TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 449.565 | Formula: C25H27N3O3S
H donors: 1 H acceptors: 5 LogP: 5.42 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C[C@@H]1CC[C@H](CC1)c1ccc(cc1)C(=O)N(c1nnc(s1)Cc1ccccc1)C
InChi: 1S/C25H27N3O3S/c1-28(25-27-26-22(32-25)15-17-5-3-2-4-6-17)24(31)21-13-11-20(12-14-21)19-9-7-18(8-10-19)16-23(29)30/h2-6,11-14,18-19H,7-10,15-16H2,1H3,(H,29,30)/t18-,19-
InChiKey: NDZFXNAIULXKNW-WGSAOQKQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Babesia bovis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium yoelii	acyl transferase-related	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	sterol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative	Get druggable targets OG5_128200	All targets in OG5_128200
Theileria parva	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium parvum	diacylglycerol acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Brugia malayi	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium knowlesi	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium hominis	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus granulosus	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium falciparum	diacylglycerol O-acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium berghei	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0055	0.0059	0.2551
Brugia malayi	hypothetical protein	0.0026	0.0008	0.0335
Onchocerca volvulus		0.0055	0.0059	1
Brugia malayi	nuclear receptor RXR	0.0026	0.0008	0.0335
Brugia malayi	MBOAT family protein	0.0026	0.0007	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0573
Entamoeba histolytica	vacuolar protein sorting 26	0.0026	0.0007	1
Brugia malayi	Hhat protein	0.0026	0.0007	0.0314
Onchocerca volvulus		0.0026	0.0008	0.1314
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0013	0.0573
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.0008	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0153	0.0232	0.0232
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0029	0.0013	0.0013
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0055	0.0059	0.2551
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0026	0.0008	0.0335
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0007	1
Brugia malayi	diacylglycerol acyltransferase	0.0153	0.0232	1
Brugia malayi	MBOAT family protein	0.0026	0.0007	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0007	0.0314
Brugia malayi	orphan nuclear receptor NR2E1	0.0026	0.0008	0.0335
Schistosoma mansoni	zinc finger protein	0.0026	0.0007	0.0007
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0055	0.0059	0.2551
Echinococcus granulosus	FTZ F1 alpha	0.0055	0.0059	0.2551
Schistosoma mansoni	coup transcription factor	0.0055	0.0059	0.0059
Onchocerca volvulus		0.0026	0.0008	0.1314
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0153	0.0232	1
Leishmania major	glycerol uptake protein, putative	0.0026	0.0007	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.0008	0.0335
Brugia malayi	ecdysone receptor	0.0026	0.0008	0.0335
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0055	0.0059	0.2551
Trypanosoma cruzi	GUP1, putative	0.0026	0.0007	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0026	0.0007	0.0007
Echinococcus multilocularis	ecdysone induced protein 78C	0.0055	0.0059	0.2551
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.5701	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0055	0.0059	0.2551
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0007	0.0314
Echinococcus granulosus	nuclear receptor nhr 48	0.0026	0.0008	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0055	0.0059	0.2551
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0007	1
Schistosoma mansoni	nuclear receptor	0.0026	0.0008	0.0008
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0026	0.0007	0.0314
Brugia malayi	nuclear receptor NHR-67	0.0026	0.0008	0.0335
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0055	0.0059	0.2551
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0573
Brugia malayi	nuclear receptor NHR-88	0.0055	0.0059	0.2551
Toxoplasma gondii	preprocathepsin c precursor, putative	0.5701	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0055	0.0059	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Schistosoma mansoni	thyroid hormone receptor	0.0055	0.0059	0.0059
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0055	0.0059	0.2551
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0153	0.0232	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0026	0.0008	0.0335
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0055	0.0059	0.2551
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0055	0.0059	0.2551
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0055	0.0059	0.2551
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0055	0.0059	0.0059
Brugia malayi	nuclear hormone receptor	0.0026	0.0008	0.0335
Schistosoma mansoni	nuclear receptor nhr-48	0.0026	0.0008	0.0008
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0008	0.0008
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0055	0.0059	0.2551
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0026	0.0008	0.0335
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.0008	0.0335
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0007	0.0012
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0029	0.0013	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0573
Treponema pallidum	alginate O-acetylation protein (algI)	0.0026	0.0007	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0055	0.0059	0.2551
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0013	0.0573
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0026	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0007	0.0314
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.2166	0.3775	0.3775
Brugia malayi	steroid hormone receptor	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hhat protein	0.0026	0.0007	0.0314
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0026	0.0008	0.1314
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0007	0.0007
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0055	0.0059	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0007	0.0012
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.5701	1	1
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0153	0.0232	1
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0026	0.0007	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0055	0.0059	0.2551
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0055	0.0059	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0007	0.0012
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.0008	0.0335
Entamoeba histolytica	hypothetical protein, conserved	0.0026	0.0007	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Leishmania major	hypothetical protein, conserved	0.0026	0.0007	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0055	0.0059	0.2551
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.5701	1	1
Schistosoma mansoni	zinc finger protein	0.0026	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0055	0.0059	0.2551
Schistosoma mansoni	sterol O-acyltransferase 1	0.0026	0.0007	0.0007
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0007	0.0314
Brugia malayi	tailless protein	0.0026	0.0008	0.0335
Brugia malayi	MBOAT family protein	0.0026	0.0007	0.0314
Brugia malayi	hypothetical protein	0.0029	0.0013	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Schistosoma mansoni	nuclear hormone receptor	0.0055	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0055	0.0059	0.2551
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0007	0.0314
Schistosoma mansoni	hypothetical protein	0.0026	0.0007	0.0007
Onchocerca volvulus	Protein ultraspiracle homolog	0.0055	0.0059	1
Brugia malayi	MBOAT family protein	0.0026	0.0007	0.0314
Loa Loa (eye worm)	steroid hormone receptor	0.0055	0.0059	0.2551
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.3539	0.6194	1
Trypanosoma cruzi	GUP1, putative	0.0026	0.0007	1
Leishmania major	glycerol uptake protein, putative	0.0026	0.0007	1
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0026	0.0007	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0007	0.0314
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0029	0.0013	0.0573
Brugia malayi	Steroid receptor seven-up type 2	0.0055	0.0059	0.2551
Trichomonas vaginalis	porcupine, putative	0.0026	0.0007	0.0012
Schistosoma mansoni	thyroid hormone receptor	0.0055	0.0059	0.0059
Onchocerca volvulus		0.0026	0.0007	0.1229
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0007	0.0314
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.0008	0.0335
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0026	0.0007	0.0012
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0573
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0026	0.0007	0.0007
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0153	0.0232	0.0232
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0055	0.0059	0.2551
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0026	0.0007	0.0314
Entamoeba histolytica	hypothetical protein	0.0026	0.0007	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0026	0.0008	0.0335
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0007	0.0314
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0026	0.0008	0.1314
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0026	0.0007	0.0314
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0055	0.0059	0.2551
Loa Loa (eye worm)	DR-78	0.0026	0.0008	0.0335
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0026	0.0008	0.0335
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0055	0.0059	0.0059
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0013	0.0013
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0007	0.0314
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0055	0.0059	0.2551
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.5701	1	1
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0026	0.0007	0.0314
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0026	0.0008	0.0008
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0026	0.0007	0.0314
Toxoplasma gondii	cathepsin CPC1	0.5701	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0055	0.0059	0.2551
Toxoplasma gondii	cathepsin CPC2	0.2166	0.3775	0.3775
Schistosoma mansoni	nuclear receptor	0.0026	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.0008	0.0335
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0026	0.0007	0.0314
Loa Loa (eye worm)	MBOAT family protein	0.0026	0.0007	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Brugia malayi	hypothetical protein	0.0026	0.0008	0.0335
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0007	0.0007
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.5701	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0026	0.0007	0.0314
Brugia malayi	MBOAT family protein	0.0026	0.0007	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.0059	0.2551
Brugia malayi	nuclear receptor RXR	0.0029	0.0013	0.0573
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0153	0.0232	0.0232
Loa Loa (eye worm)	nuclear hormone receptor	0.0026	0.0008	0.0335
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0055	0.0059	0.2551
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0007	1
Echinococcus granulosus	sterol O acyltransferase 1	0.0026	0.0007	0.0314
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0055	0.0059	0.2551
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0026	0.0007	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0007	0.0314
Brugia malayi	nuclear hormone receptor family member odr-7	0.0026	0.0008	0.0335
Trypanosoma cruzi	glycerol uptake protein, putative	0.0026	0.0007	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0007	1
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0008	0.0008
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0026	0.0008	0.0335
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0055	0.0059	0.2551
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0026	0.0007	0.0007
Brugia malayi	ecdysteroid receptor	0.0055	0.0059	0.2551
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.2166	0.3775	0.3775
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0153	0.0232	0.0232
Schistosoma mansoni	retinoic acid receptor RXR	0.0055	0.0059	0.0059
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0055	0.0059	0.2551
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0573
Echinococcus multilocularis	sterol O acyltransferase 1	0.0026	0.0007	0.0314
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0055	0.0059	0.0059
Loa Loa (eye worm)	hhat protein	0.0026	0.0007	0.0314
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0055	0.0059	0.0059
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0026	0.0007	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0059	0.2551
Leishmania major	glycerol uptake protein, putative	0.0026	0.0007	1
Brugia malayi	hypothetical protein	0.0029	0.0013	0.0573
Brugia malayi	nuclear receptor NHR-88	0.0026	0.0008	0.0335
Echinococcus granulosus	thyroid hormone receptor alpha	0.0026	0.0008	0.0335
Brugia malayi	conserved hypotetical protein	0.0026	0.0008	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0187	0.8043
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0055	0.0059	0.2551
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.0008	0.0335
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0026	0.0007	0.0314
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0029	0.0013	0.0573
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0007	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0026	0.0008	0.0335
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0055	0.0059	0.2551
Brugia malayi	nuclear hormone receptor	0.0055	0.0059	0.2551
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0055	0.0059	0.0059
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0055	0.0059	0.2551
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0055	0.0059	0.2551
Echinococcus multilocularis	nuclear receptor nhr 48	0.0026	0.0008	0.0335
Schistosoma mansoni	RAR-like nuclear receptor	0.0055	0.0059	0.0059
Brugia malayi	photoreceptor-specific nuclear receptor	0.0055	0.0059	0.2551
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0153	0.0232	1
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.0008	0.0335
Leishmania major	glycerol uptake protein, putative	0.0026	0.0007	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0008	0.0335
Trypanosoma brucei	glycerol uptake protein, putative	0.0026	0.0007	1
Leishmania major	glycerol uptake protein, putative	0.0026	0.0007	1
Onchocerca volvulus	Bile acid receptor homolog	0.0055	0.0059	1
Toxoplasma gondii	hypothetical protein	0.0026	0.0007	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human recombinant DGAT1 in Chang cells using [14C]-glycerol as substrate assessed as decrease in triglycerides synthesis after 6 hrs by HPLC analysis	ChEMBL.	22405833
IC50 (binding)	> 10 uM	Inhibition of human recombinant DGAT1 expressed in baculovirus infected Sf9 cells after 60 mins by scintillation counting method	ChEMBL.	22405833

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2012635

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1636581