Detailed information for compound 1635447

Basic information

Technical information
  • TDR Targets ID: 1635447
  • Name: NCI60_037722
  • MW: 394.447 | Formula: C20H18N4O3S
  • H donors: 2 H acceptors: 3 LogP: 2.51 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1N1Cc2c[nH]c3c2c2c1ccnc2cc3)NS(=O)(=O)C
  • InChi: 1S/C20H18N4O3S/c1-27-18-9-13(23-28(2,25)26)3-6-16(18)24-11-12-10-22-14-4-5-15-20(19(12)14)17(24)7-8-21-15/h3-10,22-23H,11H2,1-2H3
  • InChiKey: RKJDOUZCQVZPFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase 2, putative 0.0041 0.0094 0.0094
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0139 0.0552 0.0463
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0269 0.1159 0.1159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0552 0.0552
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0139 0.0552 0.0349
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2158 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0063 0.0063
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0724 0.3287 0.3143
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0139 0.0552 0.0463
Loa Loa (eye worm) phosphatidylinositol kinase 0.0139 0.0552 0.0552
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0139 0.0552 0.0552
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2158 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0552 0.0552
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0552 0.0552
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0896 0.4095 0.3968
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0041 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0139 0.0552 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.1377 0.1377
Echinococcus granulosus serine protein kinase ATM 0.0408 0.1811 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.3287 0.3287
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0139 0.0552 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.5345 0.5345
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0139 0.0552 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1165 0.5354 0.5354
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.7934 0.7934
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0113 0.0113
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0139 0.0552 0.0552
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0139 0.0552 0.0552
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0724 0.3287 0.3143
Entamoeba histolytica hypothetical protein 0.0139 0.0552 0.0552
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0724 0.3287 0.3287
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0408 0.1811 0.1635
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0139 0.0552 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0139 0.0552 0.0463
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0408 0.1811 0.1811
Echinococcus multilocularis serine protein kinase ATM 0.0408 0.1811 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.1605 0.7412 0.7412
Echinococcus granulosus serine/threonine protein kinase 0.0045 0.0113 0.0113
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0552 0.05
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0139 0.0552 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0139 0.0552 0.0552
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0408 0.1811 0.1811
Trichomonas vaginalis AGC family protein kinase 0.0066 0.021 0.021
Onchocerca volvulus 0.0139 0.0552 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0051
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0139 0.0552 0.0552
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0139 0.0552 0.0552
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0113 0.0113
Trypanosoma cruzi Protein kinase B 0.0045 0.0113 0.0019
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0139 0.0552 0.0552
Entamoeba histolytica hypothetical protein 0.0139 0.0552 0.0552
Schistosoma mansoni hypothetical protein 0.0316 0.1377 0.1377
Trypanosoma cruzi target of rapamycin kinase 3 0.1718 0.7942 0.7922
Echinococcus multilocularis rac serine:threonine kinase 0.0045 0.0113 0.0113
Entamoeba histolytica protein kinase, putative 0.0062 0.0191 0.0191
Schistosoma mansoni fkbp-rapamycin associated protein 0.0408 0.1811 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.1605 0.7412 0.7412
Trichomonas vaginalis PIKK family atypical protein kinase 0.1447 0.6675 0.6675
Entamoeba histolytica protein kinase, putative 0.0066 0.021 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.1605 0.7412 0.7412
Trichomonas vaginalis AGC family protein kinase 0.0066 0.021 0.021
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0552 0.0552
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0139 0.0552 0.0552
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0552 0.0552
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0092 0.0092
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0139 0.0552 0.0463
Giardia lamblia GTOR 0.2158 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 1 1
Loa Loa (eye worm) hypothetical protein 0.0316 0.1377 0.1377
Entamoeba histolytica hypothetical protein 0.0139 0.0552 0.0552
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2158 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0113 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0455 0.2029 0.2029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0408 0.1811 0.1811
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0139 0.0552 0.0552
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0139 0.0552 0.0552
Echinococcus multilocularis 0.0139 0.0552 0.0552
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0063 0.0063
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.009 0.009
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0113 0.0113
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0455 0.2029 0.2545
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1718 0.7942 0.7822
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2158 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0139 0.0552 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0408 0.1811 0.1811
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0139 0.0552 0.0552
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0139 0.0552 0.0463
Loa Loa (eye worm) hypothetical protein 0.0269 0.1159 0.1159
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0092 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0066 0.021 0.021
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0552 0.0552
Entamoeba histolytica hypothetical protein 0.0139 0.0552 0.0552
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0139 0.0552 0.0552
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0552 0.05
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.3287 0.3287
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0139 0.0552 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.1605 0.7412 0.7412
Entamoeba histolytica protein kinase rad3, putative 0.0408 0.1811 0.1811
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0139 0.0552 0.0552
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2158 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.5345 0.5345
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.5935 0.5935
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0139 0.0552 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.1605 0.7412 0.7412
Trichomonas vaginalis PIKK family atypical protein kinase 0.1605 0.7412 0.7412
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0139 0.0552 0.0552
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0092 0.0092
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0139 0.0552 0.0552
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0139 0.0552 0.0463
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0724 0.3287 0.3287
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0552 0.05
Loa Loa (eye worm) phosphatidylinositol 3 0.0724 0.3287 0.3287
Brugia malayi FAT domain containing protein 0.0316 0.1377 0.1377
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.7934 0.7934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0408 0.1811 0.1811
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0552 0.0552
Echinococcus granulosus nervana 2 0.0041 0.0092 0.0092
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0724 0.3287 0.3224
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2158 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0408 0.1811 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.3287 0.3287
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.3287 0.3287
Leishmania major phosphatidylinositol 3-kinase, putative 0.0724 0.3287 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.5935 0.5935
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0724 0.3287 0.3287
Echinococcus granulosus nervana 2 0.0041 0.0092 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0066 0.021 0.021
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0139 0.0552 0.0552
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2158 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0408 0.1811 0.1811
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0139 0.0552 0.0552
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0139 0.0552 0.0349
Brugia malayi p70 ribosomal S6 kinase beta 0.0062 0.0191 0.0191
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0139 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0139 0.0552 0.0552
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0074 0.0074
Entamoeba histolytica protein kinase, putative 0.0066 0.021 0.021
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2158 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0455 0.2029 0.2029
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0139 0.0552 0.0552
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0269 0.1159 0.1075
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0316 0.1377 0.1377
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.5935 0.5935
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0139 0.0552 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1718 0.7942 0.7898
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0139 0.0552 0.0552
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0139 0.0552 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.1277 0.5875 0.5875
Echinococcus multilocularis nervana 2 0.0041 0.0092 0.0092
Giardia lamblia Phosphatidylinositol 4-kinase 0.0139 0.0552 0.0463
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0062 0.0191 0.0191
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0139 0.0552 0.0552
Echinococcus granulosus serine threonine protein kinase nrc 0.0041 0.0094 0.0094
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0552 0.0552
Echinococcus multilocularis Zinc finger, PHD finger 0.0139 0.0552 0.0552
Brugia malayi Protein kinase domain containing protein 0.0066 0.021 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.5345 0.5345
Trichomonas vaginalis PIKK family atypical protein kinase 0.1165 0.5354 0.5354
Onchocerca volvulus 0.0139 0.0552 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0139 0.0552 0.0552
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0408 0.1811 0.1733
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2158 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0139 0.0552 0.0552
Echinococcus multilocularis nervana 2 0.0041 0.0092 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0066 0.021 0.021
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0074 0.0074
Toxoplasma gondii target of rapamycin (TOR), putative 0.1605 0.7412 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0139 0.0552 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0139 0.0552 0.0552
Giardia lamblia Hypothetical protein 0.0139 0.0552 0.0463
Toxoplasma gondii FATC domain-containing protein 0.0408 0.1811 0.2243
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0041 0.0094 0.0094
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0139 0.0552 0.0552
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.7934 0.7934
Mycobacterium leprae conserved hypothetical protein 0.0139 0.0552 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0408 0.1811 0.1733
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0139 0.0552 0.0552
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0139 0.0552 0.0463
Loa Loa (eye worm) hypothetical protein 0.0408 0.1811 0.1811
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0724 0.3287 0.3224
Trichomonas vaginalis AGC family protein kinase 0.0066 0.021 0.021
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0139 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.1165 0.5354 0.5354
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0316 0.1377 0.1377
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.7934 0.7934
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0408 0.1811 0.1811
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0408 0.1811 0.1811
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0139 0.0552 0.0463
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0552 0.0552
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0139 0.0552 0.0349
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2158 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0139 0.0552 0.0552
Plasmodium vivax hypothetical protein, conserved 0.0139 0.0552 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1605 0.7412 0.7412
Trichomonas vaginalis PIKK family atypical protein kinase 0.1165 0.5354 0.5354
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0139 0.0552 0.0552
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.7934 0.7934
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0552 0.05
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1021 0.4677 0.4562
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0139 0.0552 0.0552
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0139 0.0552 0.0463
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0139 0.0552 0.0552
Plasmodium vivax hypothetical protein 0.0139 0.0552 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.3287 0.3287
Loa Loa (eye worm) phosphatidylinositol 3 0.2158 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0139 0.0552 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0139 0.0552 0.0552
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0139 0.0552 0.0552
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0139 0.0552 0.0552
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.1842 0.8523 0.8523
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0552 0.0552
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2158 1 1
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0019 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0552 0.0552
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0724 0.3287 0.3287
Entamoeba histolytica hypothetical protein 0.0408 0.1811 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.2158 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0269 0.1159 0.1159
Trichomonas vaginalis PIKK family atypical protein kinase 0.1401 0.6457 0.6457
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0139 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.044 0.1958 0.1958
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0074 0.0074
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0139 0.0552 0.0463
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0139 0.0552 0.0552
Trichomonas vaginalis AGC family protein kinase 0.0066 0.021 0.021
Loa Loa (eye worm) phosphatidylinositol 3 0.0139 0.0552 0.0552
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0724 0.3287 0.2895
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.021 0.021
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0139 0.0552 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.1277 0.5875 0.5875
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0139 0.0552 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0579 0.261 0.261
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0045 0.0113 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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