TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 267.243 | Formula: C13H9N5O2
H donors: 1 H acceptors: 5 LogP: 1.66 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1nnc(o1)c1nn2c(c1)c1ccccc1nc2O
InChi: 1S/C13H9N5O2/c1-7-15-16-12(20-7)10-6-11-8-4-2-3-5-9(8)14-13(19)18(11)17-10/h2-6H,1H3,(H,14,19)
InChiKey: QUHVUVAEFZAWTP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	GABA-A receptor; anion channel	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Onchocerca volvulus	Gamma-aminobutyric acid receptor subunit beta homolog	GABA-A receptor; anion channel	467 aa	433 aa	34.6 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	GABA-A receptor; anion channel	467 aa	384 aa	19.5 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	375 aa	21.9 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	435 aa	29.7 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	GABA-A receptor; anion channel	467 aa	454 aa	29.5 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	GABA-A receptor; anion channel	467 aa	379 aa	19.3 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	447 aa	25.7 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	494 aa	25.5 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	446 aa	29.1 %
Echinococcus granulosus	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	439 aa	29.6 %
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	GABA-A receptor; anion channel	467 aa	479 aa	29.2 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	441 aa	33.8 %
Onchocerca volvulus	Eukaryotic initiation factor 4A-III homolog	GABA-A receptor; anion channel	467 aa	453 aa	26.9 %
Echinococcus multilocularis	glycine receptor subunit alpha 1	GABA-A receptor; anion channel	467 aa	430 aa	32.3 %
Loa Loa (eye worm)	hypothetical protein	GABA-A receptor; anion channel	467 aa	461 aa	27.8 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	446 aa	28.0 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	GABA-A receptor; anion channel	467 aa	496 aa	26.0 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	GABA-A receptor; anion channel	467 aa	418 aa	19.6 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	434 aa	26.7 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	468 aa	28.6 %
Brugia malayi	Cation transporter family protein	GABA-A receptor; anion channel	467 aa	453 aa	28.5 %
Echinococcus multilocularis	glycine receptor subunit beta	GABA-A receptor; anion channel	467 aa	478 aa	28.7 %
Onchocerca volvulus		GABA-A receptor; anion channel	467 aa	454 aa	30.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0524	0.0524
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.0524	0.0524
Brugia malayi	Cytochrome P450 family protein	0.0039	0.2712	0.3023
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0088	0.8972	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0023	0.0656	0.0656
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0023	0.0656	0.0732
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.0524	0.0584
Loa Loa (eye worm)	DR-78	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0023	0.0656	0.0732
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0656	0.0732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0046	0.3589	0.4
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0656	0.0732
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0656	0.0732
Brugia malayi	Cation transporter family protein	0.0023	0.0656	0.0732
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0023	0.0656	0.0656
Brugia malayi	photoreceptor-specific nuclear receptor	0.0046	0.3589	0.4
Loa Loa (eye worm)	cytochrome P450 family protein	0.0037	0.2519	0.2808
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0046	0.3589	0.4
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.0524	0.0584
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Schistosoma mansoni	nAChR subunit	0.0023	0.0656	0.0656
Brugia malayi	steroid hormone receptor	0.0046	0.3589	0.4
Brugia malayi	Steroid receptor seven-up type 2	0.0046	0.3589	0.4
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0023	0.0656	0.0732
Schistosoma mansoni	zinc finger protein	0.0022	0.0524	0.0524
Onchocerca volvulus		0.0023	0.0656	0.0433
Brugia malayi	nuclear receptor NHR-67	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0023	0.0656	0.0732
Brugia malayi	nuclear receptor RXR	0.0024	0.0852	0.095
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Schistosoma mansoni	coup transcription factor	0.0046	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.0852	0.095
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0028	0.1402	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0852	0.095
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0656	0.0732
Onchocerca volvulus	Bile acid receptor homolog	0.0046	0.3589	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Brugia malayi	nuclear receptor RXR	0.0022	0.0524	0.0584
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0046	0.3589	0.4
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.3589	0.4
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0656	0.0732
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0656	0.0732
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0023	0.0656	0.0732
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0023	0.0656	0.0732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0046	0.3589	0.4
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0852	0.095
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0046	0.3589	0.4
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0023	0.0656	0.0732
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0524	0.0584
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0524	0.0524
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0656	0.0732
Brugia malayi	Cation transporter family protein	0.0023	0.0656	0.0732
Echinococcus multilocularis	voltage gated potassium channel	0.0026	0.1028	0.1145
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0852	0.095
Schistosoma mansoni	nAChR subunit	0.0023	0.0656	0.0656
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0852	0.095
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0046	0.3589	0.4
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.0524	0.0584
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0046	0.3589	0.4
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0656	0.0732
Echinococcus multilocularis	ecdysone induced protein 78C	0.0046	0.3589	0.4
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0656	0.0656
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0026	0.1028	0.1145
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0656	0.0732
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0046	0.3589	0.4
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0046	0.3589	0.4
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0026	0.1028	0.1145
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0046	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0852	0.095
Loa Loa (eye worm)	cytochrome P450 family protein	0.0037	0.2519	0.2808
Schistosoma mansoni	nuclear hormone receptor	0.0046	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Schistosoma mansoni	nAChR subunit	0.0023	0.0656	0.0656
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0656	0.0732
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0023	0.0656	0.0732
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.0852	0.095
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.3589	0.4
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0046	0.3589	0.3589
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0524	0.0584
Echinococcus multilocularis	FTZ F1 alpha	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0076	0.7495	0.8354
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0082	0.8236	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0082	0.8236	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Echinococcus granulosus	nAChR subunit	0.0023	0.0656	0.0732
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0046	0.3589	1
Onchocerca volvulus	Putative nachr subunit	0.0023	0.0656	0.0433
Brugia malayi	ecdysteroid receptor	0.0046	0.3589	0.4
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0656	0.0732
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0023	0.0656	0.0732
Brugia malayi	Cation transporter family protein	0.0023	0.0656	0.0732
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0023	0.0656	0.0732
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0088	0.8972	1
Schistosoma mansoni	voltage-gated potassium channel	0.0096	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0046	0.3589	0.4
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0656	0.0732
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	CYP4Cod1	0.0037	0.2519	0.2808
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0524	0.0584
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0023	0.0656	0.0732
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0037	0.2519	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Brugia malayi	conserved hypotetical protein	0.0022	0.0524	0.0584
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0046	0.3589	0.3589
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.1028	0.1028
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0023	0.0656	0.0732
Onchocerca volvulus		0.0023	0.0656	0.0433
Brugia malayi	nuclear hormone receptor	0.0022	0.0524	0.0584
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0656	0.0732
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0046	0.3589	0.4
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Onchocerca volvulus		0.0023	0.0656	0.0433
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0028	0.1402	0.1563
Onchocerca volvulus		0.0023	0.0656	0.0433
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.1402	0.1702
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Schistosoma mansoni	thyroid hormone receptor	0.0046	0.3589	0.3589
Brugia malayi	Cytochrome P450 family protein	0.0037	0.2519	0.2808
Giardia lamblia	Rrm3p helicase	0.0028	0.1402	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.2712	0.3023
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Brugia malayi	hypothetical protein	0.0022	0.0524	0.0584
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0046	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0524	0.0584
Brugia malayi	Nuclear hormone receptor-like 1	0.0046	0.3589	0.4
Loa Loa (eye worm)	LGC-31 protein	0.0023	0.0656	0.0732
Brugia malayi	nuclear receptor NHR-88	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0023	0.0656	0.0732
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.3589	0.4
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0046	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0023	0.0656	0.0732
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0088	0.8972	1
Schistosoma mansoni	nuclear receptor	0.0022	0.0524	0.0524
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0524	0.0584
Trypanosoma brucei	cytochrome P450, putative	0.0037	0.2519	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.0852	0.095
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0022	0.0524	0.0584
Loa Loa (eye worm)	steroid hormone receptor	0.0046	0.3589	0.4
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0046	0.3589	0.4
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.0524	0.0584
Brugia malayi	excitatory GABA receptor EXP-1A	0.0023	0.0656	0.0732
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0524	0.0584
Schistosoma mansoni	nAChR subunit	0.0023	0.0656	0.0656
Brugia malayi	ecdysone receptor	0.0022	0.0524	0.0584
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.0524	0.0524
Echinococcus granulosus	FTZ F1 alpha	0.0046	0.3589	0.4
Brugia malayi	hypothetical protein	0.0024	0.0852	0.095
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.1028	0.1028
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0656	0.0732
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0046	0.3589	0.4
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0023	0.0656	0.0732
Brugia malayi	hypothetical protein	0.0022	0.0524	0.0584
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0046	0.3589	0.4
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0852	0.095
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0524	0.0584
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0524	0.0584
Schistosoma mansoni	hypothetical protein	0.0028	0.1402	0.1402
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0413	0.046
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0656	0.0656
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0023	0.0656	0.0732
Loa Loa (eye worm)	ACC-1 protein	0.0023	0.0656	0.0732
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.0524	0.0524
Loa Loa (eye worm)	hypothetical protein	0.0046	0.3589	0.4
Onchocerca volvulus		0.0023	0.0656	0.0433
Schistosoma mansoni	nuclear receptor	0.0022	0.0524	0.0524
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0088	0.8972	1
Echinococcus granulosus	glycine receptor subunit beta	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0023	0.0656	0.0732
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0023	0.0656	0.0732
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0028	0.1402	0.5
Brugia malayi	nuclear hormone receptor	0.0046	0.3589	0.4
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0046	0.3589	0.4
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0046	0.3589	0.4
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0023	0.0656	0.0732
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0023	0.0656	0.0732
Trypanosoma cruzi	cytochrome P450, putative	0.0037	0.2519	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0026	0.1028	0.1145
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.3589	0.4
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0046	0.3589	0.3589
Schistosoma mansoni	nAChR subunit	0.0023	0.0656	0.0656
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0023	0.0656	0.0732
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.0852	0.0852
Schistosoma mansoni	retinoic acid receptor RXR	0.0046	0.3589	0.3589
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0023	0.0656	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0046	0.3589	0.4
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0046	0.3589	0.4
Echinococcus granulosus	voltage gated potassium channel	0.0026	0.1028	0.1145
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.0524	0.0584
Schistosoma mansoni	nAChR subunit	0.0023	0.0656	0.0656
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Schistosoma mansoni	RAR-like nuclear receptor	0.0046	0.3589	0.3589
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.0524	0.0584
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0046	0.3589	0.3589
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0656	0.0732
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0023	0.0656	0.0732
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0046	0.3589	0.4
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0023	0.0656	0.0732
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0852	0.0852
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0656	0.0732
Brugia malayi	tailless protein	0.0022	0.0524	0.0584
Entamoeba histolytica	hypothetical protein, conserved	0.0028	0.1402	0.5
Schistosoma mansoni	nAChR subunit	0.0023	0.0656	0.0656
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0046	0.3589	0.4
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0524	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0852	0.095
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1028	0.1145
Onchocerca volvulus		0.0046	0.3589	1
Brugia malayi	Cytochrome P450 family protein	0.0037	0.2519	0.2808
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0023	0.0656	0.0656
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.0524	0.0584
Leishmania major	cytochrome p450-like protein	0.0037	0.2519	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0046	0.3589	0.4
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0046	0.3589	0.4
Onchocerca volvulus		0.0023	0.0656	0.0433
Trypanosoma cruzi	cytochrome P450, putative	0.0037	0.2519	1
Echinococcus multilocularis	nAChR subunit	0.0023	0.0656	0.0732
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0023	0.0656	0.0656
Echinococcus granulosus	ecdysone induced protein 78C	0.0046	0.3589	0.4
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0046	0.3589	0.4
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0023	0.0656	0.0732
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.0524	0.0584
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0046	0.3589	0.4
Onchocerca volvulus	Protein ultraspiracle homolog	0.0046	0.3589	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0023	0.0656	0.0732
Brugia malayi	hypothetical protein	0.0024	0.0852	0.095
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.0524	0.0584
Echinococcus multilocularis	glycine receptor subunit beta	0.0023	0.0656	0.0732
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.0524	0.0584
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.0524	0.0584

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 4592 nM	Displacement of [3H]-flunitrazepam at GABA-A benzodiazepine receptor in rat brain cortical membranes	ChEMBL.	8709126
Ki (binding)	= 4592 nM	Displacement of [3H]-flunitrazepam at GABA-A benzodiazepine receptor in rat brain cortical membranes	ChEMBL.	8709126

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 163642