TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 332.781 | Formula: C17H17ClN2O3
H donors: 1 H acceptors: 3 LogP: 2.4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCCN1CCCNC1=C(Cl)C(=O)c2c(C1=O)cccc2
InChi: 1S/C17H17ClN2O3/c18-14-15(19-8-4-10-20-9-3-7-13(20)21)17(23)12-6-2-1-5-11(12)16(14)22/h1-2,5-6,19H,3-4,7-10H2
InChiKey: XCYPTXXOANJQED-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0146	0.0146
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0538	0.331	0.2895
Loa Loa (eye worm)	phosphatidylinositol 3	0.0104	0.0583	0.0583
Echinococcus granulosus	nervana 2	0.002	0.0061	0.0061
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0104	0.0583	0.0583
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.014	0.014
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0104	0.0583	0.0524
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0104	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0327	0.1985	0.1985
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1042	0.6468	0.6468
Trichomonas vaginalis	PIKK family atypical protein kinase	0.02	0.1188	0.1188
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0127	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0431	0.2635	0.2635
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.095	0.5889	0.5889
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0104	0.0583	0.0583
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1606	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1606	1	1
Entamoeba histolytica	hypothetical protein	0.0304	0.1838	0.1838
Loa Loa (eye worm)	phosphatidylinositol 3	0.0104	0.0583	0.0583
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0538	0.331	0.331
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0013	0.0013
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0104	0.0583	0.0583
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0104	0.0583	0.0524
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0104	0.0583	0.0583
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0759	0.4694	0.4619
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0104	0.0583	0.0626
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1277	0.794	0.794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1371	0.8528	0.8528
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0104	0.0583	0.0583
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0075	0.0075
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0104	0.0583	0.0583
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0104	0.0583	0.0583
Loa Loa (eye worm)	phosphatidylinositol 3	0.1606	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0104	0.0583	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0538	0.331	0.331
Plasmodium vivax	hypothetical protein	0.0104	0.0583	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1277	0.794	0.794
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0867	0.5369	0.5369
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0235	0.1406	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0583	0.0583
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0161	0.0161
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0538	0.331	0.3268
Loa Loa (eye worm)	hypothetical protein	0.0304	0.1838	0.1838
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0104	0.0583	0.0524
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1194	0.7421	0.7421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0867	0.5369	0.5369
Plasmodium vivax	hypothetical protein, conserved	0.0104	0.0583	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1606	1	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0104	0.0583	0.0583
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0104	0.0583	0.045
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0104	0.0583	0.0583
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0104	0.0583	0.0524
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0304	0.1838	0.1838
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0304	0.1838	0.1838
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0161	0.0161
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0104	0.0583	0.0583
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1194	0.7421	1
Echinococcus multilocularis	nervana 2	0.002	0.0061	0.0061
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0127	0.0127
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1606	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0304	0.1838	0.1787
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0867	0.5369	0.5369
Onchocerca volvulus		0.0104	0.0583	0.5
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0104	0.0583	0.0626
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0304	0.1838	0.1787
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0104	0.0583	0.0583
Mycobacterium leprae	conserved hypothetical protein	0.0104	0.0583	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1277	0.794	0.794
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0104	0.0583	0.0583
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0061	0.0061
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0104	0.0583	0.0583
Toxoplasma gondii	FATC domain-containing protein	0.0304	0.1838	0.2346
Giardia lamblia	Hypothetical protein	0.0104	0.0583	0.0524
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0104	0.0583	0.0583
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0104	0.0583	0.0583
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1278	0.7949	0.792
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0104	0.0583	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0959	0.5949	0.5949
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0235	0.1406	0.1406
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.02	0.1188	0.1133
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0866	0.5361	0.5361
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0146	0.0146
Echinococcus multilocularis	Zinc finger, PHD finger	0.0104	0.0583	0.0583
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0104	0.0583	0.0583
Echinococcus granulosus	serine/threonine protein kinase	0.0022	0.0075	0.0075
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0104	0.0583	0.0583
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.014	0.014
Echinococcus multilocularis	rac serine:threonine kinase	0.0022	0.0075	0.0075
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0104	0.0583	0.0524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.095	0.5889	0.5889
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0104	0.0583	0.0524
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0104	0.0583	0.0583
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0304	0.1838	0.1838
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1606	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0104	0.0583	0.0583
Entamoeba histolytica	protein kinase, putative	0.0033	0.014	0.014
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0075
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0538	0.331	0.331
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0538	0.331	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0959	0.5949	0.5949
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0538	0.331	0.331
Loa Loa (eye worm)	hypothetical protein	0.0338	0.2055	0.2055
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.002	0.0062	0.0062
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1606	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0161	0.0161
Echinococcus multilocularis	nervana 2	0.002	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0583	0.0583
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.014	0.014
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0104	0.0583	0.0583
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0104	0.0583	0.045
Brugia malayi	FAT domain containing protein	0.0235	0.1406	0.1406
Loa Loa (eye worm)	phosphatidylinositol 3	0.0538	0.331	0.331
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0104	0.0583	0.0626
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0104	0.0583	0.0583
Echinococcus granulosus	nervana 2	0.002	0.0061	0.0061
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	0.0524
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0538	0.331	0.331
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0538	0.331	0.331
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	0.0583
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0304	0.1838	0.1838
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1606	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0538	0.331	0.3268
Echinococcus granulosus	serine threonine protein kinase nrc	0.002	0.0062	0.0062
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1277	0.794	0.794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0304	0.1838	0.1838
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0104	0.0583	0.0583
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0104	0.0583	0.0583
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1606	1	1
Entamoeba histolytica	protein kinase rad3, putative	0.0304	0.1838	0.1838
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0104	0.0583	0.0524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1194	0.7421	0.7421
Loa Loa (eye worm)	phosphatidylinositol 3	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0538	0.331	0.331
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0104	0.0583	0.0583
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0104	0.0583	0.0626
Entamoeba histolytica	hypothetical protein	0.0104	0.0583	0.0583
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1194	0.7421	0.7421
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0959	0.5949	0.5949
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1194	0.7421	0.7421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0866	0.5361	0.5361
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0104	0.0583	0.0583
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1606	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1278	0.7949	0.7822
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0338	0.2055	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0131	0.0131
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0075	0.0013
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0061	0.0061
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0104	0.0583	0.0583
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0161	0.0161
Entamoeba histolytica	protein kinase 2, putative	0.002	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.02	0.1188	0.1188
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0104	0.0583	0.0524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0304	0.1838	0.1838
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0104	0.0583	0.0583
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0104	0.0583	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1606	1	1
Giardia lamblia	GTOR	0.1606	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0104	0.0583	0.0524
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0104	0.0583	0.0583
Trypanosoma cruzi	Protein kinase B	0.0022	0.0075	0.0013
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0104	0.0583	0.0583
Echinococcus multilocularis		0.0104	0.0583	0.0583
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0104	0.0583	0.0583
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0304	0.1838	0.1838
Trichomonas vaginalis	conserved hypothetical protein	0.0338	0.2055	0.2055
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.014	0.014
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1606	1	1
Entamoeba histolytica	hypothetical protein	0.0104	0.0583	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0235	0.1406	0.1406
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0182	0.0182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1194	0.7421	0.7421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1077	0.6686	0.6686
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0304	0.1838	0.1838
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.014	0.014
Entamoeba histolytica	protein kinase, putative	0.0031	0.0127	0.0127
Trypanosoma cruzi	target of rapamycin kinase 3	0.1278	0.7949	0.7936
Schistosoma mansoni	hypothetical protein	0.0235	0.1406	0.1406
Entamoeba histolytica	hypothetical protein	0.0104	0.0583	0.0583
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0182	0.0182
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1194	0.7421	0.7421
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0104	0.0583	0.0583
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0104	0.0583	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0104	0.0583	0.0626
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.014	0.014
Echinococcus multilocularis	serine protein kinase ATM	0.0304	0.1838	0.1838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1194	0.7421	0.7421
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0104	0.0583	0.0583
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.014	0.014
Brugia malayi	Protein kinase domain containing protein	0.0033	0.014	0.014
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0104	0.0583	0.0583
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0104	0.0583	0.0583
Onchocerca volvulus		0.0104	0.0583	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.014	0.014
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0061	0.0061
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0304	0.1838	0.1838
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0104	0.0583	0.0583
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0104	0.0583	0.0583
Entamoeba histolytica	protein kinase, putative	0.0033	0.014	0.014
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0104	0.0583	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0867	0.5369	0.5369
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1277	0.794	0.794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1606	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0866	0.5361	0.5361
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0104	0.0583	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0104	0.0583	1
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0104	0.0583	0.0524
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0304	0.1838	0.1838
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0104	0.0583	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0304	0.1838	0.1722
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0538	0.331	0.331
Entamoeba histolytica	hypothetical protein	0.0104	0.0583	0.0583
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0538	0.331	0.3215
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1606	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0104	0.0583	0.0583
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0104	0.0583	0.0524
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0104	0.0583	0.0583
Echinococcus granulosus	serine protein kinase ATM	0.0304	0.1838	0.1838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0538	0.331	0.331
Schistosoma mansoni	hypothetical protein	0.0104	0.0583	0.0583
Trichomonas vaginalis	conserved hypothetical protein	0.0235	0.1406	0.1406
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0075	0.0075
Loa Loa (eye worm)	phosphatidylinositol 3	0.0104	0.0583	0.0583
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0667	0.4115	0.4032
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0104	0.0583	0.0583
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0061	0.0061
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0104	0.0583	0.0524
Schistosoma mansoni	serine/threonine-protein kinase	0.0022	0.0075	0.0075
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0538	0.331	0.3215
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.002	0.0062	0.0062
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1606	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0104	0.0583	0.045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0104	0.0583	0.0583
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.1188	0.1188

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 16.17 uM	Antiproliferative activity against human KB cells	ChEMBL.	22437113
IC50 (functional)	= 20.4 uM	Antiproliferative activity against human A549 cells	ChEMBL.	22437113

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	22437113

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2018803

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1638507