Detailed information for compound 1635444

Basic information

Technical information
  • TDR Targets ID: 1635444
  • Name: 2-(2-amino-3,4-dibromophenyl)-N-methyl-N-[(1S ,2S)-2-pyrrolidin-1-ylcyclohexyl]acetamide
  • MW: 473.245 | Formula: C19H27Br2N3O
  • H donors: 1 H acceptors: 1 LogP: 3.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N([C@H]1CCCC[C@@H]1N1CCCC1)C)Cc1ccc(c(c1N)Br)Br
  • InChi: 1S/C19H27Br2N3O/c1-23(15-6-2-3-7-16(15)24-10-4-5-11-24)17(25)12-13-8-9-14(20)18(21)19(13)22/h8-9,15-16H,2-7,10-12,22H2,1H3/t15-,16-/m0/s1
  • InChiKey: YPSYVLXJCIRFDK-HOTGVXAUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-amino-3,4-dibromo-phenyl)-N-methyl-N-[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]acetamide
  • 2-(2-amino-3,4-dibromophenyl)-N-methyl-N-[(1S,2S)-2-1-pyrrolidinylcyclohexyl]acetamide
  • 2-(2-amino-3,4-dibromo-phenyl)-N-methyl-N-[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]ethanamide
  • NCI60_038352

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0114 0.0114
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0273
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0111 0.0529 0.0529
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.5334 0.5334
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.5865 0.5865
Loa Loa (eye worm) phosphatidylinositol 3 0.0577 0.3271 0.3271
Echinococcus multilocularis nervana 2 0.0041 0.0114 0.0114
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1018 0.5865 0.5865
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.179 0.179
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.1137 0.1137
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0111 0.0529 0.0529
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0111 0.0529 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.2895
Loa Loa (eye worm) hypothetical protein 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.172 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Echinococcus granulosus serine threonine protein kinase nrc 0.0041 0.0117 0.0117
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.2592 0.2592
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.172 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0111 0.0529 0.0529
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0111 0.0529 0.0529
Brugia malayi FAT domain containing protein 0.0252 0.1356 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0577 0.3271 0.3271
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0111 0.0529 0.0416
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0529 0.0416
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Loa Loa (eye worm) hypothetical protein 0.0325 0.179 0.179
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0252 0.1356 0.1356
Trichomonas vaginalis conserved hypothetical protein 0.0252 0.1356 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.3191
Trichomonas vaginalis PIKK family atypical protein kinase 0.1154 0.6667 0.6667
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.172 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.172 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1117 0.6448 0.6448
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0141 0.0141
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.5334 0.5334
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0111 0.0529 0.0529
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0062 0.0239 0.0239
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0111 0.0529 0.0416
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.179 0.179
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0111 0.0529 0.0529
Echinococcus multilocularis serine protein kinase ATM 0.0325 0.179 0.179
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0325 0.179 0.179
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0325 0.179 0.179
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Echinococcus multilocularis rac serine:threonine kinase 0.0045 0.0141 0.0141
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0927 0.5334 0.5334
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.0529 0.0416
Echinococcus multilocularis nervana 2 0.0041 0.0114 0.0114
Echinococcus granulosus nervana 2 0.0041 0.0114 0.0114
Leishmania major phosphatidylinositol 3-kinase, putative 0.0577 0.3271 0.2895
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0141 0.0141
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0111 0.0529 0.0529
Schistosoma mansoni fkbp-rapamycin associated protein 0.0325 0.179 0.179
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.3191
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Entamoeba histolytica protein kinase 2, putative 0.0041 0.0117 0.0117
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0214 0.1137 0.1137
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0111 0.0529 0.0529
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0111 0.0529 0.0529
Brugia malayi Protein kinase domain containing protein 0.0066 0.0263 0.0263
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0045 0.0141 0.0024
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0529
Brugia malayi p70 ribosomal S6 kinase beta 0.0062 0.0239 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.852 0.852
Giardia lamblia GTOR 0.172 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0111 0.0529 0.0529
Trypanosoma cruzi target of rapamycin kinase 3 0.137 0.7937 0.7912
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0577 0.3271 0.3089
Echinococcus granulosus nervana 2 0.0041 0.0114 0.0114
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0577 0.3271 0.3089
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0325 0.179 0.179
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0024 0.0024
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0214 0.1137 0.1032
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0111 0.0529 0.0529
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.172 1 1
Echinococcus multilocularis 0.0111 0.0529 0.0529
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0041 0.0117 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0114 0.0114
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0363 0.2009 0.247
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.009 0.009
Giardia lamblia Hypothetical protein 0.0111 0.0529 0.0416
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.172 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0273
Plasmodium vivax hypothetical protein 0.0111 0.0529 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Giardia lamblia Phosphatidylinositol 4-kinase 0.0111 0.0529 0.0416
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0076 0.0076
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0111 0.0529 0.0529
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0111 0.0529 0.0529
Entamoeba histolytica protein kinase, putative 0.0062 0.0239 0.0239
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0111 0.0529 0.0529
Onchocerca volvulus 0.0111 0.0529 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0111 0.0529 0.0529
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.0529 0.0529
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0111 0.0529 0.0529
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.009 0.009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0416
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0325 0.179 0.1568
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.172 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0111 0.0529 0.0529
Toxoplasma gondii target of rapamycin (TOR), putative 0.1279 0.7406 1
Entamoeba histolytica protein kinase, putative 0.0066 0.0263 0.0263
Entamoeba histolytica hypothetical protein 0.0325 0.179 0.179
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.172 1 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0252 0.1356 0.1356
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0041 0.0117 0.0117
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.3271 0.3271
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.137 0.7937 0.7822
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.5925 0.5925
Loa Loa (eye worm) hypothetical protein 0.0363 0.2009 0.2009
Onchocerca volvulus 0.0111 0.0529 0.5
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0111 0.0529 1
Schistosoma mansoni hypothetical protein 0.0111 0.0529 0.0529
Mycobacterium tuberculosis Conserved hypothetical protein 0.0111 0.0529 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0111 0.0529 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.5925 0.5925
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.172 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0416
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0111 0.0529 0.0529
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0111 0.0529 0.0273
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0111 0.0529 0.0529
Trypanosoma cruzi Protein kinase B 0.0045 0.0141 0.0024
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0076 0.0076
Toxoplasma gondii FATC domain-containing protein 0.0325 0.179 0.2164
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0529 0.0273
Entamoeba histolytica protein kinase, putative 0.0066 0.0263 0.0263
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0263 0.0263
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0529 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0214 0.1137 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.5925 0.5925
Echinococcus multilocularis Zinc finger, PHD finger 0.0111 0.0529 0.0529
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.172 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0111 0.0529 0.0529
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0111 0.0529 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.172 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0141 0.0141
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0325 0.179 0.179
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0111 0.0529 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.1279 0.7406 0.7406
Trypanosoma brucei target of rapamycin kinase 3, putative 0.137 0.7937 0.7881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0929 0.5342 0.5342
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0111 0.0529 0.0529
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0111 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.172 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0061
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0263 0.0263
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Schistosoma mansoni hypothetical protein 0.0252 0.1356 0.1356
Loa Loa (eye worm) phosphatidylinositol 3 0.172 1 1
Loa Loa (eye worm) hypothetical protein 0.0351 0.1939 0.1939
Entamoeba histolytica hypothetical protein 0.0111 0.0529 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Entamoeba histolytica protein kinase rad3, putative 0.0325 0.179 0.179
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0111 0.0529 0.0416
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0111 0.0529 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0529 0.0416
Echinococcus granulosus serine/threonine protein kinase 0.0045 0.0141 0.0141
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.172 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0111 0.0529 0.0529
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0577 0.3271 0.3271
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0111 0.0529 0.0529
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0111 0.0529 0.0529
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0577 0.3271 0.3271
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0813 0.4663 0.4519
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0111 0.0529 0.0404
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0363 0.2009 0.2009
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0577 0.3271 0.3271
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0111 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0252 0.1356 0.1356
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0325 0.179 0.1693
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.009 0.009
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0141 0.0141
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0529 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0111 0.0529 0.0416
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0111 0.0529 0.0529
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.172 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0325 0.179 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.179 0.179
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.179 0.179
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0714 0.4081 0.3921
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.0529 0.0529
Loa Loa (eye worm) phosphatidylinositol kinase 0.0111 0.0529 0.0529
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0111 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.7928 0.7928
Echinococcus granulosus serine protein kinase ATM 0.0325 0.179 0.179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.179 0.179
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0111 0.0529 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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