.0109
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0416
Brugia malayi FAT domain containing protein 0.0252 0.1356 0.1356
Loa Loa (eye worm) phosphatidylinositol 3 0.0577 0.3271 0.3271
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.172 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.3191
Echinococcus granulosus nervana 2 0.0041 0.0114 0.0114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.179 0.179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.179 0.179
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0325 0.179 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0111 0.0529 0.0529
Onchocerca volvulus 0.0111 0.0529 0.5
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0111 0.0529 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Echinococcus multilocularis nervana 2 0.0041 0.0114 0.0114
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.009 0.009
Toxoplasma gondii target of rapamycin (TOR), putative 0.1279 0.7406 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0111 0.0529 0.0529
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.172 1 1
Toxoplasma gondii FATC domain-containing protein 0.0325 0.179 0.2164
Giardia lamblia Hypothetical protein 0.0111 0.0529 0.0416
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0111 0.0529 0.0529
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0325 0.179 0.1693
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0529 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0041 0.0117 0.0117
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0111 0.0529 0.0529
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0111 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.5925 0.5925
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0252 0.1356 0.1356
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0214 0.1137 0.1032
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0111 0.0529 0.0529
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Trypanosoma brucei target of rapamycin kinase 3, putative 0.137 0.7937 0.7881
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0111 0.0529 0.0529
Entamoeba histolytica protein kinase, putative 0.0062 0.0239 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.5865 0.5865
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0529 0.0416
Giardia lamblia Phosphatidylinositol 4-kinase 0.0111 0.0529 0.0416
Echinococcus multilocularis nervana 2 0.0041 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.5334 0.5334
Brugia malayi Protein kinase domain containing protein 0.0066 0.0263 0.0263
Echinococcus multilocularis Zinc finger, PHD finger 0.0111 0.0529 0.0529
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Echinococcus granulosus nervana 2 0.0041 0.0114 0.0114
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0529 0.0416
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0114 0.0114
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.172 1 1
Giardia lamblia GTOR 0.172 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0141 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0363 0.2009 0.2009
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.172 1 1
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0252 0.1356 0.1356
Echinococcus multilocularis 0.0111 0.0529 0.0529
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0111 0.0529 0.0529
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.179 0.179
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0252 0.1356 0.1356
Trypanosoma cruzi target of rapamycin kinase 3 0.137 0.7937 0.7912
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1154 0.6667 0.6667
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Schistosoma mansoni fkbp-rapamycin associated protein 0.0325 0.179 0.179
Brugia malayi p70 ribosomal S6 kinase beta 0.0062 0.0239 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Entamoeba histolytica protein kinase, putative 0.0066 0.0263 0.0263
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0111 0.0529 0.0529
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0111 0.0529 0.0529
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.172 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0325 0.179 0.179
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0111 0.0529 0.0416
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.5925 0.5925
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.5334 0.5334
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0111 0.0529 0.0529
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Echinococcus multilocularis rac serine:threonine kinase 0.0045 0.0141 0.0141
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0076 0.0076
Echinococcus granulosus serine threonine protein kinase nrc 0.0041 0.0117 0.0117
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.172 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.137 0.7937 0.7822
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0363 0.2009 0.247
Loa Loa (eye worm) hypothetical protein 0.0214 0.1137 0.1137
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.179 0.179
Mycobacterium tuberculosis Conserved hypothetical protein 0.0111 0.0529 0.5
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Entamoeba histolytica protein kinase, putative 0.0066 0.0263 0.0263
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0109 0.0109
Loa Loa (eye worm) phosphatidylinositol kinase 0.0111 0.0529 0.0529
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0111 0.0529 0.0416
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.172 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0111 0.0529 0.0529
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0114 0.0114
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0714 0.4081 0.3921
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Echinococcus granulosus serine protein kinase ATM 0.0325 0.179 0.179
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1356 0.1356
Schistosoma mansoni hypothetical protein 0.0111 0.0529 0.0529
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0041 0.0117 0.0117
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0114 0.0114
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.0529 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1137 0.1137
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0076 0.0076
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0577 0.3271 0.3089
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.172 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.0529 0.0529
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0141 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Echinococcus multilocularis serine protein kinase ATM 0.0325 0.179 0.179
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0111 0.0529 0.0529
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0111 0.0529 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0325 0.179 0.179
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0111 0.0529 0.0529
Echinococcus granulosus serine/threonine protein kinase 0.0045 0.0141 0.0141
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0045 0.0141 0.0024
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0111 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0061
Onchocerca volvulus 0.0111 0.0529 0.5
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0263 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.172 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0111 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.5334 0.5334
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0111 0.0529 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0111 0.0529 0.0529
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0111 0.0529 0.0529
Trypanosoma cruzi Protein kinase B 0.0045 0.0141 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.3089
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0111 0.0529 0.0416
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.179 0.179
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0111 0.0529 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0325 0.179 0.1568
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0577 0.3271 0.3271

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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