Detailed information for compound 1635449

Basic information

Technical information
  • TDR Targets ID: 1635449
  • Name: 5-(3,4-dihydroxyphenyl)-2-[(2-methoxyphenyl)m ethylidene]-[1,3]thiazolo[2,3-b][1,3]thiazol- 4-ium-3-one
  • MW: 384.449 | Formula: C19H14NO4S2+
  • H donors: 2 H acceptors: 3 LogP: 4.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1/C=C/1\Sc2[n+](C1=O)c(cs2)c1ccc(c(c1)O)O
  • InChi: 1S/C19H13NO4S2/c1-24-16-5-3-2-4-12(16)9-17-18(23)20-13(10-25-19(20)26-17)11-6-7-14(21)15(22)8-11/h2-10H,1H3,(H-,21,22)/p+1/b17-9-
  • InChiKey: FUMNPECDLWYZOH-MFOYZWKCSA-O  


Substructure search Similarity search

Network

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Synonyms

  • (2Z)-5-(3,4-dihydroxyphenyl)-2-[(2-methoxyphenyl)methylidene]-[1,3]thiazolo[2,3-b][1,3]thiazol-4-ium-3-one
  • 5-(3,4-dihydroxyphenyl)-2-[(2-methoxyphenyl)methylene]thiazolo[2,3-b]thiazol-4-ium-3-one
  • (2Z)-5-(3,4-dihydroxyphenyl)-2-[(2-methoxyphenyl)methylene]thiazolo[2,3-b]thiazol-4-ium-3-one
  • (2Z)-5-(3,4-dihydroxyphenyl)-2-[(2-methoxyphenyl)methylene]-3-thiazolo[2,3-b]thiazol-4-iumone
  • 5-(3,4-dihydroxyphenyl)-2-[(2-methoxyphenyl)methylene]-3-thiazolo[2,3-b]thiazol-4-iumone
  • (2Z)-5-(3,4-dihydroxyphenyl)-2-(2-methoxybenzylidene)thiazolo[2,3-b]thiazol-4-ium-3-one
  • 5-(3,4-dihydroxyphenyl)-2-(2-methoxybenzylidene)thiazolo[2,3-b]thiazol-4-ium-3-one
  • 5-(3,4-Dihydroxyphenyl)-2-(2-methoxybenzylidene)-4lambda~5~-[1,3]thiazolo[2,3-b][1,3]thiazol-3(2H)-one hydrochloride
  • AIDS-157991
  • AIDS157991
  • NSC658296 (CHLORIDE SALT)
  • NCI60_020429

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0161 0.0521 0.0518
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1182 0.4659 0.45
Trichomonas vaginalis PIKK family atypical protein kinase 0.1988 0.7927 0.7927
Plasmodium vivax hypothetical protein 0.0161 0.0521 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0161 0.0521 0.0518
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0034 0.0003 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0161 0.0521 0.0521
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0161 0.0521 0.0395
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0521 0.0518
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2499 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0521 0.0518
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0838 0.3265 0.3263
Trichomonas vaginalis PIKK family atypical protein kinase 0.2134 0.8518 0.8518
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0161 0.0521 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0161 0.0521 0.0518
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0161 0.0521 0.0395
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0065 0.0131 0.0128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0838 0.3265 0.3263
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0161 0.0521 0.0518
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0473 0.1784 0.1781
Trichomonas vaginalis AGC family protein kinase 0.0104 0.029 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.135 0.5338 0.5338
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0161 0.0521 0.0521
Brugia malayi FAT domain containing protein 0.0365 0.1349 0.1346
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.1988 0.7927 0.7927
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.0521 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0473 0.1784 0.1781
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0161 0.0521 0.0518
Loa Loa (eye worm) hypothetical protein 0.0473 0.1784 0.1783
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.7403 0.7403
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0161 0.0521 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.135 0.5338 0.5338
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2499 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0161 0.0521 0.052
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0161 0.0521 0.0518
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.1623 0.6445 0.6445
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0161 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0509 0.1932 0.1931
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0003 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0104 0.029 0.029
Plasmodium vivax hypothetical protein, conserved 0.0161 0.0521 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0022 0.0019
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0521 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0311 0.113 0.113
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0838 0.3265 0.3176
Trichomonas vaginalis AGC family protein kinase 0.0104 0.029 0.029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0521 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.2586 0.2586
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0161 0.0521 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.1479 0.5862 0.5862
Echinococcus multilocularis rac serine:threonine kinase 0.0071 0.0157 0.0154
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2499 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.0521 0.0521
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0161 0.0521 0.052
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0838 0.3265 0.3263
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0034 0.0003 0.0002
Echinococcus granulosus serine protein kinase ATM 0.0473 0.1784 0.1781
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2499 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0838 0.3265 0.3263
Trichomonas vaginalis AGC family protein kinase 0.0104 0.029 0.029
Echinococcus granulosus Glutaredoxin protein 5 0.0064 0.0128 0.0125
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0838 0.3265 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0838 0.3265 0.3265
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.5922 0.5922
Toxoplasma gondii FATC domain-containing protein 0.0473 0.1784 0.2129
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0161 0.0521 0.0521
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0003 0.0002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2499 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0161 0.0521 0.052
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0161 0.0521 0.0518
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0022 0.0019
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0003 0.0002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0521 0.036
Onchocerca volvulus 0.0161 0.0521 0.5
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0098 0.0264 0.0262
Entamoeba histolytica protein kinase, putative 0.0104 0.029 0.0287
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2499 1 1
Trichomonas vaginalis AGC family protein kinase 0.004 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0527 0.2002 0.2001
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0521 0.052
Entamoeba histolytica hypothetical protein 0.0161 0.0521 0.0518
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0838 0.3265 0.3064
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0036 0.0033
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0521 0.0518
Loa Loa (eye worm) hypothetical protein 0.0365 0.1349 0.1348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0838 0.3265 0.3265
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0838 0.3265 0.3176
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2499 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0473 0.1784 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.1988 0.7927 0.7927
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0161 0.0521 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0128 0.0125
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0161 0.0521 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0838 0.3265 0.3064
Entamoeba histolytica protein kinase rad3, putative 0.0473 0.1784 0.1781
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0473 0.1784 0.1675
Trichomonas vaginalis PIKK family atypical protein kinase 0.135 0.5338 0.5338
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0521 0.0518
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0161 0.0521 0.0238
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0161 0.0521 0.0518
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2499 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.7403 0.7403
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0022 0.0019
Entamoeba histolytica protein kinase 2, putative 0.0065 0.0131 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0104 0.029 0.029
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0521 0.052
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0161 0.0521 1
Echinococcus multilocularis serine protein kinase ATM 0.0473 0.1784 0.1781
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0161 0.0521 1
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0003 0.0003
Echinococcus multilocularis 0.0161 0.0521 0.0518
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0473 0.1784 0.1781
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.0521 0.0521
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.0521 0.0518
Echinococcus granulosus nervana 2 0.0064 0.0128 0.0125
Giardia lamblia Phosphatidylinositol 4-kinase 0.0161 0.0521 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.1988 0.7927 0.7927
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.1349 0.1349
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.5922 0.5922
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0521 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0311 0.113 0.113
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0161 0.0521 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.199 0.7935 0.7873
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0161 0.0521 0.0521
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0161 0.0521 0.0518
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.1479 0.5862 0.5862
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0065 0.0131 0.0128
Entamoeba histolytica protein kinase, putative 0.0098 0.0264 0.0261
Trichomonas vaginalis AGC family protein kinase 0.0104 0.029 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.1348 0.533 0.533
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0128 0.0125
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0161 0.0521 0.0518
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0161 0.0521 0.0521
Entamoeba histolytica hypothetical protein 0.0161 0.0521 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0521 0.052
Echinococcus granulosus serine threonine protein kinase nrc 0.0065 0.0131 0.0128
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0521 0.036
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0161 0.0521 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.2499 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2499 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2499 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0527 0.2002 0.2435
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0157 0.0154
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0365 0.1349 0.1346
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0161 0.0521 0.0395
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0161 0.0521 0.0395
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0521 0.0518
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0161 0.0521 0.0238
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0473 0.1784 0.1538
Trypanosoma cruzi target of rapamycin kinase 3 0.199 0.7935 0.7908
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0365 0.1349 0.1346
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.0157 0.0154
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.1677 0.6664 0.6664
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.7403 0.7403
Brugia malayi Protein kinase domain containing protein 0.0104 0.029 0.0287
Brugia malayi p70 ribosomal S6 kinase beta 0.0098 0.0264 0.0261
Entamoeba histolytica hypothetical protein 0.0473 0.1784 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.7403 0.7403
Loa Loa (eye worm) AGC/AKT protein kinase 0.0104 0.029 0.0288
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0161 0.0521 0.0395
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0161 0.0521 0.0395
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0521 0.0518
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0161 0.0521 0.0518
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0161 0.0521 0.0395
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0161 0.0521 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2499 1 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.0521 0.052
Leishmania major phosphatidylinositol 3-kinase, putative 0.0838 0.3265 0.2895
Schistosoma mansoni hypothetical protein 0.0161 0.0521 0.0518
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0473 0.1784 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.7403 0.7403
Trichomonas vaginalis PIKK family atypical protein kinase 0.1493 0.5922 0.5922
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.7403 0.7403
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0161 0.0521 0.0518
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0161 0.0521 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.1348 0.533 0.533
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0161 0.0521 0.0395
Toxoplasma gondii target of rapamycin (TOR), putative 0.1859 0.7403 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0011 0.0011
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.0157 0.0154
Echinococcus multilocularis Glutaredoxin protein 5 0.0064 0.0128 0.0125
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.199 0.7935 0.7822
Trichomonas vaginalis PIKK family atypical protein kinase 0.2499 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0527 0.2002 0.2002
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0161 0.0521 0.0518
Entamoeba histolytica hypothetical protein 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0473 0.1784 0.1784
Loa Loa (eye worm) hypothetical protein 0.0311 0.113 0.1129
Entamoeba histolytica hypothetical protein 0.0161 0.0521 0.0518
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0003 0.0002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.0521 0.0521
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0036 0.0033
Entamoeba histolytica protein kinase, putative 0.0104 0.029 0.0287
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0521 0.036
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0161 0.0521 0.0521
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2499 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0161 0.0521 0.0518
Loa Loa (eye worm) hypothetical protein 0.0034 0.0003 0.0002
Echinococcus multilocularis nervana 2 0.0064 0.0128 0.0125
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1038 0.4076 0.3899
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.0521 0.0518
Onchocerca volvulus 0.0161 0.0521 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0161 0.0521 0.0518
Schistosoma mansoni hypothetical protein 0.0365 0.1349 0.1346
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0473 0.1784 0.1781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0838 0.3265 0.3265
Echinococcus multilocularis nervana 2 0.0064 0.0128 0.0125
Echinococcus granulosus nervana 2 0.0064 0.0128 0.0125
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0161 0.0521 0.0518
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0311 0.113 0.1012
Giardia lamblia GTOR 0.2499 1 1
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0003 0.0003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0022 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0838 0.3265 0.3265
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0521 0.052
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0161 0.0521 0.0518
Echinococcus granulosus serine/threonine protein kinase 0.0071 0.0157 0.0154
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0161 0.0521 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.1859 0.7403 0.7403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0473 0.1784 0.1784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0161 0.0521 0.0521
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0161 0.0521 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0473 0.1784 0.1784
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0157 0.0154
Trypanosoma cruzi Protein kinase B 0.0071 0.0157 0.0026
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0161 0.0521 0.0521
Trichomonas vaginalis AGC family protein kinase 0.0104 0.029 0.029
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0161 0.0521 0.0521
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0011 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0521 0.052
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0161 0.0521 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.1348 0.533 0.533
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0161 0.0521 0.0238
Loa Loa (eye worm) phosphatidylinositol 3 0.2499 1 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0161 0.0521 0.0518
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0161 0.0521 0.0395
Mycobacterium leprae conserved hypothetical protein 0.0161 0.0521 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1988 0.7927 0.7927
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0161 0.0521 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.135 0.5338 0.5338
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0071 0.0157 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0838 0.3265 0.3265
Giardia lamblia Hypothetical protein 0.0161 0.0521 0.0395
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.0521 0.0518
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0473 0.1784 0.1675
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0161 0.0521 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.0838 0.3265 0.3264
Schistosoma mansoni fkbp-rapamycin associated protein 0.0473 0.1784 0.1781

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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